Clinical trials: Systemic Infection
Severe Sepsis
Effects of Acute Systemic Inflammation on Arterial Stiffness and Microcirculation.
This study aims to assess the effect of acute inflammation on arterial stiffness and microcirculation. Patients with severe sepsis will be compared with age-, sex- and cardiovascular risk factors-matched controls.
- Trial name
- IRIGA (NCT01556373)
- Testing
- NA : non interventional study
- Where
- 2 sites in France
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Rennes University Hospital
Coronavirus, COVID
A Phase 2 Study to Evaluate Axatilimab for Hospitalized Participants With Respiratory Involvement Secondary to COVID-19
This was a randomized, double-blind, placebo-controlled, 29-day study to assess the efficacy and safety of axatilimab plus standard of care (SOC), compared with placebo plus SOC, in participants with respiratory signs and…
- Conditions
- Coronavirus, COVID, ARDS, Cytokine Storm
- Trial name
- NCT04415073
- Testing
- SNDX-6352
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Syndax Pharmaceuticals
Sepsis, Peritonitis
Hepatic Mitochondrial Function in Sepsis
Multi-organ failure due to sepsis is a major cause of death in critically ill patients. But the mechanisms leading to this condition are not fully understood.
- Trial name
- NCT00889083
- Where
- France
- Sponsor
- Professor C ICHAI
Gram-Negative Bacterial Infections, Sepsis
A Randomised Trial on the Saftely and Efficacy of GR270774 in the Treatment of Gram-negative Sepsis in Adult
Sepsis sometimes occurs in people who have a serious infection. It is caused by toxic substances (toxins) from bacteria and other germs entering your bloodstream.
- Trial name
- NCT00563134
- Testing
- GR270774
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Hospital Authority, Hong Kong
Gram-Positive Bacterial Infections
Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria
The purpose of this study is to provide daptomycin, an antibiotic, to patients who are failing conventional therapy, or who cannot take approved antibiotics for one reason or another.
- Trial name
- NCT00055198
- Testing
- daptomycin
- Volunteers
- 75 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Septic Shock
Co-administration of Iloprost and Eptifibatide in Septic Shock Patients
Objective Evaluating the safety and efficacy of iloprost and eptifibatide co-administration compared to placebo as an addition to standard care in septic shock patients.
- Trial name
- CO-ILEPSS (NCT02204852)
- Testing
- Iloprost+eptifibatide
- Where
- Denmark
- Volunteers
- 18 people
- Sponsor
- Sisse R. Ostrowski, MD PhD DMSc
Inflammatory Disorder of Immune System, Sepsis
Effect of Midazolam on Inflammatory Response and Organ Function in Mechanically Ventilated Sepsis Patients With Different Immune Status
ICU patients always experience all kinds of pain, discomfort and sleep disturbance,especially the sepsis patients. Appropriate sedation and analgesia is must,the newest sepsis guideline strongly recommend that mechanically…
- Trial name
- NCT02135055
- Testing
- blood sample collection, Midazolam, Morphine
- Volunteers
- 80 people
- Sponsor
- Xiangya Hospital of Central South University
Hypotension, Shock, Septic
Midodrine During Recovery From Septic Shock
The purpose of this study is to determine whether midodrine administration decreases duration of intravenous vasopressors and intensive care unit length of stay for patients in septic shock.
- Conditions
- Hypotension, Shock, Septic, Sepsis
- Trial name
- NCT02771158
- Testing
- Midodrine
- Sponsor
- Northwell Health
Sepsis
Validation of Progranulin as a Biomarker for Sepsis
Progranulin blood concentrations in patients with sepsis will be analysed in relation to disease status in order to validate progranulin as a biomarker for sepsis. Patients undergoing cardiac surgery will serve as controls.
- Trial name
- PROGRANULIN (NCT03280576)
- Where
- 2 sites in Germany
- Volunteers
- 556 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Candidiasis
The Safety and Efficacy of Anidulafungin Versus Comparator in Patients With Candidemia and Invasive Candidiasis
Anidulafungin is a medicine being developed for treatment of patients with certain kinds of fungal infections. These infections due to yeast (a type of fungus) in the mouth/esophagus, in the blood or in other areas within the…
- Trial name
- NCT00056368
- Testing
- Anidulafungin, Fluconazole
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Pfizer
Sepsis, Septic Shock
Dose-response Study of Arginine Supplementation in Severe Sepsis
Pilot data in patients and data from pig studies indicate that arginine-NO metabolism is impaired in sepsis with changes in splanchnic metabolism and function, and reduced survival at low nitrate levels.
- Trial name
- NCT01775020
- Testing
- L-arginine
- Volunteers
- 8 people
- Sponsor
- Maastricht University Medical Center
Neonatal Infection, Neonatal SEPSIS
Reduction of Intravenous Antibiotics In Neonates
Randomized controlled open-label non-inferiority trial comparing complete intravenous antibiotic treatment with a short iv. course followed by oral antibiotics in neonates (0-28 days) with probable bacterial infection.
- Trial name
- RAIN (NCT03247920)
- Testing
- Amoxicillin Clavulanate, Antibiotics
- Where
- 18 sites in Netherlands
- Volunteers
- 510 people
- Sponsor
- Franciscus Gasthuis
Gross Material Loss in Endodontically Treated Upper and Lower Molars, No Systemic Infection
Clinical Performance of 3D-Printed vs. Milled Endocrowns
The goal of this clinical trial is to examine the durability of endocrowns, created using various materials and manufacturing techniques with a fully digital workflow, and their ability to maintain functionality and aesthetics in…
- Conditions
- Gross Material Loss in Endodontically Treated Upper and Lower Molars, No Systemic Infection, Gingival Steps Should be at Gum Level
- Trial name
- NCT06850649
- Testing
- endocrowns
- Where
- Turkey (Türkiye)
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gulcan COSKUN AKAR
Sepsis, Cardiopulmonary Bypass
Multi-omics Study on Gut Microbiota in Critical Ill Patients After Cardiopulmonary Bypass
Using metagenomics as well as metabolomics, the variation of the gut microbiota and host metabolite profiles of patient after undergoing CPB were explored.
- Trial name
- CPB-MUL-GM (NCT04032938)
- Testing
- extracorporeal circulation during cardiac surgery
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Systemic Inflammatory Response Syndrome, Fever
Procalcitonin (PCT) as a Diagnostic Marker of Bacterial Infection in the Patients Admitted for Fever and/or Inflammatory Syndrome to the Internal Medicine Department
Levels of PCT (a marker of bacterial infection) are highest during sepsis: in fact, PCT is normally produced by the C cells in the thyroid gland.
- Trial name
- PCT-MI (NCT02898948)
- Testing
- Procalcitonin (PCT) as a diagnostic marker of bacterial infection
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Critical Illness, Sepsis
Trial of Glutamine and Antioxidant Supplementation in Critically Ill Patients
The purpose of this study is to determine whether providing high dose glutamine and antioxidants to critically ill patients will be associated with improved survival.
- Conditions
- Critical Illness, Sepsis, Multiple Organ Failure
- Trial name
- REDOXS (NCT00133978)
- Testing
- Glutamine, Antioxidants, Glutamine + Antioxidants
- Where
- 34 sites in United States, Belgium and 3 more
- Volunteers
- 1,223 people
- Sponsor
- Daren K. Heyland
Aspergillosis, Candidemia
A Study To Assess The Anidulafungin And Voriconazole Concentration In Lung Following Intravenous Administration In Healthy Subjects
The purpose of this study is to provide anidulafungin and voriconazole to healthy subjects to determine the drug concentration in the lung.
- Trial name
- NCT00940017
- Testing
- anidulafungin and voriconazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pfizer
Sepsis
Clinical Validation of HostDx Sepsis™ on NanoString; a Prospective Observational Validation Trial
This study will analyze HostDx Sepsis results from whole blood samples collected from patients with suspected sepsis or at risk for sepsis in the surgical ICU
- Trial name
- NCT04414189
- Testing
- HostDx Sepsis
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Inflammatix
Sepsis
The Impact of Selective Vitamin D Receptor Activation on Clinical Outcomes in Septic Patients
Sufficient serum levels of vitamin D are important for immune system regulation with protective effect against severe infection and overactivated inflammatory response in sepsis.
- Trial name
- NCT06209268
- Testing
- Paricalcitol injection
- Volunteers
- 90 people
- Sponsor
- University of Split, School of Medicine
Fungal Infections Systemic
Oral Nystatin Prophylaxis to Prevent Systemic Fungal Infection in Very Low Birth Weight Preterm Infants
This study determines the effectiveness of oral nystatin as prophylaxis in order to prevent systemic fungal infection in very low birth weight preterm neonates.
- Trial name
- NCT03390374
- Testing
- Nystatin Oral
- Volunteers
- 95 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
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