Clinical trials: Tailored Condition
Crohn Disease
A Culturally Tailored Dietary Intervention to Treat Crohn's Disease
The goal of the study is to test the efficacy of a dietary intervention in inducing clinical response and remission for patients with Crohn's disease in a randomized controlled trial.
- Trial name
- DAIN (NCT05627128)
- Testing
- DAIN
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 150 people
- Sponsor
- University of Massachusetts, Worcester
Opioid-use Disorder
Tailoring a Mindful Intervention to Enhance Opioid Treatment
The main aim of this study is to better understand whether yoga can be blended with mindfulness as an additional intervention for people receiving medication assisted treatment at a Hartford-based community agency.
- Trial name
- BEING (NCT04879238)
- Testing
- BEING
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms
Substrate Remodelling and Targeted Ablation in AF
Atrial fibrillation (AF) is the most common heart rhythm disorder, affecting millions worldwide and causing symptoms such as palpitations, fatigue and breathlessness.
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Mechanisms, Catheter Ablation, Low Voltage Areas
- Trial name
- STRATA-AF (NCT07047235)
- Testing
- Pulmonary vein reisolation, Ganglionic plexi ablation, Substrate ablation
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Barts & The London NHS Trust
Amyotrophic Lateral Sclerosis (ALS)
A Patient-tailored Genetic/Biomarker/iPSC Combined Approach in ALS - PERMEALS
Amyotrophic Lateral Sclerosis (ALS) is a severe and incurable neurodegenerative disease of motor neurons with a dramatic socio-economic impact on the national health system.
- Trial name
- PERMEALS (NCT06917924)
- Testing
- lumbar puncture
- Where
- 4 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Cognitive Impairment, Psychological
Psychological Treatment to Support the Consequences of Cognitive Impairment
The burden of cognitive impairment is severe, and often hinders affected people to act independently in daily life. Individuals in different stages of cognitive decline are frequently affected by existential distress and…
- Conditions
- Cognitive Impairment, Psychological, Psychotherapy, Health Behavior
- Trial name
- NCT04356924
- Testing
- Psychological treatment, Cognitive training
- Where
- Sweden
- Volunteers
- 138 people
- Sponsor
- Karolinska Institutet
Mitral Regurgitation, Tricuspid Regurgitation
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study
ARB-PMCF is a multicenter, observational study of the safety and performance of Abbott annuloplasty devices used in surgical repair of mitral and tricuspid valve regurgitation.
- Conditions
- Mitral Regurgitation, Tricuspid Regurgitation, Valvular Heart Disease
- Trial name
- ARB-PMCF (NCT04761120)
- Testing
- Abbott SJM Rigid Saddle Ring, Abbott SJM Séguin Ring, Abbott SJM Tailor Ring
- Where
- 17 sites in United States, Estonia and 5 more
- Volunteers
- 550 people
- Sponsor
- Abbott Medical Devices
Stroke
Tailored Hospital-based Risk Reduction to Impede Vascular Events After Stroke
The purpose of this study is to determine whether a culturally-sensitive multipronged post-discharge intervention can significantly reduce blood pressure, enhance achievement of guideline recommended targets for risk factor…
- Trial name
- THRIVES (NCT01900756)
- Testing
- THRIVES
- Where
- 3 sites in Nigeria
- Volunteers
- 400 people
- Sponsor
- Medical University of South Carolina
Addictive Behavior, Substance-Related Disorders
Evaluation of the Efficacy of the Individually Adjusted Therapy Scale (ATI) on the Addiction Severity
The management of the craving is a key element in addiction treatment as the craving is linked to the probability of relapse. Several cues could induce the craving, some generic substance-induced cues or addictive…
- Trial name
- AjusT (NCT03606759)
- Testing
- Weekly assessment, Weekly assessment ajusted
- Where
- 4 sites in France
- Volunteers
- 151 people
- Sponsor
- University Hospital, Bordeaux
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus (T2DM)
Feasibility of a Tailored Online Self-compassion Intervention
The goal of this clinical trial is to examine the feasibility and acceptability of an online programme that is based on Compassionate Mind Training (CMT) over four-weeks.
- Trial name
- NCT07051005
- Testing
- Feasibility RCT of a tailored online self-compassion intervention
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Canterbury Christ Church University
Hypertension
Tailoring TM-HTN Intervention for Black Patients
Current clinic-based hypertension (HTN) management models have several limitations, resulting in episodic care that does not adequately support patients' self-care skills, and fails to achieve blood pressure (BP) control.
- Trial name
- TM-HTN (NCT06593119)
- Testing
- Telemedicine management of Hypertension, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Diabetes, Diabetes Mellitus
Computer-Assisted Cancer Risk Behavior Counseling
To test whether or not giving patients information before their doctor visits changes the care they receive and what type of information is best to give before the doctor visit.
- Conditions
- Diabetes, Diabetes Mellitus, Hypertension
- Trial name
- NCT00242645
- Testing
- Health Information, Preventive Services, Computer tailored information
- Volunteers
- 200 people
- Sponsor
- Thomas Jefferson University
Metabolic Syndrome, Primary Prevention of Atherosclerotic Cardiovascular Disease
A Tailored, Optimised, and Person-centred Programme to Promote Lifestyle Modification in People With Metabolic Syndrome
This is a mixed-methods study comprising a 2-arm randomised controlled trial and a qualitative study. This study aims to evaluate the effects of a lifestyle modification on the control of metabolic syndrome, with assessments…
- Trial name
- TOP-S (NCT06793930)
- Testing
- A tailored, optimised, and person-centred critical pathway to promote sustainable lifestyle modification, Brief advice
- Where
- Hong Kong
- Volunteers
- 152 people
- Sponsor
- The University of Hong Kong
Acute Myeloid Leukemia
Role of the Therapy Tailored to Risk Factors in Treating Adult Patients (≤60) With Acute Myeloid Leukemia
In view of the diversity of the biology of acute myeloid leukemia (AML) therapy in individual patients must be individualized. One of the tools for this is molecular-cytogenetic stratification.
- Trial name
- PALG-AML2012 (NCT02072811)
- Testing
- DAC, CLAG, Consolidation, I HAM cycle
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- dr hab. n. med. Agnieszka Wierzbowska
Critical Illness
Reducing Post-traumatic Stress Disorder After ICU Discharge With the IPREA3 Program
Reducing discomfort in the intensive care unit (ICU) should be beneficial to longterm outcomes. This study assesses whether a tailored multicomponent program for discomfort reduction may be effective in reducing post-traumatic…
- Trial name
- PTSD-REA (NCT03991611)
- Testing
- Administration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts
- Where
- 33 sites in France
- Volunteers
- 3,312 people
- Sponsor
- Centre Hospitalier of Chartres
Post-Operative Delirium, Postoperative Cognitive Dysfunction
Role of Absolute Cerebral Oximetry to Prevent Neurocognitive Injury in Elderly Patients Undergoing Cardiac Surgery
The purpose of this study is to determine whether brain oxygenation measured by cerebral oximeter has an impact on neurocognitive dysfunction.
- Trial name
- NCT00991328
- Testing
- SctO2 < 60 %.
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Knowledge on Insulin Therapy, Practice on Insulin Administration
Tittle: Effect of Video-Based Health Education Intervention on Insulin Therapy Among Adults With Diabetes Mellitus in Dhulikhel Hospital
Insulin is an essential therapy for treating diabetes, but many patients lack standard insulin injection skills. Learning the method of proper insulin injection technique is crucial for diabetes patients as it promotes treatment…
- Trial name
- NCT06435598
- Testing
- video-based health education
- Where
- Nepal
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Kathmandu University School of Medical Sciences
Opioid Use Disorder, Pregnancy Related
Personally-Tailored Opioid-overdose and Medication for Opioid Use Disorder (MOUD) Education (TOME) for Pregnant and Postpartum Persons in MOUD
The primary objective of this study is to evaluate the ability of TOME to increase Medication for Opioid Use Disorder (MOUD) and opioid-overdose knowledge in pregnant and postpartum persons.
- Conditions
- Opioid Use Disorder, Pregnancy Related, Substance Use, Drug Abuse
- Trial name
- TOME (NCT06262347)
- Testing
- Personally-Tailored Opioid-overdose and Medication for opioid use disorder (MOUD) Education (TOME), Control
- Where
- 6 sites in United States
- Volunteers
- 131 people
- Sponsor
- T. John Winhusen, PhD
Migraine
"Personalized Physiotherapy for Migraine: Effects on Pain, Fatigue, and Physical Function"
Migraine is a prevalent neurological disorder associated with pain, fatigue, and reduced physical function. The aim of this randomized controlled trial is to examine the effects of a personalized and structured physiotherapy…
- Trial name
- TIP-MIG (NCT07261384)
- Testing
- Personalized Structured Physiotherapy Intervention, Standard Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Hacettepe University
Mechanical Ventilation
Impact of an Early and Extended Rehabilitation Program Combining Individually Tailored Nutrition and Physical Activities on Patient Outcomes After Invasive Mechanical Ventilation and Vasopressor Therapy in the ICU
The NUTRIREA-4 trial will test the hypothesis that an individually tailored rehabilitation program combining nutritional therapy, physiotherapy, and physical activity and started early in the ICU then continued uninterruptedly…
- Trial name
- NUTRIREA-4 (NCT06581939)
- Testing
- Rehabilitation group, Control group
- Where
- 52 sites in France
- Volunteers
- 830 people
- Sponsor
- Nantes University Hospital
Suspected Deep Vein Thrombosis
The Designer D-dimer Deep Vein Thrombosis Diagnosis (4D) Study
This is a cohort study that will assess a new diagnostic management strategy for suspected Deep Vein Thrombosis in outpatients.The new diagnostic strategy is designed to reduce the use of ultrasound testing on the day of…
- Trial name
- 4D (NCT02038530)
- Where
- 10 sites in Canada
- Volunteers
- 1,513 people
- Sponsor
- McMaster University