Clinical trials: Systemic Infection
Septic Shock
Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock
The aim of this work is to compare two protocols (ketamine-midazolam versus fentanyl-midazolam) for induction of anesthesia in patients with septic shock aiming to find the most safe protocol with regards to hemodynamic status of…
- Trial name
- NCT03251170
- Testing
- Ketamine, Fentanyl, Midazolam
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Chronic Myeloproliferative Disorders, Leukemia
17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Systemic Mastocytosis
RATIONALE: Drugs used in chemotherapy, such as 17-N-allylamino-17-demethoxygeldanamycin (17-AAG), work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Nonneoplastic Condition
- Trial name
- NCT00132015
- Testing
- tanespimycin
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Herpes Zoster, Recombinant Zoster Vaccine
Recombinant Zoster Vaccine in Stable SLE Patients
The risk of herpers zoster reactivation is higher in SLE patients than general population. It has shown that mild or even inactive patients could also have varicella zoster virus (VZV) infections, and they account for about…
- Conditions
- Herpes Zoster, Recombinant Zoster Vaccine, Systemic Lupus Erythematosus
- Trial name
- NCT04516408
- Testing
- Recombinant zoster vaccine
- Where
- China
- Volunteers
- 464 people
- Sponsor
- RenJi Hospital
Intermittent Fasting, Septic Shock
Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit
This study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in ICU.
- Conditions
- Intermittent Fasting, Septic Shock, Organ Failure, Multiple
- Trial name
- ENNUT-CI (NCT06330610)
- Testing
- Intermittent enteral nutrition
- Where
- France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Rouen
Septicemia
Time to Appropriate Antibiotic Between Using Microarray Assay and Mass Spectrometry Technique
This is an experimental study of participants who had positive blood culture to compare time to appropriate antibiotic between using Microarray Assay and Mass Spectrometry to bacterial Identification.
- Trial name
- NCT03583762
- Testing
- Mass spectrometry, Microarray assay
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Chiang Mai University
Hepatitis C, Chronic
Response Modifier (Arabinoxylan Rice Bran/MGN-3/Biobran) With Interferon-Alpha for HCV
Current treatments for Hepatitis C virus (HCV) have severe side effects and are very expensive. There is a need to explore effective natural therapies against HCV that are less toxic and more cost-effective.
- Trial name
- NCT02690103
- Testing
- pegylated IFN, Biobran, Ribavirin
- Volunteers
- 37 people
- Sponsor
- Cairo University
Delirium, Delirium of Mixed Origin
Trazodone vs. Quetiapine for the Treatment of ICU Delirium
This is a single-center, prospective observational pilot study. The objective of this study is to evaluate the effectiveness of trazodone as compared to quetiapine, in the management of ICU delirium in adult (>=18 years old)…
- Conditions
- Delirium, Delirium of Mixed Origin, Delirium, Sepsis Associated, Delirium in Old Age
- Trial name
- TQDelirium (NCT05307003)
- Testing
- Trazodone, Quetiapine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Southern California
Sepsis, Critical Illness
Intravenous DNase I for the Treatment of Sepsis (IDEALSepsisI)
Phase I dose-escalation safety and feasibility of IV DNase I in ICU septic patients.
- Trial name
- IDEALSepsisI (NCT05453695)
- Testing
- Intravenous DNase I
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McMaster University
Chronic Hepatitis B, Chronic Hepatitis D
Lamivudine for Chronic Hepatitis B
Chronic hepatitis B is a disease of the liver caused by the hepatitis B virus. It affects nearly 1 million Americans. Approximately 25% of patients with chronic hepatitis B will develop liver cirrhosis and 5% of patients will…
- Conditions
- Chronic Hepatitis B, Chronic Hepatitis D, Glomerulonephritis, Polyarteritis Nodosa
- Trial name
- NCT00001457
- Testing
- Lamivudine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Sepsis Associated Disseminated Intravascular Coagulation (DIC)
A Study to Assess the Safety and Effects of Different Doses of an Investigational Drug, BAY 3389934, in Healthy Japanese Volunteers.
This study is designed to evaluate a new investigational drug, BAY 3389934, in healthy Japanese volunteers. The primary purpose is to see how safe the drug is and how well it is tolerated by the body when given at different…
- Trial name
- NCT07176728
- Testing
- BAY 3389934
- Where
- 2 sites in Japan
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Bayer
Sepsis, Post Intensive Care Unit Syndrome
Accelerating Recovery After ICU Admission: Post-discharge Supplementation With Pasteurized Akkermansia Muciniphila.
The goal of this clinical trial is to learn if daily oral supplementation with pasteurized Akkermansia muciniphila (PAM), an EFSA-approved food supplement, can support recovery in adults who have recently been treated in the ICU…
- Conditions
- Sepsis, Post Intensive Care Unit Syndrome, Critical Illness, Microbiome Dysbiosis
- Trial name
- PAM-ICU (NCT07295353)
- Testing
- Pasteurized Akkermansia muciniphila
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Septic Shock
Hemodynamic Effects of Vasopressin in Early Septic Shock Stage
Vasopressin is a vasopressor used in patients with septic shock. However, its systemic hemodynamic effects and its microcirculation effects are not completely known and understood.
- Trial name
- NCT02053675
- Testing
- Vasopressin infusion
- Where
- Brazil
- Volunteers
- 18 people
- Sponsor
- Federal University of São Paulo
Rheumatoid Arthritis, Staphylococcus Aureus Bacteremia
Bloodstream Infections in Patients With Rheumatoid Arthritis
Study of incidence and risk factors of staphylococcus aureus bacteremia in patients with rheumatoid arthritis compared with the general population in a nationwide cohort of all adult members of the population from 1996 until 2017…
- Trial name
- NCT03908086
- Testing
- Risk factors in RA cohort, Risk factors in general population
- Volunteers
- 6,000,000 people
- Sponsor
- Sabine Dieperink
Left Ventricular Systolic Dysfunction, Septic Shock
Simplified Assessment of Left Ventricular Systolic Function in Septic Shock Patients
The assessment of left ventricular systolic function is based on the measurement of left ventricular ejection function (LVEF) by the Simpson biplane method.
- Trial name
- MAPSE (NCT04963686)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hospital Admission Duration, Postoperative Hematoma Formation
Drain or no Drain After Thyroid Surgery: a Randomized Clinical Trial at Mulago Hospital
Thyroidectomy is one of the most commonly performed operations in general surgery. Available data seem to suggest an association between no-drain usage and a shorter duration of hospital stay.
- Conditions
- Hospital Admission Duration, Postoperative Hematoma Formation, Wound Sepsis
- Trial name
- NCT01729741
- Testing
- drain was inserted after thyroid surgery
- Where
- 2 sites in Uganda
- Volunteers
- 68 people
- Sponsor
- Makerere University
Sepsis
Smart Discharges for Older Children
This study is an observational multi-country cohort study that aims to build algorithms that can identify children between 5 and 16 years of age admitted for proven or suspected sepsis who are at risk of mortality after they are…
- Trial name
- NCT07629154
- Testing
- No Intervention: Observational Cohort
- Where
- 7 sites in United States, Canada and 3 more
- Volunteers
- 4,000 people
- Sponsor
- University of British Columbia
Bacteremia, Enterobacteriaceae Infections
Ultra Rapid Culture Independent Detection of High-Priority Carbapenem Resistant Enterobacteriaceae Directly From Blood
The purpose of this study is to develop a new and very rapid diagnostic test for identifying a certain type of bacteria called Enterobacteriaceae in blood.
- Trial name
- NCT02482051
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Denver Health and Hospital Authority
Organ Dysfunction Syndrome Sepsis
Prevention of Sepsis-related Organ Dysfunction With Allocetra-OTS
The trial evaluates the safety and efficacy of one and two doses of the study drug, Allocetra-OTS, in patients who have been diagnosed with sepsis.
- Trial name
- P-SOFA-1 (NCT03925857)
- Testing
- Allocetra-OTS
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Enlivex Therapeutics Ltd.
Septic Shock, Cirrhosis, Liver
Efficacy and Safety of Vasopressin Versus Terlipressin as a Second Vasopressor in Critically Ill Cirrhotics With Septic Shock- the VITEL-C Trial
Sepsis is a life-threatening organ dysfunction caused by dysregulated host response. A Subset of sepsis is septic shock which has almost 4-6 times the mortality when compared to sepsis.
- Trial name
- NCT05315557
- Testing
- Terlipressin, vasopressin
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
28 Day Mortality
Co-inhibitory Molecules on Treg and miR-155-5p in Patients With Sepsis
there is high mortality rate of sepsis, 36% in 90-days of sepsis in China, and there is no effective treatment. Immunosuppression mediated by sepsis is an important cause of death in patients.
- Trial name
- NCT05126537
- Testing
- no intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
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