Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease
University of Texas H.S.C. San Antonio Pioglitazone in Non-Alcoholic Steatohepatitis Trial (UTHSCSA NASH Trial)
Obesity and Type 2 diabetes are creating a silent epidemic, Non-alcoholic fatty liver disease, which is a chronic liver disease associated with insulin resistance, impaired glucose intolerance, and hepatic fat accumulation.
- Conditions
- Nonalcoholic Steatohepatitis, Nonalcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus
- Trial name
- NCT00994682
- Testing
- Pioglitazone study drug, Pioglitazone Open Label
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University of Florida
Diabetes Mellitus, Type 2
A Study of LY3549492 in Participants With Type 2 Diabetes Mellitus (T2DM)
The main purpose of this study is to evaluate the safety and tolerability of LY3549492 in participants with T2DM. Blood tests will be done to check how much LY3549492 gets into the bloodstream and how the body handles LY3549492.
- Trial name
- NCT05327595
- Testing
- LY3549492, Atorvastatin, Midazolam
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus (T2DM), Neuropathic Pain
The Effect of Aromatherapy Foot Massage on Neuropathic Pain in Patients With Type2 Diabetes
The aim of this clinical trial is to learn about the effect of aromatherapy foot massage on neuropathic pain in patients with Type 2 diabetes.
- Trial name
- NCT07271160
- Testing
- intervention I group, Intervention II group
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- TC Erciyes University
Type II Diabetes Mellitus
A Clinical Study to Evaluate the Safety, Tolerability, PK, PD, and Efficacy of KBP-089 in Patients With T2DM
KeyBioscience is developing KBP-089, a dual activator of both the amylin and calcitonin receptors, for the treatment of type II diabetes mellitus, using a subcutaneous injectable mode of administration.
- Trial name
- NCT03907202
- Where
- Germany
- Volunteers
- 25 people
- Sponsor
- KeyBioscience AG
Type 2 Diabetes Mellitus, Gene Polymorphisms
Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls
In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression. Participants (T2DM patients and controls) were recruited to identify genotypes and detect the levels of T2DM…
- Conditions
- Type 2 Diabetes Mellitus, Gene Polymorphisms, Genetic Mutations, Susceptibility, Genetic
- Trial name
- NCT06277466
- Testing
- Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected from controls and T2DM patients without hypoglycemic drugs, Fresh blood samples were collected from healthy subjects and T2DM patients without hypoglycemic drugs
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Type 2 Diabetes
Glycaemic Control of Weekly LAPS-Exendin Versus Placebo in Subjects of Type 2 Diabetes
The purpose of this study is to determine the optimal dose or doses of HM11260C, when administered once a week under the skin, to improve the control of blood sugar levels in patients with early-stage type 2 diabetes mellitus…
- Trial name
- NCT02057172
- Testing
- HM11260C, liraglutide
- Where
- United States
- Volunteers
- 254 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Type 2 Diabetes, Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy
Diabetic cardiac autonomic neuropathy (DCAN) is a common chronic complication that reduces survival in patients with diabetes. Epidemiological surveys have shown that the prevalence of DCAN is 25-75% in people with type 2…
- Trial name
- NCT06461377
- Testing
- Glucagon-like peptide-1 receptor agonist：Semaglutide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Inflammatory Arthritis, Diabetes (DM)
Validation of Hemoglobin A1c in Patients With Inflammatory Arthritis Treated With Sulfasalazine
The purpose of this study is to examine whether the blood test Hemoglobin A1c (HbA1c) gives an accurate picture of blood glucose levels in patients with inflammatory arthritis who are treated with sulfasalazine.
- Conditions
- Inflammatory Arthritis, Diabetes (DM), Rheumatoid Arthritis (RA), Type 1 Diabetes Mellitus
- Trial name
- DIA2SULFA (NCT07416656)
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Klavs Würgler Hansen
Type 2 Diabetes Mellitus (T2DM)
Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes Mellitus
Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes Mellitus
- Trial name
- NCT07187856
- Testing
- PG-102, Semaglutide
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- ProGen. Co., Ltd.
Type 2 Diabetes Mellitus (T2DM)
Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCL 25mg/5mg/1000mg Extended-Release Tablets Versus Trijardy® XR Extended Release Film Coated Tablets
Randomized, Single Oral Dose, Two-period, Two Sequence, Open-label, Crossover, Bioequivalence Study to Compare Empagliflozin-Linagliptin-Metformin XR Tablet 25mg/ 5mg/1000mg (25mg Empagliflozin /5mg Linagliptin /1000mgMetformin…
- Trial name
- NCT07213895
- Testing
- Empagliflozin/Linagliptin/Metformin HCL, Trijardy® XR Extended release film coated tablets
- Where
- Jordan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Humanis Saglık Anonim Sirketi
Diabetes Mellitus, Type 2
Chronic Effects of Two Aerobic-training Models Performed in Water and on Dry Land in Patients With Type 2 Diabetes Mellitus (T2DM).
The aim of this study was to analyse the acute and chronic effects of two aerobic-training models performed in water and on dry land on cardiorespiratory, functional, metabolic, hormonal and quality-of-life parameters in patients…
- Trial name
- NCT01956357
- Testing
- Aquatic exercise, Land Exercise
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetes Mellitus, Type 2
The Effect of Remote SMBG Combined With the Application of APP on the Improvement of T2DM Management in the Community
To investigate whether strengthen community diabetes patients self-monitoring of blood glucose can improve the patient's blood glucose control under Chinese guidelines for the prevention and treatment of diabetes (CDS 2017) and…
- Trial name
- NCT03588000
- Testing
- Strengthen self-monitoring of blood glucose
- Where
- China
- Volunteers
- 498 people
- Sponsor
- Yuwen Zhang
Type 2 Diabetes, Hyperglycemia
Basal Bolus Versus Basal Insulin in Type 2 Diabetes Mellitus (T2DM)
The study is a prospective randomized study comparing safety and effectiveness of a basal-bolus regimen with glargine once daily and glulisine before meals, a basal plus regimen with glargine once daily and supplemental doses of…
- Trial name
- Basal-Plus (NCT00979628)
- Testing
- sliding scale regular insulin (SSRI), Basal Bolus, Basal Plus
- Where
- 5 sites in United States
- Volunteers
- 375 people
- Sponsor
- Guillermo Umpierrez, MD
Hypertension (HTN), Type 2 Diabetes Mellitus (T2DM)
Effectiveness of Digital Health Intervention on Community Health Care in Middle-aged and Older Population in Taiwan
This study aims to evaluate the effectiveness of a digital health intervention for community-dwelling middle-aged and older adults in Taiwan.
- Conditions
- Hypertension (HTN), Type 2 Diabetes Mellitus (T2DM), Hyperuricemia, Hypercholesterolemia and Hyperlipidemia
- Trial name
- NCT07238257
- Testing
- Digital Health Program with Smart Devices
- Where
- Taiwan
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Type 2 Diabetes Mellitus (T2DM), Chronic Heart Failure (CHF)
Efficacy Evaluation of Glimepiride in Patients With Type 2 Diabetes Mellitus and Chronic Heart Failure With Reduced Ejection Fraction.
Evaluating the safety and efficacy of glimepiride in patients with type 2 diabetes and chronic heart failure with reduced ejection fraction--a multicenter randomized controlled study.
- Trial name
- GLID-HF (NCT07288749)
- Testing
- Glimepiride (oral)
- Where
- China
- Volunteers
- 1,484 people
- Sponsor
- Tongji Hospital
Type 2 Diabetes Mellitus
A Study to Assess the Safety and Tolerability of Sitagliptin/Simvastatin Fixed-dose Combination (FDC) in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-312)
The purpose of this study is to examine the safety and tolerability of sitagliptin 100 mg/simvastatin 40 mg FDC (MK-0431D) in Vietnamese participants with type 2 diabetes mellitus with inadequate glycemic control on metformin.
- Trial name
- NCT01702298
- Testing
- Sitagliptin 100 mg/simvastatin 40 mg FDC, Metformin
- Volunteers
- 42 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 2
Dulce Digital-Me: An Adaptive mHealth Intervention for Underserved Hispanics With Diabetes
This study will compare Dulce Digital (i.e., the investigators' proven-effective combination of "one-size-fits-all" educational text messages and nurse monitoring of patient-transmitted blood glucose values) and Dulce Digital-Me…
- Trial name
- DD-Me (NCT03130699)
- Testing
- Dulce Digital, Dulce Digital-Me (Automated Delivery), Dulce Digital-Me (Medical Assistant)
- Where
- 2 sites in United States
- Volunteers
- 310 people
- Sponsor
- Scripps Whittier Diabetes Institute
T2DM
A Research Study to Investigate the Efficacy and Safety of HRS9531 Tablets in Participants With Type 2 Diabetes Mellitus
The aim of the trial is to investigate the efficacy and safety of HRS9531 tablets versus placebo in participants with type 2 diabetes mellitus who failed to achieve adequate glycemic control on lifestyle intervention alone or on…
- Trial name
- NCT07599410
- Testing
- HRS9531 Tablet
- Where
- 2 sites in China
- Volunteers
- 240 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Diabetes Mellitus, Type 2
Study To Understand Efficacy And Safety Of Investigational Agent (PF-04937319) Compared To Approved Agent (Glimepiride) In Patients With Diabetes On Metformin
This is a study to understand efficacy and safety of investigational agent (PF-04937319) compared to approved agent (glimepiride) in patients with diabetes on metformin
- Trial name
- NCT01517373
- Testing
- PF-04937319 10 mg, PF-04937319 50 mg, PF-04937319 100 mg
- Where
- 53 sites in United States, Bulgaria and 5 more
- Volunteers
- 304 people
- Sponsor
- Pfizer
Type 2 Diabetes Mellitus
Bone Marrow Derived Stem Cell Transplantation in T2DM
The purpose of this study is to improve the blood glucose level in type 2 diabetic patients.
- Trial name
- NCT01759823
- Testing
- mesenchymal stem cell transplantation, control, MNC's TRANSPLANTATION
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh