Clinical trials: Systemic Lupus
Systemic Lupus Erythematosus, CAR-T Cell Therapy
Study of Therapeutic Efficacy of Anti-CD19 CAR-T Cells in Refractory Systemic Lupus Erythematosus
This is an investigator-initiated trial aimed at assessing the safety of anti-CD19 CAR-T cells in the treatment of refractory systemic lupus erythematosus.
- Trial name
- NCT06222853
- Testing
- anti-CD19-CAR-T cells
- Where
- China
- Volunteers
- 22 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Systemic Lupus Erythematosus, Placenta-mediated Pregnancy Complications
At the Heart of the Matter - Speckle Tracking Echocardiography in Lupus Mothers and Their Offspring
Women with systemic lupus erythematosus (SLE) have a high risk of placenta-mediated complications, which can lead to substantial cardiac morbidities in affected women and their offspring.
- Conditions
- Systemic Lupus Erythematosus, Placenta-mediated Pregnancy Complications, Hydroxychloroquine, Speckle Tracking Echocardiography
- Trial name
- NCT05451277
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Evelyne Vinet
Systemic Lupus Erythematosus
ALPN-101 (Acazicolcept) in Systemic Lupus Erythematosus
This is Phase 2, multinational, randomized, blinded study to evaluate the safety, tolerability, efficacy, immunogenicity, pharmacokinetics and pharmacodynamics of ALPN-101 (acazicolcept) in adults with moderate to severe active…
- Trial name
- Synergy (NCT04835441)
- Testing
- ALPN-101
- Where
- 46 sites in United States, France and 5 more
- Volunteers
- 76 people
- Sponsor
- Alpine Immune Sciences Inc, A Subsidiary of Vertex
Systemic Lupus Erythematosus, Cutaneous Lupus
Duke Lupus Registry
Lupus is a systemic autoimmune disease that can present with many varied symptoms, including joint pain, fevers, kidney disease, and rashes. Lupus can affect anyone, but it is most common in younger women.
- Trial name
- NCT00512694
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Duke University
Lupus Nephritis, Systemic Lupus Erythematosus (SLE)
Induction Therapy for Lupus Nephritis With no Added Oral Steroids: A Trial Comparing Oral Corticosteroids Plus Mycophenolate Mofetil (MMF) Versus Obinutuzumab and MMF
This is a randomised, open label, controlled non-inferiority phase III multicentre trial. As primary objective, the study aims to demonstrate that a regimen free of additional oral corticosteroids but with obinutuzumab (and MMF)…
- Trial name
- OBILUP (NCT04702256)
- Testing
- Obinutuzumab administration, Administration of Methylprednisolone + Prednisone + Mycophenolate mofetil, Administration of methylprednisolone, paracetamol and dexchlorpheniramine
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anti-Phospholipids Syndrome (APS), Systemic Lupus Erythematosus (SLE)
Register of Patients With Anti-Phospholipids Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE)
The purpose of that register is to collect medical information about patients suffering of APS with or without associated SLE.
- Trial name
- SAPL-LUPUS (NCT02782039)
- Where
- 2 sites in France
- Volunteers
- 868 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus
NOX-E36 First-in-Human (FIH) Study
This is the first time NOX-E36 will be administered to man. The principal aim of this study is to obtain safety and tolerability data when NOX-E36 is administered by single intravenous (IV) and subcutaneous (SC) doses to healthy…
- Conditions
- Chronic Inflammatory Diseases, Type 2 Diabetes Mellitus, Systemic Lupus Erythematosus
- Trial name
- NCT00976729
- Testing
- NOX-E36
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Systemic Lupus Erythematosus
A Study of CM313 Injection in Subjects With Systemic Lupus Erythematosus
A study of CM313 in subjects with systemic lupus erythematosus
- Trial name
- NCT05465707
- Testing
- CM313 2 mg/kg, CM313 4 mg/kg, CM313 8 mg/kg
- Volunteers
- 40 people
- Sponsor
- Keymed Biosciences Co.Ltd
Systemic Lupus Erythematosus
Study Evaluating the Pharmacokinetics and Safety of Epratuzumab in Japanese Systemic Lupus Erythematosus (SLE)
The primary objective of the study is to evaluate the safety, tolerability and Pharmacokinetics (PK) of Epratuzumab in Japanese subjects with moderate to severe general SLE as add on to standard of care treatment during the trial.
- Trial name
- NCT01449071
- Testing
- Epratuzumab 400 mg, Epratuzumab 1200 mg, Epratuzumab 100 mg
- Where
- 7 sites in Japan
- Volunteers
- 20 people
- Sponsor
- UCB Pharma
Systemic Lupus Erythematosus
Anti-infection of Low-does IL-2 in SLE
The objective of this clinical study is to evaluate the potential effect of anti-infection of low-does IL-2 in patients with SLE.
- Trial name
- NCT02932137
- Testing
- Interleukin-2
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking University People's Hospital
Systemic Lupus Erythematosus (SLE)
Efficacy of Vitamin C Supplementation on Malondialdehid Levels and Disease Activity in SLE Patients
The study aimed to evaluate the efficacy of vitamin C supplementation compared to placebo towards malondialdehid levels and disease activity with the MEX-SLEDAI score in Systemic Lupus Erythematosus (SLE) patients.
- Trial name
- NCT07083622
- Testing
- Vitamin C
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Universitas Sriwijaya
Systemic Lupus Erythematosus
Dose Escalation Study of RSLV-132 in Subjects With Systemic Lupus Erythematosus
A one month multi-dose study will evaluate the safety and tolerability of 3 intravenous infusions of RSLV-132 in subjects with inactive to mild SLE.
- Trial name
- NCT02194400
- Testing
- RSLV-132
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Resolve Therapeutics
Arthritis, Rheumatoid Arthritis
Delivery of Enhance Fitness Trial
Arthritis is a common condition in the United States, and a leading cause of pain and disability. Physical exercise is recommended for managing arthritis, but access to evidence-based exercise programs is limited, particularly in…
- Conditions
- Arthritis, Rheumatoid Arthritis, Fibromyalgia, Gout
- Trial name
- DEFT (NCT05275348)
- Testing
- Tele-Enhance Fitness, In-person Enhance Fitness
- Where
- United States
- Volunteers
- 310 people
- Sponsor
- University of Washington
Systemic Lupus Erythematosus
Safety of IFNa Kinoid in Systemic Lupus Erythematosus
Interferon alpha (IFNa) is involved in the pathogenesis of systemic lupus erythematosus (SLE)and IFNa levels are associated with the severity of the disease. Blocking IFNa could be an attractive therapeutic strategy.
- Trial name
- NCT01058343
- Testing
- IFN-K
- Where
- 15 sites in Belgium, Bulgaria and 4 more
- Volunteers
- 28 people
- Sponsor
- Neovacs
Lupus Nephritis
RY_SW01 Cell Injection Therapy in Active Lupus Nephritis
RY_SW01 Cell Injection's preclinical research results have shown that the injection significantly improved urine biochemical indicators and tissue damage in two lupus nephritis animal models after MSC administration, with no…
- Trial name
- NCT06058078
- Testing
- RY_SW01 cell injection, Basic treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jiangsu Renocell Biotech Company
Lupus Erythematosus, Systemic
An Open-label Study to Evaluate the Long-term Safety of MEDI-546, for the Treatment of SLE, in Adults
The purpose of this study is to evaluate the long-term safety of anifrolumab (MEDI-546) in adults with moderate to severe active systemic lupus erythematosus (SLE).
- Trial name
- NCT01753193
- Testing
- Anifrolumab
- Where
- 57 sites in United States, Brazil and 11 more
- Volunteers
- 218 people
- Sponsor
- MedImmune LLC
Systemic, Lupus
Aerobic Exercise Versus Whole-Body Vibration on Fatigue, Functional Capacity, Quality of Life in Systemic Lupus
PURPOSE: … The aim of this study will be conducted to investigate the therapeutic efficacy of Aerobic exercise versus whole-body vibration on fatigue, functional capacity and quality of life in patients with systemic lupus…
- Trial name
- NCT05321108
- Testing
- Group A (GA)(Aerobic exercise group), Group B (GB) (Whole-body vibration (WBV) group)
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Cairo University
Healthy Volunteer, Rheumatoid Arthritis
Phenomics in Autoimmune and Inflammatory Diseases
The family of inflammatory/autoimmune systemic diseases (IAD) form a continuum from pure inflammatory diseases to pure autoimmune diseases, encompassing a large panel of inflammatory diseases with some autoimmune components, and…
- Conditions
- Healthy Volunteer, Rheumatoid Arthritis, Ankylosing Spondylitis, Systemic Lupus Erythematosus/Antiphospholipid Syndrome
- Trial name
- TRANSIMMUNOM (NCT02466217)
- Testing
- 1: AID groups, 2: Control groups
- Where
- 2 sites in France
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lupus Nephritis (LN)
Lupus Nephritis Care Pathway
The purpose of this study is to evaluate an approach to managing patients with lupus nephritis called the Lupus Nephritis (LN) Pathway among approximately 25 patients.
- Trial name
- NCT07783152
- Testing
- Lupus Nephritis (LN) Care Pathway
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Lupus Nephritis
To Compare the Efficacy and Safety of FK506 vs IVC in the Treatment of Class III-IV LN
1. To compare the efficacy of FK506 vs intravenous cyclophosphamide pulses in the treatment of class III-IV LN. 2. To compare the safety and tolerability of FK506 vs intravenous cyclophosphamide pulses in the treatment of class…
- Trial name
- NCT00302549
- Testing
- FK506
- Where
- China
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
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