Clinical trials: Systemic Lupus
Systemic Lupus Erythematosus
Effect of Curcumin on Systemic Lupus Erythematosus
The purpose of this investigator initiated study is to determine the efficacy of curcumin on disease activity of subjects with systemic lupus erythematous.
- Trial name
- NCT03953261
- Testing
- Curcumin supplement
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Loma Linda University
Rheumatoid Arthritis, Psoriatic Arthritis
COVID-19 Infection in Vulnerable Patients With Inflammatory Rheumatic Diseases
The trial is a prospective, observational study aiming to identify risk factors for serious COVID-19 infection by evaluating clinical measures and biomarkers of inflammation in patients with inflammatory rheumatic disease…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- NCT04335747
- Testing
- COVID-19 infection
- Where
- Denmark
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Salome Kristensen
Systemic Lupus Erythematosus
International Prospective Study on Adherence to Treatment in Patients With Active Systemic Lupus Erythematosus
The treatment of systemic lupus erythematosus (SLE) may change in the future due to the availability of new biological treatments, especially monoclonal antibodies in patients with active disease.
- Trial name
- Adherence-SLE (NCT01509989)
- Where
- France
- Volunteers
- 307 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lupus Nephritis
Fibrinogen to Albumin Ratio (FAR) as a Predictive Biomarker for Lupus Nephritis (LN)
Fibrinogen to Albumin ratio as a predictive biomarker for lupus nephritis (LN)
- Trial name
- NCT06288308
- Testing
- fibronigin to albumin ratio
- Volunteers
- 90 people
- Sponsor
- Assiut University
Systemic Lupus Erythematosus
Care Coordination Approaches to Learning Lupus Self-management
The Care-coordination Approach to Learning Lupus Self-Management (CALLS) study was designed to examine whether modeling and reinforcement from a lay patient navigator/care coordinator improves disease self-management, indicators…
- Trial name
- CALLS (NCT04400240)
- Testing
- CALLS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Systemic Lupus Erythematosus
Fatigue, Depression, and Cortical Excitability in Systemic Lupus
Systemic lupus erythematosus is a chronic inflammatory autoimmune disease with an unknown cause and many challenges. Whilst corticosteroids and effective immunosuppressive therapy have transformed the management of patients with…
- Trial name
- NCT03165682
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
Carotid Ultrasound-Based Strategy for Primary Prevention of Cardiovascular Events in Inflammatory Rheumatic Disease (PREVENER)
PREVENER is a randomized, open-label, multicenter, phase IV clinical trial designed to evaluate the efficacy and safety of a carotid ultrasound-based strategy for the primary prevention of cardiovascular events in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondy, Systemic Lupus Erythematosus (SLE)
- Trial name
- PREVENER (NCT07611747)
- Testing
- Carotid Ultrasound, High-intensity lipid-lowering therapy, Standard care according to ESC 2021 guidelines
- Where
- 17 sites in Spain
- Volunteers
- 1,944 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Rheumatoid Arthritis, Systemic Lupus Erythematosus
Study During Pregnancy of Expression of miRNAs in RA or SLE
Rheumatoid arthritis (RA) is a systemic disease, which mainly targets joints and results in osteoarticular destruction and serious disability.
- Trial name
- SPIRALE (NCT02350491)
- Testing
- Collection of biological samples
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Lupus Nephritis, Systemic Lupus Erythematosus
SII and SIRI as Prognostic Biomarkers in Lupus Nephritis
This prospective observational study aims to evaluate the prognostic utility of the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) as novel inflammatory biomarkers for monitoring disease…
- Conditions
- Lupus Nephritis, Systemic Lupus Erythematosus, Kidney Diseases
- Trial name
- NCT07780045
- Volunteers
- 100 people
- Sponsor
- Assiut University
Systemic Lupus Erythematosus
Intervention to Improve Communication and Medication Adherence in Lupus
CO-LEAD is an intervention to improve patient-provider communication and medication adherence among patients with systemic lupus erythematosus (SLE).
- Trial name
- CO-LEAD (NCT06458075)
- Testing
- CO-LEAD
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Duke University
Lupus Nephritis (LN)
Predictors of ICU Admission and In-Hospital Mortality in Hospitalized Patients With Lupus Nephritis: The Prognostic Value of Neutrophil-to-Lymphocyte Ratio and C Reactive Protein to Serum Albumin Ratio
To identify clinical and laboratory predictors of ICU admission and in-hospital mortality among hospitalized adults with lupus nephritis by evaluating the prognostic performance of NLR and CAR, comparing them with CRP and albumin…
- Trial name
- NCT07783711
- Volunteers
- 55 people
- Sponsor
- Khaled Samir Malak Nashed
Systemic Lupus Erythematosus, Sleep Disorders
Aerobic Exercise on Improving Sleep in Systemic Lupus Erythematosus.
The purpose of this study is to determine the effectiveness of exercise training on improving sleep in patients with systemic lupus erythematosus.
- Trial name
- EFEXO (NCT02037971)
- Testing
- Aerobic Exercise, Control Group
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of São Paulo
Immune System Diseases, Autoimmune Diseases
Safety Study of CDP7657 in Healthy Volunteers and Patients With Systemic Lupus Erythematosus (SLE)
To evaluate safety, tolerability, pharmacokinetics and immunogenicity of CDP7657
- Conditions
- Immune System Diseases, Autoimmune Diseases, Lupus Erythematosus, Systemic, Skin and Connective Tissue Diseases
- Trial name
- NCT01093911
- Testing
- CDP7657
- Where
- 8 sites in Belgium, Bulgaria and 1 more
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- UCB Pharma
Systemic Lupus Erythematosus
Serum Levels of Angiotensin Converting Enzyme in Systemic Lupus Erythematous Patients
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that involve many different organs and display a variable clinical course.The prevalence of SLE varies across gender, race/ethnicity, and geographic…
- Trial name
- NCT05516511
- Testing
- Angiotensin Converting Enzyme test
- Where
- Egypt
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Sohag University
Lupus Nephritis
Efficacy and Safety of Tacrolimus Versus Mycophenolate in Lupus Nephritis
Prospective, randomized, parallel-group controlled, open-label, international (Asian) multicenter, comparison of corticosteroids combined with tacrolimus and corticosteroids combined with mycophenolate mofetil.
- Trial name
- NCT02630628
- Testing
- Tacrolimus, Mycophenolate mofetil
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- The University of Hong Kong
Active Systemic Lupus Erythematosus
Anifrolumab Asian PhIII Efficacy Study for Systemic Lupus Erythematosus (SLE)
The purpose of this study is to evaluate the efficacy and safety of an intravenous treatment regimen of anifrolumab versus placebo in Asian participants with active systemic lupus erythematosus (SLE).
- Trial name
- NCT04931563
- Testing
- Anifrolumab
- Where
- 65 sites in China, Hong Kong and 4 more
- Volunteers
- 277 people
- Sponsor
- AstraZeneca
Systemic Lupus Erythematosus
Steroid Induced Osteoporosis in Patients With Systemic Lupus Erythematosus
The primary aim of the present study was to investigate the prevalence of low bone mineral density (BMD) and vertebral fractures, as determined by a standardized assessment, and to elucidate the role of bone qualities, including…
- Trial name
- NCT00668330
- Testing
- Ibandronate+alfacalcidol+calcium
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Quality of Life
The Effect of Listening to Qur'an Recital on Quality of Life in Systemic Lupus Erythematosus Patients
The goal of this quasi-experimental study is to evaluate the effect of listening to the Qur'an recital on quality of life among systemic lupus erythematosus patients. There will be intervention and control groups.
- Trial name
- NCT06263764
- Testing
- Listening to Qur'an Recital
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Systemic Lupus Erythematosus
Immune Ablation and Hematopoietic Stem Cell Support in Patients With Systemic Lupus Erythematosus: A Phase II Study
In patients with systemic lupus erythematosus, immunosuppressive therapy to the point of complete immune ablation and hematopoietic stem cell recovery.
- Trial name
- NCT00271934
- Testing
- Immune ablation and hematopoietic stem cell support.
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Northwestern University
Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Discoid
Autologous Polyclonal Tregs for Lupus
The primary purpose of this Phase 1 study is to evaluate the safety, tolerability, and effect of 3 different doses of Treg therapy in adults with skin (cutaneous) involvement of their lupus.
- Conditions
- Lupus Erythematosus, Cutaneous, Lupus Erythematosus, Discoid, Lupus Erythematosus, Systemic
- Trial name
- NCT02428309
- Testing
- Ex vivo Expanded Human Autologous Polyclonal Regulatory T Cells
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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