Clinical trials: Tear Film
Dry Eye
Comparative Efficacy of SYSTANE® ULTRA vs Optive™ in Improving Tear Film Break-up Time
The primary objective of this study is assess the Tear Film break-up time (TBUT) in mild to moderate dry eye subjects.
- Trial name
- NCT01417013
- Testing
- Systane Ultra, Optive
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alcon Research
Meibomian Gland Dysfunction, Evaporative Dry Eye
Tear Film Innovations iLux Safety Study
The objective of this study was to measure the temperature of the cornea and surrounding eye tissue temperature immediately after heating the eyelids with the iLux device using the protocol treatment profile.
- Trial name
- NCT03055897
- Testing
- iLux 2020 System
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tear Film Innovations, Inc.
Dry Eye
Clinical Outcomes Following Treatment With Systane® Balance in Dry Eye Subjects
The purpose of this study is to demonstrate the superior efficacy of Systane® Balance over Preservative-Free 0.9% Saline following 35 days of QID (4 times a day) dosing in treating dry eye subjects with lipid deficiency.
- Trial name
- NCT01967147
- Testing
- Propylene Glycol, 0.6% eye drops, Preservative-free 0.9% Saline solution
- Volunteers
- 279 people
- Sponsor
- Alcon Research
Corneal Staining
Assessment of Tear Film-Based Proteins Associated With Care Solution Induced Corneal Staining
The purpose of this study was to investigate the association of inflammatory mediators found in the tear film during the development and following the induction of contact lens solution-induced corneal staining.
- Trial name
- NCT01100424
- Testing
- Opti-Free RepleniSH, ReNu MultiPlus, Balafilcon A
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Tear Film Thickness
Pilot Study Evaluation of 2 Artificial Tears. Evaluation of TBUT, Tear Meniscus Height and Tear Thickness
To determine baseline tear thickness and improvement immediately post installation of two artificial tear solutions:(9582X) and Allergan Refresh Tears.
- Trial name
- NCT00469521
- Testing
- Refresh Tears, 9582X
- Where
- United States
- Sponsor
- Innovative Medical
Dry Eye
Study of Blinking as a Function of Tear Film Quality
The goal of this study is to better understand how eye blinking behavior is linked to the stability of the tear film, in adults aged 18 to 65 years, with or without symptoms of dry eye.
- Trial name
- WINK (NCT07499193)
- Testing
- Blink behaviour
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Essilor International
Allergic Conjunctivitis
The Effect of BEPREVE 1.5% on Tear Film Osmolarity and Tear Film Lipid Layer
The purpose of this study is to compare the effect of Bepreve® with an artificial-tear eye drop on the quality of your tears.
- Trial name
- NCT01346371
- Testing
- Refresh Tears 0.5% Lubricant Eye Drops, Bepreve 1.5% Ophthalmic Solution
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Minnesota Eye Consultants, P.A.
Dry Eye Syndrome, Tear Film Insufficiency
Tolerability, Safety and Efficacy of Lubricin vs Sodium Hyaluronate Eye Drops in Subjects With Moderate Dry Eye
The objective of the clinical investigation was to evaluate tolerability, safety and efficacy of the tested medical device, eye drop containing Lubricin 150 µg/mL, as compared with a standard sodium hyaluronate 0.13% eye drop…
- Trial name
- NCT02510235
- Testing
- Lubricin, Sodium Hyaluronate
- Where
- 2 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Dompé Farmaceutici S.p.A
Dry Eye
Efficacy and Safety Study of FID 119515A
The purpose of this study was to compare the effect of FID 119515A to Blink® Tears on the integrity of tear film in adults with a history of dry eye in both eyes.
- Trial name
- NCT01833117
- Testing
- FID 119515A, Blink® Tears
- Volunteers
- 75 people
- Sponsor
- Alcon Research
Refractive Error
DAILIES TOTAL1® - Comparative Assessment of Tear Film Evaporation
The purpose of this study is to evaluate the tear film evaporation of symptomatic soft contact lens wearers in the absence of contact lens wear and after at least 8 hours of contact lens wear.
- Trial name
- NCT02517567
- Testing
- Delefilcon A contact lenses, Narafilcon A contact lenses, Somofilcon A contact lenses
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Dry Eye Syndromes
Diagnostic Evaluation of the Tear Film
The objectives of this study are to assess for a difference between normal and dry eye subjects in tear film quality using a diagnostic interferometry device and to determine whether there are associations between tear film…
- Trial name
- NCT00761917
- Testing
- Tear Film Analyzer
- Where
- 8 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- TearScience, Inc.
Refractive Error
Tear Film Stability of DAILIES® AquaComfort Plus® Contact Lenses vs. MyDay® Daily Disposable Contact Lenses
The purpose of this study is to evaluate tear film stability of DAILIES® AquaComfort Plus® (DACP) compared to MyDay® after 12 hours of lens wear.
- Trial name
- NCT02089191
- Testing
- Nelfilcon A contact lenses, Stenfilcon A contact lenses
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Alcon Research
Dry Eye Disease
Influence of Perfluorohexyloctane (NovaTears) on Tear Film Thickness in Patients With Mild to Moderate Dry Eye Disease
Patients with mild to moderate dry eye disease will be randomized to receive either NovaTears® or Hydrabak® eye drops as control.
- Trial name
- NCT03048526
- Testing
- NovaTears®, Hydrabak®
- Where
- Austria
- Volunteers
- 48 people
- Sponsor
- Novaliq GmbH
Dry Eye Disease
Evaluation of the Tolerability and Efficacy of CWT-f-002 Lubricant Eye Drops
The primary objective is to evaluate the tolerability and efficacy of CWT-f-002 lubricant eye drops in the treatment of the signs and symptoms of dry eye disease.
- Trial name
- NCT05660681
- Testing
- glycerin 0.7%/PEG 400 0.3%, polyethylene glycol 400 0.4%/propylene glycol 0.3%
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Calm Water Therapeutics LLC
Dry Eye
Symptom Response in Normal and Dry Eye Patients Secondary to Application of a Menthol-Containing Eyedrop (Rohto® Hydra)
The purpose of the study is to analyze the sensation to eye drops containing menthol in people with healthy eyes and in people with dry eyes. This study also examines the temperature of your eye using an Infrared Camera.
- Trial name
- NCT02985827
- Testing
- Rohto (r) Hydra, Systane (r) Ultra
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
Dry Eye
The Effect of SYSTANE® BALANCE on Tear Film Break Up Time in Dry Eye Subjects
The purpose of this study was to evaluate the ability of SYSTANE® BALANCE dosed 4 times a day for 30 days to increase non-invasive tear film break up time over baseline, compared to a saline control, in dry eye subjects with…
- Trial name
- NCT01718028
- Testing
- Propylene glycol 0.6% ocular emulsion, Sodium chloride 0.9% saline solution
- Where
- Argentina
- Volunteers
- 51 people
- Sponsor
- Alcon Research
Visual Acuity
Influence of Lens Design on Particulate Exchange in the Post-lens Tear Film
This is a 5-visit, controlled, bilateral, randomized, subject-masked, crossover (4 treatments x 4 period), non-dispensing study.
- Trial name
- NCT03782571
- Testing
- etafilcon a Test 1, etafilcon A Test 2, etafilcon A Test 3
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Dry Eye
Evaluation of FID 114657 on Tear Film Lipid Layer Thickness
To evaluate the effects of FID 114657 on the tear film lipid layer thickness of patients with dry eye.
- Trial name
- NCT00848068
- Testing
- FID 114657, OPTIVE Lubricant Eye Drops
- Volunteers
- 40 people
- Sponsor
- Alcon Research
Myopia
Pre-Lens Tear Film Performance of Silicone Hydrogel Daily Disposable Contact Lenses
The purpose of this study was to compare the pre-lens tear film stability of DAILIES TOTAL1® silicone hydrogel daily disposable contact lenses with that of two other silicone hydrogel daily disposable contact lenses.
- Trial name
- NCT01548833
- Testing
- Delefilcon A contact lens, Narafilcon A contact lens, Filcon II 3 contact lens
- Volunteers
- 39 people
- Sponsor
- Alcon Research
Dry Eye
Tear Film Break-Up Time Evaluation of FID 114657
To evaluate the effects of FID 114657 on tear film break-up time in dry eye patients.
- Trial name
- NCT01023464
- Testing
- FID114657, SootheXP Emollient (Lubricant) Eye Drops
- Volunteers
- 38 people
- Sponsor
- Alcon Research