Clinical trials: Tear Disorder, active
Anxiety
An Informative Video About Perineal Tears During Labor for Anxiety Reduction: A Randomized Controlled Trial
This study evaluates the impact of an informative video about perineal tears on maternal anxiety during labor. Perineal trauma during childbirth, especially severe tears such as obstetric anal sphincter injuries (OASIS), is…
- Trial name
- VITAL (NCT07064213)
- Testing
- Behavioral: Educational Video
- Where
- Israel
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
Dry Eye
A Single Center, Open-Label Study to Evaluate the Ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to Detect Tear Film Stability Utilizing Miebo®
A study to investigate the ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to detect tear film stability utilizing Miebo®
- Trial name
- TFSTAB (NCT07722624)
- Testing
- Determine the ability of the TearScience™ LipiView™ II Ocular Surface Interferometer and the Keratograph® 5M to detect tear film stability utilizing Miebo®
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Eye Care Institute
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University
Dry Eye
Efficacy of Kera Sol Tears on Signs and Symptoms of Surgical Temporary Ocular Discomfort Syndrome (STODS) in Subjects Following LASIK
Collecting data using Kera Sol tear usage during the initial two-week post-operative period after Laser-Assisted In Situ Keratomileusis (LASIK) has on the signs and symptoms of surgical temporary ocular discomfort syndrome (STODS)
- Trial name
- NCT07155070
- Testing
- Kera Sol Eye Drops
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Intracranial Aneurysms, Unruptured Intracranial Aneurysm
ANEURYSM@RISK: Automatic Intracranial Aneurysm Quantification and Feature Learning Modelling to Optimize Intracranial Aneurysm Rupture Prediction
ANEURYSM@RISK is an observational study aiming to develop and validate an artificial intelligence (AI)-based prediction model for the growth and rupture of intracranial aneurysms (IAs).
- Conditions
- Intracranial Aneurysms, Unruptured Intracranial Aneurysm, Subarachnoid Hemorrhage (SAH) From Ruptured Aneurysm
- Trial name
- NCT07111975
- Where
- Netherlands
- Volunteers
- 3,800 people
- Sponsor
- UMC Utrecht
Shoulder Impingement Syndrome, Rotator Cuff Injuries
The Role of Pectoralis Minor Tightness in the Development of Rotator Cuff Tears
This study investigates whether tightness of a small chest muscle called the pectoralis minor is associated with the development of partial rotator cuff tears in the shoulder.
- Conditions
- Shoulder Impingement Syndrome, Rotator Cuff Injuries, Pectoralis Minor Tightness, Pectoralis Minor Muscle Tension
- Trial name
- PMinor-Rotator (NCT07228936)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Gazi University
Primary Osteoarthritis, Secondary Osteoarthritis
Clinical and Radiological Outcomes of Medacta Shoulder System FR
This is a post-marketing surveillance on Medacta Shoulder System
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Rotator Cuff Tear Arthropathy, Rheumatoid Arthritis Shoulder
- Trial name
- NCT05926622
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Glaucoma
Nicotinamide Levels in Serum, Aqueous Humor, and Tear Film in Glaucoma and Correlations With Mitochondrial Damage-Associated Molecular Patterns (mtDAMPs) and Senescence-Associated Secretory Phenotype (SASP)
Background Glaucoma is a multifactorial, chronic, and progressive eye disease characterized by the irreversible loss of retinal ganglion cells (RGCs).
- Trial name
- NCT07006194
- Testing
- Nicotinamide Tablet
- Where
- 3 sites in Italy
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Keratitis Bacterial, Keratitis Fungal
Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment
As conventional corneal scraping with bacterial culturing has several disadvantages such as long duration until diagnosis, invasiveness and lacks alternatives, there is demand for a novel non-invasive, rapid test in keratitis…
- Trial name
- VICTORIA (NCT05620264)
- Testing
- Tear Sample Probe
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Johannes Kepler University of Linz
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Vibration on Patellofemoral Joint Pain After ACLR
Anterior cruciate ligament (ACL) injury is a prevailing problem among sports participants, especially in non-contact sports. Studies have reported that 70-84% of ACL injuries are non-contact in nature, and movements like changing…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Patellofemoral Pain
- Trial name
- NCT05501210
- Testing
- WBV, PEMF
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- Chinese University of Hong Kong
Intrapartum Fever, Chorioamnionitis
Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT)
Chorioamnionitis, or intraamniotic infection, is a common condition affecting 2-5% of all term births. This condition poses well-recognized maternal and neonatal risks, and entails a series of clinical management decisions…
- Trial name
- PARADIP (NCT06950840)
- Testing
- Acetaminophen, dipyrone
- Where
- Israel
- Volunteers
- 140 people
- Sponsor
- Wolfson Medical Center
Kidney Cancer, Renal Neoplasms
Tumor Rupture During Robotic Partial Nephrectomy
The RUPTURE Project is a multi-center observational study aiming to understand tumor rupture during robotic partial nephrectomy (RAPN), a minimally invasive surgery used to treat kidney tumors.
- Trial name
- RUPTURE (NCT07065825)
- Testing
- robot-assisted partial nephrectomy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Flat Feet, Flexor Tendon Rupture
Medial Displacement Calcaneal Osteotomy and FDL- Transfer - With a Human, Allogeneic Cortical Bone Screw
The goal of this observational study is to compare the use of a screw made of human bone (Shark-Screw®, Surgebright-GmbH) with the metal/Bio-Tenodesis screw (Arthrex) in the treatment of the symptomatic flatfoot using the…
- Conditions
- Flat Feet, Flexor Tendon Rupture, Tibialis Posterior Dysfunction, Deformity, Foot
- Trial name
- NCT05643079
- Testing
- medializing calcaneal osteotomy and/or transfer of the flexor digitorum longus tendon (FDL) with metal/Bio-Tenodesis screws, medializing calcaneal osteotomy and/or transfer of the flexor digitorum longus tendon (FDL) with Shark Screws®
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Orthopedic Hospital Vienna Speising
Dry Eye Disease (DED)
Effect of Behavioral Intervention (Baduanjin Alone or Laughter Exercise Plus Artificial Tears) Versus Artificial Tear on Dry Eye Disease: a Randomised Controlled Trial
The goal of this clinical trial is to compare the effect of behavioral intervention (Baduanjin alone or laughter exercise plus artificial tears) versus artificial tears in patients with dry eye disease.
- Trial name
- NCT07524725
- Testing
- Baduanjin, Laughter exercise, Artificial tears
- Volunteers
- 540 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Dry Eye Syndromes, Dry Eye Disease (DED)
Clinical Investigation Between the Topical Administration of a Tear Substitute With Ancillary Medicinal Substance and Hyaluronic Acid 0.3% (FBV_01) vs Hyaluronic Acid 0.3% in Subjects in the Treatment From Moderate to Severe DED
The goal of this clinical investigation plan is to evaluate the performance, tolerability, safety, and compliance of an ophthalmic solution containing an ancillary medicinal substance and hyaluronic acid 0.3% (FBV_01) compared…
- Trial name
- NCT07412860
- Testing
- FBV_01, HYLO-VISION® SafeDrop® Gel
- Where
- 2 sites in Italy
- Volunteers
- 74 people
- Sponsor
- FB Vision S.p.A
Epiphora
Low-Dose Atropine Eye Drops for Excessive Tearing (Epiphora)
This study tests whether a very low concentration of atropine eye drops (0.005%) reduces excessive tearing (epiphora) in adults.
- Trial name
- NCT07816224
- Testing
- Atropine sulfate ophthalmic solution 0.005%, Vehicle arm
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Rehan Ahmed
Rotator Cuff Tears, Rotator Cuff Tear Arthropathy
Bioinductive Patch for Full-Thickness Rotator Cuff Tears
The purpose of this randomized-controlled study is to compare outcomes of arthroscopic rotator cuff repair augmented with a Bioinductive Implant (study group) to standard arthroscopic rotator cuff repair (control group).
- Trial name
- NCT05439850
- Testing
- arthroscopic rotator cuff repair, Bioinductive implant, Ultrasound Imaging
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Henry Ford Health System
Dry Eye Syndromes, Computer Vision Syndrome
Protecting the Eyes of Gamers With Lubricating Eyedrops
The excessive use of screens particularly amongst digital gamers can adversely impact the health of the surface of the eyes with symptoms and signs of surface damage.
- Trial name
- PROTEGE (NCT06163989)
- Testing
- TheaLoz Duo Eyedrop
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Aston University
Tear Disorder, Resectable Locally Advanced Non-Squamous NSCLC
A Prospective Trial of SFI Plus PD-1 Inhibitors and PBC in Resectable NSCLC (SFI-NSCLC)
This prospective, single-center clinical trial will enroll 30 treatment-naïve patients with locally advanced, resectable stage II-IIIA non-small cell lung cancer (NSCLC) to receive neoadjuvant Shenqi Fuzheng Injection (SFI) in…
- Trial name
- SFI-NSCLC (NCT07843251)
- Testing
- Shenqi Fuzheng Injection
- Volunteers
- 30 people
- Sponsor
- Anhui Provincial Cancer Hospital
Aortic Dissection, Distal Entry Tear
Guo&Amp;'s Distal Entry Tear Repair With WeFlow-EndoPatch System (Gallant Study)
A Multicenter, Randomized Controlled Study About the Safety and Efficacy of WeFlow-EndoPatch Aortic Endovascular Patch System manufactured by EndoNom Medtech (Hangzhou) Co., Ltd. for Chronic Aortic Dissection . (GALLANT Study)
- Trial name
- Gallant (NCT06945809)
- Testing
- WeFlow-EndoPatch Aortic Endovascular Patch System, Conventional Treatment group
- Where
- China
- Volunteers
- 216 people
- Sponsor
- Hangzhou Endonom Medtech Co., Ltd.