Clinical trials: TB - Tuberculosis
HIV Infections
Evaluation of Three Regimens of Chemoprophylaxis for Tuberculosis in Patients co-Infected by HIV and Mycobacterium Tuberculosis
To evaluate adherence and safety of three regimens of chemoprophylaxis for tuberculosis (TB) in HIV-infected patients with positive tuberculin skin test.
- Trial name
- NCT00402454
- Testing
- isoniazid, rifampin + isoniazid or rifampin + pyrazinamide
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Sociedad Andaluza de Enfermedades Infecciosas
Tuberculosis Infection
A Phase II Study of H56:IC31 in Healthy Adolescents
This clinical trial will evaluate safety, immunogenicity, and efficacy (prevention of Mtb infection as measured by IGRA conversions) of H56:IC31 in remotely BCG vaccinated adolescents.
- Trial name
- A-043 (NCT03265977)
- Testing
- H56:IC31
- Where
- 4 sites in South Africa, Tanzania
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aeras
Tuberculosis
A Pan-TB Regimen Targeting Host and Microbe
This project will develop the first regimen meeting WHO criteria for a pan-TB indication, ie, not requiring knowledge of RIF susceptibility.
- Trial name
- panTB-HM (NCT05686356)
- Testing
- Sutezolid, N-acetyl cysteine, Pretomanid
- Where
- 8 sites in Mozambique, South Africa and 1 more
- Volunteers
- 352 people
- Sponsor
- The Aurum Institute NPC
Tuberculosis
A Study to Investigate the Repeat-dose Pharmacokinetics of a Combined Oral Contraceptive When Given Alone and in Combination With Ganfeborole in Female Participants of Non-childbearing Potential
This study is designed to assess the pharmacokinetics (PK), safety, and tolerability of Ganfeborole and Microgynon, an oral contraceptive containing ethinylestradiol (EE) and levonorgestrel (LNG), when Microgynon is administered…
- Trial name
- NCT07784894
- Testing
- Ganfeborole, Microgynon
- Where
- Spain
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Tuberculosis
Local Anesthesia and Tuberculin Skin Test in Infants and Children
The use of local anaesthesia efficiently reduces pain due to needle puncture. However, when tuberculin skin test is performed it is the skin reaction to tuberculin injection that is studied.
- Trial name
- NCT00309673
- Testing
- lidocaine / Prilocaine
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Latent Tuberculosis Infection
TB mHealth Study - Use of Cell Phones to Improve Compliance in Patients on LTBI Treatment
This study will examine the impact of use of mobile phones and text messaging on adherence to treatment for patients with latent TB infection.
- Trial name
- NCT01549457
- Testing
- Cell phone text messages
- Where
- 3 sites in Canada
- Volunteers
- 350 people
- Sponsor
- University of British Columbia
Pulmonary Tuberculosis
Channa Striata and Curcuma Domestica Supplementation in Patients With Active Pulmonary Tuberculosis
This study aims to evaluate the effect of combined supplementation with Channa striata extract and Curcuma domestica rhizome on nutritional status, inflammatory markers, and quality of life in patients with active pulmonary…
- Trial name
- NCT07887724
- Testing
- CHANA STRIATA AND CURCUMA
- Where
- 2 sites in Indonesia
- Volunteers
- 80 people
- Sponsor
- DINA KEUMALA SARI
Lung Diseases, Tuberculosis
Behavioral Interventions for Control of Tuberculosis
To develop and test various educational strategies targeting primarily minority TB-infected adolescents at two health centers in Los Angeles in an experimental design to assess the relative effectiveness on medication adherence…
- Trial name
- NCT00005742
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Tuberculosis
Safety and Immunogenicity of MVA85A in Volunteers Latently Infected With TB.
This study is designed to evaluate the safety of MVA85A in healthy volunteers in the UK who are latently infected with M.tb. A single vaccination with MVA85A, when administeredat a dose of 5 x 107pfu intradermally, is safe in…
- Trial name
- NCT00456183
- Testing
- MVA 85A
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Tuberculosis
Assessing the Ability of the T-SPOT®.TB Test (IQ)
The primary objective of this clinical research study is to demonstrate performance of the normalized TB specific lymphocyte response (NTBSLR) in identifying patients with active TB disease.
- Trial name
- IQ (NCT03973970)
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Oxford Immunotec
Sensitive Pulmonary Tuberculosis
Early Bactericidal Activity Safety Pulmonary Tuberculosis Pyrifazimine (TBI-166)
The new drug pyrifazimine (previous name: TBI-166) developed by the Institute of Materia Medica of the Chinese Academy of Medical Sciences which is Beijing Union Pharmaceutical Second Factory relied on is obtained by retaining…
- Trial name
- NCT04670120
- Testing
- Pyrifazimine (TBI-166)
- Where
- 3 sites in China
- Volunteers
- 56 people
- Sponsor
- Beijing Chest Hospital
Tuberculosis, Pulmonary
Impact of Malnutrition on Pharmacokinetic of Rifampicin, Isoniazid, Pyrazinamide and Ethambutol in TB-HIV Co-infected Children (TB-Speed TB-PK)
TB-Speed TB-PK is a cross-sectional PK study of anti-TB treatment nested in the TB-Speed HIV and TB-Speed SAM studies aiming at assessing the impact of malnutrition on PK of rifampicin, isoniazid, pyrazinamide, and ethambutol in…
- Trial name
- NCT04972903
- Where
- 4 sites in Uganda, Zambia
- Volunteers
- 85 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Tuberculosis
Xpert Active Case-finding Trial 2: Community-based Active Case-finding for Tuberculosis in South Africa
TB kills most people with HIV in Africa. TB is out of control. Radically different approaches to deal with the disease is therefor needed. It is known that intensified case finding works in high HIV prevalence environments.
- Trial name
- XACT-2 (NCT03168945)
- Testing
- GeneXpert MTB/RIF, Smear microscopy
- Where
- South Africa
- Volunteers
- 608 people
- Sponsor
- University of Cape Town
Latent Tuberculosis Infection
Latent Tuberculosis Infection Screening Using QuantiFERON at Pre-Employment Assessment in Hospital Workers CHu Nice
This retrospective observational single-center study aims to evaluate the medical and occupational relevance of systematic screening for latent tuberculosis infection using QuantiFERON-TB Gold Plus during pre-employment…
- Trial name
- NCT07608601
- Testing
- QuantiFERON-TB Gold Plus
- Where
- France
- Volunteers
- 1,185 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Post-tuberculosis Lung Disease, Tuberculosis (TB)
Pulmonary Rehabilitation Program in Patients With Post-Tuberculosis Lung Disease
Post-tuberculosis lung disease (PTLD) refers to persistent respiratory symptoms, functional limitation, and/or structural or physiological abnormalities after completion of anti-tuberculosis treatment.
- Trial name
- NCT07709507
- Testing
- Individualized Pulmonary Rehabilitation Program, Standard Post-Tuberculosis Care
- Volunteers
- 80 people
- Sponsor
- Filantropia Hospital
HIV Infections, Tuberculosis
Prevalence of HIV +ve Cases With AIDS Defining Opportunistic Infections Among ART Naive Patients Attending ART Centre
HIV patients are likely to suffer from opportunistic infections, in absence of highly active retroviral therapy. This happens due to lack of awareness of HIV status among patients or unresponsive to anti retroviral drugs.
- Conditions
- HIV Infections, Tuberculosis, Candidiasis, Esophageal, Cryptococcosis
- Trial name
- ADC (NCT03993093)
- Testing
- CD4 cell count
- Where
- India
- Volunteers
- 257 people
- Sponsor
- Singh, Ranjan Kumar, M.D.
HIV-1 Infection, Tuberculosis
Raltegravir Versus Efavirenz in Naive HIV-1-infected Patients Receiving Rifampin for Active Tuberculosis
Phase III trial evaluating raltegravir as an alternative to efavirenz for antiretroviral treatment of HIV-infected patients with tuberculosis.
- Trial name
- REFLATE TB2 (NCT02273765)
- Testing
- Tenofovir + lamivudine + raltegravir, Tenofovir + lamivudine + efavirenz
- Where
- 5 sites in Brazil, Côte d’Ivoire and 3 more
- Volunteers
- 460 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Tuberculosis
Efficacy and Safety of Immunomodulator as an Adjunct Therapy in New Pulmonary Tuberculosis(Category I) Patients.
The purpose of the study is to evaluate the efficacy and safety of Mycobacterium w in new lung tuberculosis patients. Mycobacterium w is a strain of bacterium which is being used as vaccine and adjunct drug against leprosy.
- Trial name
- NCT00341328
- Testing
- Intradermal injection of Mycobacterium w
- Where
- 2 sites in India
- Volunteers
- 300 people
- Sponsor
- Ministry of Science and Technology, India
Tuberculosis, Pulmonary
Optimizing(O) RIfapentine-based(RI) Regimen and shortENing(EN) the Treatment of Drug-sensitive Tuberculosis(T)
Tuberculosis (TB) remains the most important infectious disease in the world. A major barrier to tuberculosis control is poor adherence to long-term and complex treatment regimens.
- Trial name
- ORIENT (NCT05401071)
- Testing
- Short Regimen with Rifapentine 10mg/kg, Standardized Regimen, Short Regimen with Rifapentine 15mg/kg
- Where
- 6 sites in China
- Volunteers
- 2,442 people
- Sponsor
- Huashan Hospital
Tuberculosis, Pulmonary
Personalization of AntiTB Treatment: Evaluation of Pharmacological Determinants of Treatment Response
The aim of the study is to investigate the possible correlation of plasma drug concentrations with Time To Positivity (TTP) in liquid culture in patients with active pulmonary multi sensitive TB in the first two weeks of…
- Trial name
- PAT (NCT03416309)
- Where
- Italy
- Volunteers
- 257 people
- Sponsor
- University of Turin, Italy