Clinical trials: System Sclerosis
Multiple Sclerosis
A Study to Assess COVID-19 Vaccination Immune Response in Multiple Sclerosis Patients Treated With Ofatumumab
This was a non-interventional, retrospective, observational cohort study involving the abstraction and review of pertinent data from medical records by participating physicians, who completed a customized electronic case report…
- Trial name
- NCT06460324
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Novartis Pharmaceuticals
Relapsing Remitting Multiple Sclerosis
A Tolerability Study of ALKS 8700 in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS) EVOLVE-MS-2
The objectives of this study are to evaluate the utility of two gastrointestinal (GI) symptom scales (Individual GI Symptom and Impact Scale {IGISIS} and Global GI Symptom and Impact Scale {GGISIS}) in assessing GI tolerability…
- Trial name
- NCT03093324
- Testing
- ALKS 8700, Dimethyl Fumarate
- Where
- 67 sites in United States, Germany and 1 more
- Volunteers
- 506 people
- Sponsor
- Biogen
Centreal Neurological Condition, Acquired Brain Injury (Including Stroke)
Individualised Cryoneurolysis to Treat Pain in the Context of Spasticity in the Upper and Lower Extremities
Spasticity is an umbrella term for impairments of muscle tone and control in people with damage to the brain and spinal cord. It is highly prevalent and results in pain, stiffness, and contribute to difficulties in activities of…
- Conditions
- Centreal Neurological Condition, Acquired Brain Injury (Including Stroke), Multiple Sclerosis, Spinal Cord Injury
- Trial name
- ICE (NCT07303582)
- Testing
- Cryoneurolysis, Botulinum toxin
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Oxford University Hospitals NHS Trust
Multiple Sclerosis
Exercise Therapy in Multiple Sclerosis
Exercise or active rehabilitation is a non-pharmacological approach increasingly used for people with Multiple Sclerosis (MS), in support of disease-modifying therapies (DMTs), with the aim of improving the quality of life and…
- Trial name
- RehaMS (NCT04294979)
- Testing
- Physical Therapy
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Neurological Conditions, Brain Diseases
NEO-REEDUC - Mixed Reality for Motor Rehabilitation: a Prospective, Multicenter, Controlled, Randomized, Open Study.
This study aims to assess the effectiveness of a motor rehabilitation protocol that includes mixed reality activities, compared to conventional rehabilitation, on postural stability in children and adult patients with…
- Conditions
- Neurological Conditions, Brain Diseases, Cerebral Palsy, Parkinson Disease (PD)
- Trial name
- NCT07063810
- Testing
- Mixed Reality Rehabilitation
- Where
- 5 sites in France
- Volunteers
- 76 people
- Sponsor
- Slb Pharma
Adult Lymphocyte Depletion Hodgkin Lymphoma, Adult Lymphocyte Predominant Hodgkin Lymphoma
Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma
This phase II trial studies how well giving brentuximab vedotin together with combination chemotherapy works in treating older patients with previously untreated stage II-IV Hodgkin lymphoma (HL).
- Conditions
- Adult Lymphocyte Depletion Hodgkin Lymphoma, Adult Lymphocyte Predominant Hodgkin Lymphoma, Adult Mixed Cellularity Hodgkin Lymphoma, Adult Nodular Sclerosis Hodgkin Lymphoma
- Trial name
- NCT01476410
- Testing
- brentuximab vedotin, doxorubicin hydrochloride, vinblastine
- Where
- 7 sites in United States
- Volunteers
- 49 people
- Sponsor
- Northwestern University
Trigeminal Neuralgia, Multiple Sclerosis
Symptomatic Trigeminal Neuralgia Attributed to Multiple Sclerosis - a Prospective Study in 60 Patients
Clinical characteristics, neuroanatomical findings and efficacy of medical and surgical treatment of symptomatic trigeminal neuralgia - a systematic prospective study of 60 consecutive patients
- Conditions
- Trigeminal Neuralgia, Multiple Sclerosis, Pain, Neuropathic
- Trial name
- NCT04371575
- Testing
- Carbamazepine
- Volunteers
- 60 people
- Sponsor
- Stine Maarbjerg, MD PhD
Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorders
The French Multiple Sclerosis Registry
OFSEP is an observational cohort of Multiple Sclerosis (MS) and related disorders set up in France. It aims to provide a major epidemiological tool on MS for the scientific community in France and abroad.
- Trial name
- OFSEP (NCT02889965)
- Where
- France
- Volunteers
- 54,000 people
- Sponsor
- Hospices Civils de Lyon
Systemic Sclerosis
Recombinant Human Relaxin in the Treatment of Diffuse Scleroderma
Relaxin is a naturally occurring protein prduced by the ovary or placenta in pregnancy. It has ani-fibrotic properties. Previous studies have shown that relaxin is safe at concentrations upto 60 times higher than achieved in…
- Trial name
- NCT00704665
- Testing
- Relaxin
- Volunteers
- 231 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Multiple Sclerosis
Balance and Falls in Multiple Sclerosis
The study hypothesis is that for people with moderate to severe multiple sclerosis postural balance and walking improve and the risk of accidental falls are reduced after participating in a specific training intervention of 7…
- Trial name
- NCT02209467
- Testing
- Group balance training
- Where
- 7 sites in Sweden
- Volunteers
- 52 people
- Sponsor
- Örebro County Council
Systemic Sclerosis
The Effect of Cognitive Exercise Therapy Approach in Individuals With Systemic Sclerosis
The aim of this study is to investigate the effects of Cognitive Exercise Therapy Approach (BETY) on vascularization, muscle strength, functionality, anti-inflammatory and biopsychosocial status in individuals with systemic…
- Trial name
- NCT05453071
- Testing
- Cognitive Exercise Therapy Approach (BETY)
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Hacettepe University
Multiple Sclerosis
Safety Trial of High Dose Oral Vitamin D3 With Calcium in Multiple Sclerosis
Vitamin D likely plays a role in the geography of Multiple Sclerosis (MS), and patients at risk and with MS have relatively low Vitamin D levels compared to their normal counterparts.
- Trial name
- VitD4MS (NCT00644904)
- Testing
- Vitamin D3
- Where
- Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Multiple Sclerosis, West Nile Virus
Investigating Visuo-spatial Abilities and Psychological Effects in West Nile and Multiple Sclerosis Patients with a Focus on a Possible Rehabilitation Protocol
The study aims to investigate visuospatial abilities and psychological outcomes in patients with multiple scleroris (MS) and patients with West Nile virus infection (vWN).
- Trial name
- Visuomind (NCT06640660)
- Testing
- Mindlenses Professional, Conventional rehabilitation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Amyotrophic Lateral Sclerosis
Repetitive Transcranial Magnetic Stimulation as Therapy for Apathy in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of central and peripheral motor neurons. ALS leads to death usually within 3 to 5 years from the onset of the symptoms.
- Trial name
- NCT03892382
- Testing
- rTMS
- Where
- Poland
- Sponsor
- Jagiellonian University
Relapsing Remitting Multiple Sclerosis
Safety, Tolerability And Mechanism Of Action Of Boswellic Acids (BA) In Multiple Sclerosis (SABA)
To determine the safety and tolerability of BOSWELAN in subjects with multiple sclerosis or clinically isolated syndrome and to describe the effect of Boswellic acids on the disease activity as assessed by monthly MRI measures.
- Trial name
- SABA (NCT01450124)
- Testing
- Boswellic acids (BOSWELAN)
- Where
- 2 sites in Germany
- Volunteers
- 29 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Amyotrophic Lateral Sclerosis
Enoxacin for Amyotrophic Lateral Sclerosis (ALS)
The study will assess the safety of the drug enoxacin at specific dose levels in adults with ALS.
- Trial name
- REALS-1 (NCT04840823)
- Testing
- Enoxacin
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- McGill University
Multiple Sclerosis
Effects of a Multiple Sclerosis Relapse Therapy on Offspring Neurocognitive Development and Behaviour
Introduction: Fetal exposure to glucocorticoids (GCs) used to induce fetal lung maturation in women threatened by premature labour is known to induce aberrations in brain development and stress sensitivity, cognitive dysfunction…
- Trial name
- MS-Children (NCT04832269)
- Testing
- Exposure to methylprednisolone during pregnancy
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Multiple Sclerosis
MRI Study of the Mechanisms Underlying Irreversible Disability in Multiple Sclerosis
Multiple sclerosis (MS) is the first non-traumatic cause of disability in young people, responsible for physical but also cognitive deficits.
- Trial name
- SEP-MRI (NCT03356366)
- Testing
- MRI 3T, MRI 1,5T, MRI 7T
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple Sclerosis, Lower Urinary Tract Symptoms
Effectiveness of TTNS in MS Patients With Lower Urinary Track Symptoms
Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system. It is characterized with demyelinated plaques affecting subcortical, brain stem, and spinal cord nerve fibers.
- Trial name
- NCT06263556
- Testing
- Pelvic floor exercises, Transcutaneous posterior tibial nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Multiple Sclerosis
BrainAgeMS - a Comparative Study of Brain Aging in Healthy and Patients With Multiple Sclerosis
The purpose of this study is to investigate new quantitative MRI-sequences for assessment of age-specific data for the prediction of brain aging.
- Trial name
- BrainAgeMS (NCT06221631)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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