Clinical trials: Systemic Inflammatory Response Syndrome
SIRS, Sepsis
SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU
Aim of the study : The primary aim of the investigators study is to highlight the presence of biomarkers (biological indicators of the presence of inflammation or infection) of infectious processes during the systemic…
- Conditions
- SIRS, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- Captain (NCT01378169)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Substance Use Disorders, Infection, Soft Tissue
Anchoring Sequential Intermittent Long Acting Antimicrobials With Medication for Opioid Use Disorder (MOUD) for Invasive Infections Related to Opioid Use
Standard of care for patients with opioid use disorder and complicated infections is discharge to subacute nursing facilities on IV antibiotics until completion of treatment course.
- Conditions
- Substance Use Disorders, Infection, Soft Tissue, Bacteremia, Osteomyelitis Acute
- Trial name
- AIM-STOP (NCT05521880)
- Testing
- Oritavancin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Maryland, Baltimore
Immunology of Septic Shock
Evaluation of Immunosuppression in Septic Shock: Biomarkers and Pharmacological Restoration (IMMUNOSEPSIS)
Septic syndromes (systemic inflammatory response associated with infection) remain a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units.
- Trial name
- IMMUNOSEPSIS (NCT02803346)
- Testing
- Circulating blood (leukocytes)
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Intensive Care Unit Acquired Weakness, Shock, Septic
Hemodynamic Phenotype-Based,Capillary Refill Time-Targeted Resuscitation In Early Septic Shock:ANDROMEDA-SHOCK-2
Over-resuscitation including fluid overload has been associated with increased morbidity (prolonged duration of organ failure) and mortality in septic shock.
- Trial name
- ANDROMEDA-FR (NCT06062303)
- Testing
- Usual care (UC)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis, Septic Shock
Ventriculo-arterial Coupling and Myocardial Work in Sepsis and Septic Shock
Sepsis is a term which describes an excessive response of the body to an infection and, if not promptly treated, can turn into septic shock a condition in which the organs don't receive enough oxygen to satisfy their needs.
- Trial name
- NCT06853574
- Testing
- Fluid therapy, Noradrenaline infusion
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- General and Teaching Hospital Celje
Malaria
Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment in Malian Children
Background: The disease malaria can cause very serious health problems. Researchers want to see if malaria affects the way T cells and vaccines work in the body.
- Trial name
- NCT02504918
- Where
- Mali
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Severe Sepsis
Pharmacokinetics, Safety, Tolerability and Pharmacodynamics of BMS-986189 in Healthy Subjects
The main purpose of this study is to measure the amount of study drug (BMS-986189) in the blood and urine and to see if BMS-986189 is safe and well-tolerated in healthy people after a single dose.
- Trial name
- NCT02739373
- Testing
- BMS-986189
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Bacteremia
Safety and Efficacy of Dalbavancin Versus Vancomycin in the Treatment of Catheter-Related Bloodstream Infections
This is a study to evaluate a new medication dosed once a week in the treatment of bacterial infections in the blood from intravenous catheters (CR-BSI).
- Trial name
- NCT00057369
- Testing
- dalbavancin
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Vicuron Pharmaceuticals
Bacteremia
Spanish Bacteriemia Cohort 2016: Epidemiology, Clinical Management and Prognosis Factors
Bacteremia The Hypothesis of the study are the followings: To demonstrate relevant epidemiologic and clinical changes with potentially impact in the management and prognosis of the patients with bacteremia.
- Trial name
- PRO-BAC (NCT03148769)
- Where
- 29 sites in Spain
- Volunteers
- 5,320 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Sepsis
The Influences of Early Mobilization on Myokines, Body Composition and Outcomes in ICU Septic Patients
the investigators' preliminary data revealed that early physical therapy in patients with sepsis in ICU could promote recovery of function (liver and kidney) and decrease the length of stay in hospitalization.
- Trial name
- NCT06061224
- Testing
- early mobilization (physical therapy)
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- Chang Gung Memorial Hospital
Bacteremia, Sepsis
Fast Assay for Pathogen Identification and Characterization
Sepsis is a life-threatening disease caused by a dysregulated host response to infection. This can lead to organ-dysfunction and septic shock, which is a subset of sepsis where underlying abnormalities increase mortality…
- Conditions
- Bacteremia, Sepsis, Septic Shock
- Trial name
- FAPIC (NCT03841162)
- Where
- Belgium
- Volunteers
- 1,957 people
- Sponsor
- Hasselt University
Critical Illness, Septic Shock
Microcirculatory Alterations in Critical Disease: New Ultrasound Technology
Aim of this study is (1) to test and further develop a new non-invasive ultrasound method, and (2) to gain new insight into microcirculatory alterations during critical disease, particularly in critical septic shock patients.
- Trial name
- SepCease (NCT03311568)
- Testing
- ultrasound for microcirculatory assessment
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Sepsis, Immune System Disorder
The Th17/Treg Cells and IL-23/IL-17 Axis and Early Enteral Nutrition in Sepsis
The investigators aim to evaluate the roles of Th17/Treg cells and IL-23/IL-17 axis in the mechanisms of early enteral nutrition (EEN) correcting immune imbalance of sepsis by means of improving the intestinal flora disturbance.
- Conditions
- Sepsis, Immune System Disorder, Enteral Feeding
- Trial name
- NCT03385850
- Testing
- enteral nutrition
- Where
- China
- Volunteers
- 53 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Intraventricular Hemorrhage, Sepsis
Protective Effects of Delayed Cord Clamping in Very Low Birth Weight (VLBW) Infants
The purpose of this study is to determine whether the intervention of delaying cord clamping for 30 to 45 seconds followed by one milking of the cord while simultaneously lowering the VLBW infants below the introitus will result…
- Trial name
- NCT00818220
- Testing
- delayed umbilical cord clamping, Immediate cord clamping
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- University of Rhode Island
Sepsis, Septic Shock
ICITRU : Randomized Trial of Immunonutrition With L-citrulline in Patients Hospitalized in Intensive Care for Sepsis or Septic Shock
Immunonutrition in intensive care has not yet demonstrated a beneficial effect on organ failure, the acquisition of nosocomial infections, or mortality.
- Trial name
- ICITRU (NCT04513288)
- Testing
- Experimental treatment L-citrulline (Protéocit®)
- Where
- 5 sites in France
- Volunteers
- 130 people
- Sponsor
- Rennes University Hospital
Sepsis
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
Comparison of Microcirculation Indexes and Hemodynamic Indexes to Guide Resuscitation in Patients With Septic Shock
- Trial name
- NCT05118646
- Testing
- sublingual microcirculation,, hemodynamic monitoring
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Xiangya Hospital of Central South University
Augmented Renal Clearance (ARC), Systemic Inflammatory Response Syndrome (SIRS)
Pharmacokinetic Study of Ceftaroline Fosamil/Avibactam in Adults With Augmented Renal Clearance
To evaluate the pharmacokinetic (PK) profiles of ceftaroline and avibactam in adults with augmented renal clearance (ARC).
- Trial name
- NCT01624246
- Testing
- Ceftaroline fosamil/Avibactam (CXL)
- Where
- 21 sites in United States, Australia
- Volunteers
- 12 people
- Sponsor
- Forest Laboratories
Sepsis
Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis
Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU…
- Trial name
- Aminoside_II (NCT02898961)
- Testing
- 30 mg/kg amikacin or 8 mg/kg gentamicin
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Systemic Inflammatory Response Syndrome, Coronary Artery Bypass Grafting
Immunomodulation of EA-230 Following On-pump Coronary Artery Bypass Grafting (CABG)
EA-230 is a newly developed synthetic compound with anti-inflammatory properties, it is a linear tetrapeptide derived from the human chorionic gonadotropin hormone (hCG).
- Trial name
- EASI (NCT03145220)
- Testing
- EA-230
- Where
- Netherlands
- Volunteers
- 180 people
- Sponsor
- Radboud University Medical Center
Severe Sepsis
Safety and Efficacy of Talactoferrin Alfa in Patients With Severe Sepsis
Study will evaluate the safety and potential benefit of talactoferrin (recombinant human lactoferrin) as an addition to the standard care for severe sepsis.
- Trial name
- OASIS (NCT01273779)
- Testing
- Talactoferrin alfa
- Where
- 100 sites in United States, Belgium and 8 more
- Volunteers
- 1,280 people
- Sponsor
- Agennix