Clinical trials: Systemic Disease
Scleroderma, Systemic, Ulcer
Light Treatment for Scleroderma Finger Ulcers
Digital (finger) ulcers are common in patients with systemic sclerosis (SSc) and causes much pain and affects how patients use their hands.
- Trial name
- DULight (NCT02472743)
- Testing
- Custom-built phototherapy lamp
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Manchester
Periodontitis
Multi-omics Analysis of Oral-gut Microbial Profiles
Periodontitis is a chronic inflammatory disease of the tooth supporting structures induced by a dysbiosis in the oral and subgingival microenvironment of susceptible patients.
- Trial name
- NCT06261515
- Testing
- Active periodontal treatment
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Systemic Lupus Erythematosus
A Prospective, Single Arm, Open Label, Proof of Concept Clinical Study of Sulfasalazine in the Treatment of Active Systemic Lupus Erythematosus
The goal of this clinical trial is to learn if sulfasalazine is safe and feasible in the treatment of active lupus erythematosus (SLE).
- Trial name
- NCT06360068
- Testing
- Sulfasalazine Tablets
- Volunteers
- 20 people
- Sponsor
- Qiong Fu
Chronic Graft Versus Host Disease
A Clinical Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Belumosudil in Chinese Adolescents With cGVHD Who Have Had an Inadequate Response to Glucocorticoids or Other Systemic Therapies
This is a single group, Phase 4, single-arm post-marketing study for treatment. The purpose of this study is to verify the pharmacokinetics, efficacy, and safety of belumosudil mesylate tablets in Chinese adolescent participants…
- Trial name
- NCT06616415
- Testing
- Belumosudil
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- Sanofi
Neural Tube Defects, Newborn Sepsis
Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Neural Tube Defects?
We aimed to investigate whether Neutrophil Lymphocyte Ratio is a Prognostic Factor of Sepsis in Newborns with operated Neural Tube Defects?
- Trial name
- NCT04135274
- Testing
- Neutrophil to lymphocyte ratio
- Volunteers
- 57 people
- Sponsor
- Tepecik Training and Research Hospital
Post Dural Puncture Headache
Post Dural Puncture Headache After Accidental Dural Puncture
Epidural anesthesia is associated with potential risks and complications, post dural puncture headache (PDPH) one of the most recognized with epidural or spinal anesthesia.
- Trial name
- NCT01448590
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Scleroderma (Limited and Diffuse)
Respiratory Muscle Training in Scleroderma
The aim of this study is to investigate the effects of IMT on respiratory muscle strength, pulmonary function tests, quality of life aerobic capacity, dyspnea, fatigue and physical activity level in scleroderma patients with ILD.
- Trial name
- NCT06684132
- Testing
- Inspiratory muscle training, Exercise
- Volunteers
- 30 people
- Sponsor
- Firat University
Scleroderma
Respiratory Muscle Strength and Aerobic Capacity in Scleroderma
Primary aim of this study was to compare respiratory muscle strength, aerobic capacity, dyspnea, pulmonary function tests and fatigue values with healthy controls.
- Trial name
- NCT06554132
- Testing
- Scleroderma Group, Healthy group
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Firat University
Schizophrenia, Physical Exercise
Physical Exercise on Simple Inflammatory Markers, Systemic Immune Inflammation Index, and Systemic Immune Response Index
Mental health is defined as a state of well-being in which a person can realize their talents, cope with the normal stresses of life, and support society by working efficiently and productively.
- Trial name
- NCT06574893
- Testing
- physical exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Systemic Sclerosis, Digital Ulcer
Mesenchymal Stromal Cells as Treatment for Digital Ulcers in Systemic Sclerosis
The MANUS Trial aims to examine the safety, feasibility and potential efficacy of intramuscularly injected allogeneic mesenchymal stromal cells as treatment for digital ulcers of systemic sclerosis.
- Trial name
- MANUS (NCT03211793)
- Testing
- Mesenchymal stromal cells
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Primary Systemic (AL) Amyloidosis
The VITAL Amyloidosis Study, a Global Phase 3, Efficacy and Safety Study of NEOD001 in Patients With AL Amyloidosis
This is a multi-center, international, randomized, double-blind, placebo-controlled, two-arm efficacy and safety study in subjects newly diagnosed with AL amyloidosis.
- Trial name
- VITAL (NCT02312206)
- Testing
- NEOD001
- Where
- 79 sites in United States, Australia and 13 more
- Volunteers
- 260 people
- Sponsor
- Prothena Biosciences Ltd.
Uterine Cervical Cancer, Endometrial Cancer
Clinical Trial of PM00104 (Zalypsis®) in Patients With Advanced and/or Metastatic Endometrial or Cervical Cancer Previously Treated With One Line of Systemic Chemotherapy
This study is a phase II clinical and pharmacokinetic trial of PM00104 (Zalypsis®) in patients with advanced and/or metastatic endometrial or cervical cancer previously treated with one line of systemic chemotherapy to evaluate…
- Trial name
- NCT00900562
- Testing
- Zalypsis ( PM00104)
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- PharmaMar
Eosinophilic Granulomatosis With Polyangiitis
Efficacy and Safety of Depemokimab Compared With Mepolizumab in Adults With Relapsing or Refractory Eosinophilic Granulomatosis With Polyangiitis (EGPA)
This study aims to investigate the efficacy and safety of depemokimab compared with mepolizumab in adults with relapsing or refractory EGPA receiving SoC therapy.
- Trial name
- OCEAN (NCT05263934)
- Testing
- Depemokimab, Mepolizumab
- Where
- 63 sites in United States, Argentina and 16 more
- Volunteers
- 163 people
- Sponsor
- GlaxoSmithKline
Follicular Lymphoma, Lymphoma
A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma
The purpose of this study is to find out if mosunetuzumab is an effective treatment in people with follicular lymphoma that was recently diagnosed and have not yet received any treatments for their disease.
- Trial name
- NCT05389293
- Testing
- Mosunetuzumab, Zanubrutinib
- Where
- 9 sites in United States
- Volunteers
- 152 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Septic Shock, Acute Kidney Injury
Safety and Efficacy of HA380 Hemoadsorption in Patients With Septic Shock
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Intensive care unit (ICU) mortality in patients with septic shock and acute kidney injury (AKI) requiring continuous…
- Trial name
- HEMOX-HDF (NCT04997421)
- Testing
- Combined HA380 hemoadsorption and continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes, Continuous veno-venous hemodiafiltration (CVVHDF) with Oxiris®-AN69 membranes
- Where
- Finland
- Volunteers
- 40 people
- Sponsor
- Turku University Hospital
Immune and Microbial Reconstitution, Systemic Viral Infection
Monitoring of Immune and Microbial Reconstitution in (HCT) and Novel Immunotherapies
This protocol serves as a mechanism to collect, store, and distribute bodily fluid and tissue samples obtained from Hematopoietic Cell Transplant (HCT) or novel immunotherapy patients and their donors at the Masonic Cancer Center…
- Conditions
- Immune and Microbial Reconstitution, Systemic Viral Infection, Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
- Trial name
- NCT03557749
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Infant, Newborn, Neonatal SEPSIS
7 Days Versus 14 Days of Antibiotics for Neonatal Sepsis
The optimum duration of intravenous antibiotic therapy for culture-proven neonatal bacterial sepsis is not known. Current practices, ranging from 7 days to 14 days of antibiotics, are not evidence-based.
- Conditions
- Infant, Newborn, Neonatal SEPSIS, Anti-bacterial Agents, Recurrence
- Trial name
- NCT03280147
- Testing
- 7-day course of antibiotics, 14-day course of antibiotics
- Where
- 7 sites in India
- Volunteers
- 261 people
- Sponsor
- Indian Council of Medical Research
COVID-19, Methylprednisolone
Investigation of Hospitalisation Times and Mortality According to Drug Dose in Patients Given Systemic Methylprednisolone With a Pre-diagnosis of Covid-19 Pneumonia; Retrospective Study
Aim:There is still not enough data to determine methylprednisolone treatment timing, dosage, duration of use and indication in Covid 19 pneumonia.
- Conditions
- COVID-19, Methylprednisolone, Pneumonia
- Trial name
- NCT04847687
- Testing
- methylprednisolone
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Maternal Sepsis, Neonatal Sepsis
Smart Discharges for Mom & Baby
This study aims to build a predictive algorithm that identifies mother-newborn dyads most at risk of death or complications in the 6 weeks after birth.
- Trial name
- NCT05730387
- Testing
- Observational only
- Where
- Canada
- Volunteers
- 7,182 people
- Sponsor
- University of British Columbia
Systemic Lupus Erythematosus
Addressing Disparities in Lupus Care Through an Integrated Care Management Program
The aim of this study is to identify lupus patients receiving care at Brigham and Women's Hospital (BWH) who are at high risk for potentially avoidable acute care utilization, inconsistent ambulatory care use, and adverse…
- Trial name
- Rheum-iCMP (NCT03915652)
- Testing
- Rheum iCMP
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Brigham and Women's Hospital