Clinical trials: Systemic Infection
Sepsis
Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial
PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments.
- Trial name
- PALETTE (NCT06381661)
- Testing
- Tocilizumab, Baricitinib, Anakinra
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Septic Shock, Sepsis
Vitamin C and Septic Shock
This is a randomized, double-blind, placebo-controlled clinical trial to compare Vitamin C versus placebo for patients presenting to the ICU with a diagnosis of septic shock.
- Trial name
- NCT03338569
- Testing
- Vitamin C
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Minnesota
Lymphoma
Combination Chemotherapy in Treating Patients With Hodgkin's Disease and HIV Infection
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003262
- Testing
- bleomycin sulfate, filgrastim, Stanford V regimen
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia
Study to Evaluate the Efficacy and Safety of Intravenous Sulbactam-ETX2514 in the Treatment of Patients With Infections Caused by Acinetobacter Baumannii-calcoaceticus Complex
This is a 2-part study, with Part A being the randomized, controlled portion of the study in patients with ABC hospital-acquired bacterial pneumonia (HABP), ventilator-associated bacterial pneumonia (VABP), or bacteremia.
- Conditions
- Acinetobacter Baumannii-calcoaceticus Complex, Hospital-acquired Bacterial Pneumonia, Ventilator-associated Bacterial Pneumonia, Bacteremia
- Trial name
- ATTACK (NCT03894046)
- Testing
- Sulbactam, Durlobactam, Colistin
- Where
- 90 sites in United States, Belarus and 15 more
- Volunteers
- 207 people
- Sponsor
- Entasis Therapeutics
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Septic Shock, Adult Respiratory Distress Syndrome
Hyperoxia and Hypertonic Saline in Septic Shock
Assessment of the effect of hyperoxia and hypertonic saline on survival in patients with septic shock Hyperoxia and hypertonic saline may have beneficial effects on organ perfusion and oxygenation and may reduce the organ failure…
- Trial name
- Hyper2S (NCT01722422)
- Testing
- oxygen and saline
- Where
- France
- Volunteers
- 441 people
- Sponsor
- University Hospital, Angers
Septic Shock, Vasodilatory Shock
Heparin Anticoagulation in Septic Shock
This study is a pragmatic open-label international randomized trial comparing therapeutic dose intravenous unfractionated heparin (UFH) to standard care venous thromboprophylaxis in patients diagnosed with septic shock.
- Trial name
- HALO (NCT03378466)
- Testing
- Unfractionated heparin, Venous thromboprophylaxis (VTE)
- Where
- 51 sites in United States, Brazil and 5 more
- Volunteers
- 178 people
- Sponsor
- University of Manitoba
Bacteremia, Streptococcus Infection
Beta-lactam Plus Levofloxacin to Enhance Therapy in Streptococcal Septicemia
A double-blind randomized controlled trial comparing beta-lactam plus levofloxacin versus beta-lactam monotherapy for the treatment of Streptococcal bacteremia
- Trial name
- BLESS (NCT07240077)
- Testing
- Beta-lactam monotherapy, Beta-lactam plus levofloxacin combination therapy
- Where
- 4 sites in Thailand
- Volunteers
- 165 people
- Sponsor
- Mahidol University
Sepsis, Antimicrobial Resistance (AMR)
Implementation of a Sepsis Chart and Its Effects on Mortality Rate in Indonesian Primary Referral Hospitals
The goal of this observational study is to evaluate the effectiveness of implementing Koran Sepsis, or sepsis chart, a paper-based order set designed to guide the implementation of the One-hour Sepsis Bundle, in improving…
- Trial name
- NCT07843277
- Testing
- Sepsis chart (koran sepsis), Usual care
- Where
- 2 sites in Indonesia
- Volunteers
- 304 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Candidemia Prognostic Factor and Mycobiological Analysis.
The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia
Candida albicans is the most common and important clinical fungal pathogen. Our previous surveillance disclosed that fluconazole could induce different morphological changes in clinical strains. Our current study on C.
- Trial name
- NCT01211041
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University WanFang Hospital
Oxidative Stress, Septic Shock
Clinical Trial of Antioxidant Therapy in Patients With Septic Shock
Sepsis and septic shock are public health problems worldwide that represents an excessive cost for health systems. Despite the great technological and research advances, mortality can reach up to 80% in patients with multiple…
- Trial name
- NCT03557229
- Testing
- Melatonin 5 mg, Vitamin C 1 GM Oral Tablet, Vitamin E 400 UNT
- Where
- Mexico
- Volunteers
- 131 people
- Sponsor
- American British Cowdray Medical Center
Septic Shock, Delirium
Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)
Delirium in the ICU is a prevalent problem occurring in up to 80% of ICU patients. A potential cause of delirium in ICU patients could be cerebral hypoxia. Septic shock is associated with high rates of delirium.
- Conditions
- Septic Shock, Delirium, Renal Failure
- Trial name
- NCT01836302
- Testing
- Observation
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- University of Manitoba
Neonatal Sepsis
Salivary C- Reactive Protein, Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Diagnostic Markers for Neonatal Sepsis
To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis
- Trial name
- NCT04800445
- Testing
- Salivary CRP
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Liver Failure, Sepsis
Transcriptional Analysis of Mechanisms in Liver Failure and Sepsis
Context Acute liver failure (ALF) is a life-threatening condition that occurs on the background of a healthy liver. The most common cause of acute liver failure in the UK is paracetamol overdose.
- Trial name
- MAP-ALF (NCT07131969)
- Testing
- blood draw
- Where
- 7 sites in United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Cambridge
Critical Illness, Intensive Care Patients
IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients
This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU).
- Conditions
- Critical Illness, Intensive Care Patients, Critical Illness Requiring Intensive Care - Sepsis, Critical Illness Requiring Intensive Care - Acute Brain Injury
- Trial name
- IMMUNOREA (NCT07345169)
- Where
- France
- Volunteers
- 540 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Invasive Mycosis
Perception and Prevalence of Fungal Infections in Berlin - Brandenburg
This is a structured web-based survey in selected hospitals with intensive care units in Berlin- Brandenburg that will focus on the analysis of current knowledge in ICUs in the field of invasive mycoses.
- Trial name
- IFI_ICU (NCT01393002)
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- Charite University, Berlin, Germany
Sepsis, Severe Infection
Mechanisms of Prognostic Regulation andPrecision Phenotype Ldentification in Severe Infections Driven by SpecializedPro-Resolving Mediators
This is a prospective observational study involving adult patients with severe infection who are admitted to the intensive care unit (ICU). Severe infection and sepsis are major causes of death worldwide.
- Conditions
- Sepsis, Severe Infection, Multiple Organ Dysfunction Syndrome, Critical Illness
- Trial name
- MPR-PPI-SPMs (NCT07353970)
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Septic Shock, Severe Sepsis
Early Use of Norepinephrine in Septic Shock Resuscitation
Current septic shock guideline recommends fluid resuscitation as the first treatment. Vasopressors, including norepinephrine is recommended to start after achieve adequate fluid therapy.
- Trial name
- CENSER (NCT01945983)
- Testing
- Early norepinephrine
- Where
- Thailand
- Volunteers
- 310 people
- Sponsor
- Mahidol University
Severe Sepsis, Septic Shock
Investigate the Activity of Endotoxin in Severe Sepsis
Endotoxin is the major mediator of gram-negative bacteria which cause the systemic inflammation and result in microcirculatory dysfunction, and it leads to multiple organ dysfunction and death in patients with severe sepsis and…
- Trial name
- NCT01957254
- Where
- Taiwan
- Volunteers
- 2 people
- Sponsor
- National Taiwan University Hospital
Sepsis
Neutrophil Extracellular Traps and Neonatal (PV4991) & Pediatric Sepsis (PV5063)
This study is designed to assess the role of neutrophil extracellular traps (NETs) in neonatal and pediatric sepsis as well as to evaluate markers of NETs formation as early predictors of neonatal and pediatric sepsis.
- Trial name
- NCT02567305
- Testing
- Markers of NET formation
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
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