Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Food Insecurity, Type 2 Diabetes Mellitus (T2DM)
Food Insecurity, Social Determinants of Health
Food is Medicine for the whole will test an intervention which provides medically tailored meals, or grocery voucher cards, or a combination of these food and nutrition resources to a caregiver and children living in the…
- Conditions
- Food Insecurity, Type 2 Diabetes Mellitus (T2DM), Hypertension
- Trial name
- NCT06784310
- Testing
- Medically Tailored Meals, Grocery Prescription, Medically Tailored Meals and Grocery Prescription
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Alison Gustafson
Type 2 Diabetes Mellitus (T2DM)
Sitagliptin and Pioglitazone Mechanism of Action Study in Type 2 Diabetes Mellitus (0431-061)
A clinical study to determine the safety, efficacy and mechanism of action of sitagliptin alone and in combination with pioglitazone, in patients with type 2 diabetes mellitus who have inadequate glycemic (blood sugar) control.
- Trial name
- NCT00511108
- Testing
- Comparator: sitagliptin phosphate, Comparator: pioglitazone
- Volunteers
- 211 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus (T2DM)
Student Pharmacist Non-Pharmacological Intervention on Type 2 Diabetes Management in Older Asian Adult Populations
This study is being done to assess the impact of student pharmacist involvement on blood glucose control through non-pharmacological interventions in people of Asian and Asian descent over the age of 50 with type 2 diabetes.
- Trial name
- SPY-DM (NCT06861491)
- Testing
- Non-pharmacological
- Sponsor
- University of California, San Francisco
Type 2 Diabetes Mellitus (T2DM)
Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus
This is a randomized, double-blind, placebo- and active-controlled, multicenter Phase II clinical trial designed to evaluate the efficacy, safety, and pharmacokinetic characteristics of MWN109 tablets in participants with type 2…
- Trial name
- NCT07801820
- Testing
- MWN109 1, MWN109 2, MWN109 3
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Diabetes Mellitus Type 2
Study of Duodenal Mucosal RF Vapor Ablation in Subjects With Type-2 Diabetes Mellitus
The purpose of this clinical study is to test the hypothesis that RF vapor ablation of the duodenal mucosa will result in improvement in glycemic parameters, without complications (bleeding/ stricture / perforation).
- Trial name
- STEAM T-2DM (NCT05887635)
- Testing
- RF Vapor Ablation
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- Aqua Medical, Inc.
Type 2 Diabetes Mellitus
Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes
A Phase 2 study Comparing the effects on glucose control of MEDI0382 in combination with Dapagliflozin and Metformin compared to placebo in combination with Dapagliflozin and Metformin in overweight/obese participants with Type 2…
- Trial name
- NCT03444584
- Testing
- MEDI0382, Dapaglifozin, Metformin
- Where
- 8 sites in Germany, Hungary and 1 more
- Volunteers
- 49 people
- Sponsor
- MedImmune LLC
Diabetes Mellitus
Feasibility of Using a Smart Phone Application for Self-titration of Insulin on Glycemic Control in Patients With T2DM
The primary aim of this study is to investigate the feasibility of using a patient-centered smart phone application for insulin self-titration on glycemic control.
- Trial name
- NCT01950676
- Testing
- Smart phone application
- Where
- Singapore
- Volunteers
- 66 people
- Sponsor
- National University of Singapore
Prediabetic State, Non-alcoholic Fatty Liver Disease
ORION: Effects of Cenicriviroc on Insulin Sensitivity in Subjects With Prediabetes or Type 2 Diabetes Mellitus (T2DM) and Suspected NAFLD
A Phase 2a, randomized, double-blind, placebo-controlled, multi-center study of cenicriviroc (CVC) to be conducted in approximately 50 adult obese subjects [body mass index (BMI) ≥ 30 kg/m^2] with prediabetes or type 2 diabetes…
- Conditions
- Prediabetic State, Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT02330549
- Testing
- Cenicriviroc 150 mg
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 45 people
- Sponsor
- Tobira Therapeutics, Inc.
T2DM (Type 2 Diabetes Mellitus)
GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM
Type II diabetes mellitus (T2DM) is a chronic disease associated with a very high risk of developing cardiovascular (CV) events, especially because of its long-term effects.
- Trial name
- STABLE-GLP1 (NCT07314684)
- Testing
- semaglutide, Standard Treatment (Guideline-Based)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Federico II University
Diabetes Mellitus, Type 2, Cognitive Dysfunction, Epigenetics, Exercise
Using Polar Unite Fitness Watch to Improve Cognition for T2DM Patients
Type 2 diabetes mellitus (T2DM) impairs the brain, leading to cognitive dysfunction, which carries substantial lifetime consequences.
- Trial name
- NCT04603885
- Testing
- Aerobic exercise program, Stretching exercise
- Volunteers
- 42 people
- Sponsor
- University of Arkansas, Fayetteville
T2DM (Type 2 Diabetes Mellitus)
Chiglitazar Added to SGLT-2 Inhibitors for Type 2 Diabetes
The goal of this observational study is to evaluate the comprehensive clinical efficacy, cardiovascular, renal, and hepatic benefits, as well as the safety of adding Chiglitazar to SGLT-2 inhibitor therapy in adult patients with…
- Trial name
- NCT07580638
- Testing
- SGLT-2 inhibitor and Chiglitazar, SGLT-2 inhibitor and Other Oral Antidiabetic Drugs (OADs)
- Where
- 2 sites in China
- Volunteers
- 3,550 people
- Sponsor
- Chipscreen Biosciences, Ltd.
Healthy, Diabetes Mellitus, Type 2
A Study of LC542019 in Healthy Subjects and Subjects With T2DM
to assess the safety, tolerability, Pharmacokinetics and Pharmacodynamics in healthy subjects and subjects with type 2 diabetes (T2DM).
- Trial name
- NCT06333977
- Testing
- LC542019
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- LG Chem
Type 2 Diabetes Mellitus (T2DM)
A Double-Blind, Randomized, Placebo-Controlled Phase IIa Clinical Trial to Evaluate the Safety and Efficacy of DT2-SCT in Subjects With Type 2 Diabetes Mellitus
The goal of this clinical trial is to evaluate the safety and effectiveness of DT2-SCT, a therapy using autologous adipose-derived mesenchymal stem cells, in adults with Type 2 Diabetes Mellitus (T2DM).
- Trial name
- NCT06789302
- Testing
- DT2-SCT intravenous infusion
- Volunteers
- 120 people
- Sponsor
- Global Institute of Stem Cell Therapy and Research
Type 2 Diabetes Mellitus(T2DM)
A Bioequivalence Study of the Fixed Dose Combinations of Saxagliptin/Metformin XR Relative to Co-Administration
The primary objective of this study is to assess the pharmacokinetic parameters of saxagliptin and metformin in healthy male Chinese subjects.
- Trial name
- SAXA (NCT01755494)
- Testing
- Saxagliptin 5 mg, Metformin XR 500 mg, Mertformin XR 2 x 500 mg
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Chronic Periodontitis, Type 2 Diabetes Mellitus
Glycemic Control in T2DM Through Non-Surgical Periodontal Therapy
It is submitted that incident and prevalent chronic periodontal infection, known as chronic periodontitis (CP) possibly has a causal relationship with diabetes mellitus (DM) having effects on HbA1c, fasting plasma/ blood glucose…
- Trial name
- NCT03343366
- Testing
- Metronidazole, Scaling Root Planing, Oral Hygiene Instructions
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Dow University of Health Sciences
Type 2 Diabetes
Mediterranean Diet vs DASH and MIND in T2DM
In our study, we aimed to comparatively evaluate the relative effects of the Mediterranean, DASH, and MIND diets on metabolic parameters in individuals with type 2 diabetes.
- Trial name
- NCT07310225
- Testing
- No intervention (observational study)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Abant Izzet Baysal University
Type 2 Diabetes Mellitus
A Study to Assess the Addition of Sitagliptin to Metformin Compared With the Addition of Dapagliflozin to Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) and Mild Renal Impairment Who Have Inadequate Glycemic Control on Metformin With or Without a Sulfonylurea (MK-0431-838)
The purpose of the study is to assess the effect of the addition of sitagliptin to metformin with or without a sulfonylurea compared with the addition of dapagliflozin to metformin with or without a sulfonylurea on hemoglobin A1c…
- Trial name
- NCT02532855
- Testing
- Sitagliptin, Dapagliflozin, Metformin
- Volunteers
- 614 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus (T2DM)
Comparison of Once-Weekly Trelagliptin Vs. Once-Daily Vildagliptin for HbA1c Reduction in Type 2 Diabetes
This randomized controlled trial evaluated the efficacy of once-weekly trelagliptin compared to once-daily vildagliptin in reducing HbA1c levels in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT06889909
- Testing
- Trelagliptin 100 mg, Vildagliptin 50 mg
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- Lahore General Hospital
Type 2 Diabetes Mellitus
Multiple-dose Study to Evaluate the Safety,Tolerability, Pharmacokinetics and Pharmacodynamics of HSK7653 in T2DM
To evaluate the safety, tolerability and pharmacokinetic (PK)/pharmacodynamic (PD) characteristics of HSK7653 tablets in Type 2 Diabetes Mellitus Patients.
- Trial name
- NCT06059326
- Testing
- HSK7653 10 mg, HSK7653 25 mg, HSK7653 50 mg
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Type 2 Diabetes Mellitus (T2DM)
Short-Term Effects of Sucralose and Saccharin on Blood Sugar and Gut Microbiota in Type 2 Diabetes
This clinical trial investigates the short-term effects of two commonly used non-nutritive sweeteners (NNS), saccharin and sucralose, on blood glucose regulation and the gut microbiota in adults with Type 2 Diabetes Mellitus…
- Trial name
- NCT07124585
- Testing
- Sucralose, Saccharin
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- National University of Malaysia