Clinical trials: Systemic Infection
Helicobacter Pylori Infection, Iron Deficiency Anemia
Is Helicobacter Pylori Infection a Cause or Treatment Failure of Iron Deficiency Anemia in Children in Bangladesh?
Helicobacter pylori is recognized as a major gastrointestinal pathogen in developing countries. This microorganism infects up to 60% of children less than five years in those countries and is strongly associated with chronic…
- Conditions
- Helicobacter Pylori Infection, Iron Deficiency Anemia, Not Severely Malnourished, No Systemic Infection
- Trial name
- NCT00284700
- Testing
- Iron
- Where
- Bangladesh
- Volunteers
- 260 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Sepsis, Severe
Procalcitonin in Diagnosis of Sepsis in Critically Ill Patient
correlation between procalcitonin levels and the severity of sepsis and it's possibility to be used as a prognostic marker in patients with sepsis and severe sepsis
- Trial name
- NCT04105400
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Acute Infection
Individualized Multiplex Pathophysiological Treatment of Severe Acute Infections: N-Acetylcysteine
The primary objective of the IMPACT-NAC trial is to assess the effects of N-acetylcysteine on survival and hospital length of stay in adults admitted to the emergency department with acute infection or sepsis and evidence of…
- Conditions
- Sepsis, Acute Infection, Severe Infection
- Trial name
- IMPACT-NAC (NCT07273071)
- Testing
- N-Acetylcysteine (NAC) Treatment
- Where
- Denmark
- Volunteers
- 360 people
- Sponsor
- Theis S. Itenov
Streptococcal Sepsis, Hematologic Malignancies
Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation
This is a randomized 2-arm study to compare two different times of giving the drug vancomycin. Half of the patients will begin vancomycin two days before a bone marrow transplant.
- Trial name
- NCT00138112
- Testing
- Empirical Vancomycin, Prophylactic Vancomycin
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sepsis and Septic Shock
Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using…
- Trial name
- NCT07516236
- Testing
- Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Menoufia University
Sepsis, Acute Lung Injury
Biological Markers to Identify Early Sepsis and Acute Lung Injury
There are no clear markers to identify sepsis and acute lung injury at early stage in clinical settings which would result in improved survival of the patients. In collaboration with the research team led by Dr. Zhang at St.
- Trial name
- NCT00825357
- Where
- Taiwan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chimei Medical Center
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Vitamin D Deficiency
Comparison of Maternal and Neonatal Vitamin D Levels in Term Neonates With and Without Early Onset Sepsis
Neonatal sepsis is a clinical syndrome characterized by signs and symptoms of infection with or without accompanying bacteremia in the first month of life which is still an important cause of morbidity and mortality.
- Trial name
- NCT02019836
- Testing
- Determining maternal and neonatal vitamin D levels
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Septic Shock, Severe Sepsis
Selenium, as Sodium Selenite, in the Treatment of Septic Shock
Septic shock is a frequent syndrome with a 45% mortality rate despite intensive care unit (ICU) care, where free radicals may play a key role, and a >40% decrease in plasma selenium concentration is observed.
- Trial name
- NCT00207844
- Testing
- Selenium as sodium selenite
- Where
- 7 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier de Meaux
Supraventricular Arrhythmia, Septic Shock
Rate, Rhythm or Risk Control for New-onset Supraventricular Arrhythmia During Septic Shock: a Randomized Controlled Trial
New-onset supraventricular arrhythmia (NOSVA) is reported in 40 % of patients with septic shock and is associated with hemodynamic alterations and mortality.
- Trial name
- CAFS (NCT04844801)
- Testing
- Risk control strategy, Heart-Rate control strategy:, Rhythm control strategy:
- Where
- France
- Volunteers
- 240 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
IgM-enriched Immunoglobulin Attenuates Systemic Endotoxin Activity in Early Severe Sepsis
The purpose of this study is to evaluate the effect of IgM-enriched immunoglobulins (Pentaglobin) on the endotoxin activity, conventional coagulation parameters, viscoelastic and aggregometric measurements of patients with severe…
- Trial name
- NCT02444871
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Goethe University
Acute Respiratory Failure, Critical Illness
ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers
This study will investigate whether a family-centered intervention that has been adapted for patients with critical illness and their caregivers is possible, acceptable, and helpful
- Conditions
- Acute Respiratory Failure, Critical Illness, Sepsis, Hypoxia
- Trial name
- ICU-SUCCEED (NCT07778004)
- Testing
- ICU-SUCCEED, Augmented Usual Care
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of North Carolina, Chapel Hill
Sepsis
HSPA12B as a Potential Biomarker for Sepsis and Severe Sepsis
Molecules indicating endothelial injury may serve as biomarkers for severe sepsis because of the critical role of endothelial injury in organ dysfunction during severe sepsis.
- Trial name
- NCT01847248
- Where
- China
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Lymphoma, Small Intestine Cancer
Irinotecan in Treating Patients With Solid Tumors or Lymphoma Who Have Abnormal Liver or Kidney Function or Who Have Received Radiation Therapy to the Pelvis
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Irinotecan may be effective in treating patients with abnormal liver or kidney function or who have received…
- Conditions
- Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00003368
- Testing
- irinotecan hydrochloride
- Where
- 45 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Uveitis
Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment
The purpose of this study is to evaluate the efficacy of gevokizumab in reducing the risk of recurrent uveitic disease in subjects with non-infectious uveitis whose disease is currently controlled with systemic treatment.
- Trial name
- EYEGUARD™-C (NCT01747538)
- Testing
- Dose 1 gevokizumab, Dose 2 gevokizumab
- Where
- 115 sites in United States, Argentina and 20 more
- Volunteers
- 281 people
- Sponsor
- XOMA (US) LLC
Clostridioides Difficile Infection
Oral Vancomycin Vs Placebo in the Prevention of Recurrence of Clostridioides Difficile's Infection
A phase III randomized clinical trial in proportion 2:1 in favor of oral vancomycin (experimental treatment), multicentric, national, double-blinded, controlled with placebo.
- Trial name
- PREVAN (NCT05320068)
- Testing
- Oral Vancomycin
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Julia Orígüen
Systemic Lupus Erythematosus (SLE), Lupus Nephritis
Lupus Landmark Study: A Prospective Registry and Biorepository
The purpose of the registry and biorepository is to provide a mechanism to store clinical data, linked biospecimens and molecular data to support the conduct of future research on Systemic Lupus Erythematosus (SLE), including…
- Conditions
- Systemic Lupus Erythematosus (SLE), Lupus Nephritis, Neuropsychiatric Systemic Lupus Erythematosus
- Trial name
- NCT05934149
- Where
- 25 sites in United States, Canada
- Volunteers
- 3,500 people
- Sponsor
- Lupus Research Alliance
CRBSI - Catheter Related Bloodstream Infection
Investigational Study With the BD PosiFlush™ SafeScrub on NADs
This study is an investigational study to evaluate the safety and performance of the BD PosiFlush™ SafeScrub on needleless access devices.
- Trial name
- NCT06604026
- Testing
- BD PosiFlush™ SafeScrub, BD PosiFlush™
- Where
- 2 sites in Austria
- Volunteers
- 222 people
- Sponsor
- Becton, Dickinson and Company
Catheter-Related Infections, Catheter Complications
Impact of Tubing Colonization on the Incidence of Central Venous Catheter Infection
The objective of this study is to assess the relationship between infusion system colonization (ramps or multi-lumen devices) and the occurrence of CVC infection/colonization.
- Conditions
- Catheter-Related Infections, Catheter Complications, Catheter Infection, Catheter-related Bloodstream Infection
- Trial name
- CRIC (NCT06019897)
- Volunteers
- 200 people
- Sponsor
- University Hospital, Angers
Shock, Septic
Effects of Hydrocortison Treatment on Angiotensin II and Angiotensin II Receptors in Patients With Septic Shock
This study aims to evaluate the role of angiotensin II, AT1, and AT2 on catecholomine responsive and catecholomine resistant septic shock, and the effect of hydrocortisone traetment on catecholomine resistant septic shock and…
- Trial name
- NCT04647552
- Testing
- Drug Steroid
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Inonu University
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