Clinical trials: T2DM
Diabetes Mellitus, Type 2
Feasibility Testing an Exercise Program to Improve Cognition for T2DM Patients
This proposed study will advance science by providing evidence on the feasibility of a standardized, rigorously designed and delivered exercise program to improve cognition and plasma brain-derived neurotrophic factor (BDNF)…
- Trial name
- NCT04590833
- Testing
- Supervised walking on a treadmill, Supervised stretching exercise
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Florida State University
Type 2 Diabetes Mellitus (T2DM)
Impact of LLL and Aerobic Exercise on Peripheral Arterial Outcomes in Patients With Type 2 Diabetes
Diabetes is one of the fastest-growing diseases worldwide, It has Devastating macrovascular complications (cardiovascular disease) and microvascular complications (such as diabetic kidney disease, diabetic retinopathy, and…
- Trial name
- LLLT (NCT06827171)
- Testing
- aerobic exercise + low-level laser therapy, Aerobic exercise
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nouran Hesham Slama Younis
T2DM (Type 2 Diabetes Mellitus)
A Study of RAY1225 in Participants With Type 2 Diabetes
The main purpose of this study is to learn more about the Tolerability of RAY1225 in participants with type 2 diabetes mellitus. The study will also explore the efficacy of RAY1225.
- Trial name
- NCT06254274
- Testing
- RAY1225
- Where
- China
- Volunteers
- 210 people
- Sponsor
- Guangdong Raynovent Biotech Co., Ltd
Diabetes Mellitus, Type II
Effects of Fatty Acid Delivery on Heart Metabolism and Function in Type 2 Diabetes (T2DM
Type 2 Diabetes Mellitus (T2DM) is a disease that interferes with the body's proper production and use of insulin, a hormone needed to convert sugar into usable energy.
- Trial name
- T2DM (NCT00577590)
- Testing
- Metformin, Rosiglitazone, Lovaza
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Washington University School of Medicine
Type 2 Diabetes Mellitus (T2DM), Psychological Distress
Effectiveness of a Diabetes Self-Management Program Among Ethnic Minority Elderly in Rural Thailand
Type 2 diabetes is a serious health condition that affects many older adults from ethnic minority communities in Northern Thailand.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Psychological Distress, Hyperglycemia
- Trial name
- DSM-EME (NCT07669389)
- Testing
- Diabetes Self-Management Education (DSME) Program, Usual Care
- Where
- Thailand
- Volunteers
- 108 people
- Sponsor
- Taipei Medical University
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepal
The goal of this clinical trial is to evaluate whether a multifaceted community-based intervention, comprising 1) screening and lifestyle counseling by female community health volunteers (FCHVs); community health workers in…
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Tobacco Smoking
- Trial name
- SCALE NCD (NCT06740708)
- Testing
- SCALE-NCD
- Where
- Nepal
- Volunteers
- 2,100 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Painful Diabetic Neuropathy, Diabetes Mellitus
A 12-Week Study of Topical Pirenzepine or Placebo in Type 2 Diabetic Patients (T2DM) With Painful Peripheral Neuropathy
This is a 12 week, 2-arm, blinded, single-site, placebo-controlled Phase II study in subjects with Type II Diabetes and painful peripheral neuropathy.
- Trial name
- NCT04786340
- Testing
- Active: WST-057 4mL (146 mg pirenzepine free base monohydrate) topical solution
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- WinSanTor, Inc
Type 2 Diabetes Mellitus
Omarigliptin Add-on to Insulin in Japanese Participants With Type 2 Diabetes Mellitus (T2DM, MK-3102-039)
This study will examine the efficacy of omarigliptin 25 mg once weekly compared to placebo in Japanese patients with T2DM who have inadequate glycemic control on insulin monotherapy in addition to diet and exercise therapy.
- Trial name
- NCT02906709
- Testing
- Omarigliptin, Insulin
- Volunteers
- 184 people
- Sponsor
- Merck Sharp & Dohme LLC
T2DM (Type 2 Diabetes Mellitus)
Pilot Bioequivalence Study of Chiglitazar/Metformin Extended-Release Tablets
This is a pilot bioequivalence study. It is a randomized, open-label, single-dose, crossover study. The primary objective of this study is to preliminarily evaluate the pharmacokinetic parameters and their variability of the test…
- Trial name
- NCT07412015
- Testing
- treatment T (dose 1), treatment T (dose 2), treatment R (dose 1)
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chipscreen Biosciences, Ltd.
Type 2 Diabetes Mellitus
Multiple-dose Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Pharmacodynamics of HSK7653 in T2DM
To evaluate the safety, tolerability and pharmacokinetic (PK)/pharmacodynamic (PD) characteristics of HSK7653 tablets in Type 2 Diabetes Mellitus Patients.
- Trial name
- NCT06059326
- Testing
- HSK7653 10 mg, HSK7653 25 mg, HSK7653 50 mg
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Type 2 Diabetes Mellitus (T2DM), Body Mass Index
The Effect of Body Weight on Physical Activity Level, Functional Capacity, Balance, and Quality of Life in Individuals With Type 2 Diabetes Mellitus
This study aims to investigate the effects of body weight on physical activity level, functional capacity, balance, and quality of life in patients with type 2 diabetes mellitus (T2DM).
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Body Mass Index, Functional Capacity, Balance
- Trial name
- NCT07152509
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Bezmialem Vakif University
Type 2 Diabetes Mellitus (T2DM)
Effect of Tai Chi Versus Moderate-intensity Combined Exercise Training on Cardiovascular Health and Physical Functional Performance in Older Men and Women With T2DM: the Tai Chi Intervention for Diabetes Management During Aging (TIDA) Study
This randomized, single-blind, controlled clinical trial compares the effects of a 12-week Tai Chi program versus moderate-intensity combined exercise (MICE) training on cardiovascular health, glycemic control, and physical…
- Trial name
- TIDA (NCT07131761)
- Testing
- Tai chi, Moderate-Intensity Combined Exercise (MICE), Control ( No Exercise )
- Volunteers
- 66 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Diabetes Mellitus, Type 2
4 Weeks Treatment With Empagliflozin (BI 10773) in Japanese Type 2 Diabetic Patients (T2DM)
The objective of this trial is to evaluate the pharmacodynamics, pharmacokinetics, safety, and tolerability of once daily oral administration of BI 10773 administered for 28 days in Japanese patients with T2DM.
- Trial name
- NCT00885118
- Testing
- BI 10773
- Where
- 5 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Boehringer Ingelheim
Type 2 Diabetes Mellitus (T2DM)
Phase I Study to Evaluate the Pharmacokinetics and Safety After Co-administration of L03RD1 and L03RD2 or Administration of CT-L03 in Healthy Volunteers
This is a randomized, open, single-dose, crossover-design, phase I study to evaluate the pharmacokinetics and safety after co-administration of L03RD1 and L03RD2 or administration of CT-L03 in healthy volunteers.
- Trial name
- NCT07158346
- Testing
- L03RD1, L03RD2, CT-L03
- Where
- South Korea
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Celltrion
Type 2 Diabetes Mellitus (T2DM), Mild Cognitive Impairment (MCI)
The Cognitive Protective Effect of VR-based Cognitive Training in Type 2 Diabetes Patients With Mild Cognitive Impairment
A multi-center prospective, open-label, parallel-group randomized controlled trial is conducted to investigate the cognitive-protective efficacy of a novel, diabetes-specific virtual reality (VR)-based cognitive training system…
- Trial name
- NCT07650318
- Testing
- VR-Based Cognitive Training Plus Standard Diabetes Care, Traditional Paper-and-Pencil Cognitive Training Plus Standard Diabetes Care
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
DIABETES MELLITUS, NONINSULIN-DEPENDENT, 2 (Disorder)
Examining The Role of CGM in T2DM
Continuous glucose monitoring (CGM) technology has advanced the treatment of people with diabetes, however to date this technology had been primarily limited to use in patients treated with insulin.
- Trial name
- NCT01614262
- Testing
- Continuous Glucose Monitoring with treatment algorithm
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of North Carolina, Chapel Hill
Type 2 Diabetes Mellitus (T2DM)
DP-DCT 1.0：A Comparative Clinical Study on the Effect of Dapagliflozin Combined With CGM Versus SMBG on Glycemic Control in Patients With Type 2 Diabetes Mellitus Based on the DP-DCT Platform
The goal of this clinical trial is to: 1) evaluate the feasibility of conducting decentralized clinical trials (DCT) in collaboration with community resources; 2) test the reliability of a self-developed Digital Platform for…
- Trial name
- DP DCT (NCT07595289)
- Testing
- Dapagliflozin (10mg Tab), Continuous Glucose Monitoring (CGM), Self-Monitoring of Blood Glucose (SMBG)
- Volunteers
- 120 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Type 2 Diabetes, Type 1 Diabetes
The Effect of GLP-1 on the Inhibition of Glucagon Secretion
Diabetes(both types) are recognized by high levels of glucagon in the circulation. Glucagon is known to increase blood glucose, and might therefore contribute to the respective diseases.
- Trial name
- NCT01507597
- Testing
- Native human Glucagon-like Peptide-1 ( GLP-1(7-36)), NaCl
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Microbiome
Supplementation of Inulin + L. Acidophilus in Elders With T2DM
This study investigates the effects of a symbotic supplement (Inulin + Lactobacillus acidophilus) on cognitive impairment in older adults with type 2 diabetes mellitus (T2DM).
- Conditions
- Diabetes Mellitus, Microbiome, Cognition Disorders
- Trial name
- NCT06830824
- Testing
- Lactobacillus acidophilus
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Anahuac University
Type-2 Diabetes Mellitus (T2DM)
Patient Preference Study in Type-2 Diabetes Mellitus: Discrete Choice Experiment (DCE) to Support Novo Nordisk's Long-Acting Insulin
The primary objective of this research is to assess T2DM patient preferences for a once weekly insulin treatment. The study involves a qualitative interview phase and quantitative survey phase with a Discrete Choice Experiment…
- Trial name
- DCE (NCT06592950)
- Testing
- No treatment given
- Where
- Denmark
- Volunteers
- 513 people
- Sponsor
- Novo Nordisk A/S