Clinical trials: Systemic Inflammation
Staphylococcus Aureus
A Study to Evaluate AZD7760 Safety and Pharmacokinetics in Healthy Adults (Phase I) and Adults With End-stage Kidney Disease on Hemodialysis With a Central Venous Catheter (Phase IIa)
The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of AZD7760 when given as an intravenous infusion to healthy participants (Phase I) or participants with end-stage kidney disease receiving hemodialysis…
- Trial name
- PEAK (NCT06749457)
- Testing
- AZD7760
- Where
- 40 sites in United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Critical Illness, Sepsis
Implementation of a Web Based Real Time Clinical Decision Support Tool.
In the developed world critical illness is routinely treated in an intensive care unit (ICU) by highly specialized physicians, nurses and support staff.
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, Shock
- Trial name
- CERTAINp (NCT02398981)
- Testing
- Clinical decision support tool
- Where
- 10 sites in China, Croatia and 4 more
- Volunteers
- 962 people
- Sponsor
- Mayo Clinic
Sepsis, Septic Shock
Rotational Thromboelastometry Versus DIC Score in Sepsis
Sepsis results in activation of the coagulation system, which is commonly described as disseminated intravascular coagulation (DIC).
- Trial name
- RODSS (NCT04610853)
- Testing
- rotational thromboelastometry
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Severe Sepsis or Septic Shock (ICD-10-GM, R65.0, R65.1)
Jena Sepsis Registry
Despite the burden of severe sepsis and septic shock deficiencies in the quality of sepsis management are recognized. Investigators present a population-based registry with easy feasibility as part of German Center for Sepsis…
- Trial name
- JenaSepsisReg (NCT02165501)
- Where
- Germany
- Volunteers
- 1,995 people
- Sponsor
- University of Jena
Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS)
Study of Nogapendekin Alfa Inbakicept and iNKT Cells in Critically Ill Adults With Severe Community-Acquired Pneumonia
This is a Phase 3, randomized, blinded, and placebo-controlled clinical trial investigating a new combination treatment for critically ill adults who have severe community-acquired pneumonia, especially if they also have sepsis…
- Conditions
- Community-Acquired Pneumonia (CAP), Acute Respiratory Distress Syndrome (ARDS), Sepsis, Lymphopenia
- Trial name
- NCT07492875
- Testing
- Nogapendekin alfa inbakicept (NAI), agenT-797
- Sponsor
- ImmunityBio, Inc.
Sepsis
Methylene Blue and Ozone in Early Sepsis
effects of methylene blue and ozone O3 therapy effects in early sepsis management , and their implications upon outcome
- Trial name
- NCT02910765
- Testing
- methylene blue, ozone, saline infusion
- Volunteers
- 40 people
- Sponsor
- Assiut University
Sepsis
The Study of NT-proBNP Combined With HS-cTnT in Evaluating the Prognosis of Sepsis
To study the clinical value of combined detection of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-cTnT) in assessing the prognosis of patients with sepsis.
- Trial name
- NCT04963699
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Endotoxemia, Sepsis
Low-Dose Endotoxemia and the Acute Phase Response
The purpuse of this study is to examine the acute phase respons when different doses of E. Coli Endotoxin is injected in healty volunters.
- Trial name
- NCT00197899
- Testing
- E. Coli endotoxin
- Where
- Denmark
- Sponsor
- Herlev Hospital
Obesity, Sepsis
Adiposity and Immunometabolism in Sepsis
Obesity has been shown to increase adverse outcomes in some critically ill patients e.g. those with COVID-19. For patients with sepsis this association is less clear cut but there is evidence that body fat distribution, resulting…
- Trial name
- AIMS (NCT06307509)
- Testing
- Diagnosis of sepsis
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- NHS Greater Glasgow and Clyde
Hypomagnesemia, Coagulopathy
Association Between Hypomagnesemia and Coagulopathy in Sepsis
This study aimed to investigate the association between hypomagnesemia and coagulopathy in patients with sepsis, with a focus on evaluating whether low serum magnesium levels are independently linked to the development of…
- Conditions
- Hypomagnesemia, Coagulopathy, Sepsis
- Trial name
- NCT07576621
- Testing
- Serum magnesium concentration
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Severe Sepsis
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis
Activation of caspase-4 and human caspase-5 (orthologs of caspase-11 in mice) in innate immune cells.
- Trial name
- CASPASEs (NCT02539147)
- Testing
- blood samples
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Septic Shock
Evaluation of Early Association of Terlipressin and Norepinephrine During Septic Shock; the TerliNor Study
In guidelines norepinephrine is the first line vasopressor recommended in case of septic shock. Use of vasopressin is recommended when norepinephrine fails to maintain a mean arterial pressure above 65mmHg or in salvage.
- Trial name
- TERLINOR (NCT03336814)
- Testing
- Terlipressin
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Sepsis
Assessment of a Proposed Microbiological Alert and Its Impact on a Sepsis Campaign
The aim of the present study was to evaluate the ability of health-care professionals in addressing sepsis, and the impact of a telephone call upon receival of blood cultures in the clinical microbiology department, from a…
- Trial name
- NCT02325258
- Testing
- Telephone call
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Emilio Bouza
Sepsis, Diastolic Dysfunction
Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients
Sepsis is one of the most challenging conditions with an exceptionally high mortality rate. Diastolic Dysfunction is common in septic patients and has been found to be associated with mortality.
- Conditions
- Sepsis, Diastolic Dysfunction, Lung Edema, Fluid Overload
- Trial name
- NCT03768752
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Septic Shock
Selepressin Evaluation Programme for Sepsis-Induced Shock - Adaptive Clinical Trial
This is a double-blind, randomised, placebo-controlled, two-part adaptive clinical trial. The trial is designed to investigate the efficacy and safety of multiple dosing regimens of selepressin and to confirm the efficacy and…
- Trial name
- SEPSIS-ACT (NCT02508649)
- Testing
- selepressin
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 868 people
- Sponsor
- Ferring Pharmaceuticals
Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal
Effect of Targeted Temperature Management on Cerebral Autoregulation in Patients With Neurocritical Diseases
Change and effect of cerebral autoregulation during targeted temperature management in neurocritical patients
- Conditions
- Ischemic Stroke, Subarachnoid Hemorrhage, Aneurysmal, Sepsis, TBI (Traumatic Brain Injury)
- Trial name
- NCT04728438
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiangya Hospital of Central South University
Acute Kidney Injury, Sepsis
Predictive Value of Doppler RSI for Prediction of AKI in Septic Patients in ICU
Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ…
- Trial name
- NCT04426032
- Testing
- Renal Doppler Ultrasound
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Enterocolitis, Necrotizing, Bacteremia
Antibiotic "Dysbiosis" in Preterm Infants
Prolonged antibiotic use in preterm neonates has significant consequences on the developing intestinal microbiome, metabolome and host response, predisposing the neonate to various major morbidities, including necrotizing…
- Conditions
- Enterocolitis, Necrotizing, Bacteremia, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage
- Trial name
- NCT02784821
- Testing
- Antibiotic, Gastric fluid, Breast milk
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- University of Florida
Immune and Microbial Reconstitution, Systemic Viral Infection
Monitoring of Immune and Microbial Reconstitution in (HCT) and Novel Immunotherapies
This protocol serves as a mechanism to collect, store, and distribute bodily fluid and tissue samples obtained from Hematopoietic Cell Transplant (HCT) or novel immunotherapy patients and their donors at the Masonic Cancer Center…
- Conditions
- Immune and Microbial Reconstitution, Systemic Viral Infection, Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
- Trial name
- NCT03557749
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Bloodstream Infection, Pneumonia - Bacterial
Combination vs. Monotherapy for Stenotrophomonas Maltophilia Infections
The goal of this multicentre observational study is to analyse the treatment strategies and the outcomes for patients with S. maltophilia infections using target trial emulation methodology.
- Conditions
- Bloodstream Infection, Pneumonia - Bacterial, S Maltophilia Infections
- Trial name
- EMULATE-Sm (NCT07593547)
- Where
- Spain
- Volunteers
- 1,718 people
- Sponsor
- Instituto de Investigación Sanitaria Gregorio Marañón