Clinical trials: Tear
Osteoarthritis, Knee
Arthroscopy in the Treatment of Degenerative Medial Meniscus Tear
Degenerative meniscal tears are the most common etiology for knee pain, swelling and loss of function. Partial arthroscopic meniscectomy is the most common orthopaedic procedure to treat meniscal tears.
- Trial name
- NCT00549172
- Testing
- Operative (partial arthroscopy), Conservative (diagnostic arthroscopy)
- Where
- 5 sites in Finland
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Tampere University
Dry Eye Syndromes, Sjogren's Syndrome
TrueTear in Sjogren's Disease Patients
The purpose of this study is to evaluate acute tear production produced by the intranasal tear neurostimulator in participants with Sjögrens syndrome and aqueous tear deficiency.
- Trial name
- NCT03719885
- Testing
- TrueTear Intranasal Tear Neurostimulator
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Acetabular Labrum Tear
Intra-articular Platelet-Rich Plasma for Acetabular Labral Tears
Platelets are small cells found in the blood that help form clots and stop bleeding. Platelet-rich plasma is blood that contains more platelets than normal and can be given to help people with pain.
- Trial name
- PRP for ALT (NCT06332352)
- Testing
- PRP
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Lacerations
Study to Show Equivalence of DERMABOND PROTAPE to DERMABOND HVD for Wound Closure
This is a multicenter, prospective, randomized controlled study for the purpose of comparing DERMABOND PROTAPE to DERMABOND HVD for closure of wounds in the Emergency Department.
- Trial name
- NCT00547638
- Testing
- cyanoacrylate with pressure sensitive mesh, cyanoacrylate
- Where
- 9 sites in United States
- Volunteers
- 216 people
- Sponsor
- Ethicon, Inc.
Meniscus Tear
Effects of TENS Therapy Following Arthroscopic Knee Surgery
Following standard of care procedures for arthroscopy knee surgery it is anticipated that Transcutaneous Electrical Nerve Stimulation (TENS) will provide improved pain relief and improve functional outcomes.
- Trial name
- TENS (NCT01528228)
- Testing
- TENS Treatment with functional or disabled unit
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- A.T. Still University of Health Sciences
Preterm Premature Rupture of Membranes (PPROM)
Treatment of ppROM With Erythromycin vs. Azithromycin Trial
Preterm premature rupture of membranes (PPROM) complicates 4% of pregnancies annually. This pregnancy complication is a major contributor to preterm births and results in neonatal morbidity and mortality.
- Trial name
- TREAT (NCT03060473)
- Testing
- Azithromycin, Erythromycin, Ampicillin
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Children, Lacerations
Pain and Anxiety Management With Oral Narcotic for Pediatric Suture Repair
The purpose of this study is: To determine whether oral narcotic medication versus placebo improves the pain and anxiety scores for pediatric patients requiring laceration repair in the pediatric emergency department and…
- Conditions
- Children, Lacerations, Procedures, Child
- Trial name
- NCT01053637
- Testing
- hydrocodone/acetaminophen, Sugar water
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Baylor College of Medicine
Rotator Cuff Tears
Punch vs. Drill Tunnel Use for Anchor Tunnel Creation and Correlation With Post-operative Pain
To determine if different techniques used in the creation of suture anchor socket creation can influence post-op pain following rotator cuff repair.
- Trial name
- Punch/Drill (NCT04288570)
- Testing
- suture anchor socket creation with punch, suture anchor socket creation with drill
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Matt Smith
Blood Flow Restriction, ACL Tear
Blood Flow Restriction Training (BFR) in an Adolescent Population
While there are a number studies that have reported on the use of BFR in the adult population, there is limited information about the use of BFR in the adolescent population.
- Conditions
- Blood Flow Restriction, ACL Tear, ACL Injury
- Trial name
- NCT04285879
- Testing
- Blood Flow Restriction using Delfi Personalized Tourniquet System
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Connecticut Children's Medical Center
Tear of Meniscus of Knee
Clinical Application of BioCleanse Meniscus
This study will follow patients after routine surgery of a meniscal allograft transplant.
- Trial name
- Meniscus (NCT00659880)
- Testing
- BioCleanse Meniscus
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- RTI Surgical
Refractive Error
DAILIES TOTAL1® - Comparative Assessment of Tear Film Evaporation
The purpose of this study is to evaluate the tear film evaporation of symptomatic soft contact lens wearers in the absence of contact lens wear and after at least 8 hours of contact lens wear.
- Trial name
- NCT02517567
- Testing
- Delefilcon A contact lenses, Narafilcon A contact lenses, Somofilcon A contact lenses
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Meniscus Tear, Tibial, Meniscus Lesion
JuggerStitch Post Market Clinical Follow-up Study
This study is a post-market follow-up study. The data collected from this study will serve the purpose of confirming the safety and performance of the JuggerStitch Device used for meniscal repair according to the product…
- Trial name
- NCT04228367
- Testing
- JuggerStitch Meniscal Repair Device
- Where
- 6 sites in United States, France and 2 more
- Volunteers
- 103 people
- Sponsor
- Zimmer Biomet
Rotator Cuff Tear
Types of Fixation in Arthroscopic Rotator Cuff Repair
The study will identify if there is a difference of quality of life after surgery between two techniques used in surgery. The two different techniques are either the Single Row Fixation or the Double Row Fixation.
- Trial name
- NCT00508183
- Testing
- single row, double row fixation
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Anterior Cruciate Ligament (ACL) Tear, Physical Therapy
The Effect of Various Strength Training Protocols in ACL Reconstructed Participants
The purpose of the study is to determine how two different blood flow restriction training programs used in conjunction with standard rehabilitation affect leg strength.
- Trial name
- NCT03364647
- Testing
- Arm A - blood flow restriction training, Arm B - standard of care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- Brian W. Noehren
Dry Eye Syndromes
Clinical Study to Evaluate Tear Characteristics Following Acute TrueTear™ Use
This study will evaluate the change in tear meniscus height (TMH) produced by intranasal stimulation with TrueTear™ compared with the same device applied extranasally (control).
- Trial name
- NCT03274999
- Testing
- TrueTear™ Application
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Allergan
Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament
Comparison of Three Methods for Anterior Cruciate Ligament Reconstruction
The purpose of this randomized clinical trial is to determine the difference in quality of life outcome at two years, in patients undergoing an Anterior Cruciate Ligament (ACL) reconstruction procedure with either a patellar…
- Conditions
- Anterior Cruciate Ligament Rupture, Deficiency of Anterior Cruciate Ligament, Chronic Instability of Knee, Anterior Cruciate Ligament Injury
- Trial name
- NCT00529958
- Testing
- Patellar Tendon, Hamstring Tendon, Double-Bundle
- Where
- Canada
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Dry Eye Syndromes
Multicenter Trial Evaluating Quality of Tears Produced by Nasal Neurostimulation
The objectives of this study are: To compare the change in levels of tear proteins and inflammatory mediators pre and post administration between the intranasal and extranasal applications To compare the goblet cell count…
- Trial name
- NCT02385292
- Testing
- Oculeve Intranasal Lacrimal Neurostimulator
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Oculeve, Inc.
Dry Eye Syndrome
Piiloset Trehalose Emulsion Eye Drop Study in Moderate or Severe Dry Eye
The study evaluates the safety, ocular tolerability and efficacy of emulsion eye drops with sacha inchi seed oil, trehalose and hyaluronic acid in the treatment of moderate or severe dry eye in adult patients.
- Trial name
- NCT03569202
- Testing
- Piiloset Trehalose Emulsion Eye Drops, Control Eye Drops
- Where
- Finland
- Volunteers
- 64 people
- Sponsor
- Kuopio University Hospital
Meniscal Tear, Meniscus Tear
Study of Suture Repair of Torn Meniscus in the Knee
Horizontal meniscus tears meeting specified criteria will be repaired by any commonly used suture technique. Subjects will be followed for 2 years to evaluate the effectiveness of the repair, by assessing the re-operation rate…
- Trial name
- STITCH (NCT02237001)
- Testing
- Suture-based meniscal repair
- Where
- 8 sites in United States
- Volunteers
- 30 people
- Sponsor
- Smith & Nephew, Inc.
Achilles Tendon Rupture
E-Stim and Achilles Tendon Repair Study
Calf muscle atrophy (muscle degeneration) is common following Achilles tendon repair due to the immobilization period necessary to ensure optimal healing.
- Trial name
- E-Stim (NCT01833936)
- Testing
- Compex® muscle stimulator, (inactive) muscle stimulator
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Orthopedic Foot and Ankle Center, Ohio