Clinical trials: Tear Film
Dry Eye Syndrome
Efficacy of Warm Compress Therapy in Enhancing Tear Film Quality and Reducing Postoperative DES
Dry eye disease (DED) is a multifactorial condition often exacerbated by cataract surgery, leading to discomfort and visual disturbances.
- Trial name
- NCT06914232
- Testing
- Warm Compress, Standard Care
- Where
- Pakistan
- Volunteers
- 54 people
- Sponsor
- Superior University
Dry Eye
Tear Film Markers in Dry Eye Syndrome
Dry eye is the most common reason for visit to an ophthalmologist's office. The prevalence is on the rise and is mainly attributed to factors such as increased environmental pollution and contact lens use.
- Trial name
- NCT04515329
- Testing
- Cyclosporine, Artificial tear
- Where
- United States
- Sponsor
- Vishal Jhanji
Keratoconjunctivitis Sicca
Tear Film Break-up Time After Instillation of Artificial Tears
This study is an exploratory trial evaluating the tear film break-up time after a single eye drop instillation of over-the-counter artificial tears.
- Trial name
- NCT00681265
- Testing
- glycerin, polyethylene glycol 400/propylene glycol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Calm Water Therapeutics LLC
Tear Film Characteristics
Clinical Evaluation of An Approved Contact Lens
This is an 8-visit, bilateral, dispensing clinical study to evaluate the change in tear fluid pH and tear film osmolarity in an FDA-cleared contact lens in new contact lens users over a 14-day period.
- Trial name
- NCT02760810
- Testing
- Marketed Contact Lens
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Dry Eye Syndromes
Effect of Lipid Based Eye Drops on Tear Film Lipid Layer Thickness
Dry eye disease (DED) is a common ocular disease, especially in the elderly population. Despite many treatment approaches, instillation of topical lubricants remains the mainstay of therapy.
- Trial name
- NCT03399292
- Testing
- Cationorm MD sine eye drops
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Dry Eye Syndrome
Correlation of Different Signs for Assessment of Dry Eye Syndrome
Dry eye syndrome (DES) is a highly prevalent ocular condition inducing an inflammatory response of the ocular surface. Common symptoms include ocular discomfort, visual impairment and instability of the tear film with potential…
- Trial name
- NCT01753687
- Testing
- Ocular scattering of the tear film, Optical Coherence Tomography (OCT), Measurement of tear film osmolarity
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Dry Eye, Cataract
Assessment of CataClear, Tear Film Stability, Tear Volume, and Dry Eye Symptoms Using Stem Cells Fortified Eye Drops
Dry Eye Disease (DED) is a multifactorial condition that affects the ocular surface, leading to discomfort, tear film instability, and potential visual disturbances.
- Trial name
- CataClear (NCT07191847)
- Testing
- eye drops
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ace Cells Lab Limited
Tear Film Hyperosmolarity
Tear Osmolarity Changes in Habitual Contact Lens Wearers
Tear osmolarity refers to the amount of osmotically active particles in tears and has been reported as one of the best diagnostic test for dry eye disease.
- Trial name
- NCT03531346
- Testing
- Daily-disposable soft contact lens
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Dry Eye
Artificial Tears, Tear Lipids and Tear Film Dynamics
Dry eye disease (DED) is pervasive with some reports estimating over 16 million adults diagnosed in the United States. Currently, artificial tears remain an integral part of managing dry eyes and are mainly used for symptomatic…
- Trial name
- AlconAT (NCT05705518)
- Testing
- Systane Complete PF, Refresh Relieva PF, Refresh Optive Mega-3 PF
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Dry Eye Disease, Tear Film
Corneal and Tear Film Changes in Chinese Patients With Type 2 Diabetes
Diabetes mellitus has been associated with ocular surface damage and exacerbates dry eye disease (DED) pathology. To investigate clinical and inflammatory changes in the ocular surface of insulin-independent type II diabetic…
- Conditions
- Dry Eye Disease, Tear Film, Corneal Nerve
- Trial name
- NCT06218992
- Where
- China
- Volunteers
- 80 people
- Sponsor
- He Eye Hospital
Dry Eye
The Effect of Eyeliner on Tear Composition, Tear Secretion and Tear Film Stability.
Eyeliner is one of the most common eye cosmetics. The main ingredients are titanium oxide, pigment, grease and preservative. The user will apply the eyeliner to the eyelid and eyelash.
- Trial name
- NCT05632887
- Testing
- no intervention
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Wound, Rupture
Study Comparing the Polyurethane Films and Sugarcane Biopolymer Used as Dressings
The aim of this study is validate the use of biopolymer from sugar cane molasses film (POLYSHAFT®) a product developed in Experimental Station research laboratories (UFRPE) comparing to polyurethane film, or similar, used as a…
- Conditions
- Wound, Rupture, Surgery, Cesarean Section
- Trial name
- NCT02531828
- Testing
- Application of dressings for surgical correction., POLYSHAFT®
- Where
- Brazil
- Volunteers
- 141 people
- Sponsor
- Polisa - Biopolímeros para Saúde
Dry Eye Syndromes
Topical Omega-3 Fatty Acids (REMOGEN® OMEGA) in the Treatment of Dry Eye
The primary objective of this study is to evaluate the efficacy of REMOGEN® OMEGA in reducing Dry Eye Syndrome (DES) symptoms.
- Trial name
- REMOTOP (NCT02908282)
- Testing
- REMOGEN OMEGA, Povidone
- Where
- 5 sites in Germany
- Volunteers
- 81 people
- Sponsor
- TRB Chemedica AG
Keratoconjunctivitis Sicca
A Phase 4 Study Investigating the Efficacy of Retaine™ in Managing Signs and Symptoms Associated With Dry Eye Syndrome
This study will evaluate the efficacy of Retaine™ ophthalmic emulsion in treating the signs and symptoms of dry eye syndrome.
- Trial name
- NCT02139033
- Testing
- Retaine™
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Ocusoft, Inc.
White Blood Cells
Study of the Cell Response in the Tear Film After Overnight Contact Lens Wear
The purpose of this study was to count and analyze the white blood cells in tear samples collected from study participants following sleep.
- Trial name
- CORNWALL (NCT01379768)
- Testing
- Lotrafilcon A contact lens, Lotrafilcon B contact lens, Clear Care Cleaning and Disinfection Solution
- Where
- Canada
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- CIBA VISION
Meibomian Gland Dysfunction
Changes of Tear-film Lipid Layer Thickness and Ocular Aberration After Treatment of Meibomian Gland Dysfunction
In this study, investigator aim to evaluate the changes of tear-film lipid layer thickness and ocular aberration after treatment of meibomian gland dysfunction.
- Trial name
- NCT02618304
- Testing
- Treatment of Meibomian gland dysfunction
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Yonsei University
Dry Eye
A Study To Investigate The Effects Of A Low Humidity Environment And Visual Tasking On Tear Film Protein Composition
The purpose of the study is to collect valuable data on the role of controlled humidity, temperature, airflow, and visual tasking in altering the tear film protein composition.
- Trial name
- NCT02005874
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Inflamax Research Incorporated
Dry Eye
I-DROP MGD Symptomatic Relief and Tear Film Stability
The objective of the study is to compare the difference in tear film stability and symptomatic relief between I-DROP MGD and another commercially available drop in the Canadian market.
- Trial name
- NCT05011708
- Testing
- I-DROP MGD, Thealoz Duo
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- I-MED Pharma
Dry Eye
Comparative Efficacy of SYSTANE® ULTRA vs Optive™ in Improving Tear Film Break-up Time
The primary objective of this study is assess the Tear Film break-up time (TBUT) in mild to moderate dry eye subjects.
- Trial name
- NCT01417013
- Testing
- Systane Ultra, Optive
- Volunteers
- healthy volunteers welcome
- Sponsor
- Alcon Research
Meibomian Gland Dysfunction, Evaporative Dry Eye
Tear Film Innovations iLux Safety Study
The objective of this study was to measure the temperature of the cornea and surrounding eye tissue temperature immediately after heating the eyelids with the iLux device using the protocol treatment profile.
- Trial name
- NCT03055897
- Testing
- iLux 2020 System
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Tear Film Innovations, Inc.