Clinical trials: Systemic Infection
Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection
Impact of Nurses' Behavior Change and Evidence-Based Practice Implementation on Quality Indicators in Intensive Care Units in Low- and Middle-Income Countries
Study title: Impact of nurses' behavior change and implementing evidence-based practice to improve quality indicators in intensive care units in low-and middle-income countries Background and Rationale: Quality care is crucial…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection, Pressure Ulcers (Hospital-acquired Pressure Injuries), Prolonged Intensive Care Unit Length of Stay
- Trial name
- NCT07397364
- Testing
- Evidence based practices bundles of care
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Circadian Rhythm Disorders, Sepsis
Functionality of Endogenous Biological Clock in Sepsis
The aim of the current study is to demonstrate dysregulation of immune system΄s circadian rhythms as a consequence of sepsis, as well as marked malfunction of the central circadian clock in comparison with patients without sepsis…
- Trial name
- NCT04063332
- Where
- 2 sites in Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Sepsis
Study of Early Enteral Dextrose in Sepsis
This study is a prospective single-center randomized double-blinded placebo-controlled clinical trial testing the effects of early enteral dextrose as a therapeutic agent in critically ill patients with sepsis.
- Trial name
- SEEDS (NCT03454087)
- Testing
- Enteral Dextrose Infusion, Free Water Infusion
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Pittsburgh
Influenza, Human, Vaccination; Sepsis
Nudging for Vaccination : Efficacity and Acceptability Among Medical Students
Nudge is a set of methods aimed at helping people adopt a behavior by a gentle prompt, conscious or not. Classically, Nudges rely on heuristics and cognitive biases.
- Trial name
- NCT03768596
- Testing
- Nudge, vaccination form
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Adriaan Barbaroux
Septic Shock, Sepsis
Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control
Study of the lipid metabolism under glycemic control in septic patients who got an university 14 bed ICU. Hypothesis: establish a relationship between lipid metabolism alterations and glycemic control or infusion of exogenous…
- Trial name
- NCT01013662
- Testing
- glycemic control
- Volunteers
- 69 people
- Sponsor
- University of Sao Paulo
Pneumonia, Ventilator-Associated
Human Recombinant Interferon Gamma in the Treatment of Ventilator-acquired Pneumonia in ICU Patients
Clinical presentation of patients after severe injury such as a severe infection, trauma or extensive burns is characterized by the simultaneous occurrence of dysregulation of the initial inflammatory response and…
- Trial name
- IGNORANT (NCT05843786)
- Testing
- Interferon gamma
- Where
- 9 sites in France
- Volunteers
- 132 people
- Sponsor
- Hospices Civils de Lyon
Sepsis, Cognitive Impairment
HMGB1 in ICU-survivors
Is HMGB1 (High Mobility Group Box 1) elevated in sepsis patients for weeks after recovery from severe sepsis/septic shock, similar to what has been observed in mice? Do patients recovering from severe sepsis/septic shock suffer…
- Trial name
- NCT02914756
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska University Hospital
Influenza
Mucosal and Systemic Immunity After Viral Challenge of Healthy Volunteers Vaccinated With Inactivated Influenza Vaccine Via the Intranasal Versus Intramuscular Route
Background: Influenza (flu) is a contagious respiratory virus that makes humans sick. Usually its symptoms are mild, but they can be dangerous.
- Trial name
- NCT03845231
- Testing
- Flucelvax(R), Human Challenge virus
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Bloodstream Infection, Sepsis
Clinical Performance Study of Microbio InfectID-BSI for Detection of Bacteria and Yeast With Patient Blood Samples
The objective of the study is to determine the efficacy of the Microbio InfectID-BSI qPCR kit in a clinical laboratory environment using patient whole blood for pathogen detection and identification versus standard of care…
- Conditions
- Bloodstream Infection, Sepsis, Septic Shock
- Trial name
- IID-BSIqPCR (NCT06531031)
- Testing
- InfectID-BSI (Bloodstream Infection) qPCR Assay
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 1,500 people
- Sponsor
- Microbio Co Ltd
Staphylococcus Aureus
Prospective Study of Staphylococcus Aureus Clinical Isolates Versus Colonization: RNAs as Potential Biomarkers for Bloodstream Infections
The primary objective is to demonstrate that the risk of S. aureus bacteremia (SAB) is correlated to the RNA III and SprD RNAs expression
- Trial name
- PROSAC (NCT03833102)
- Testing
- biological analysis
- Where
- France
- Volunteers
- 165 people
- Sponsor
- Rennes University Hospital
Septic Shock, Vein Collapsibility
Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination
The study aims at clarification of venous collapsibility measures with real venous flow measurements during dynamic maneuver testing fluid responsiveness in septic shock patients.
- Conditions
- Septic Shock, Vein Collapsibility, Intravascular Doppler, Volume Responsiveness in Septic Shock
- Trial name
- FRIEND (NCT02676427)
- Testing
- passive leg raising
- Where
- Czechia
- Volunteers
- 60 people
- Sponsor
- Charles University, Czech Republic
Endotoxemia
Ethnic Differences in the Inflammatory Response in Systemic Inflammation
The purpose of this study is to investigate putative ethnic differences in the proinflammatory response in human endotoxemia.
- Trial name
- NCT00284869
- Testing
- LPS
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Sepsis
Prebiotic Fiber to Prevent Pathogen Colonization in the ICU
This is a pilot trial testing enteral feeds that are high versus low in prebiotic fiber in 20 critically ill adults. The long-term goal is to determine the efficacy of fiber for the prevention of pathogen colonization/infection…
- Trial name
- NCT03509753
- Testing
- High Fiber, Low Fiber
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Sepsis, Sepsis Bacterial
Clinical Outcomes and Inflammatory Responses in Viral vs. Bacterial Sepsis
This observational cohort study aims to compare clinical outcomes and inflammatory responses between patients with viral sepsis, specifically COVID-19-associated sepsis, and those with bacterial sepsis.
- Conditions
- Sepsis, Sepsis Bacterial, Viral Sepsis, Inflammatory Response
- Trial name
- NCT06491966
- Testing
- observation
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Sichuan Provincial People's Hospital
Bacterial Infections
An Evaluation of a Antimicrobial Stewardship Recommendation Bundle for Staphylococcus Aureus Bloodstream Infections
In July 2020, a bundle (Appendix C) was implemented at Methodist Dallas Medical Center where all patients with SAB were reviewed by the antimicrobial stewardship pharmacist (Monday - Friday from 0700 to 1500), a note outlining…
- Trial name
- NCT06211829
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Methodist Health System
Sepsis, Septic Shock
Early and Late Neutrophil CD64 and Monocyte HLA-DR as Biomarkers for Septic Shock
Study Summary: Neutrophil CD64 \& Monocyte HLA-DR in Septic Shock What is studied? Doctors looked at two blood markers: Neutrophil CD64 (nCD64): rises quickly when the body fights infection.
- Trial name
- NCT07401329
- Where
- India
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Pandit Bhagwat Dayal Sharma, PGIMS, Rohtak
Septic Shock
Effect of IV Vitamin C, Thiamine, and Steroids on Mortality of Septic Shock
Preliminary studies show that giving a "cocktail" of intravenous vitamin C, vitamin B1, and steroids to critically ill patients with septic shock may dramatically improve mortality in those patients.
- Trial name
- NCT03828929
- Testing
- Vitamin C, Normal saline
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Central Venous Catheter, Catheter-Related Bloodstream Infection (CRBSI) Nos
Access in Dialysis for Better Outcomes in Patient Therapy
This is a prospective, multi-center health economic study in Canada. Participants will be randomly assigned to receive either the study or control dialysis catheter.
- Trial name
- ADOPT (NCT03109574)
- Testing
- BioFlo DuraMax Chronic Hemodialysis Catheter, Standard of Care Catheter
- Where
- 3 sites in Canada
- Volunteers
- 92 people
- Sponsor
- William Osler Health System
Type 2 Diabetes, Healthy
Type 2 Diabetes and the Effect of Probiotics
Insulin-resistance in type 2 diabetes is associated with chronic inflammation. Anti-inflammatory actions might increase sensitivity to insulin.
- Conditions
- Type 2 Diabetes, Healthy, Endotoxemia
- Trial name
- NCT00413348
- Testing
- Lactobacillus acidophilus NCFM
- Where
- Denmark
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Surgical Site Infection (SSI)
Prophylaxis Against Surgical Site Infections Using Local as Well as Systemic Antibiotic
Surgical site infections were defined as infections that developed in the area of an operation within 30 days after surgery. They remained a common problem after surgery and could increase pain, delay wound healing, prolong…
- Trial name
- NCT07478874
- Testing
- Cefazolin plus Gentamicin, Cefazolin
- Where
- Pakistan
- Volunteers
- 284 people
- Sponsor
- Lahore General Hospital
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