Clinical trials: TACS
Aging, Noninvasive Brain Stimulation
Memory Enhancement in Aging With Optimal Dosing
This project optimizes high-resolution transcranial Alternating Current Stimulation (tACS) to improve memory in healthy older adults, advancing drug-free approaches for Alzheimer's disease and related dementia (ADRD).
- Conditions
- Aging, Noninvasive Brain Stimulation, Memory
- Trial name
- NCT07461584
- Testing
- 1-day patterned tACS, 3-day patterned tACS, 5-day patterned tACS
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Adults With Variability in Their Mood
Restorative Neurophysiology: Backing up and Restoring the Brain (BandR)
Study to examine the extent to which neurophysiological states recorded for a specific person on one day can be induced on a subsequent day
- Trial name
- BandR (NCT07252011)
- Testing
- Transcranial alternating current stimulation (tACS), Neuro/biofeedback, Recall
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Alzheimer Disease
Gamma tACS in Alzheimer's Disease
Brain oscillations are ubiquitous in the human brain and have been implicated in cognitive and behavioral states defined in precisely tuned neural networks.
- Trial name
- GammAD (NCT04515433)
- Testing
- Gamma tACS (40 Hz) over the superior parietal cortex
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Schizophrenia, Schizoaffective Disorder
STimulation to Improve Auditory haLLucinations
Investigating the effects of non-invasive transcranial current stimulation as a treatment for auditory hallucinations in patients with schizophrenia.
- Trial name
- STILL 2 (NCT02360228)
- Testing
- tACS (alpha), tDCS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of North Carolina, Chapel Hill
Essential Tremor
Cerebello-thalamo-cortical Coupling in Essential Tremor
Essential tremor (ET) is a frequent and disabling disorder with progressive worsening of postural tremor of the upper limbs that impairs most of the manual activities of every day life (feeding, drinking, etc.).
- Trial name
- CERESTIM (NCT02346409)
- Testing
- tACS of the cerebellum
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Major Depressive Disorder
CARED : A Novel Rapid Treatment Paradigm for Depression
The purpose of this study is to primarily assess the feasibility and secondarily assess the efficacy of a single session intervention (SSI) that combines non-invasive brain stimulation and psychotherapy for Major Depressive…
- Trial name
- CARED (NCT07507370)
- Testing
- Intermittent Theta Burst Stimulation (iTBS), Transcranial Alternating Current Stimulation (tACS), Psychotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis of the Shoulder, Osteoarthritis of the Hip
Study to Compare Exposure of TA Following Administration of FX006 or TAcs in Patients With OA of the Shoulder or Hip
This is an open-label study to compare systemic exposure to triamcinolone acetonide following a dose of extended-release FX006 or immediate-release TAcs (triamcinolone acetonide suspension) in patients with osteoarthritis of the…
- Trial name
- NCT03382262
- Testing
- FX006 32 mg, TAcs 40 mg
- Where
- 6 sites in United States
- Volunteers
- 55 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Cluster Headache - Episodic and Chronic, Migraine Headache
Yogabased Movements for Primary Headaches (Migraine and/or Cluster Headache) - YOURHEAD - a Pilot Study
Migraine and/or Cluster Headache: Study Overview Background: Migraine and cluster headache are two primary headache disorders that significantly impact quality of life and functionality in those affected.
- Conditions
- Cluster Headache - Episodic and Chronic, Migraine Headache, Migraine Headache, With or Without Aura, Migraine in Adults
- Trial name
- NCT07292090
- Testing
- Intervention yogabased movements
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska Institutet
Understand the Effects of tACS on the Brain
Investigating Transcranial Alternating Current Stimulation (tACS) Preconditioning Effects on Resting and Active Motor Threshold
Previous studies have looked at the potential of using transcranial direct current stimulation (tDCS) to prime the brain in order to lower the resting motor threshold.
- Trial name
- NCT05503823
- Testing
- tACS or tRNS and TMS
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Generalized Anxiety Disorder (GAD)
Transcranial Alternating Current Stimulation to Enhance Mindfulness Therapy in Generalized Anxiety Disorder
This randomized, double-blind, sham-controlled clinical trial will evaluate whether individualized alpha-frequency transcranial alternating current stimulation (tACS) can enhance the effects of mindfulness therapy in adults with…
- Trial name
- NCT07648797
- Testing
- Synchronous Individualized Alpha-Frequency tACS, Desynchronous Individualized Alpha-Frequency tACS, Mindfulness Therapy
- Where
- China
- Volunteers
- 99 people
- Sponsor
- Central South University
Healthy
Effects of Alpha tACS
**Follow-up Control Study for Creativity Study Purpose: To investigate the effect of transcranial alternating current stimulation (tACS), a form of noninvasive brain stimulation, in healthy subjects.
- Trial name
- PACS (NCT03135639)
- Testing
- NeuroConn Plus Stimulator tACS
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Suicidal Ideation Active, Depression Disorders
Personalized TACS to Reduce Rumination in Patients with Active Suicidal Ideation
The goal of this clinical trial is to determine whether modulating default mode network (DMN) alpha connectivity using transcranial alternating current stimulation (tACS) can reduce rumination and, in turn, mitigate feelings of…
- Trial name
- Alpha-MOD (NCT06832124)
- Testing
- alpha-tACS
- Volunteers
- 50 people
- Sponsor
- Sebastian Olbrich
Visual Impairment, Stroke
Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery
This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients…
- Conditions
- Visual Impairment, Stroke, Parkinson Disease
- Trial name
- R4V (NCT05220449)
- Testing
- Cross-frequency dual-site tACS
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Disorder of Consciousness
tACS Alters EEG Microstates in DoC
Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), remain difficult to diagnose at the bedside.
- Trial name
- NCT07699055
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul Medipol University Hospital
Tremor, Limb
Effects of High Amplitude and Focused tACS on Entraining Physiological Tremor
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that works by passing alternating electric current between electrodes where at least one of them is attached to the head.
- Trial name
- NCT03337334
- Testing
- tACS at tremor frequency
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Mild Cognitive Impairment (MCI)
TACS to Engage Theta-Gamma Coupling and Enhance Working Memory in Patients With MCI (tACS-MCI)
This study is looking at a new non-invasive brain stimulation methods called transcranial alternating current stimulation (tACS) to see if it can improve working memory and thinking processes in people with Mild Cognitive…
- Trial name
- tACS-MCI (NCT06783283)
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Centre for Addiction and Mental Health
Sub-acute Stroke
Comparative Effects of Sensorimotor Training and tACS on Upper Limb Function and Cervical Proprioception in Subacute Stroke
Stroke is leading cause of death and disability worldwide, resulting in significant functional limitations and disabilities experienced by stroke survivors.
- Trial name
- NCT07905716
- Testing
- sensorimotor training with TACS
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- University of Management and Technology Lahore
Alzheimer Disease
At Home Gamma tACS in Alzheimer's Disease (tACS@Home)
Brain oscillations are ubiquitous in the human brain and have been implicated in cognitive and behavioral states defined in precisely tuned neural networks.
- Trial name
- tACS@Home (NCT05643326)
- Testing
- 40 Hz transcranial alternating current stimulation
- Where
- Italy
- Volunteers
- 53 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Neuroimmune Diseases With Insomnia
Study on the Clinical Efficacy of Transcranial Strong Alternating Current (Hi-tACS) in Patients With Neuroimmune Diseases With Insomnia
This study aims to comprehensively evaluate the therapeutic effects of high-intensity transcranial alternating current stimulation (hi-tACS) on insomnia symptoms in patients with idiopathic inflammatory demyelinating disorders…
- Trial name
- NCT07558616
- Testing
- high-intensity transcranial alternating current stimulation, hi-tACS
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xuanwu Hospital, Beijing
Tremor, Limb
The Trans-cutaneous Effects on Physiological Tremor Entertainment During tACS
Transcranial alternating current stimulation (tACS) is a noninvasive neuromodulation method that works by passing alternating electric current between electrodes where at least one of them is attached to the head.
- Trial name
- NCT04065022
- Testing
- tACS at tremor frequency
- Where
- Belgium
- Volunteers
- 22 people
- Sponsor
- KU Leuven