Clinical trials: THC, open to volunteers
Age-related Cognitive Decline
Acute Effects of THC in Older Adult
The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding…
- Trial name
- THC-Aging (NCT06948136)
- Testing
- Delta-9-THC Low Dose, Delta-9-THC Medium Dose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yale University
Autism Spectrum Disorder, Anxiety
Investigating a Marijuana-based Compound as a Treatment for Anxiety in Autistic Adults
The goal of this clinical trial is to learn if drug ABC works to treat severe asthma in adults. It will also learn about the safety of drug ABC.
- Trial name
- NCT06526208
- Testing
- MB-IMP
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Southwest Autism Research & Resource Center
Pain, Abuse, Drug
Age-dependent Effects of Smoked and Oral Delta-9-THC
This study will assess the age-dependent effects of smoked and oral THC on abuse liability, intoxication, analgesia and impairment as a function of age.
- Conditions
- Pain, Abuse, Drug, Intoxication; Cannabinoids
- Trial name
- SAGE (NCT05865470)
- Testing
- Cannabis, Dronabinol
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cannabis
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I
The purpose of the study is to characterize the acute effects of cannabinoids in women relative to men and to begin probing the mechanisms that may underlie gender differences.
- Trial name
- THC-Gender-I (NCT02811510)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Pain, Depression Disorders
Analysis of the Therapeutic and Clinical Profile of Cannabinoid Treatments: A Real-World Study
What is the purpose of this study? The use of medicinal cannabis has grown significantly in Brazil. However, because many patients use these products through "compassionate use" (when traditional treatments haven't worked), there…
- Conditions
- Chronic Pain, Depression Disorders, Anxiety Disorders, Quality of Life
- Trial name
- CANAREAL (NCT07362407)
- Testing
- Participants are followed while using cannabis-based products (such as CBD or THC oils, extracts, or isolates) as prescribed by their own physicians for therapeutic purposes.
- Where
- Brazil
- Volunteers
- 384 people
- Sponsor
- Santa Catarina Federal University
Menopause, Perimenopause
Effects of Hemp-Derived Cannabinoids on Menopause Symptoms
The purpose of the study is to examine the impact of hemp-derived minor cannabinoids on symptoms of menopause/perimenopause.
- Trial name
- NCT07393672
- Testing
- Hemp-derived cannabinoids
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Washington State University
THC
Pilot fMRI Studies of Aging-Related Effects of THC
The purpose of this study is to begin investigating acute impairment of various forms of memory and learning by Tetrahydrocannabinol (THC) in cannabis (CNB) compared to placebo, in a 2-session per subject double-blind, random…
- Trial name
- NCT06647524
- Testing
- THC
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
The objective of this study is to evaluate the efficacy of using a reduced-intensity condition (RIC) regimen with umbilical cord blood transplant (UCBT), double cord UCBT, matched unrelated donor (MUD) bone marrow transplant…
- Conditions
- Primary Immunodeficiency (PID), Congenital Bone Marrow Failure Syndromes, Inherited Metabolic Disorders (IMD), Hereditary Anemias
- Trial name
- HSCT+RIC (NCT01962415)
- Testing
- Hydroxyurea, Alemtuzumab, Fludarabine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Paul Szabolcs
Cannabis Intoxication
Pregnenolone as a Treatment for Cannabis Intoxication
The present study will characterize the ability of pregnenolone to reverse the acute intoxication and associated symptoms of cannabis.
- Trial name
- NCT07216690
- Testing
- Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pain
Effects of Dronabinol in Opioid Maintained Patients
Twenty male and female (ages 18-70) participants with OUD currently receiving methadone or buprenorphine will be enrolled. Prior to their daily methadone or buprenorphine dose and thus at trough plasma levels of opioid…
- Trial name
- THC (NCT04025359)
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
THC, Cannabis
Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration
This is a crossover, randomized, double-blinded clinical pharmacology study enrolling dual cannabis-tobacco smokers to better understand the combined effects of co-administering cannabis and tobacco.
- Conditions
- THC, Cannabis, Cannabis Use, Cannabis Smoking
- Trial name
- CANNIC (NCT05999383)
- Testing
- Cannabis, Nicotine, Pax Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Autism, Autism Spectrum Disorder
Placebo-Controlled Study of Terpenes-Enriched Cannabis Oil T1/C28 for Children With Autism
The goal of this clinical trial is to determine whether cannabidiol (CBD, 28%) combined with terpenes and a small amount of THC (1%) can help reduce symptoms of autism, and to evaluate the safety of this treatment.
- Trial name
- TECA (NCT07199218)
- Testing
- Terpenes-Enriched CBD-Predominant Oil, Terpenes-Enriched CBD Oil (THC-Free)
- Where
- Israel
- Volunteers
- 78 people
- Sponsor
- Bazelet Nehushtan LtD.
Cannabis, THC
Modulation of THC Effects by CBD: a Dose-ranging Study
The purposes of this study are 1) to determine if CBD modulates THC-induced acute psychoactive effects at different CBD:THC ratios, compared with the control product (0:20, 20:20, 40:20, 80:20, 120:20) and 2) to determine if…
- Trial name
- SPECTRE (NCT06099379)
- Testing
- ∆9-tetrahydrocannabinol
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Pruritus
Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study
Chronic pruritus affects 10-20% of the population and causes a major reduction in quality of life, comparable to pain, with significant psychological, social, and functional consequences.
- Trial name
- CANNA-ITCH (NCT06435299)
- Testing
- Cannabis oil
- Where
- 6 sites in France
- Volunteers
- 218 people
- Sponsor
- University Hospital, Brest
Hepatocellular Carcinoma, Cannabis
A Pilot Study on the Effect of Cannabis Oil in Untreatable Liver Cancer Patients
to study the anti-tumor effect of cannabis oil (THC10% / CBD5%) in untreatable HCC patients based on mRECIST and RECIST criteria
- Trial name
- CanHep (NCT06518434)
- Testing
- Medical Cannabis
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Cannabis Use, Tobacco Use
Effect of Cannabis on Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Cigarette Smoking
- Trial name
- NCT06609083
- Testing
- THC 30mg, THC 5mg, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use
Acute Effects of Cannabis on Cognition and Affect
This study will examine how a moderate dose of THC affects mood and cognitive functioning in regular cannabis users. The study uses a double-blind, placebo-controlled, crossover design, meaning each participant will complete two…
- Trial name
- NCT07296874
- Testing
- THC 20mg
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Washington State University
Cannabis Intoxication
Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)
This study will evaluate the subjective and behavioral effects of cannabis products containing delta-9-tetrahydrocannabinol and cannabidiol
- Trial name
- NCT07870187
- Testing
- 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis
Sex Hormones Impact on Cannabis Response
The goal of this study is to systematically determine whether the cannabis response in human females is related to SH fluctuations throughout the menstrual cycle.
- Trial name
- NCT07417059
- Testing
- Cannabis, Knaster Hemp
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Maastricht University