Clinical trials: THC, active
Cannabis, THC
Modulation of THC Effects by CBD: a Dose-ranging Study
The purposes of this study are 1) to determine if CBD modulates THC-induced acute psychoactive effects at different CBD:THC ratios, compared with the control product (0:20, 20:20, 40:20, 80:20, 120:20) and 2) to determine if…
- Trial name
- SPECTRE (NCT06099379)
- Testing
- ∆9-tetrahydrocannabinol
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Healthy Volunteer
Challenging the Endocannabinoid System in Sleep Restricted Healthy Volunteers to Modulate Physiological Arousal (CANISLEEP) Study
The goal of this study is to learn about the body's response to cannabis based products in sleep deprived people who are currently experiencing anxiety but are otherwise healthy.
- Trial name
- CANISLEEP (NCT07656350)
- Testing
- THC, CBD, THC + CBD
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King's College London
Psychosis, Cannabis Use
Probing the Cannabinoid System in Individuals With a Family History of Psychosis
The overall purpose of this study is to determine whether a family history of psychosis is associated with an altered cannabinoid system.
- Conditions
- Psychosis, Cannabis Use, THC, Marijuana
- Trial name
- NCT02102113
- Testing
- Very Low Dose THC, Low Dose THC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Yale University
Abuse Cannabis, Pain
High Potency Cannabis: Acute and Protracted Effects
The purpose of this research is to assess the effects of smoked cananbis when cannabis is smoked during periods of cannabis use as usual and after a brief period of abstinence.
- Conditions
- Abuse Cannabis, Pain, Pharmacokinetics
- Trial name
- HIGH-CAP (NCT06859723)
- Testing
- Low dose THC, High dose THC
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Intrusive Memories
The Effect of Dronabinol on the Acquisition and Consolidation of Trauma-Associated Memories
The aim of the current project is to investigate the impact of an activation of the cannabinoid system with an exogenous cannabinoid dronabinol (delta-9-tetrahydrocannabinol) on the formation of intrusive memories after analog…
- Trial name
- NCT04871269
- Testing
- Dronabinol
- Where
- Germany
- Volunteers
- 291 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Cannabis Use Disorder
Endocannabinoids in Reward
This study will examine sex differences in the effects of cannabis in people that regularly use it. Men and women that use cannabis at least 4 days a week will participate in a study involving 3 in-person visits.
- Trial name
- NCT07815691
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Medical University of South Carolina
Obstructive Sleep Apnea (OSA)
DReAMzz- Dronabinol and Acetazolamide Medication for Sleep Apnea (ZZ). Dose Confirmation Crossover Study for IHL-42X in Subjects With Obstructive Sleep Apnea.
The goal of this randomized, double-blind, multi-dose crossover clinical trial is to determine the safety and efficacy of IHL-42X in subjects with obstructive sleep apnea.
- Trial name
- DReAMzz (NCT07635563)
- Testing
- IHL-42X: 2.5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 5 mg dronabinol + 125 mg acetazolamide, IHL-42X: 7.5 mg dronabinol + 125 mg acetazolamide
- Where
- 13 sites in United States
- Volunteers
- 120 people
- Sponsor
- Incannex Healthcare Ltd
THC
THC Titration of High-Potency Cannabis Concentrates
High-potency cannabis use is associated with public health risks, such as cannabis use disorder, psychotic disorders, and impaired cognition.
- Trial name
- THC Titration (NCT07105449)
- Testing
- Cannabis (30% THC Concentrate), Cannabis (60% THC Concentrate), Cannabis (90% THC Concentrate)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Cannabis Intoxication
Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC)
This study will evaluate the subjective and behavioral effects of cannabis products containing delta-9-tetrahydrocannabinol and cannabidiol
- Trial name
- NCT07870187
- Testing
- 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cannabis Use, Tobacco Use
Effect of Cannabis on E-Cigarette Use Behavior
The purpose of this study is to determine the impact of tetrahydrocannabinol (THC) administration on motivational, subjective, and physiological effects of electronic cigarettes.
- Conditions
- Cannabis Use, Tobacco Use, Electronic Cigarette Use
- Trial name
- NCT06609109
- Testing
- THC High Dose, THC Low Dose, THC 0mg
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Evaluate PK Profile, Evaluate PD Profile
A Study Testing the Effects of Different THC Doses on Psychological and Biological Function
The goal of this clinical trial is to learn how a investigational medicinal product (THC) affects psychological and physical responses in healthy adults with prior cannabis use experience.
- Conditions
- Evaluate PK Profile, Evaluate PD Profile, Healthy Adults, Safety and Tolerability in Healthy Volunteers
- Trial name
- DRATT (NCT07346690)
- Testing
- AVCN319301b (6mg), AVCN319301b (9mg), AVCN319301b (15mg)
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Pain, Appetite Loss
AnalgeSiC and appEtite-stimulating Effects of caNnabigerol and THC (ASCENT)
This study will assess the analgesic, appetite-stimulating, and subjective effects of cannabigerol (CBG) alone and in combination with THC.
- Conditions
- Pain, Appetite Loss, Abuse, Drug
- Trial name
- ASCENT (NCT04859296)
- Testing
- Low CBG, High CBG, Low THC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Severe Combined Immunodeficiency (SCID), Immunodeficiency With Predominant T-cell Defect, Unspecified
Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases
The purpose of this study is to determine whether bilateral orthotopic lung transplantation (BOLT) followed by cadaveric partially-matched hematopoietic stem cell transplantation (HSCT) is safe and effective for patients aged…
- Conditions
- Severe Combined Immunodeficiency (SCID), Immunodeficiency With Predominant T-cell Defect, Unspecified, Severe Chronic Neutropenia, Chronic Granulomatous Disease (CGD)
- Trial name
- BOLT+BMT (NCT01852370)
- Testing
- CD3/CD19 negative allogeneic hematopoietic stem cells
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Paul Szabolcs
Cannabis Use Disorder
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use.
- Trial name
- NCT06446479
- Testing
- Dronabinol Pill
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Agitation in Dementia
To Evaluate the Efficacy, Safety, and Tolerability of Dronabinol Oral Solution for Agitation in Patients With Alzheimer's Disease
This study tests a medication called dronabinol in people with Alzheimer's disease. First, participants go through up to 4 weeks of screening. Then, over 2 weeks, the dose of the study drug is slowly increased.
- Trial name
- NCT07422311
- Testing
- Dronabinol Oral Solution
- Where
- Australia
- Volunteers
- 140 people
- Sponsor
- Benuvia Therapeutics Inc.
Abuse, Drug, Pain
THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy
The purpose of this research is to assess the impact of CBD on the effects of THC.
- Trial name
- THC-REDUX (NCT06859710)
- Testing
- THC, CBD 20 mg, CBD 40 mg
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Cannabis
Sex Hormones Impact on Cannabis Response
The goal of this study is to systematically determine whether the cannabis response in human females is related to SH fluctuations throughout the menstrual cycle.
- Trial name
- NCT07417059
- Testing
- Cannabis, Knaster Hemp
- Where
- Netherlands
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Cannabis Intoxication
Pregnenolone as a Treatment for Cannabis Intoxication
The present study will characterize the ability of pregnenolone to reverse the acute intoxication and associated symptoms of cannabis.
- Trial name
- NCT07216690
- Testing
- Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Subjective Drug Effects, THC
Behavioral Pharmacology of Orally Administered THC and D-limonene
The current clinical trial will investigate the effects of orally administered d-limonene (limonene), delta-9-tetrahydrocannabinol (THC) and the combination in healthy adult volunteers.
- Conditions
- Subjective Drug Effects, THC, D-limonene
- Trial name
- NCT06378957
- Testing
- D-Limonene, Delta-9-THC
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Pain, Opioid Use Disorder
Combined THC and CBD for OUD and Chronic Pain
The primary objective of this phase 2 study is to investigate the therapeutic potential of orally administered combined delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in relieving both pain and cue-induced opioid…
- Trial name
- NCT06544291
- Testing
- CBD 300mg, CBD 600mg
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- Yale University