Clinical trials: T2DM
T2DM, CKD
A Mechanistic Study on the Effect of HTD1801 Versus Placebo on Kidney Function in Patients With Type 2 Diabetes and Chronic Kidney Disease.
Goal: The goal of this clinical trial is to learn if the investigational drug HTD1801 can slow the progression of kidney damage in adults diagnosed with both Type 2 Diabetes (T2DM) and Chronic Kidney Disease (CKD).
- Trial name
- Negentropy (NCT07496177)
- Testing
- HTD1801
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Type 2 Diabetes (T2DM), Metabolic Dysfunction-Associated Steatotic Liver Disease
Cardiovascular Risk in T2DM With MAFLD: A Cohort Study
This study aims to address the following key scientific question by establishing a large-scale, high-standard clinical cohort: the independent contribution of MASLD and its progression to liver fibrosis on cardiovascular outcomes…
- Trial name
- NCT07706010
- Where
- China
- Volunteers
- 7,000 people
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Type 2 Diabetes Mellitus (T2DM), Time Restricted Eating
Time Restricted Eating in Patients With Microalbuminuria
This is a clinical trial to assess how time-restricted eating (TRE) may improve kidney health and filtration patients with type 2 diabetes and increased protein content in their urine.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Time Restricted Eating, Microalbuminuria
- Trial name
- TREK (NCT06884059)
- Testing
- Time Restricted Eating
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Obesity & Overweight, Type 2 Diabetes (T2DM)
Effect of Ajwa Seed Powder on HbA1c and Body Composition in Overweight and Obese Patients With Type 2 Diabetes Mellitus
The goal of this interventional study (clinical trial) is to check if ajwa seed powder can treat type 2 diabetes mellitus in overweight and and obese patients with type 2 diabetes mellitus including both male and female of the…
- Trial name
- NCT07702097
- Testing
- Ajwa Seed powder
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
Periodontitis, Type 2 Diabetes Mellitus (T2DM)
Salivary Apelin, Chemerin, Ghrelin, and Lipocalin-2 Levels in Diabetic Patients With Periodontitis
This observational cross-sectional study will evaluate salivary apelin, chemerin, ghrelin, and lipocalin-2 levels in individuals with different periodontal and systemic conditions.
- Trial name
- NCT07703345
- Testing
- Salivary Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Type 2 Diabetes Mellitus (T2DM), Cognitive Dysfunction
SGLT2 Inhibitors and Cognitive Function in Adults With Type 2 Diabetes (SaveMinD)
This study is a prospective, randomized, open-label trial with blinded outcome assessment (PROBE design) designed to evaluate the effects of sodium-glucose cotransporter-2 (SGLT2) inhibitor therapy on cognitive function in adults…
- Trial name
- SaveMinD (NCT07694596)
- Testing
- SGLT2 Inhibitor, Standard Diabetes Care
- Where
- Slovenia
- Volunteers
- 200 people
- Sponsor
- University of Primorska
Type 2 Diabetes Mellitus (T2DM)
Effectiveness of and Implementation Strategies for 'Disfrutando'.
Despite much research that has focused on enhancing type 2 diabetes mellitus (T2DM) health outcomes for high burden populations, more remains to be done.
- Trial name
- Disfrutando 2 (NCT07023406)
- Testing
- Disfrutando
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- University of Missouri-Columbia
Type 2 Diabetes Mellitus (T2DM)
Postprandial Glycemic and Physiological Responses to Walking With a Wearable Hip Exoskeleton in Patients With Type 2 Diabetes
This randomized crossover proof-of-concept study evaluated the effects of walking with a wearable hip exoskeleton on postprandial glycemic and physiological responses in patients with type 2 diabetes.
- Trial name
- Bot-Fit T2D St (NCT07692802)
- Testing
- Bot-Fit Aqua Mode, Bot-Fit Boost Mode, Non-Assisted Walking
- Where
- South Korea
- Volunteers
- 14 people
- Sponsor
- CHA University
Type 2 Diabetes Mellitus (T2DM)
hUC-MSC-Exosomes for T2DM - Safety & Efficacy
The goal of this clinical trial is to Evaluate the Safety and Preliminary Efficacy of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Adult Type 2 Diabetes Mellitus.
- Trial name
- HOPE-T2DM (NCT07693036)
- Testing
- exosomes treatment group, control group
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Peking University First Hospital
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin/ Metformin 25 mg/ 1000 mg Extended-Release Tablet Versus Synjardy XR Tablets 25mg/1000mg
An open label, randomized, two-period, two treatment, two-sequence, crossover, balanced, single dose oral bioequivalence study to compare Empagliflozin / Metformin 25 mg/ 1000 mg Extended-Release Tablet versus Synjardy XR tablets…
- Trial name
- NCT07694115
- Testing
- Empagliflozin / Metformin Extended-Release Tablet, Synjardy XR tablets
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
T2DM (Type 2 Diabetes Mellitus), Hypertension
Virtual Diabetes Group Visits Across Health Systems
The purpose of this project is to evaluate the effectiveness of a virtual diabetes group visits on patients with type 2 diabetes mellitus (T2DM).
- Conditions
- T2DM (Type 2 Diabetes Mellitus), Hypertension, Heart Disease Chronic, Stroke
- Trial name
- VIDA (NCT06094491)
- Testing
- Virtual Group Visit
- Where
- 2 sites in United States
- Volunteers
- 720 people
- Sponsor
- University of Chicago
Type 2 Diabetes (T2DM)
TriGlytza®-01 Versus Metformin in Overweight and Obese Adults With Type 2 Diabetes and Inadequate Glycaemic Control Despite Metformin Therapy
This Phase 2a, randomized, double-blind, active-controlled study will evaluate the safety, tolerability, and preliminary efficacy of TriGlytza®-01 compared with metformin in adults with Type 2 diabetes inadequately controlled…
- Trial name
- RESILIENCE-2a (NCT07139405)
- Testing
- Metformin XR, Celecoxib, Valsartan
- Where
- 3 sites in Australia
- Volunteers
- 48 people
- Sponsor
- Myopharm Limited
Type 2 Diabetes Mellitus (T2DM), Diabetes Self-Management Education
Effects of Online Diabetes Self-management Education on Knowledge Retention, BMI, and HbA1c in Newly Diagnosed Adults With Type 2 Diabetes
Type 2 diabetes requires active self-management from the time of diagnosis, but participation in traditional face-to-face diabetes self-management education is often limited by access-related and personal barriers.
- Trial name
- NCT07669038
- Testing
- Online Diabetes Self-Management Education, Traditional Face-to-Face Diabetes Self-Management Education
- Where
- Slovenia
- Volunteers
- 123 people
- Sponsor
- University of Primorska
Type 2 Diabetes Mellitus (T2DM), Cardiovascular Diseases
Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCl 25 mg/5 mg/1000 mg Extended Release Tablet Versus Trijardy® XR 25 mg/5 mg/1000 mg Extended- Release Tablets
An open label, randomized, two-period, two treatment, two-sequence, crossover, balanced, single dose oral bioequivalence study to compare Empagliflozin/ Linagliptin/ Metformin HCl 25 mg/5 mg/1000 mg Extended Release Tablet versus…
- Trial name
- NCT07691203
- Testing
- Empagliflozin/Linagliptin/Metformin HCl Extended Release Tablet, Trijardy® XR Tablets
- Where
- India
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Type 2 Diabetes (T2DM), Hepatocellular Carcinoma (HCC)
HCC Risk and Monitoring in Patients With Type 2 Diabetes
Liver cancer is a significant malignancy in Taiwan. With the widespread implementation of antiviral therapies, hepatitis B and C-related liver cancer has gradually declined; however, metabolic dysfunction-associated liver cancer…
- Trial name
- GAAD-DM (NCT07675187)
- Testing
- GAAD score
- Where
- Taiwan
- Volunteers
- 2,400 people
- Sponsor
- National Taiwan University Hospital
Type 2 Diabetes Mellitus (T2DM)
AI-Assisted Antidiabetic Drug Consultation System for Glycemic Control in Type 2 Diabetes Patients Managed by Non-Specialist Physicians
This study tests whether an artificial intelligence (AI) tool can help doctors choose better diabetes medicines for their patients.
- Trial name
- AI-ADCS (NCT07684690)
- Testing
- AI-assisted antidiabetic drug consultation system, Manual antidiabetic prescribing (without AI)
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Taiwan University Hospital
Type 2 Diabetes Mellitus (T2DM), Type2Diabetes
Post-market SUrveiLlance RegiStry for the Endogenex System (Endogenex PULSE Registry)
This registry is designed to collect long-term data and support ongoing post-market surveillance of real-world data for the Endogenex System.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type2Diabetes, Diabetes Mellitus, Type 2, Type 2 Diabetes
- Trial name
- NCT07197775
- Where
- 4 sites in United States, Australia
- Volunteers
- 500 people
- Sponsor
- Endogenex, Inc.
Menopause, Sleep Disruption
Endocrine Disruption, Menopause, and Poor Sleep in wOmen With Type 2 Diabetes: Effects on Cardiovascular Health
EMPOWER aims to determine the overall effect of menopause and sleep disruption on cardiac remodeling in women with type 2 diabetes.
- Conditions
- Menopause, Sleep Disruption, T2DM
- Trial name
- EMPOWER (NCT07486986)
- Testing
- 4 years of clinical evaluations.
- Volunteers
- 381 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Type 2 Diabetes (T2DM)
Evaluate the Efficacy and Safety of GZR33 Injection in Patients With Type 2 Diabetes
Evaluate the efficacy of GZR33 Injection and Insulin Degludec Injection (Tresiba®) in Patients with Type 2 Diabetes Mellitus Inadequately Controlled with Oral Antidiabetic Drugs.
- Trial name
- NCT07527078
- Testing
- GZR33 Injection, Insulin Degludec Injection (Tresiba®)
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Type 2 Diabetes Mellitus (T2DM)
A Preliminary Clinical Study Protocol for Evaluating the Efficacy and Safety of Pulse Electric Field Ablation Systems in Treating Adult Type 2 Diabetes Mellitus With Suboptimal Drug Control
experiment design: Single-center, single-arm, open-label trial Inclusion Criteria: 1. Ages 18-70. 2. At least 6 months prior to enrollment, the patient must have been diagnosed with type 2 diabetes mellitus. 3.
- Trial name
- NCT07678866
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai East Hospital