Clinical trials: THC
Nausea Post Chemotherapy, Vomiting
Pharmacokinetic and Pharmacodynamic Evaluation of Formulations of Δ9-THC
Study based on the pharmacokinetic, pharmacodynamic, safety and stability evaluation of 3 standardized formulations of THC, to be used in healthy volunteers and post-chemotherapy patients as an adjuvant in the symptomatic…
- Conditions
- Nausea Post Chemotherapy, Vomiting, Cancer Pain, Cancer Related Pain
- Trial name
- NCT05272865
- Testing
- Pharmacokinetic and pharmacodynamic profile of THC oral formulations with Dronabinol as comparator
- Where
- Colombia
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- LaSanta S A S
Healthy Volunteers
Study to Evaluate the Safety of SP-104
Evaluate the safety and tolerability of 3-day repeat-dose of SP-104 compared to naltrexone hydrochloride immediate release.
- Trial name
- NCT04958876
- Testing
- SP-104, Naltrexone immediate release oral capsules
- Where
- 2 sites in New Zealand
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Pharmacokinetic, Tolerability
Clinical Trial on Pharmacokinetic and Tolerability of AP701
This study aims to investigate the uptake of AP701, a preparation from cannabis flowers, into the bloodstream after in single administration in healthy volunteers.
- Conditions
- Pharmacokinetic, Tolerability, Safety
- Trial name
- NCT04708795
- Testing
- AP701
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- CannaXan GmbH
Bioavailability
Comparative Bioavailability of Dronabinol Oral Solution Versus Branded Capsule 5 mg Under Fasting Conditions
This is a comparative study to assess bioavailability of a proposed alternate dosage form against the current FDA-approved branded product.
- Trial name
- NCT01448772
- Testing
- Dronabinol Capsules, 5 mg, Dronabinol Oral Solution
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Healthy
Single and Multiple Dose Study of VER-01 in Healthy Volunteers
Evaluation of pharmacokinetics, tolerability and safety of VER-01 in healthy volunteers
- Trial name
- NCT04930809
- Testing
- VER-01
- Where
- Austria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Vertanical GmbH
Healthy Volonteers
Safety and Pharmacokinetics of Vaped Cannabis in Healthy Volunteers
The primary objective of this study was to evaluate the pharmacokinetics (PK) of THC, 11-OH-THC and CBD following a single inhaled dose of PPP001 administered by vaporization.
- Trial name
- NCT04461756
- Testing
- PPP001
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Tetra Bio-Pharma
Chronic Pain
Dronabinol Opioid Sparing Evaluation (DOSE) Trial
This study will be a 12-week, open-label trial that is designed to evaluate the Opioid-Sparing effect of Dronabinol at ranging doses when coadministered with the opioid analgesics that are currently being prescribed to patients…
- Trial name
- NCT03766269
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Daisy Pharma Opioid Venture, LLC
Cannabis Abuse
Drug-Drug Interaction Between THC and AEF0117
This trial is a single center, double blind, placebo-controlled trial in healthy male and female recreational cannabis users with placebo and AEF0117 dosed in a fixed sequence.
- Trial name
- DDI (NCT06395688)
- Testing
- 3ß-(4-methoxybenzyloxy)pregn-5-en-20-one
- Volunteers
- healthy volunteers welcome
- Sponsor
- Aelis Farma
To Determine Bioequivalence Under Fasting Conditions
Bioavailability Study of Dronabinol Capsules 10 mg Under Fasting Conditions
The purpose of this study is to compare the rate and extent of absorption of Dronabinol 10 mg capsules verses Marinol.
- Trial name
- NCT01380457
- Testing
- Dronabinol, Marinol
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Par Pharmaceutical, Inc.
Drug Abuse, Medication
A Study of the Abuse Potential of Dronabinol in Recreational Cannabinoid Users
The primary objective of this study is to evaluate the abuse potential of dronabinol oral solution in recreational cannabinoid users.
- Trial name
- NCT02094599
- Testing
- Dronabinol 10 mg, Dronabinol 30 mg
- Where
- Canada
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Healthy
Comparative Bioavailability of Dronabinol Oral Solution in Healthy Volunteers
The primary objective of this study is to evaluate the comparative bioavailability of a test product of dronabinol oral solution administered under fed conditions to the reference listed drug (RLD) administered to participants…
- Trial name
- NCT02604992
- Testing
- Treatment A, Treatment B, Treatment C
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- INSYS Therapeutics Inc
Healthy Volunteers
Safety and Pharmacokinetics of Smoked Cannabis in Healthy Patients
No actual human data for pharmacokinetics, metabolism, safety, pharmacodynamics, nor efficacy parameters are available for inhaled medical cannabis.
- Trial name
- NCT04314804
- Testing
- PPP001
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tetra Bio-Pharma
Healthy
Food Effect Study of VER-01 in Healthy Volunteers
Evaluation of pharmacokinetics, tolerability and safety of VER-01 depending on the intake a high-fat meal in healthy volunteers
- Trial name
- NCT04930796
- Testing
- VER-01
- Where
- Austria
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Vertanical GmbH
THC
A Bioavailability Study on Dronabinol
This study is a two part study
- Trial name
- NCT03098940
- Testing
- Chewing Gum
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Axim Biotechnologies
Pharmacokinetics, Tolerability
Clinical Trial on Pharmacokinetics and Tolerability of AP707
Brief Summary:This study aims to investigate the uptake of AP707, a preparation from cannabis flowers, into the bloodstream after in single administration in healthy volunteers.
- Conditions
- Pharmacokinetics, Tolerability, Safety
- Trial name
- NCT05267769
- Testing
- AP707
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- CannaXan GmbH
Acute Cannabinoid Intoxication
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of CB1 Antagonist ANEB-001 in a THC Challenge Test
The aim of this study is to investigate whether ANEB-001 effectively penetrates the brain and inhibits the psychotropic effects of Δ9-Tetrahydrocannabinol (THC), the main psychoactive constituent of cannabis.
- Trial name
- NCT05282797
- Testing
- ANEB-001
- Where
- Netherlands
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Anebulo Pharmaceuticals
Healthy, Cannabis
A Study Investigating the Bioavailability of CBD and THC in an Emulsion Product in a Healthy Population
The objective of this study is to investigate the bioavailability of Cannabidiol (CBD) and Tetrahydrocannabinol (THC) in an emulsion product against a comparator product.
- Trial name
- NCT04601207
- Testing
- Cannabis Preparation
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- New Age Ventures LLC
Anxiety, Generalized Anxiety Disorder
Evaluation of Effects of CBD Products on Anxiety Among U.S. Women
The investigators will conduct a retrospective cohort analysis of a consumer trial conducted by Rae Wellness. The trial took place between October 15, 2020 and December 30, 2020 and involved 1350 U.S.
- Trial name
- NCT05108220
- Testing
- Cannabidiol (CBD)- containing consumer products
- Where
- United States
- Volunteers
- 1,350 people, healthy volunteers welcome
- Sponsor
- Radicle Science
Healthy
Pharmacokinetics of SP-104
This open-label, 3-period, 3-treatment, randomized study will characterize the pharmacokinetics and safety and tolerability of SP-104 under fasting and fed conditions as compared to the pharmacokinetics of Naltrexone…
- Trial name
- NCT05002946
- Testing
- SP-104, Naltrexone Hydrochloride 50Mg Oral Tablet
- Where
- New Zealand
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Hepatic Impairment
Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients
A Phase I open-label study to evaluate the pharmacokinetics (what the body does to a drug), safety and tolerability of a single dose of Sativex (containing 10.8 mg tetrahydrocannabinol [THC] and 10 mg cannabidiol [CBD]) in…
- Trial name
- NCT01887301
- Testing
- Sativex
- Where
- 2 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals