Clinical trials: Taxane-Induced Peripheral Neuropathy
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Docetaxel or Paclitaxel in Reducing Chemotherapy-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer
This phase II trial studies how well docetaxel or paclitaxel work in reducing chemotherapy-induced peripheral neuropathy in African American patients with stages I-III breast cancer.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT04001829
- Testing
- Docetaxel, Paclitaxel, Quality-of-Life Assessment
- Where
- 482 sites in United States
- Volunteers
- 249 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Taxane-induced Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy (CIPN)
A Pilot Study of Acupuncture for Chemotherapy-induced Peripheral Neuropathy in Breast Cancer Patients
This study is being done to evaluate the potential benefits of using acupuncture to reduce symptoms of tingling, burning, numbness and pain in the hands and feet of women with peripheral neuropathy after completion of…
- Conditions
- Taxane-induced Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy (CIPN), Early-Stage Breast Carcinoma, Stage I Breast Cancer
- Trial name
- NCT02129686
- Testing
- Immediate Acupuncture Group, Delayed Acupuncture Group
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Dana-Farber Cancer Institute
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
CIPN in Early Stage Breast Cancer Patients
Chemotherapy uses anti-cancer drugs to destroy cancer cells and is a common treatment for many cancers. Taxanes are the most widely used chemotherapy drugs given to breast cancer patients.
- Trial name
- NCT05441722
- Testing
- Exercise prehabilitation
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Northumbria University
Chemotherapy-induced Peripheral Neuropathy
Cannabinoids for Taxane Induced Peripheral Neuropathy
Taxane-induced peripheral neuropathy (TIPN) affects a significant number of women undergoing breast cancer treatment. Some patients may need to shorten their course of treatment, and do not receive the full benefit of…
- Trial name
- NCT03782402
- Testing
- Cannabinoids
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York State Psychiatric Institute
Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy
Lidocaine Versus Duloxetine for the Prevention of Taxane-Induced Peripheral Neuropathy In Breast Cancer Patients
The aim of the study is to evaluate the effect of intravenous (IV) lidocaine versus oral duloxetine on the onset and severity of TIPN in patient with breast cancer as well as evaluation of Patients' quality of life and estimation…
- Conditions
- Peripheral Neuropathy, Chemotherapy-induced Peripheral Neuropathy, Breast Cancer
- Trial name
- TIPN (NCT04732455)
- Testing
- Lidocaine in Saline, Duloxetine 30 MG, Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Gamal Mohamed Taha Abouelmagd
Chemotherapy-induced Peripheral Neuropathy, Pain
Efficacy and Safety of Duloxetine in Chinese Solid Tumor Patients With Taxanes-induced Painful Peripheral Neuropathy
The study is to evaluate the efficacy and safety of duloxetine in Chinese solid tumor patients with taxanes-induced painful peripheral neuropathy.
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Pain, Solid Tumor
- Trial name
- NCT04970121
- Testing
- Duloxetine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Yan Yang, MD, Ph.D
Peripheral Neuropathy Due to Chemotherapy, Peripheral Neuropathy, Chemotherapy-induced
Study on the Efficacy and Safety of Mecobalamin in Preventing Taxane-related Peripheral Neuropathy
Some patients receiving taxane-based chemotherapy experience numbness, tingling, or pain in their hands and feet, known as chemotherapy-induced peripheral neuropathy (CIPN).
- Trial name
- NCT07423390
- Testing
- Mecobalamin
- Where
- 4 sites in China
- Volunteers
- 326 people
- Sponsor
- Qinghai Red Cross Hospital
Breast Cancer, Colorectal Cancer
Chemotherapy-Induced Peripheral Neuropathy Survey
The goal of this research study is to learn more about pain and other symptoms that patients may experience while receiving chemotherapy treatment with platinum agents, taxanes, and/or bortezomib.
- Conditions
- Breast Cancer, Colorectal Cancer, Myeloma, Chemotherapy-induced Peripheral Neuropathy
- Trial name
- NCT01016028
- Testing
- Questionnaire, Sensory Tests, Interview
- Sponsor
- M.D. Anderson Cancer Center
Chemotherapy-induced Peripheral Neuropathy (CIPN), Acupuncture
Efficacy of Acupuncture on Chemotherapy-Induced Peripheral Neuropathy (CIPN)-TMANH
This three-armed, multicenter, randomized, parallel, sham-controlled clinical trial will conduct in three centers in Taiwan. The investigators will randomly assign 234 eligible patients into three groups, an acupuncture group…
- Trial name
- AcuCIPN (NCT07693335)
- Testing
- Acupuncture, Minimal acupuncture
- Where
- Taiwan
- Volunteers
- 28 people
- Sponsor
- Taiwan Municipal An-Nan Hospital-China Medical University
Chemotherapy-Induced Peripheral Neuropathy (CIPN)
Efficacy of Acupuncture on Chemotherapy-Induced Peripheral Neuropathy (CIPN)
The purpose of this study is to assess the neurological efficacy of acupuncture in patients with cancer who experienced peripheral neuropathy, which is induced by chemotherapy.
- Trial name
- NCT04651907
- Testing
- acupuncture, minimal acupuncture
- Where
- 3 sites in Taiwan
- Volunteers
- 69 people
- Sponsor
- China Medical University Hospital
Breast Cancer Female, Breast Cancer Patients
Effect of Pentoxifylline on Preventing Chemotherapy-induced Toxicities in Patients With Breast Cancer
This clinical trial is a randomized clinical trial that aims to assess the usefulness of adding pentoxifylline to the neoadjuvant chemotherapy treatment protocol of doxorubicin/cyclophosphamide fllowed by taxane for breast cancer…
- Conditions
- Breast Cancer Female, Breast Cancer Patients, Neoadjuvant Therapy, Doxorubicin
- Trial name
- NCT06186700
- Testing
- Pentoxifylline 400mg plus chemotherapy, Chemotherapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Peripheral Neuropathy Due to Chemotherapy
Preventive Approach Using Venlafaxine
Peripheral and Motor neuropathy represent a main obstacle for a better quality of life for cancer patients, Venlafaxine is introduced in a new dosing regimen for treating of oxaliplatin and taxanes induced peripheral neuropathy…
- Trial name
- NCT05875610
- Testing
- Venlafaxine 75 MG, Gabapentin 400 mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mit Ghamr Oncology Center
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy (CIPN)
Acupuncture and Compression for the Prevention of CIPN in Breast Cancer Patients
As a core component of comprehensive breast cancer treatment, chemotherapy frequently induces chemotherapy-induced peripheral neuropathy (CIPN), particularly with taxane-based agents.
- Trial name
- NCT07377279
- Testing
- Compression, Acupuncture, Compression combined with acupuncture
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer, Chemotherapy-induced Peripheral Neuropathy
Involvement of SK3 Calcium Channel in Taxane Neuropathy
Taxane neuropathy is a common and long-term side effect of long-term morbidity in patients surviving cancer. No preventive or symptomatic treatment has been shown to be effective.
- Conditions
- Breast Cancer, Chemotherapy-induced Peripheral Neuropathy, Prostate Cancer
- Trial name
- NEUROTAX (NCT03816904)
- Testing
- Blood samples
- Where
- 2 sites in France
- Volunteers
- 97 people
- Sponsor
- University Hospital, Tours
Neuropathic Pain
Vitamin D Supplementation on Reported Rates of Taxane-Induced Neuropathy
This is a two-arm randomized clinical trial in which 80 participants with Vitamin D deficiency and scheduled to begin taxane-based chemotherapy will be randomized to either: 1) prescribed vitamin D replacement or 2) standard of…
- Trial name
- NCT05259527
- Testing
- Ergocalciferol Capsules, Cholecalciferol Capsules
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Virginia Commonwealth University
Peripheral Neuropathy Due to Chemotherapy
Compression Therapy of Hands and Feet for the Prevention of Taxane- or Oxaliplatin-induced Peripheral Neuropathy
Population Cohort 1 Taxane: Breast cancer patients; (neo-)adjuvant treatment Cohort 2 Oxaliplatin: Colorectal cancer patients; (neo-)adjuvant treatment Study design Multicentre, unblinded randomised controlled study Study…
- Trial name
- KompXX (NCT07464769)
- Testing
- Compression therapy
- Where
- Sweden
- Volunteers
- 358 people
- Sponsor
- Region Jönköping County
Chemotherapy-induced Peripheral Neuropathy
EGCG for the Prevention and Treatment of TIPN
Patients treated with paclitaxel analogs and experiencing Taxane-induced peripheral neurotoxicity (TIPN) of degree I or higher were treated with EGCG solution.
- Trial name
- NCT06524609
- Testing
- Epigallocatechin-3-Gallate, Alcohol
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Han Xi Zhao
Peripheral Neuropathy
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Purpose: The purpose of the study is to test a new way of measuring nerve damage in women with breast cancer receiving chemotherapy drug paclitaxel (Taxol).
- Trial name
- NCT02549534
- Testing
- Axon Reflexes, Axon Flares, Self-Reported Signs & Symptoms of CIPN
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Indiana University
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Transcutaneous Electrical Nerve Stimulation in Chemotherapy Induced Peripheral Neuropathy in Patients With Stage I-III Early Stage Breast Cancer
This phase II trial examines transcutaneous electrical nerve stimulation (TENS) in patients with stage I-III breast cancer with chemotherapy induced peripheral neuropathy.
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT05368428
- Testing
- Transcutaneous Electrical Nerve Stimulation
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Emory University
Chemotherapy-induced Peripheral Neuropathy, Chemotherapeutic Toxicity
Cryotherapy vs. Cryocompression for Preventing Chemotherapy-induced-peripheral-neuropathy in Women Undergoing Chemotherapy
This study's aim is to show a benefit of Cryocompression (cooling hands with additional compression of the hands) in comparison to Cryotherapy (just cooling hands) in female cancer patients (with gynecological cancer) receiving…
- Conditions
- Chemotherapy-induced Peripheral Neuropathy, Chemotherapeutic Toxicity, Chemotherapeutic Agent Toxicity
- Trial name
- NCT04632797
- Testing
- Hilotherm Chemo Care
- Where
- Austria
- Volunteers
- 196 people
- Sponsor
- Medical University Innsbruck