Clinical trials: Systolic Murmurs
Heart Failure
Acute Oral Ketones or Carbohydrate Supplement Modify Heart Function in Heart Failure?
Does oral intake of exogenous ketone salt improve heart function measured by cardiac MRI in heart failure compared to oral intake of a carbohydrate placebo?
- Trial name
- NCT05651529
- Testing
- exogenous ketone salt supplement, exogenous carbohydrate supplement
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- Université de Sherbrooke
Type 1 Diabetes
Liraglutide in the Treatment of Type 1 Diabetes Mellitus
Hypothesis 1: Treatment with Liraglutide in patients with type 1 diabetes decreases fasting, postprandial and the overall mean glucose concentrations.
- Trial name
- NCT01722266
- Testing
- Liraglutide
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Heart Failure, Systolic
Observational and Prospective Registry on Cardiac Contractility Modulation (CCM) Therapy
Observational and perspective study with acute and chronic endpoint.
- Trial name
- REPORT-CCM (NCT04902079)
- Testing
- Device for Cardiac Contractility Modulation Therapy (CCM)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Monaldi Hospital
Isolated Systolic Hypertension
Blood Pressure and Lipids Reduction in High Risk Elderly Patients With Isolated Systolic Hypertension
1. Study name: Blood Pressure and Lipids Reduction in High Risk Elderly Patients with Isolated Systolic Hypertension. 2. Medicine: amlodipine/atorvastatin tablet (5mg/10mg) and amlodipine (5mg). 3.
- Trial name
- NCT05165251
- Testing
- Amlodipine/Atorvastatin 5 Mg-10 Mg ORAL TABLET, Amlodipine 5mg, Lifestyle intervention
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Hypertension
Effects of Nebivolol on Exercise Tolerance and Left Ventricular Systolic and Diastolic Function
The goal of this pilot study is to effectively treat hypertension in subjects with either known or newly diagnosed hypertension and concurrent evidence of diastolic dysfunction.
- Trial name
- NCT01056718
- Testing
- Nebivolol
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Mercy Research
Heart Failure, Ventricular Premature Complex
Shensong Yangxin Capsule in the Treatment of Heart Failure Complicated With Ventricular Premature Beat
The purpose of this study is to assess the effects of Chinese medicine Shensong Yangxin capsule for the chronic cardiac dysfunction complicated with ventricular premature beats.
- Trial name
- NCT01612260
- Testing
- Shensong Yangxin capsule
- Where
- 20 sites in China
- Volunteers
- 460 people
- Sponsor
- Cong-xin Huang
Fetal Growth Restriction
Evaluation of Fetal Heart
Evaluation of fetal cardiac functions in cases complicated with growth restriction
- Trial name
- NCT07760194
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Assiut University
Heart Failure, Dilated Cardiomyopathy
Danish ICD Study in Patients With Dilated Cardiomyopathy
The primary objective of this study is to determine the efficacy of ICD therapy compared with control on the endpoint of death from any cause in patients with heart failure of non-ischemic oetiology.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Reduced LVEF
- Trial name
- DANISH (NCT00542945)
- Testing
- ICD, Optimal medical treatment
- Where
- Denmark
- Volunteers
- 1,116 people
- Sponsor
- Danish Study Group
Heart Failure, Iron Deficiencies
IRONHEART: Intravenous Iron in Non-ischaemic Heart Failure
The aim of this study is to observe the effect of intravenous ferric derisomaltose in participants with non-ischaemic heart failure (LVEF<40%), iron deficiency (TSATS<20%) and established on heart failure therapy including…
- Trial name
- IRONHEART (NCT06542822)
- Testing
- Ferric derisomaltose
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cardiovascular Diseases, Heart Diseases
Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function
The purpose of this study is to evaluate the effectiveness of aldosterone antagonist therapy in reducing cardiovascular mortality, aborted cardiac arrest, and heart failure hospitalization in patients who have heart failure with…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Heart Failure, Congestive
- Trial name
- TOPCAT (NCT00094302)
- Testing
- Spironolactone
- Where
- 270 sites in United States, Argentina and 4 more
- Volunteers
- 3,445 people
- Sponsor
- Carelon Research
Systolic Heart Failure
Effectiveness of a Repetitive Use of 24-hour Levosimendan Infusions in Patients With Severe Systolic Heart Failure in Order to Prevent Rehospitalizations
Rehospitalizations due to exacerbation of chronic heart failure are an important problem for patients suffering from heart failure.
- Trial name
- NCT03764722
- Testing
- Levosimendan
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Collegium Medicum w Bydgoszczy
Diabetes Mellitus, Type 2, Left Ventricular Systolic Dysfunction
Effects of Linagliptin on Left Ventricular Myocardial DYsfunction in Patients With Type 2 DiAbetes Mellitus and Concentric Left Ventricular Geometry
The primary objective of the study is to evaluate the effect of linagliptin 5 mg daily versus the corresponding placebo on the LV systolic function (measured by midwall shortening analysis) in patients with T2DM and a documented…
- Trial name
- DYDA2 (NCT02851745)
- Testing
- Linagliptin
- Where
- 19 sites in Italy
- Volunteers
- 188 people
- Sponsor
- Heart Care Foundation
Heart Failure Congestive
Effect of omega3 on Congestive Heart Failure
In this double blinded study patients with resynchronization pacemaker- AICD were assigned to Omega3 and placebo randomly, results indicated that Omega3 had no more effect than placebo in mortality, BNP level and 6 minutes walk…
- Trial name
- NCT01227837
- Testing
- omga3
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Shiraz University of Medical Sciences
Heart Failure, Systolic Heart Failure
Manipal Heart Failure Registry (MHFR)
Burden of HF in India is approximate 2-5 million patients with an estimated prevalence of 2-3/1000 population. HF is responsible for approx1.8 million admissions annually in India.
- Conditions
- Heart Failure, Systolic Heart Failure, Diastolic Heart Failure, Decompensated Heart Failure
- Trial name
- MHFR (NCT03157219)
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Manipal University
Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction
Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass
This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better…
- Conditions
- Coronary Artery Disease (CAD), Left Ventricular (LV) Systolic Dysfunction, Induction Anesthesia, Coronary Bypass Graft Surgery
- Trial name
- NCT07248202
- Testing
- Fentanyl (IV), lidocaine
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Cardiac Anaesthesia, Cardiopulmonary Bypass
Comparison of Milrinone and Epinephrine on TAPSE
Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures.
- Trial name
- Milrinone (NCT07144267)
- Testing
- Epinephrine, Milrinone Injection
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Mansoura University
Hypertension
Efficacy and Safety of the Angiotensin II Receptor Antagonist Micardis® (Telmisartan) or Hydrochlorothiazide in the Management of Patients With Isolated Systolic Hypertension (ISH)
Primary: To identify doses of Micardis®(telmisartan) which, administered once daily, are more effective than placebo and not inferior to HCTZ in lowering systolic blood pressure (SBP) in patients with isolated systolic…
- Trial name
- ARAMIS (NCT02175355)
- Testing
- Low dose of Micardis®, Medium dose of Micardis®, High dose of Micardis®
- Volunteers
- 1,039 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Telmisartan 80mg Plus Hydrochlorothiazide 25mg First Line in Moderate or Severe Hypertension
The primary objective of this trial is to demonstrate that the fixed-dose combination of T80/HCTZ25 is superior as first line therapy in reducing seated trough cuff Systolic Blood Pressure(SBP) compared to the monotherapy of T80…
- Trial name
- NCT00926289
- Testing
- Telmisartan, Hydrochlorothiazide
- Where
- 106 sites in United States, Bulgaria and 6 more
- Volunteers
- 894 people
- Sponsor
- Boehringer Ingelheim
Chagas Cardiomyopathy, Cardiac Arrhythmia
The Signal-averaged ElectrocArdiogram in Long Term Follow-up of Chronic CHagas Disease - RIO de Janeiro Cohort
The study investigated 100 subjects, both genders, with chronic Chagas disease, confirmed by at least two distinct serological tests, and classified according to Los Andes classification in a long term follow-up aiming at…
- Conditions
- Chagas Cardiomyopathy, Cardiac Arrhythmia, Stroke, Left Ventricular Function Systolic Dysfunction
- Trial name
- SEARCH-Rio (NCT01340963)
- Where
- 4 sites in United States, Brazil
- Volunteers
- 100 people
- Sponsor
- Universidade Gama Filho
Cardiovascular Responses in Elderly With Isolated Systolic Hypertension
Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension
Aim to study the exercise responses to both static and dynamic exercise in elderly people with and without essential isolated systolic hypertension, seeking to identify potentially dangerously high responses
- Trial name
- NCT02270216
- Testing
- static hand grip exercise, cycling exercise
- Where
- Thailand
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sahachat Aueyingsak