Clinical trials: T2DM (Type 2 Diabetes Mellitus)
Diabetes Mellitus, Type 2
Study of Efficacy and Safety LMF237 in Patients With Type 2 Diabetes Mellitus (T2DM) Inadequately Controlled With Vildagliptin Monotherapy
The purpose of the study was to evaluate the efficacy and safety of LMF237 50/250 mg and 50/500 mg bid in Japanese patients with T2DM inadequately controlled with vildagliptin monotherapy.
- Trial name
- CLMF237A1303 (NCT01811485)
- Testing
- LMF237 50/250 mg, LMF237 50/500 mg
- Where
- 30 sites in Japan
- Volunteers
- 171 people
- Sponsor
- Novartis Pharmaceuticals
Type 2 Diabetes Mellitus
Effect of Exenatide on Glucose Homeostasis Determinants in Type 2 Diabetes
The purpose of this study is to determine in type 2 diabetic patients in secondary failure to combined oral therapy whether, besides improvement in glycemic control, addition of exenatide, a new drug introduced to treat diabetes…
- Trial name
- NCT00948168
- Testing
- exenatide (Byetta)
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Obesity, Type 2 Diabetes Mellitus (T2DM)
Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus
The goal of this clinical trial is to learn if semaglutide can help with weight loss in overweight or obese adults in Bangladesh. The study will also look at how safe semaglutide is for these participants.
- Trial name
- NCT06616961
- Testing
- Semaglutide Pen
- Where
- Bangladesh
- Volunteers
- 480 people
- Sponsor
- Popular Medical College Hospital
Economics, Behavioral, Hypertension
Health Behavior Nudge Strategies for Chronic Disease Patients: the Study of Hypertension and Type 2 Diabetes
This study is conducted from the perspective of behavioral economics, where individuals often display bounded rationality in decision-making, opting for habitual choices rather than those most advantageous to themselves.
- Conditions
- Economics, Behavioral, Hypertension, Type 2 Diabetes Mellitus (T2DM), Self-management Behavior
- Trial name
- NCT06588127
- Testing
- nudge
- Where
- China
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- Lin Han
Diabetes Mellitus Type 2 in Obese
DMBSS-A Randomized Trial of Different Laparoscopic Gastric Bypass Surgery in Patients With Obesity-related T2DM
The investigators would like to conduct a randomized clinical trial to compare the efficacy of diabetes treatment between different gastric bypass procedures involving type 2 diabetics patients with BMI from 27.5 to 35 kg/m2
- Trial name
- DMBSS (NCT01989988)
- Testing
- LMGB, LRYGB, SADJB
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Min-Sheng General Hospital
Type 2 Diabetes Mellitus
The Role of Vitamin D3 and Calcium Supplementation in Attenuating T2DM Severity
The purpose of this study is to investigate the effect of vitamin D3 and calcium supplementation in attenuating type 2 diabetes mellitus outcomes in ethnic diverse, diabetic patiens.
- Trial name
- NCT02464462
- Testing
- vitamin D3 and calcium
- Volunteers
- 11 people
- Sponsor
- York University
Diabetes Mellitus Type 2 (T2DM)
Empagliflozin as a Modulator of Systemic Vascular Resistance and Cardiac Output in Patients With Type 2 Diabetes
SGLT2 inhibitors are a novel class of glucose lowering drugs that act in the kidney by inhibiting SGLT2-mediated glucose reabsorption in the proximal tubule.
- Trial name
- EMPA (NCT03132181)
- Testing
- Empagliflozin
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- RWTH Aachen University
Type 2 Diabetes Mellitus (T2DM)
Precision Lifestyle Interventions Guided by Continuous Glucose Monitoring: Impact on Glycemic Outcomes in Type 2 Diabetes Mellitus
This study is an interventional research. Through scientific evaluation, it explores the effect of precise lifestyle intervention based on CGM data on the control of chronic type 2 diabetes mellitus.
- Trial name
- NCT06960512
- Testing
- Precision Lifestyle Intervention (PLI) group
- Volunteers
- 200 people
- Sponsor
- He Eye Hospital
Type 2 Diabetes Mellitus
Personality of Diabetic Patients Will Influence Their Medical compliance-a 5 Years Cohort Follow up With Type D Personality
Diabetes is one of the most common causes of death in Taiwan. With the raising prevalence of diabetes, it became the fourth most common cause of death since 2002.
- Trial name
- NCT01151293
- Sponsor
- Far Eastern Memorial Hospital
Type 2 Diabetes Mellitus
Tenelia Triple Combination Study
After a screening, a 2-week, single-blind placebo run-in, 200 patients will be randomized in a 1 : 1 ratio to the addition of either once-daily Teneligliptin 20mg or sitagliptin 100mg to ongoing stable doses of glimepiride in…
- Trial name
- TETRIS (NCT02567994)
- Testing
- Teneligliptin
- Where
- South Korea
- Volunteers
- 201 people
- Sponsor
- Handok Inc.
Diabetes Mellitus, Type 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK1362885 in Type 2 Diabetics
This study is the second administration of GSK1362885 in humans. GSK1362885 is a novel, potent inhibitor of human glycogen phosphorylase (GP) under development for the treatment of type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01013766
- Testing
- GSK1362885
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- GlaxoSmithKline
Diabetes Mellitus, Type II, Overweight or Obesity
Differences in Postprandial Glucose Changes
Following a meal, in nondiabetic individuals, blood glucose rises to peak at 1hr and returns to baseline in 2 - 3 hours. In T2DM, this peak is higher and prolonged.
- Trial name
- NCT05957224
- Testing
- Shake 1 then Shake 2, Shake 2 then Shake 1
- Volunteers
- 25 people
- Sponsor
- The University of The West Indies
Type 2 Diabetes Mellitus, High-Intensity Interval Training
Development of Structured Exercise Program for T2DM Management
The study started by the process of designing a structured exercise that will manage the T2DM with regards to the effectiveness in glycemic control, the benefit for physical fitness, and safe.
- Conditions
- Type 2 Diabetes Mellitus, High-Intensity Interval Training, Resistance Training, Oxidative Stress
- Trial name
- NCT03563456
- Testing
- structured combined exercise, cardiorespiratory exercise
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Indonesia
Mental Health Issue, Depression
Development and Validation of Psycho-Social Program (PSP)
The study aims to determine the effectiveness of a structured psycho-social program (PSP) in improving mental health outcomes among patients with Type 2 diabetes mellitus (T2DM).
- Conditions
- Mental Health Issue, Depression, Diabetes Distress, Quality of Life
- Trial name
- PSP-T2DM (NCT07456410)
- Testing
- Psycho-Social Program
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Government College University Faisalabad
Type 2 Diabetes Mellitus, Cognitive Impairment
Intensive Aerobic and Resistance Exercise Program (IAREP)
A 12-week Intensive Aerobic and Resistance Exercise Program (IAREP) intervention was implemented on high-risk and low-risk subjects with cognitive impairment in type 2 Diabetes Mellitus.
- Conditions
- Type 2 Diabetes Mellitus, Cognitive Impairment, Non-insulin-dependent Diabetes Mellitus, Cognitive Dysfunction
- Trial name
- NCT06401733
- Testing
- Intensive Aerobic and Resistance Exercise Program (IAREP)
- Where
- Singapore
- Volunteers
- 58 people
- Sponsor
- National University of Singapore
Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus)
Effect of Viscous Soluble Fibres on Body Weight
Abstract: Background: Obesity is a global pandemic affects all age groups and is independent risk factors for most chronic diseases. Dietary intervention is an essential component of obesity management.
- Conditions
- Overweight and Obesity, T2DM (Type 2 Diabetes Mellitus), General Population
- Trial name
- NCT03257449
- Testing
- Viscous Fibre
- Where
- Canada
- Volunteers
- 1,268 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Type 2 Diabetes Mellitus
A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM Patients
The main purpose of this study is to investigate the efficacy and safety of JY09 versus placebo in patients with type 2 diabetes mellitus (T2DM) inadequately controlled by diet and exercise alone
- Trial name
- NCT06254014
- Testing
- Exendin-4 Fc fusion protein injection
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Beijing Dongfang Biotech Co., Ltd.
Type 2 Diabetes Mellitus (T2DM), Obesity, Overweight
Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
The primary objective of this study is to demonstrate that maridebart cafraglutide is superior to placebo for percent change in body weight.
- Trial name
- MARITIME-2 (NCT06858878)
- Testing
- Maridebart cafraglutide
- Where
- 187 sites in United States, Argentina and 11 more
- Volunteers
- 1,105 people
- Sponsor
- Amgen
Diabetes Mellitus, Type 2
A Study of LY3437943 in Japanese Participants With Type 2 Diabetes Mellitus (T2DM)
The main purpose of this study is to learn about the side effects of LY3437943 when given to Japanese participants with type 2 diabetes mellitus.
- Trial name
- NCT04823208
- Testing
- LY3437943
- Where
- 4 sites in Japan
- Volunteers
- 64 people
- Sponsor
- Eli Lilly and Company
Albuminuria, Type 2 Diabetes Mellitus (T2DM)
Finerenone for Regression of Albuminuria in Type 2 Diabetes With Chronic Kidney Disease
This is a multicenter, randomized, double-blind, placebo-controlled clinical trial evaluating the efficacy and safety of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, for the early regression of albuminuria in…
- Conditions
- Albuminuria, Type 2 Diabetes Mellitus (T2DM), Chronic Kidney Diseases
- Trial name
- NCT07667517
- Testing
- Finerenone (BAY 94-8862)
- Where
- 13 sites in China
- Volunteers
- 148 people
- Sponsor
- First Affiliated Hospital of Zhejiang University