Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Type 2 Diabetes Mellitus (T2DM), Continuous Glucose Monitoring
Transition to Hospital Discharge in Insulinized Patients With Type 2 Diabetes Mellitus
This clinical study explores whether adding technological tools during hospital discharge can help people with type 2 diabetes who are starting insulin therapy achieve better treatment adherence and blood glucose control once…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Continuous Glucose Monitoring, CGM, Transition to Discharge
- Trial name
- TRANHOSPIN (NCT07061301)
- Testing
- Usual Care group, Technological group
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation
Individualized Medical Nutrition Therapy in Adults With Type 2 Diabetes Mellitus
This study aims to investigate the effects of intensive medical nutrition therapy on blood sugar control, systemic inflammation, and gut barrier function in adults with type 2 diabetes mellitus.
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Systemic Inflammation, Intestinal Permeability, Glycemic Control
- Trial name
- NCT07037212
- Testing
- Intensive Medical Nutrition Therapy (MNT), Standard Dietary Counseling
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Serap Balaban Barta
Influenza, Vaccine Reaction
Effectiveness of Trivalent Influenza Vaccine (TIV) in Type 2 Diabetes Mellitus (T2DM) Patients With and Without Complications of Chronic Kidney Disease (CKD)
This study assesses the effectiveness of the seasonal flu vaccine in individuals with Type 2 Diabetes Mellitus (T2DM) with and without Chronic Kidney Disease (CKD), as well as in healthy individuals.
- Conditions
- Influenza, Vaccine Reaction, Diabetes Mellitus, Chronic Kidney Diseases
- Trial name
- NCT06252051
- Testing
- Trivalent Influenza Vaccine
- Where
- Indonesia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Coronary Artery Disease, Type 2 Diabetes
Empagliflozin Versus Vildagliptin in CAD Patients With T2DM
We compared the cardioprotective effects of empagliflozin, an SGLT2 inhibitor, with those of vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, focusing on various inflammatory biomarkers lipid profile, and cardiac…
- Trial name
- NCT06313008
- Testing
- Empagliflozin 10 MG, Vildagliptin 50 MG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Damanhour University
Type 2 Diabetes Mellitus
Effect of Exenatide on Glucose Homeostasis Determinants in Type 2 Diabetes
The purpose of this study is to determine in type 2 diabetic patients in secondary failure to combined oral therapy whether, besides improvement in glycemic control, addition of exenatide, a new drug introduced to treat diabetes…
- Trial name
- NCT00948168
- Testing
- exenatide (Byetta)
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
T2DM
Hydroxyl Free Radical Associated Effects of SGLT-2 Inhibitors in Type 2 Diabetes
Beyond their metabolic effect, SGLT-2 inhibitors reduce the risk of heart failure and have cardiovascular and nephroprotective effects, yet their exact mechanism of action remains unclear.
- Trial name
- NCT06797115
- Testing
- SGLT-2 inhibitor
- Where
- Hungary
- Volunteers
- 40 people
- Sponsor
- University of Pecs
Type 2 Diabetes, Physical Exercise
The Use of Short SMS Messaging With Type 2 Diabetes (T2DM)
Physical activity (PA) can play a vital and an independent role in type 2 diabetes (T2DM) management care. Health research studies have shown evidence that PA can improve glycaemic control and glucose levels.
- Trial name
- mHealth (NCT04243174)
- Testing
- SMS Messaging
- Where
- Saudi Arabia
- Volunteers
- 57 people
- Sponsor
- University of Nottingham
Type 2 Diabetes (T2DM)
CGM-Assisted Community Management for Type 2 Diabetes
This non-randomised, parallel-group pragmatic study used a type 2 effectiveness-implementation hybrid design to evaluate a continuous glucose monitoring (CGM)-assisted community management strategy for adults with type 2 diabetes…
- Trial name
- NCT07097415
- Testing
- Yuwell Anytime CT3A Continuous Glucose Monitoring System, CGM-Assisted Community Management Strategy
- Where
- 2 sites in China
- Volunteers
- 599 people
- Sponsor
- Peking University
T2DM
A Phase 1 Trial to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-3167 Single Injection in Healthy Subjects and Patients With Type 2 Diabetes
This is a randomized, double-blind, placebo-controlled, single-dose escalation trial was designed. There are 6 dose groups and 1 optional dose group: 0.5 mg, 2 mg, 8 mg, 25mg, 50 mg, 100 mg and 150 mg (optional).
- Trial name
- NCT05996380
- Testing
- SHR-3167
- Where
- China
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Menopause, Sleep Disruption
Endocrine Disruption, Menopause, and Poor Sleep in wOmen With Type 2 Diabetes: Effects on Cardiovascular Health
EMPOWER aims to determine the overall effect of menopause and sleep disruption on cardiac remodeling in women with type 2 diabetes.
- Conditions
- Menopause, Sleep Disruption, T2DM
- Trial name
- EMPOWER (NCT07486986)
- Testing
- 4 years of clinical evaluations.
- Volunteers
- 381 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Diabetes Mellitus, Obesity
Single Loop DJB Sleeve Gastrectomy for Poorly Controlled T2DM
Type 2 diabetes mellitus (T2DM) is a chronic progressive illness affecting a substantial percentage of the general population. While pharmacotherapy remains the mainstay of treatment, around 60% of patients cannot achieve the…
- Conditions
- Diabetes Mellitus, Obesity, Bariatric Surgery Candidate, Weight Loss
- Trial name
- NCT03125369
- Testing
- Sleeve gastrectomy + duodeno-jejunal bypass, Roux-Y gastric bypass
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese University of Hong Kong
Type 2 Diabetes Mellitus (T2DM)
A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the effect of a single dose of ALN-4324 on whole-body insulin sensitivity in participants with T2DM
- Trial name
- NCT07465224
- Testing
- ALN-4324
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Alnylam Pharmaceuticals
Diabetes Mellitus Type 2 in Obese
DMBSS-A Randomized Trial of Different Laparoscopic Gastric Bypass Surgery in Patients With Obesity-related T2DM
The investigators would like to conduct a randomized clinical trial to compare the efficacy of diabetes treatment between different gastric bypass procedures involving type 2 diabetics patients with BMI from 27.5 to 35 kg/m2
- Trial name
- DMBSS (NCT01989988)
- Testing
- LMGB, LRYGB, SADJB
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Min-Sheng General Hospital
T2DM (Type 2 Diabetes Mellitus)
Clinical Trial to Investigate the Pharmacokinetics and Safety of CKD-393
A Clinical Trial to evaluate the Pharmacokinetics and safety of CKD-393 0.5/100/1000 mg under fed condition
- Trial name
- NCT04706286
- Testing
- CKD-501, D759, D150, CKD-393 0.5/100/1000 mg
- Where
- South Korea
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Type 2 Diabetes Mellitus (T2DM), Type 1 Diabetes Mellitus (T1DM)
Continuous Glucose Monitoring for Outpatient Diabetes Management After Hospital Discharge
This study aims to improve patient awareness of the utility of continuous glucose monitoring systems in blood glucose monitoring and to improve patient satisfaction regarding diabetes care, particularly in the matter of blood…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Type 1 Diabetes Mellitus (T1DM), Hyperglycemia
- Trial name
- NCT06852950
- Testing
- Libre 3 Plus Continuous Glucose Monitor, Dexcom G7 Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension, Type 2 Diabetes Mellitus (T2DM)
Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepal
The goal of this clinical trial is to evaluate whether a multifaceted community-based intervention, comprising 1) screening and lifestyle counseling by female community health volunteers (FCHVs); community health workers in…
- Conditions
- Hypertension, Type 2 Diabetes Mellitus (T2DM), Tobacco Smoking
- Trial name
- SCALE NCD (NCT06740708)
- Testing
- SCALE-NCD
- Where
- Nepal
- Volunteers
- 2,100 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
T2DM (Type 2 Diabetes Mellitus)
Anti-inflammatory Dietary Intervention in Patients With Type 2 Diabetes: A Randomized Controlled Trial
The goal of this clinical trial is to evaluate whether an evidence-based anti-inflammatory dietary intervention can reduce inflammation and improve glycemic control in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT07656805
- Testing
- Anti-inflammatory Dietary Intervention, Standard Diabetes Dietary Advice
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Anhui Medical University
Type 2 Diabetes Mellitus, Gene Polymorphisms
Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls
In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression. Participants (T2DM patients and controls) were recruited to identify genotypes and detect the levels of T2DM…
- Conditions
- Type 2 Diabetes Mellitus, Gene Polymorphisms, Genetic Mutations, Susceptibility, Genetic
- Trial name
- NCT06277466
- Testing
- Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected from controls and T2DM patients without hypoglycemic drugs, Fresh blood samples were collected from healthy subjects and T2DM patients without hypoglycemic drugs
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Type 2 Diabetes, Non Celiac Gluten Sensitivity
Evaluation of the Effects of Gluten Free Diet on Clinical Symptoms and Glycemic Index in Type 2 Diabetic Patients With Non-celiac Gluten Sensitivity
Confirmed cases of type 2 diabetes who have presented with gastrointestinal symptoms and have no diagnosed gastrointestinal diseases will be referred to the laboratory for testing of tTG IgA and total IgA antibodies to rule out…
- Trial name
- NCT06900946
- Testing
- gluten, cornstarch
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- National Nutrition and Food Technology Institute
Diabetes Mellitus Type 2
Multiple Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of THDBH120 in Chinese Patients With T2DM
The aim of this trial is to investigate the safety, tolerability, pharmacokinetics, and efficacy of THDBH120 injection in participants with T2DM. This study includes three multiple-ascending dose cohorts.
- Trial name
- NCT07020949
- Testing
- THDBH120 injection
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Tonghua Dongbao Pharmaceutical Co.,Ltd