Clinical trials: Systemic Infection
Sepsis, Respiratory Failure
Safety, Tolerability and Performance of the NucleoCapture Device in the Reduction of Circulating CfDNA/NETs in Subjects with Sepsis
This is a prospective, multinational, multicentre, randomised, parallel-group, open-label study to assess the safety, tolerability and performance of the NucleoCapture extracorporeal apheresis device in the reduction of…
- Trial name
- NUC-CAP (NCT05647096)
- Testing
- NucleoCapture device
- Where
- 9 sites in Germany, Switzerland and 1 more
- Volunteers
- 73 people
- Sponsor
- Santersus AG
Acute Necrotizing Pancreatitis
Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis
Acute necrotizing pancreatitis is a frequent and potentially lethal disease, especially in case of infected pancreatic necrosis (IPN). IPN usually occurs after the first week of evolution.
- Trial name
- PANIC (NCT03234166)
- Testing
- Non interventional study
- Where
- 4 sites in France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Plague, Plague, Bubonic
Yersinia Pestis Lateral Flow Immunoassay for Blood Samples
Plague is a deadly but highly treatable disease caused by the bacterium Y. pestis. Due to the historical development of Y. pestis as a bioweapon by several nation states, it is listed by the US as a potential bioweapon that could…
- Conditions
- Plague, Plague, Bubonic, Plague, Pneumonic, Yersinia Pestis Plague
- Trial name
- SMARTPRT (NCT04688996)
- Testing
- Lateral Flow Assay for Pathogens of the Plague
- Where
- 2 sites in United States, Madagascar
- Volunteers
- 500 people
- Sponsor
- Brimrose Technology Corporation
Bloodstream Infection
Antimicrobial Catheter Securement Dressings for the Prevention of Cvc-related Bloodstream Infections in Cancer Patients
In neutropenic cancer patients, catheter-related bloodstream infections may cause severe infections and even death. To assess the prophylactic effect of a chlorhexidine coated catheter securement dressing on the incidence of…
- Trial name
- COAT (NCT01544686)
- Testing
- 3M™ Tegaderm™ CHG IV and 3M™ Tegaderm™ Advanced IV
- Where
- 5 sites in Germany
- Volunteers
- 630 people
- Sponsor
- University of Cologne
Infections, Infections - Bacterial
Human Neutrophil Lipocalin as an Aid in the Diagnosis of Bacterial Infection in the Emergency Department
The aim of this study is to improve the medical care of patients with infections for which the cause cannot be clearly identified as bacterial or viral.
- Conditions
- Infections, Infections - Bacterial, Viral Infection, Sepsis
- Trial name
- BEDS (NCT07796945)
- Where
- Switzerland
- Volunteers
- 516 people
- Sponsor
- University Hospital, Basel, Switzerland
Nephrolithiasis
Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy
Efficacy of ciprofloxacin therapy in avoidance of sepsis in patient undergoing percutanous nephrolithotomy. A randomized controlled trial.
- Trial name
- NCT04374188
- Testing
- Ciprofloxacin, Levofloxacin
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Diaa Eldin Taha Ramadan Mohamed
Sepsis, Pre-Eclampsia
Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the…
- Conditions
- Sepsis, Pre-Eclampsia, Granulomatosis With Polyangiitis, Microscopic Polyangiitis
- Trial name
- NCT05703802
- Testing
- Procalcitonin-variants ELISA-Assay
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Septic Shock
Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients
The investigators hypothesize that dobutamine is able to revert negative redistribution of flow by inducing a selective vasodilatory effect on hypoperfused territories, particularly at the sublingual and gastric mucosa, and at…
- Trial name
- NCT01271153
- Testing
- Dobutamine
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Infant, Premature, Hypoperfusion in Newborn
Monitoring of Systemic or Organ Perfusion for Preterm Infants
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants.
- Conditions
- Infant, Premature, Hypoperfusion in Newborn, Necrotizing Enterocolitis of Newborn, Sepsis Newborn
- Trial name
- NCT03136172
- Testing
- NIRS (near Infra-red spectroscopy)
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Inha University Hospital
Sepsis
Normal Saline Versus Ringer's Lactate for Initial Fluid Resuscitation in Sepsis
This clinical trial aims to determine if the type of intravenous fluid used for initial resuscitation affects the short-term outcomes of adult patients with sepsis who are treated in the emergency department.
- Trial name
- NCT07240701
- Testing
- Ringer's Lactate, Normal Saline (0.9% Sodium Chloride)
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people
- Sponsor
- Egemen Yildiz
Septic Shock
Vitamin C Deficiency in Septic Shock
Objectives: investigators aim to study the effect of addition of vitamin C as a part of treatment in septic shock patients on: Hemodynamics, Inflammation status and ICU outcome.
- Trial name
- NCT06224881
- Testing
- Ascorbic acid
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Cairo University
Chronic Hepatitis B, Chronic Hepatitis D
Lamivudine for Chronic Hepatitis B
Chronic hepatitis B is a disease of the liver caused by the hepatitis B virus. It affects nearly 1 million Americans. Approximately 25% of patients with chronic hepatitis B will develop liver cirrhosis and 5% of patients will…
- Conditions
- Chronic Hepatitis B, Chronic Hepatitis D, Glomerulonephritis, Polyarteritis Nodosa
- Trial name
- NCT00001457
- Testing
- Lamivudine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Group B Streptococcus, Sepsis
Management of Infants Born to Group B Streptococcus Positive Mothers.
Intrapartum antibiotic prophylaxis has greatly decreased but not abolished early-onset neonatal sepsis caused by GBS. According to current recommendations, the evaluation of infants at risk for GBS sepsis should include a…
- Conditions
- Group B Streptococcus, Sepsis, Infant, Newborn
- Trial name
- NCT00716781
- Volunteers
- 16,394 people
- Sponsor
- IRCCS Burlo Garofolo
Periodontal Diseases, Periodontal Inflammation
Oral and Systemic aMMP-8 in Periodontal Disease
Periodontal disease is an inflammatory process that can result in tooth loss and also is considered a modifying factor for systemic health.
- Trial name
- NCT04268381
- Testing
- Biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Sepsis
Effect of Citrulline on the Clinical and Biochemical Evolution of Patients With Sepsis.
Triple blind placebo-controlled study to determine if administering citrulline in patients with sepsis and severe sepsis slows progression to multiple organ failure and death, measuring biomarkers of endothelial dysfunction.
- Trial name
- CITRUSEP (NCT02370030)
- Testing
- Citrulline malate
- Where
- 2 sites in Mexico
- Volunteers
- 160 people
- Sponsor
- Instituto Mexicano del Seguro Social
Sepsis
The Application of SERS and Metabolomics in Sepsis
It has always been a real challenge to treat sepsis in critically ill patients. The mortality is as high as 20％ in patients with severe sepsis and 46％ with septic shock develops.
- Trial name
- NCT02213237
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Sepsis, Severe Sepsis
Simplified Severe Sepsis Protocol-2 (SSSP-2) in Zambia
This study is a randomized control trial assessing the impact of a simple evidence-based protocol for the treatment severe sepsis with hypotension in Zambia.
- Conditions
- Sepsis, Severe Sepsis, Tuberculosis
- Trial name
- SSSP-2 (NCT01663701)
- Testing
- Simplified severe sepsis protocol, Usual care
- Where
- Zambia
- Volunteers
- 212 people
- Sponsor
- Vanderbilt University
Optimal Intensity of Renal Replacement Therapy on Sepsis Patients
Effect of the Intensity of Continuous Renal Replacement Therapy
In patients with sepsis and AKI, increasing the intensity of renal replacement therapy from 50 mL/kg/h (HVHF) to 85 mL/kg/h (EHVHF)will increase the survival at 28 days and 90 days.
- Trial name
- NCT01251081
- Testing
- extra high volume hemofiltration, high volume hemofiltration
- Where
- China
- Volunteers
- 280 people
- Sponsor
- Zhejiang University
Sepsis
Effect of Taurolidin on Prevention of Bloodstream Infection
Home parenteral nutrition (HPN) is a validated technique for patients with various intestinal disease leading to chronic malabsorption or obstruction, whatever the aetiology.
- Trial name
- Nutrilock (NCT00545831)
- Testing
- Taurolidine, Physiologic Serum
- Where
- 7 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Rouen
Severe Sepsis
The Effect of Dexmedetomidine on Microcirculation in Severe Sepsis
Despite early goal-directed maintenance of normal macrocirculation, the reduction of 60-day mortality of patients with severe sepsis and septic shock remained unsatisfied (56.9% to 44.3%).
- Trial name
- NCT02109965
- Testing
- Dexmedetomidine, Midazolam, Propofol
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Taiwan University Hospital
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