Clinical trials: TMD/Orofacial Pain
Myofascial Pain, Temporomandibular Disorders
Study on the Effect of Granisetron on Myofascial Pain in the Orofacial Muscles
The aim of this study is to to investigate if local treatment with intramuscular injections of granisetron are effective in alleviating pain in patients with chronic myofascial pain in the orofacial muscles The study hypothesis…
- Trial name
- NCT02230371
- Testing
- Granisetron
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
TMD, TMD/Orofacial Pain
Occlusal Splint Combined With Granisetron Injection for Management of Myofascial Pain Related to Temporomandibular Disorders
The goal of this clinical trial is to evaluate whether a combination of occlusal splint therapy and granisetron injection into the masseter muscle is effective in managing myofascial pain related to temporomandibular disorders…
- Conditions
- TMD, TMD/Orofacial Pain, Temporomandibular Disorder (TMD)
- Trial name
- TMD (NCT07401745)
- Testing
- Granisetron, lidocaine, occlusal splint
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Mansoura University
TMD/Orofacial Pain, Fibromyalgia (FM)
Diagnostic and Prognostic Salivary Biomarkers in Chronic Muscle Pain
A large proportion of the adult population worldwide currently lives with chronic muscle pain, with more than half of those affected experiencing pain localized to the face and jaw.
- Trial name
- NCT06994156
- Where
- Sweden
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Temporomandibular Joint Disorders, Dry Needling
Effectiveness of Dry Needling vs Manual Therapy in Patients With Temporomandibular Joint Disorders.
Temporomandibular Joint Disorders (TJD) represent a set of conditions that involve pain and dysfunction of the temporomandibular joint.
- Conditions
- Temporomandibular Joint Disorders, Dry Needling, Musculoskeletal Manipulations
- Trial name
- NCT04469088
- Testing
- Dry needling, Manual Therapy Treatment
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- University of Jaén
TMD, TMD/Orofacial Pain
Effects Exercises in Temporomandibular Joint Disorders on Pain, Joint and Tongue Functions
The goal of this clinical trial is to learn if orofacial exercises works to treat temporomandibular disorders in adults. It will also learn about the safety of orofacial exercises on temporomandibular disorders.
- Trial name
- NCT07304557
- Testing
- Exercise, Manual therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Tayfun ISIK
Facial Pain, Temporomandibular Joint Disorder
Diagnosis and Evaluation of Patients Needing Third Molar (Wisdom Tooth) Extraction and Patients With Chronic Facial Pain
This study provides a mechanism for evaluating patients for possible participation in NIDCR clinical research studies. NIDCR studies involve three major areas-pain, neurosensory mechanisms, and pain-relieving drugs-all of which…
- Trial name
- NCT00001600
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Temporomandibular Disorder, Temporomandibular Joint Disorders
Influence of Stabilization Splint Thickness on The Temporomandibular Disorders
The aim of the study is assessing the effect of the stabilization splint (SS) thickness on the temporomandibular disorder's and their symptoms; such as muscle or temporomandibular joint (TMJ) pain, TMJ sounds, and limitation of…
- Conditions
- Temporomandibular Disorder, Temporomandibular Joint Disorders, Orofacial Pain
- Trial name
- NCT04524806
- Testing
- stabilization splint
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Temporomandibular Disorder, Headache Disorders
Validation of the TMD Pain Screener in a Specialized Headache Center
The purpose of the study is to investigate whether a questionnaire can be used to detect whether patients referred to the Danish Headache Center have a painful temporomandibular disorder (TMD).
- Trial name
- NCT04193111
- Testing
- TMD pain screener
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Myofascial Pain Syndrome, Temporomandibular Joint Disorders
Comparison of Lidocaine, Mepivacaine, and Dry Needling in Myofascial Pain Syndrome
This randomized clinical trial will aim to compare the effectiveness of dry needling, lidocaine injection, and mepivacaine injection in the treatment of myofascial pain in the masticatory muscles.
- Conditions
- Myofascial Pain Syndrome, Temporomandibular Joint Disorders, Facial Pain
- Trial name
- NCT07079449
- Testing
- Dry Needling, Lidocaine Hydrochloride, Mepivacaine Hydrochloride
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Sümer Münevveroğlu
Temporomandibular Dysfunction (TMD), Orofacial Pain
Electrostimulation Therapies With Implementation of Multifractal Electromyographic Analysis
The objective is to compare the neuromuscular electrical activity and muscle fatigue of the masseter muscles in three groups of patients with different treatments for TMD (GA = Transcutaneous electrostimulation and splint, GB =…
- Trial name
- NCT04704778
- Testing
- Transcutaneus electrostimulation therapies, Percutaneus electrostimulation therapies, Oclusal splint
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional Autonoma de Mexico
Temporomandibular Joint Dysfunction Syndrome, Burning Mouth Syndrome
Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial Pain
Patients with chronic masticatory muscle pain (i.e., pain greater than three months) or patients with burning mouth syndrome participate in this study.
- Trial name
- NCT00716807
- Testing
- nalbuphine plus naloxone
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of California, San Francisco
Temporomandibular Disorder (TMD)
Marine Lipids Ease Painful TMD
The ADAPT study is a single-site, Phase 2b, randomized, quadruple-masked, placebo-controlled trial evaluating an omega-3 dietary supplement enriched with specialized pro-resolving mediator (SPM) precursors in adults with chronic…
- Trial name
- ADAPT (NCT07437313)
- Testing
- SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Orofacial Pain, Temporomandibular Joint Disorders
Ozone Therapy for Masticatory Muscle Pain (OTMMP)
This study investigates the efficacy of bio-oxidative ozone application in the treatment of TMD of muscular origin.
- Trial name
- OTMMP (NCT02997410)
- Testing
- Ozone, Dental treatment with occlusal splint
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Temporomandibular Disorders (TMD)
Aerobic Physical Activity and Orofacial Myofascial Pain
Orofacial myofascial pain, most commonly represented by Temporomandibular Disorders (TMD) a significant public health, affecting approximately 12% to 14% of the general population.
- Trial name
- AERODOF (NCT07526688)
- Testing
- Temporal Summation of Pain and Questionnaire
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Temporomandibular Disorders (TMD)
Prevalence of Temporomandibular Joint Disorders in Wind Musicians
This study aims to analyze the prevalence of temporomandibular joint disorders (TMD) in wind musicians, differentiating the impact by instrument type (woodwind vs.
- Trial name
- TMD-WIND (NCT06823531)
- Testing
- Not applicable (Observational Study)
- Volunteers
- 50 people
- Sponsor
- University of Oviedo
TMD, TMD/Orofacial Pain
Treatment Outcomes in Patients With Muscular Temporo-mandibular Joint Disorders
The aim of the present study was to assess the treatment outcomes in patients affected by M-TMDs in terms of pain scores assessed with pressure pain threshold (PPT).
- Trial name
- NCT06339736
- Testing
- Questionnaires administered to all study participants
- Where
- Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pisa
TMJ Disc Disorder, Temporomandibular Joint Disc Displacement, Without Reduction
Arthroscopic Lysis and Lavage With and Without Intra-articular Injection of Hyaluronic Acid in Patients With DDwoR in TMJ
The study aims to assess the outcomes of arthroscopic lysis and lavage procedure with and without single intra-articular injection of hyaluronic acid in managing patients with anterior disc displacement without reduction.
- Conditions
- TMJ Disc Disorder, Temporomandibular Joint Disc Displacement, Without Reduction, TMD/Orofacial Pain, Temporomandibular Disorder
- Trial name
- NCT07614932
- Testing
- Arthroscopic lysis and lavage, arthroscopic lysis and lavage with intra-articular injection of hyaluronic acid
- Where
- Egypt
- Volunteers
- 52 people
- Sponsor
- Cairo University
Chronic Masticatory Myofascial Pain
Masticatory Muscle Activity Using a 24-Hour Wearable Device
Patients with chronic masticatory myofascial pain (MFP) often report that stress and parafunctional oral habits aggravate their pain, consistent with the widespread belief that stress and parafunctional habits lead to…
- Trial name
- NCT07861906
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Midwestern University
Temporomandibular Joint Disorders
Acute Effects of Alcohol Use on Chronic Orofacial Pain
Self-medication of pain with alcohol is a common, yet risky, behavior among individuals with chronic orofacial pain. Chronic pain status may affect the degree to which alcohol use relieves pain, but the independent contributions…
- Trial name
- NCT04019093
- Testing
- Ethanol
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Florida
Temporomandibular Disorders
Effects of Mandibular Exercises Effect on Pain Perception and Sensitivity in Mandibular Myofascial Pain
The effectiveness of mandibular exercises as a treatment of muscular Orofacial Pain is yet unknown. This study hypothesized that training exercises can be an effective therapy improving pain perception.
- Trial name
- NCT03339739
- Testing
- Isometric mandibular exercises, Isotonic mandibular exercises, Counseling group
- Volunteers
- 45 people
- Sponsor
- Universidad Nacional Andres Bello