Clinical trials: Systemic Infection
Febrile Neutropenia
Next-Generation-Sequencing Approach to Neutropenic Sepsis
The aim of this prospective, observational, non-interventional, multi-centre study of the diagnostic use of DISQVER in neutropenic patients with FN is to provide further evidence of the efficacy of an NGS-based approach for…
- Trial name
- NEXUS (NCT05815628)
- Testing
- DISQVER
- Where
- 6 sites in Germany
- Volunteers
- 400 people
- Sponsor
- Boris Böll
Sepsis
Perfusion Efficiency-Guided MAP De-escalation in Elderly Septic Shock
This is a single-center, prospective, randomized crossover physiological trial conducted in elderly patients (≥65 years) with septic shock in the intensive care unit (ICU).
- Trial name
- NCT07887854
- Testing
- Ascending MAP titration sequence, Descending MAP titration sequence
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Critical Illness, Sepsis
Enteral Glutamine in Critical Illness
Glutamine is an amino acid which is rapidly depleted in critical illness. It is used as energy by cells that line the gut, vital for immune system function, and works as an anti-oxidant.
- Conditions
- Critical Illness, Sepsis, Respiratory Insufficiency
- Trial name
- NCT00318331
- Testing
- Glutamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christiana Care Health Services
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Pediatric Patients With Hypotension
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) or reduction in sum norepinephrine (NE) equivalent dosing, at Hour 2 after the start of LJPC-501, in pediatric patients…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Sepsis
- Trial name
- NCT03431077
- Testing
- Angiotensin II
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- La Jolla Pharmaceutical Company
ARDS, Human
The Mechanism of Extracellular Vesicles Containing Mitochondrial DNA in ARDS Lung Injury Caused by Extrapulmonary Sepsis
The acute respiratory distress syndrome (ARDS) remains a common and morbid complication of critical illness. Sepsis contribute to a lot of ARDS cases, but mechanisms by which non-pulmonary insults such as extrapulmonary sepsis…
- Trial name
- NCT05061212
- Volunteers
- 50 people
- Sponsor
- Southeast University, China
Sepsis
Electronic Early Notification of Sepsis in Hospitalized Ward Patients
Screening for sepsis has been recommended by the Surviving Sepsis Campaign Clinical Practice Guidelines to facilitate early identification and early management of sepsis.
- Trial name
- SCREEN (NCT04078594)
- Testing
- sepsis e-alert
- Where
- Saudi Arabia
- Volunteers
- 65,250 people
- Sponsor
- King Abdullah International Medical Research Center
Gingivitis
Dose-Response Study of Iocide Oral Rinse
The purpose of this study is to explore the dose-response relationship of Iocide oral rinse in a clinical trial of gingivitis. Approximately sixty (60) otherwise healthy subjects having gingivitis will be randomized into the…
- Trial name
- NCT01103102
- Testing
- Iocide Oral Rinse
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Biomedical Development Corporation
Septic Shock
Early Haemodynamic Optimization Using Preload Dependence During Septic Shock = EHOSS-1
Haemodynamic optimization is of paramount importance in septic shock, but is really consensual and standardized during the first 6 hours of treatment.
- Trial name
- EHOSS-1 (NCT01972828)
- Testing
- FLUID MANAGEMENT GUIDED WITH PRELOAD-DEPENDENCE PARAMETERS (VOLUVEN ®), STANDARD-GUIDED FLUID MANAGEMENT (VOLUVEN ®)
- Volunteers
- 61 people
- Sponsor
- Hospices Civils de Lyon
Covid19
Is Bio-adrenomedullin (Bio-ADM) a Prognostic Factor in Patients With COVID-19 Treated in the ICU?
This is prospective, observational study using point of care test to determine bio-ADM whole blood concentrations and its predictive value in patients with COVID-19 treated in the ICU.
- Trial name
- NCT04813939
- Testing
- IB10 sphingotest® bio-ADM® apparatus (Sphingotec GmbH, Hennigsdorf, Germany)
- Where
- Poland
- Volunteers
- 32 people
- Sponsor
- Medical University of Warsaw
Catheter Related Infection
Catheter Early Withdrawal or Maintenance in Sepsis or Septic Shock
Central venous catheter(CVC)-related infection is an inherent complication of this device that should be treated promptly. However, there are doubts about the need for the immediate withdrawal of CVC while there is still no…
- Trial name
- NCT01947751
- Testing
- CVC exchange, CVC maintenance
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Nossa Senhora da Conceicao
Sepsis, Pre-Eclampsia
Establishment of an ELISA for the Recognition of Procalcitonin Variants in Patients With Hyperprocalcitonemia.
Procalcitonin is a protein consisting of 116 amino-acids which can rapidly rise under inflammatory conditions and sepsis. More than 20 years ago it has been shown that dipeptidylpeptidase-4 (DPP-4) cleaves procalcitonin from the…
- Conditions
- Sepsis, Pre-Eclampsia, Granulomatosis With Polyangiitis, Microscopic Polyangiitis
- Trial name
- NCT05703802
- Testing
- Procalcitonin-variants ELISA-Assay
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Acute Respiratory Distress Syndrome, Septic Shock
Assessment of Preload Responsiveness in ARDS Patients During Prone Position
Evaluation of preload responsiveness in ARDS patients during prone position is difficult and only one study showed Trendelenburg manoeuvre can be used in this group of patients.
- Conditions
- Acute Respiratory Distress Syndrome, Septic Shock, Hemodynamic Instability
- Trial name
- PR-ARDS-PP (NCT04457739)
- Testing
- Tidal volume challenge, End-expiratory occlusion test, Trendelenburg maneuver
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Bicetre Hospital
Sepsis
Infraclavicular Axillary Vein Collapsibility Index as a Predictor of Fluid Responsiveness
Fluid responsiveness refers to the ability of the left ventricle to significantly increase stroke volume following fluid administration, and its assessment is critical in managing acute circulatory failure while avoiding fluid…
- Trial name
- NCT07507877
- Testing
- Infraclavicular axillary vein collapsibility index
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Lymphoma, Unspecified Adult Solid Tumor, Protocol Specific
Combination Chemotherapy in Treating Patients With Advanced Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00003956
- Testing
- fluorouracil, leucovorin calcium, lonafarnib
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Neonatal Sepsis, Sepsis
Simplified Antibiotic Therapy for Sepsis in Young Infants
This trial evaluates primary care clinic-based simplified antibiotic therapy options for young infants, 0-59 days old in high neonatal mortality settings in peri-urban Karachi where hospital referral is frequently refused by…
- Conditions
- Neonatal Sepsis, Sepsis, Infection
- Trial name
- SATT (NCT01027429)
- Testing
- procaine penicillin and gentamicin, amoxicillin and gentamicin, procaine penicillin, gentamicin, amoxicillin
- Where
- Pakistan
- Volunteers
- 2,543 people
- Sponsor
- Aga Khan University
Sepsis
Efficacy and Safety of Resatorvid in Patients With Sepsis-induced Cardiovascular and Respiratory Failure
The purpose of this study is to determine the effect of resatorvid on subjects with sepsis.
- Trial name
- NCT00633477
- Testing
- Resatorvid
- Where
- Japan
- Volunteers
- 18 people
- Sponsor
- Takeda
Sepsis
Epidemiology of Sepsis at Yuetan Subdistrict in Beijing
The purpose of this study is to determine the epidemiology and outcome of sepsis at Yuetan subdistrict in Beijing in mainland China).
- Trial name
- NCT02285257
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Sepsis
Evaluating the Diagnostic Performance and Impact on Clinical Outcomes of the NuRapid-CRISPR Pathogen Profile Assay in ICU Patients With Sepsis
This study is a prospective, multicenter, integrated trial designed to evaluate, from the perspectives of diagnostic performance and clinical utility, whether a diagnostic and treatment strategy based on the NuRapid-CRISPR rapid…
- Trial name
- NCT07580001
- Testing
- NuRapid-CRISPR Rapid Pathogen Detection Technology, Traditional pathogen culture
- Where
- 3 sites in China
- Volunteers
- 396 people
- Sponsor
- Shanghai 10th People's Hospital
Chorioamnionitis, Puerperal Endometritis
Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term
The aims of this study are to determine whether antibiotics administered routinely in women presenting with premature rupture of membranes later than the 37+0 weeks of gestation can alter the rate of maternal and neonatal…
- Conditions
- Chorioamnionitis, Puerperal Endometritis, Neonatal Early Onset Sepsis, Neonatal Meningitis
- Trial name
- NCT01633294
- Testing
- Ampicillin + gentamicin
- Where
- Portugal
- Volunteers
- 161 people
- Sponsor
- Hospital de Santa Maria, Portugal
Severe Sepsis, Septic Shock
German Lactat Clearance in Severe Sepsis
The aim of this study is to investigate if there is a correlation between lactate clearance and the course at patients with severe sepsis and septic shock at german intensive care units.
- Trial name
- GLASS (NCT01929772)
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- RWTH Aachen University
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