Clinical trials: TKA Outcomes
Total Knee Anthroplasty, Postoperative Pain
Proximal Spread in Adductor Canal Block(ACB)
This prospective, randomized clinical study is designed to evaluate the effects of two different injection levels of adductor canal block (ACB) on the proximal spread of local anesthetic and clinical outcomes in patients…
- Trial name
- ACB (NCT07595471)
- Testing
- Comparison of Proximal Adductor Canal Block, Comparison True Distal Adductor Canal Block.
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara Etlik City Hospital
Arthritis Knee
Tourniquet on Total Knee Arthroplasty
The purpose of this study is determine the effect on novel pressure-regulating tourniquet use on pain, functional recovery, sleep and total blood loss following total knee arthroplasty.
- Trial name
- NCT04923724
- Testing
- tourniquet, No tourniquet
- Where
- United States
- Volunteers
- 165 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis (OA) of the Knee, Knee Pain Arthritis
Imageless Navigation Versus Image-Based Navigation in Robotic-Assisted Total Knee Arthroplasty for Knee Osteoarthritis
The goal of this clinical trial is to learn if imageless navigation is not inferior to image-based navigation in robotic-assisted total knee arthroplasty (RA-TKA) for treating patients with knee osteoarthritis.
- Conditions
- Osteoarthritis (OA) of the Knee, Knee Pain Arthritis, Total Knee Arthroplasty (TKA), Robotic Assisted Arthroplasty
- Trial name
- NCT07522489
- Testing
- Imageless Robotic-Assisted Total Knee Arthroplasty, Image-based Robotic-Assisted Total Knee Arthroplasty
- Where
- Poland
- Volunteers
- 146 people
- Sponsor
- Medical University of Warsaw
Knee Osteoarthritis, Total Knee Arthroplasty
Robotic-Assisted Total Knee Arthroplasty: Cruciate-Retaining Versus Bi-Cruciate Stabilized
The global prevalence of osteoarthritis of the knee with total knee arthroplasty performed is projected to substantially rise in the near future.
- Trial name
- NCT06838663
- Testing
- Robotic assisted Cruciate-Retaining (CR) TKA procedures, Robotic assisted Bi-Cruciate Stabilized (BCS) TKA procedures
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Knee Injuries
Evaluation of Patient Reported Outcomes (PRO) After Total Knee Arthroplasty (TKA) Under Spinal Anesthesia
The purpose of this study will be to evaluate and compare patients undergoing total knee arthroplasty (TKA) with sensor guidance versus that of a standard technique.
- Trial name
- NCT03053453
- Testing
- Spinal Surgery, Verasense Knee System device
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- NYU Langone Health
Unilateral Knee Arthroplasty
Intra-Venous Acetaminophen and Muscle Relaxants After Total Knee
This is a prospective, three-arm, randomized, open-label trial to determine if a new pain control protocol which includes regular dosing of intravenous acetaminophen and orphenadrine for 48 hours after total knee surgery reduces…
- Trial name
- IVAM (NCT02449369)
- Testing
- Preop acetaminophen IV, Preop orphenadrine IV, Postop oral oxycodone & acetaminophen
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Osteoarthritis, Knee
Safety and Efficacy of the Journey II BCS Total Knee System
Assess the safety and efficacy of the JOURNEY II BCS Total Knee System in subjects with degenerative knee disease requiring primary total knee replacement.
- Trial name
- NIMBLE (NCT01705067)
- Testing
- TKA with Journey II BCS Total Knee System
- Where
- 12 sites in United States
- Volunteers
- 209 people
- Sponsor
- Smith & Nephew, Inc.
Pain Postoperative, Total Knee Anthroplasty
Comparative Analgesic Effect After Total Knee Arthroplasty Between Intraosseous and Peri-articular Injection
The goal of this RCT is to compare analgesic effect after total knee arthroplasty between intraosseous multimodal analgesic agent injection versus periarticular injection.
- Conditions
- Pain Postoperative, Total Knee Anthroplasty, Functional Outcomes
- Trial name
- NCT06800846
- Testing
- Intraosseous Morphine, Periarticular Injection
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Thammasat University Hospital
Anesthesia, Regional
Adductor Canal Block (ACB) Before and After Primary Total Knee Arthroplasty (TKA)
Total knee arthroplasty (TKA) is associated with severe postoperative pain. Multimodal analgesia, including peripheral nerve block, is recommended for post-operative pain relief 1.
- Trial name
- NCT02908711
- Testing
- 0.5% ropivacaine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Total Knee Arthroplasty, Post-operative Pain Control
Adductor Canal Block Versus Liposomal Bupivacaine in TKA
This is a randomized prospective study of 60 patients undergoing total knee arthroplasty evaluating the clinical outcomes of liposomal bupivacaine periarticular injections (PAI) when compared to single shot adductor canal block…
- Trial name
- NCT04086186
- Testing
- Liposomal Bupivacaine Peri-articular Injection, Adductor canal block
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Good Samaritan Regional Medical Center, Oregon
Osteoarthritis, RheumatoId Arthritis
Zimmer POLAR - Total Knee Arthroplasty (TKA)
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Osteoarthritis, RheumatoId Arthritis, Traumatic Arthritis, Polyarthritis
- Trial name
- NCT01859130
- Testing
- Zimmer Persona Total Knee System
- Where
- 4 sites in United States
- Volunteers
- 299 people
- Sponsor
- Zimmer Biomet
Tantalum, Bone Loss
Allograft and Tantalum Cone Reconstruction in TKA Revision
A new surgical technique of reconstruction for bone loss in TKA revision using tantalum cone and allograft. Study of radiological and clinical outcomes.
- Conditions
- Tantalum, Bone Loss, Allograft
- Trial name
- NCT05510011
- Where
- France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Montpellier
Knee Osteoarthritis
ROM Outcomes in Patients Undergoing a Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of patients undergoing primary TKA after photographing final knee range of motion immediately post-operatively and sharing these photographs with patients…
- Trial name
- NCT04217486
- Testing
- Patient will be shown a photograph of their knee at 2 weeks postop, Patient will not be shown a photograph of their knee at 2 weeks postop
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Louisville
Total Knee Arthroplasty, Robotic
Early Radiographic and Clinical Outcomes of Robotic-Arm-Assisted Versus Conventional TKA
Purpose: A robotic system was recently introduced to improve prosthetic alignment during total knee arthroplasty (TKA). The purpose of this multicenter prospective randomized controlled trial (RCT) study was to determine whether…
- Trial name
- TKA (NCT05987839)
- Testing
- robotic system
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Peking University Third Hospital
Total Knee Arthroplasty
Can the Use of Virtual Reality Improve TKA Outcomes
Virtual reality (VR) uses computer technology to create a three-dimensional environment which the user can explore and interact with.
- Trial name
- VR-TKA (NCT06962046)
- Testing
- Virtual Reality
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Belfast Health and Social Care Trust
Infection
Infection Prevention After TKA With or Without Vancomycin
Prospective, Randomized, Double Blinded Trial Comparing Clinical, Radiological and Laboratory Outcomes in prevention of infection after Total Knee Arthroplasty With or Without Vancomycin.
- Trial name
- TKA_Vanco (NCT05461651)
- Testing
- Knee arthroplasty
- Where
- Poland
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Arthroplasty, Replacement, Knee, Arthroplasty, Replacement, Hip
Improvement of Patient Satisfaction and Overall Outcomes Using HealthLoop
The purpose of this study is to assess the usefulness and results of orthopedic patients having access to a cell phone App called HealthLoop to utilize during the postoperative time period, compared to patients who have the usual…
- Trial name
- NCT03481595
- Testing
- HealthLoop mobile application
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- The Cleveland Clinic
Catastrophization
Preoperative Cognitive Therapy for Improving Health Outcomes After TKA in High-risk Catastrophizing Subjects
The investigators propose a randomized controlled trial to evaluate the effects of treatment intended to reduce pain catastrophizing among patients reporting high pain catastrophizing prior to total knee replacement(TKR), total…
- Trial name
- CT_TKA (NCT01772329)
- Testing
- Cognitive Therapy, Routine Care
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Arthroplasty, Replacement, Knee, Nerve Block
Study to Evaluate ACB Versus FNB Early Postoperative Period Functional Outcomes After TKA
The purpose of this study is to determine if patients undergoing a Total Knee Arthroplasty who receive a single shot Adductor Canal nerve block and local infiltration will have improved functional outcomes compared to individuals…
- Trial name
- ACB (NCT02218814)
- Testing
- Adductor Canal Block, Bupivacaine, Femoral Nerve Block, Bupivacaine
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- George Macrinici
Pain, Postoperative, Osteoarthritis, Knee / Osteoarthritis, Hip
iPACK Block vs. Periarticular Infiltration for TKA Pain Control
This study aims to retrospectively compare two different multimodal analgesic techniques for pain management after total knee arthroplasty (TKA).
- Trial name
- NCT07267650
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Turgutlu State Hospital