Clinical trials: Systolic Hypertension
Postoperative Complications
Effect of Different Anesthetic Techniques for Isolated Systolic Hypertensive Patients of Abdominal Surgery on Postoperative Hospital Stay and Morbidity
In General anesthesia, two main ways of pain control are used intra-operatively, one is opioids, the other is epidural. Many colleges prefer using epidural analgesia because it is potent and more effective , and also the benefits…
- Trial name
- NCT01884298
- Where
- China
- Sponsor
- Peking University First Hospital
Bradycardia, Hypertension, Systolic
Preload and Autonomic Responses With Cardiac Neuromodulation Therapy (CNT) (CS-06)
This investigation will evaluate the effect of RV pacing lead position on cardiac function and the modulation of the autonomic nervous system with Cardiac Neuromodulation Therapy (CNT) pacing signals.
- Trial name
- CS-06 (NCT04463121)
- Testing
- Moderato IPG's CNT pacing signals, CD Leycom Pressure/Volume Combination Catheters
- Where
- Czechia
- Volunteers
- 22 people
- Sponsor
- BackBeat Medical Inc
Hypertension
The SAPPHIRE Study (Systolic And Pulse Pressure Hemodynamic Improvement By Restoring Elasticity)
The purpose of this study is to evaluate the safety and efficacy of ALT-711 in the treatment of isolated systolic hypertension in a formal dose-ranging study in patients without left ventricular hypertrophy.
- Trial name
- NCT00045981
- Testing
- ALT-711
- Volunteers
- 450 people
- Sponsor
- Synvista Therapeutics, Inc
Cardiovascular Responses in Elderly With Isolated Systolic Hypertension
Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension
Aim to study the exercise responses to both static and dynamic exercise in elderly people with and without essential isolated systolic hypertension, seeking to identify potentially dangerously high responses
- Trial name
- NCT02270216
- Testing
- static hand grip exercise, cycling exercise
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sahachat Aueyingsak
Hypertension
Obese Hypertension Study (0954-315)
This is a 16-week study to evaluate high systolic and diastolic blood pressure following treatment in obese, hypertensive, adult patients.
- Trial name
- NCT00289887
- Testing
- Comparator: losartan +/- HCTZ
- Volunteers
- 261 people
- Sponsor
- Organon and Co
Hypertension, Pulmonary, Ventricular Dysfunction, Left
Hemodynamic and Echocardiographic Assessment of Riociguat Effects on Myocardial Wall Contractility and Relaxation Kinetics
The aim of this study is to assess whether oral Riociguat affects the left ventricular contractility and relaxation in patients with pulmonary hypertension associated with left ventricular systolic dysfunction
- Trial name
- HEARTWORK (NCT01065051)
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Bayer
Hypertension, Atherosclerotic Cardiovascular Disease
Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure
In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse…
- Trial name
- PRISM-BP (NCT06962488)
- Testing
- Regular Care, SBP PRS Dissemination
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Alabama at Birmingham
Systolic Hypertension, Brachial Artery Flow-mediated Dilation
Dose-Response Effects of Inspiratory Muscle Strength Training on Blood Pressure and Vascular Function
This study will assess the dose-response effects of Inspiratory Muscle Strength Training (IMST) in adults with above-normal systolic blood pressure over a 6-week period.
- Trial name
- NCT07109739
- Testing
- POWERbreathe K5
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Minnesota
Hypertension
Blood Pressure Lowering of Aliskiren HCTZ Compared to HCTZ in Stage 2 Systolic Hypertension in Older Population
The purpose of the study is to evaluate the efficacy and safety of initial use of a fixed dose combination of aliskiren Hydrochlorothiazide (HCTZ) compared to Hydrochlorothiazide in older population with Stage 2 systolic…
- Trial name
- ACTION (NCT00760266)
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Novartis
Hypertensive Disorders of Pregnancy, Pre-eclampsia
Ophthalmic Artery Doppler in the Puerperium After Hypertensive Disorders of Pregnancy (OPHELIA-PP)
Hypertensive disorders of pregnancy frequently fail to resolve at delivery. A substantial proportion of women remain hypertensive at the six-week postnatal review, postpartum eclampsia occurs days to weeks after birth, and a…
- Conditions
- Hypertensive Disorders of Pregnancy, Pre-eclampsia, Postpartum Hypertension, Puerperal Disorders
- Trial name
- OPHELIA-PP (NCT07841795)
- Where
- Italy
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Hypertension
Aliskiren Plus HCTZ Compared to Aliskiren in Metabolic Syndrome Patients With Stage 2 Systolic Hypertension
The purpose of the study is to evaluate the blood pressure lowering effect and safety of aliskiren in combination with Hydrochlorothiazide (HCTZ) compared to aliskiren monotherapy when given to metabolic syndrome patients with…
- Trial name
- AIMS (NCT00797316)
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 532 people
- Sponsor
- Novartis
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Prognostic Value of the Right Ventricular Function by Portable Ultrasound in Patients With Pulmonary Hypertension.
Pulmonary arterial hypertension (PAH) is a disease characterized by obliteration and remodeling of small-caliber pulmonary arteries, progressively generating an increase in pulmonary vascular resistance, right heart failure, and…
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Cardiac Ultrasound
- Trial name
- NCT05343091
- Testing
- cardiac ultrasound
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Hypertension
An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension
Effect of increasing doses of olmesartan medoxomil and olmesartan medoxomil/hydrochlorothiazide on blood pressure in patients with hypertension
- Trial name
- NCT00185068
- Testing
- Olmesartan medoxomil, Olmesartan medoxomil/hydrochlorothiazide, Hydrochlorothiazide
- Where
- 16 sites in United States
- Volunteers
- 110 people
- Sponsor
- Daiichi Sankyo
Isolated Systolic Hypertension
Isolated Systolic Hypertension in the Elderly and Very Elderly
To evaluate the efficacy of long-term treatment of individually optimized doses of olmesartan medoxomil compared to nitrendipine in elderly and very elderly patients with isolated systolic hypertension.
- Trial name
- NCT00751829
- Testing
- olmesartan medoxomil + hydrochlorothiazide, if necessary, nitrendipine + hydrochlorothiazide, if necessary
- Where
- Germany
- Volunteers
- 417 people
- Sponsor
- Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company
Hypertension on Emergence
Proseal Laryngeal Mask Airway or Endotracheal Tube for Emergence From Neuroanesthesia
Extubation and emergence from anesthesia lead to systemic and cerebral hemodynamic changes that can cause cerebral edema and hemorrhage.
- Trial name
- NCT01718470
- Testing
- Endotracheal tube, LMA
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- Ricard Valero
Renal Artery Stenosis, Hypertension, Renovascular
Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension
The purpose of this trial is to test how well the iCAST™ RX Stent works in patients diagnosed with atherosclerotic renal artery stenosis and whether or not increased blood flow by the stent will help to control blood pressure.
- Trial name
- ARTISAN (NCT01673373)
- Testing
- iCAST™ Rx Stent System
- Where
- 12 sites in United States
- Volunteers
- 68 people
- Sponsor
- Atrium Medical Corporation
Essential Hypertension
To Assess Allisartan Isoproxil/Sustained-Release Indapamide in Patients With Essential Hypertension Uncontrolled With Allisartan Isoproxil
The main objective of the study will be to assess the efficacy and safety of Allisartan Isoproxil/sustained-release indapamide (240 mg/1.5 mg) in patients with mild to moderate essential hypertension uncontrolled after 4-week…
- Trial name
- NCT06500689
- Testing
- Allisartan Isoproxil/Sustained-Release Indapamide, Allisartan Isoproxil
- Where
- 40 sites in China
- Volunteers
- 366 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Isolated Systolic Hypertension
Systolic Hypertension in Europe Placebo-Controlled Trial
The Syst-Eur Trial is a concerted action of the European Community's Medical and Health Research Programme. The trial is carried out in consultation with the World Health Organization, the International Society of Hypertension…
- Trial name
- Syst-Eur (NCT02088450)
- Testing
- Active treatment with nitrendipine (10-40 mg/day).
- Volunteers
- 4,695 people
- Sponsor
- KU Leuven
Cardiovascular Diseases, Heart Diseases
Systolic Hypertension in the Elderly Program (SHEP) (Pilot Study)
The SHEP Pilot Study had six objectives, each designed to develop and test critical components of a full scale trial directed at the health consequences of treating isolated systolic hypertension (ISH) in the elderly. l.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000499
- Testing
- chlorthalidone, reserpine, hydralazine
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertension
Vitamin D and Blood Pressure
Vitamin D is a natural nutrient in normal daily diet. It can also be made in the skin after exposure to sunlight and is essential for maintaining normal calcium balance.
- Trial name
- NCT00459563
- Testing
- Vitamin D, calcitriol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Atlanta VA Medical Center