Clinical trials: T1DM, active
T1D, T1DM
Pre-Exercise Whey and Pea Protein in Adolescents With Type 1 Diabetes
The goal of this clinical trial is to learn whether drinking whey protein or pea protein before exercise affects blood sugar levels and appetite in adolescents with type 1 diabetes.
- Trial name
- NCT07836673
- Testing
- low whey protein, moderate whey protein, low Pea protein
- Volunteers
- 30 people
- Sponsor
- University of Jordan
Type 1 Diabetes Mellitus (T1DM), End-Stage Renal Disease
Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden
The researchers study time trends of childhood-onset type 1 diabetes and its most serious complication, end-stage renal disease.
- Trial name
- NCT06883318
- Where
- Sweden
- Volunteers
- 115,000 people
- Sponsor
- Umeå University
Type 2 Diabetes Mellitus (T2DM), Type 1 Diabetes Mellitus (T1DM)
Continuous Glucose Monitoring for Outpatient Diabetes Management After Hospital Discharge
This study aims to improve patient awareness of the utility of continuous glucose monitoring systems in blood glucose monitoring and to improve patient satisfaction regarding diabetes care, particularly in the matter of blood…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type 1 Diabetes Mellitus (T1DM), Hyperglycemia
- Trial name
- NCT06852950
- Testing
- Libre 3 Plus Continuous Glucose Monitor, Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 1
A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.
- Trial name
- NCT07222332
- Testing
- Baricitinib
- Where
- 130 sites in United States, Australia and 18 more
- Volunteers
- 300 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes Mellitus, Type 1 Diabetes (T1D)
AI-Assisted Remote Insulin Pump Optimization in T1DM
This study evaluates an AI-assisted remote parameter optimization tool for individuals with type 1 diabetes （T1D） using insulin pump and continuous glucose monitoring (CGM).
- Trial name
- NCT07732777
- Testing
- AI-Assisted Insulin Pump Settings Optimization System, Conventional Insulin Pump Therapy
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Type1 Diabetes Mellitus
The Survey of Treatment and Metabolic Status of Type 1 Diabetes Mellitus (T1DM).
This study is a multicenter cross-sectional research project, planning to enroll 1000 patients with Type 1 Diabetes Mellitus (T1DM).
- Trial name
- NCT06606509
- Testing
- Continuous Glucose Monitoring System (GX-01S)
- Where
- 101 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Type 1 Diabetes Mellitus
Dapagliflozin Plus Pioglitazone in T1DM
Purpose: To examine the effect of addition of combination therapy with dapagliflozin plus pioglitazone to insulin on glucose control and plasma ketone concentration in patients with type 1 diabetes (T1DM) Research Design: 120…
- Trial name
- NCT03878459
- Testing
- Pioglitazone 45 mg
- Where
- 3 sites in United States, Israel and 1 more
- Volunteers
- 120 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Diabete Type 1, Chronic Kidney Disease
Breakthrough - T1DM and Chronic Kidney Disease
Single arm- subject treated with Tegoprubart and everolimus. The purpose of this research is to gather information on the safety and effectiveness of investigational regimen containing 2 experimental components: An…
- Trial name
- NCT07592000
- Testing
- Tegoprubart, Islet Cell Transplant
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Type 1 Diabetes
GLP-1Ra Impact on Metabolic Outcomes in Stage 2 T1DM While Receiving Teplizumab
The goal of this study is to determine how a drug class called glucagon-like peptide-1 receptor agonists (GLP-1Ra) affects people during an early stage of Type 1 Diabetes undergoing clinical teplizumab treatment.
- Trial name
- GLP-TEP (NCT06338553)
- Testing
- Semaglutide (Rybelsus®)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Vanderbilt University Medical Center
T1DM - Type 1 Diabetes Mellitus
JAK1 Inhibitor Ivarmacitinib for Improving Pancreatic Islet Function in T1D
This is a double-blind, randomized, placebo-parallel-controlled, multicenter study. The objective is to evaluate the efficacy and safety of Ivarmacitinib 8 mg administered for 52 weeks in preserving pancreatic β cell function in…
- Trial name
- INSPIRE-T1D (NCT07845955)
- Testing
- Ivarmacitinib
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Huijie Zhang
Type 1 Diabetes Mellitus
Immunotherapy with Autologous Tregs in T1DM
Type 1 diabetes (T1D) is an autoimmune disease characterized by a progressive immune distruction of pancreat beta cells and deterioration of endogenous insulin secretion.
- Trial name
- NCT06708780
- Testing
- Ex vivo Expanded Human Autologous Regulatory T Cells, Routine Care
- Where
- China
- Volunteers
- 20 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Type 1 Diabetes, Type 1 Diabetes Mellitus
A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
This research study is testing whether a weekly medication called tirzepatide can help adults with type 1 diabetes use their insulin pump more easily, specifically by reducing or eliminating the need to count carbohydrates at…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, T1D, T1DM
- Trial name
- TZP (NCT07284511)
- Testing
- Tirzepatide, Tandem Control-IQ Automated Insulin Delivery System (with Dexcom G7 CGM), Carbohydrate Counting
- Where
- 4 sites in Canada, Switzerland
- Volunteers
- 105 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetes
A Study on the Safety, Preliminary Efficacy, and Cellular Kinetics of Allo-CD7 CAR-T Cells in T1DM
This is an open clinical pharmacological translational Research Study, aiming to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of RD13-02 in patients with aT1DM
- Trial name
- NCT07142161
- Testing
- RD13-02 cell infusion
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
Type 1 Diabetes Mellitus (T1DM), Type 1 Diabetes Mellitus
Sequential Immune Modulation and Antigen-Specific Tolerance Induction for Disease Modification in Recent-Onset Type 1 Diabetes
This study tests a three-phase immune treatment for people recently diagnosed with Type 1 diabetes (within 6 months, with some insulin production remaining).
- Conditions
- Type 1 Diabetes Mellitus (T1DM), Type 1 Diabetes Mellitus, Autoimmune Diabetes
- Trial name
- MATIN-2 (NCT07610213)
- Testing
- Teplizumab, Intralymphatic Insulin Immunotherapy (ILIT)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Abdullah Kars
Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes
Effect of a Structured Educational Intervention Through Mobile App on Hemoglobin A1c (HbA1c), Self-Efficacy and Self- Care in Adolescent With Type 1 Diabetes (T1DM)
This study aims to evaluate the effectiveness of a mobile health (mHealth) educational intervention for adolescents with Type 1 Diabetes Mellitus (T1DM).
- Conditions
- Type 1 Diabetes (Juvenile Onset), Type 1 Diabetes, Type 1 Diabetes Mellitus, HbA1c
- Trial name
- (T1DM) (NCT07689318)
- Testing
- educational intervention via mobile app
- Volunteers
- 84 people
- Sponsor
- Shifa Tameer-e-Millat University
Diabetes Mellitus, Type 1
TrialNet Pathway to Prevention of T1D
Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM).
- Trial name
- NCT00097292
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Type 1 Diabetes Mellitus, Exercise Physiology
Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise
This study evaluates a clinician-facing decision-support toolkit designed to assist adults with type 1 diabetes in preparing for moderate-intensity exercise.
- Trial name
- NEXT (NCT07226583)
- Testing
- Standard-of-Care Guidance (SoC), Usual Care (UC), netIOB & Exercise Toolkit (NEXT)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation)
Thai PainPREDICT Validation Study
Painful diabetic neuropathy (PDN) is one of the most common and disabling complications of diabetes mellitus, substantially affecting quality of life, daily functioning, and health system burden.
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathy, Distal Symmetric Polyneuropathy (Manifestation), Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- PainPREDICT-Th (NCT07195045)
- Testing
- Thai PainPREDICT Questionnaire and Mobile Application
- Where
- Thailand
- Volunteers
- 277 people
- Sponsor
- Chulalongkorn University
NAFLD, Type 1 Diabetes
Prevalence of NAFLD in T1DM Patients
To determine the prevalence of NAFLD in T1DM patients.
- Conditions
- NAFLD, Type 1 Diabetes, Fatty Liver, Nonalcoholic
- Trial name
- PAD1ZOL (NCT06445361)
- Testing
- FibroScan
- Where
- Belgium
- Volunteers
- 138 people
- Sponsor
- Ziekenhuis Oost-Limburg
Type 1 Diabetes
Safety and Efficacy of Fecal Microbiota Transplantation on Cognitive Function in T1DM
This study is a prospective, single-center, parallel-design,1:1 randomized controlled trial with triple blinding. It aims to investigate the effects of fecal microbiota transplantation (FMT) on cognitive function in patients with…
- Trial name
- NCT06496412
- Testing
- fecal microbiota transplantation
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Second Xiangya Hospital of Central South University