Clinical trials: Tear Disorder
- Condition Tear Disorder
- Funder type Industry (pharma, biotech, devices)
- Accepts healthy volunteers yes
Allergic Conjunctivitis
To Evaluate the Efficacy of AL-38583 in the Reduction of Tear Eosinophil Count Following Conjunctival Allergen Challenge
The purpose of the study is to determine whether Al38583 Ophthalmic Solution is safe and effective in reducing tear eosinophil levels at 5-8 hours after Conjunctival Allergen Challenge (CAC).
- Trial name
- NCT00881673
- Testing
- AL38583 Ophthalmic Solution, Maxidex, Vehicle
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alcon Research
Eye Infections, Bacterial
Azithromycin Level in Tears and in Conjunctiva in 36 Healthy Volunteers
To evaluate azithromycin ocular conjunctiva concentrations 7 and 14 days after treatment initiation. To assess ocular and systemic tolerance/safety and azithromycin tear concentrations on Day 7
- Trial name
- NCT00356772
- Testing
- Azithromycin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laboratoires Thea
Healthy, Dry Eyes
Topical Menthol For Tear Secretion
Tears are the natural way to keep eyes moist, and tears are important for good vision and healthy eyes. Eyes without enought tears get dry and sore.
- Trial name
- TMTS (NCT07109609)
- Testing
- Topical application of 20% menthol solution in MCT oil.
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Reinhold Vieth
Dry Eye Disease
Clinical Pharmacological Study of AL-43546 Ophthalmic Product in Subjects With Shortened Tear Film Break Up Time
The purpose of the study is to observe lacrimal fluid condition (tear film break-up time) chronologically after a single dose of AL-43546 ophthalmic products（0.15%, 0.25% and vehicle）and 0.1% sodium hyaluronate ophthalmic…
- Trial name
- NCT00760045
- Testing
- Hydroxypropyl Guar Galactomannan, 0.1% sodium hyaluronate ophthalmic solution
- Where
- Japan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Cataract
Analysis of Cataract Surgery Induced Dry Eye
This is a retrospective study to determine if rates of osmolarity and dry eye disease symptoms increase following cataract surgery.
- Trial name
- NCT01471561
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Dry Eye Disease
Evaluating the Efficacy of Dry Eye (DE) Disease Treatment Using Novel Tear Film Imager (TFI)
Dry Eye disease signs and symptoms are reduced in patients who receive topical steroids and topical hyaluronic acid. AdOM's Tear Film Imager measurements are reproducible and it can diagnose the dry eye disease state in a single…
- Trial name
- NCT04670263
- Testing
- Tear Film Imager
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Adom Advanced Optical Technologies Ltd.
Knee Medial Meniscus Tears, Meniscus Lesion
Predictors of Early Success From Circumferential Compression STITCH Meniscal Repairs
This is a retrospective study of meniscal tear repairs at least one-year post repair status. All patients were treated with Ceterix NovoStitch devices.
- Conditions
- Knee Medial Meniscus Tears, Meniscus Lesion, Meniscus; Rupture, Bucket Handle, Meniscus Disorder
- Trial name
- STITCHRetro (NCT03097744)
- Testing
- Ceterix NovoStitch
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Dry Eye
Tobramycin Tear Concentrations
To evaluate the Tobramycin tear concentration values of TOBRADEX® Ophthalmic Suspension, Tobramycin 0.3% / Dexamethasone 0.05% Ophthalmic Suspension versus TOBREX® Ophthalmic Solution in normal volunteers.
- Trial name
- NCT00695435
- Testing
- TOBRADEX Ophthalmic Suspension, Tobramycin 0.3% / Dexamethasone 0.05% Ophthalmic Suspension, TOBREX Ophthalmic Solution
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye Syndromes
TearLab Refractive Surgery Dry Eye Study
The primary objective of this study is to determine how pre \& post-operative tear osmolarity levels relate to rates of dry eye symptoms related to refractive surgery and if differences exist in patients who are pre-treated with…
- Trial name
- NCT01176045
- Where
- 8 sites in United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Dry Eye
Efficacy of Systane Balance to Stabilize the Tear Film in Dry Eye Subjects
Evaluation of the optical effects of Systane Ultra
- Trial name
- NCT01086774
- Testing
- Systane Ultra Lubricant Eye Drops
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Dry Eye
Evaluation of Dry Eye by Tear Film Imager in a Low Humidity Environmental Exposure Chamber (TFI-LH16)
The study consists of 3 study visits to the clinic over at least 9 days. Visit 1 - the medical screening visit: subjects will undergo informed consent and will be tested for signs and symptoms of Dry Eye Syndrome (DES) including…
- Trial name
- TFI-LH16 (NCT03061578)
- Testing
- Tear Film Imager, Low Humidity Environmental Exposure Chamber (LH-EEC)
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Adom Advanced Optical Technologies Ltd.
Evaporative Dry Eye
Impact of Tear Substitute Use on Dry Eye in Gamers.
Clinical, prospective, comparative, controlled, single-blind study, on the signs and symptoms of dry eye before and after 3 days of playing video games with the use of artificial tears (Hyabak) versus no intervention.
- Trial name
- HYAGAME (NCT05536661)
- Testing
- Preservative free hyaluronic acid artificial tear
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laboratorios Thea, Spain
Keratoconjunctivitis Sicca
Tear Film Break-up Time After Instillation of Artificial Tears
This study is an exploratory trial evaluating the tear film break-up time after a single eye drop instillation of over-the-counter artificial tears.
- Trial name
- NCT00681265
- Testing
- glycerin, polyethylene glycol 400/propylene glycol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Calm Water Therapeutics LLC
Bacterial Infections, Eye Infections
Study of AzaSite Versus Vigamox in the Tears of Healthy Volunteers
The purpose of this study is to evaluate the drug concentrations of AzaSite compared to Vigamox in tears of healthy volunteers
- Trial name
- NCT00575367
- Testing
- AzaSite (azithromycin ophthalmic solution), Vigamox (moxifloxacin hydrochloride ophthalmic solution)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Dry Eye
A Study To Investigate The Effects Of A Low Humidity Environment And Visual Tasking On Tear Film Protein Composition
The purpose of the study is to collect valuable data on the role of controlled humidity, temperature, airflow, and visual tasking in altering the tear film protein composition.
- Trial name
- NCT02005874
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Inflamax Research Incorporated
Dry Eye Syndromes, Lubricant Allergy
Safety and Tolerability of PRO-087 Versus Xyel Ofteno® and Systane Ultra®, on the Ocular Surface of Healthy Subjects
Phase I clinical study, to evaluate the safety and tolerability of the preservative-free ophthalmic solution PRO-087 versus Xyel Ofteno® and Systane Ultra®, on the ocular surface of ophthalmological and clinically healthy…
- Conditions
- Dry Eye Syndromes, Lubricant Allergy, Tear Disorder
- Trial name
- PRO-087/I (NCT03524157)
- Testing
- PRO-087, Systane Ultra, Xyel Ofteno
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye
I-DROP MGD Symptomatic Relief and Tear Film Stability
The objective of the study is to compare the difference in tear film stability and symptomatic relief between I-DROP MGD and another commercially available drop in the Canadian market.
- Trial name
- NCT05011708
- Testing
- I-DROP MGD, Thealoz Duo
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- I-MED Pharma
Dry Eye
Comparative Efficacy of SYSTANE® ULTRA vs Optive™ in Improving Tear Film Break-up Time
The primary objective of this study is assess the Tear Film break-up time (TBUT) in mild to moderate dry eye subjects.
- Trial name
- NCT01417013
- Testing
- Systane Ultra, Optive
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alcon Research
Meibomian Gland Dysfunction, Evaporative Dry Eye
Tear Film Innovations iLux Safety Study
The objective of this study was to measure the temperature of the cornea and surrounding eye tissue temperature immediately after heating the eyelids with the iLux device using the protocol treatment profile.
- Trial name
- NCT03055897
- Testing
- iLux 2020 System
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tear Film Innovations, Inc.
Dry Eye Syndromes
Altaire Gel Forming Solution Versus Refresh Tears for the Treatment of Dry Eye Signs and Symptoms
The purpose of this study is to evaluate and compare the effects of Altaire Gel forming solution and Refresh Tears in mild-moderate dry eye patients.
- Trial name
- NCT01382810
- Testing
- Altaire Gel forming solution, Refresh Tears
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Innovative Medical