Clinical trials: Tear Film
Dry Eye, Vision Disorders
Visual Quality Change of Eyes Implanted With Diffractive Multifocal Intraocular Lens After Cataract Surgery
In this study, the investigators examined the subjective visual quality including LogMAR uncorrected distance visual acuity (UCDVA), best corrected distance visual acuity (BCDVA),uncorrected intermediate visual acuity (UCIVA)…
- Conditions
- Dry Eye, Vision Disorders, Quality of Life
- Trial name
- NCT02234635
- Testing
- Diffractive multifocal IOLs group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Wenzhou Medical University
Dry Eye, Tear Film
Effects of Two Tear Substitutes in Patients With Dry Eye Syndrome
With the potential to address evaporative dry eye, Liposic and Tears Naturale Forte have been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid.
- Conditions
- Dry Eye, Tear Film, Lipid Layer, Liposic
- Trial name
- NCT03211351
- Testing
- Liposic, Tears Naturale Forte
- Where
- China
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Huaxia Eye Hospital Group
Dry Eye Syndrome, Tear Film Insufficiency
Tolerability, Safety and Efficacy of Lubricin vs Sodium Hyaluronate Eye Drops in Subjects With Moderate Dry Eye
The objective of the clinical investigation was to evaluate tolerability, safety and efficacy of the tested medical device, eye drop containing Lubricin 150 µg/mL, as compared with a standard sodium hyaluronate 0.13% eye drop…
- Trial name
- NCT02510235
- Testing
- Lubricin, Sodium Hyaluronate
- Where
- 2 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Dompé Farmaceutici S.p.A
Dry Eye Syndromes
Assessment of TFT by OCT in Healthy Subjects and Subjects With DES
Dry eye syndrome (DES) is a highly prevalent ocular condition with potential severe consequences for affected patients. DES can be either caused by decreased tear production or increased tear evaporation, both leading to an…
- Trial name
- NCT02585414
- Where
- Austria
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye
Efficacy and Safety Study of FID 119515A
The purpose of this study was to compare the effect of FID 119515A to Blink® Tears on the integrity of tear film in adults with a history of dry eye in both eyes.
- Trial name
- NCT01833117
- Testing
- FID 119515A, Blink® Tears
- Volunteers
- 75 people
- Sponsor
- Alcon Research
Glaucoma, Open-Angle, Ocular Hypertension
Inflammatory Biomarkers in Ocular Surface in Primary Open Angle Glaucoma or Ocular Hypertension Under Topical Prostaglandins
Glaucoma is a chronic optic neuropathy whose main modifiable risk factor is an abnormally elevated intraocular pressure. The aim of glaucoma treatment is to slow the progression of the disease by reducing intraocular pressure.
- Trial name
- NCT05039684
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA
Dry Eye Disease
Four-Week Ocular-Surface Evaluation of an Experimental Ophthalmic Liposomal Nanocarrier in Dry Eye Disease
This prospective, single-group research medical experiment evaluated the ocular-surface response to repeated bilateral use of an experimental ophthalmic liposomal nanocarrier in adults with dry eye disease.
- Trial name
- NCT07793344
- Testing
- Experimental ophthalmic liposomal nanocarrier
- Where
- Poland
- Volunteers
- 26 people
- Sponsor
- Regional Specialist Hospital in Wroclaw
Keratitis Bacterial, Keratitis Fungal
Validation of Interleukins and Other Cytokines Together With OCT Imaging for Rapid Infectious Keratitis Assessment
As conventional corneal scraping with bacterial culturing has several disadvantages such as long duration until diagnosis, invasiveness and lacks alternatives, there is demand for a novel non-invasive, rapid test in keratitis…
- Trial name
- VICTORIA (NCT05620264)
- Testing
- Tear Sample Probe
- Where
- Austria
- Volunteers
- 392 people
- Sponsor
- Johannes Kepler University of Linz
Refractive Error
DAILIES TOTAL1® - Comparative Assessment of Tear Film Evaporation
The purpose of this study is to evaluate the tear film evaporation of symptomatic soft contact lens wearers in the absence of contact lens wear and after at least 8 hours of contact lens wear.
- Trial name
- NCT02517567
- Testing
- Delefilcon A contact lenses, Narafilcon A contact lenses, Somofilcon A contact lenses
- Volunteers
- 37 people
- Sponsor
- Alcon Research
Dry Eye Syndrome, Tear Film Insufficiency
Corneal Tear Film Imaging of the Cornea Before and After Restasis Therapy
Dry Eye Syndrome (DES) is a disease affects the production and stability of the tear film, leading to vision disturbances and a major decrease in quality of life.
- Trial name
- NCT03403023
- Testing
- Tear Film Imager, Restasis
- Volunteers
- 40 people
- Sponsor
- Meir Medical Center
Healthy Subjects, Moderate to Severe Keratoconjunctivitis Sicca (KCS)
Three Dimension Tomography of Eye Structures by White Light Imaging Device
The purpose of this study is to investigate the ability of an imaging device, developed by AdOM Advanced Optical Technologies Ltd. ("AdOM").
- Conditions
- Healthy Subjects, Moderate to Severe Keratoconjunctivitis Sicca (KCS), Dry Eye Syndrome (DES)
- Trial name
- 3D-WLT (NCT02424266)
- Testing
- None invasive imaging of the tear film (AdOM)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Dry Eye, Dry Eye Syndromes
Effect of Lifitegrast 5% on Tear Film Markers
The purpose of this study is to assess the duration of time (in weeks) for improvement in objective dry eye markers for people who are placed on lifitegrast 0.5% (Xiidra®), an FDA-approved therapy for dry eyes.
- Conditions
- Dry Eye, Dry Eye Syndromes, Dry Eyes Chronic
- Trial name
- NCT03952481
- Testing
- Lifitegrast 5% Ophthalmic Solution
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Dry Eye Syndromes
Comparison of Evaporimetry With the Established Methods of Tear Film Measurement
Purpose: To establish whether there is a correlation between dry eye symptoms, age and gender, a difference in symptom intensity in different times of the day, which test (Schirmer or TBUT) better correlates with dry eye…
- Trial name
- NCT01496482
- Testing
- Only measurements done on subjects in both groups.
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Dry Eye
Analysis of the Diagnostic Performance of LacryDiag, a New Analyzer of the Ocular Surface in the Dry Eye
LacryDiag is a new Conformity European (CE) marked diagnostic imaging device devoted to the analysis of the ocular surface. It is an "all in one" device that provides 4 data: non-invasive break-up time (Non-Invasive Break-Up-Time…
- Trial name
- LACRYMOSA (NCT04093037)
- Testing
- Time #1: Non Invasive Break-Up Time (NIBUT), Time #2: MicroInstillation Break-Up Time (MIBUT) + Oxford score, Time #3: Standard Break-Up Time (SBUT)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Dry Eye Syndromes
Diagnostic Evaluation of the Tear Film
The objectives of this study are to assess for a difference between normal and dry eye subjects in tear film quality using a diagnostic interferometry device and to determine whether there are associations between tear film…
- Trial name
- NCT00761917
- Testing
- Tear Film Analyzer
- Where
- 8 sites in United States
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- TearScience, Inc.
Refractive Error
Tear Film Stability of DAILIES® AquaComfort Plus® Contact Lenses vs. MyDay® Daily Disposable Contact Lenses
The purpose of this study is to evaluate tear film stability of DAILIES® AquaComfort Plus® (DACP) compared to MyDay® after 12 hours of lens wear.
- Trial name
- NCT02089191
- Testing
- Nelfilcon A contact lenses, Stenfilcon A contact lenses
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Alcon Research
Glaucoma, Ocular Hypertension
Latanoprost Preserved Versus Unpreserved: Effect on Tear Film Thickness as Measured With OCT
Topical antihypertensive eye drops are a key element of modern antiglaucoma treatment. Most of these eye drops contain preservatives to allow for the use of multi-dose containers.
- Trial name
- NCT02585375
- Testing
- Preservative-free latanoprost 50µg/ml, Preserved latanoprost 0.005%
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Medical University of Vienna
Diabetic Eye Problems
Diquafosol Ophthalmic Solution for Dry Eye Symptoms
Diquafosol ophthalmic solution (DQS) stimulates P2Y2 receptors on the ocular surface, which enhances mucin secretion from goblet cells.
- Trial name
- NCT04980144
- Testing
- 3% Diquafosol tetrasodium, 0.1% hyaluronate
- Where
- China
- Volunteers
- 101 people
- Sponsor
- He Eye Hospital
Contact Lens, Tear Film Thickness
High-resolution Imaging of Tear Film Thickness in Contact Lenses Wearers With Optical Coherence Tomography (OCT). A Pilot Study
A refractive error is the most common reason for reduced visual acuity. Myopia, hyperopia, astigmatism and presbyopia belong to the four basic refractive errors and, unfortunately, cannot be prevented.
- Trial name
- NCT02713399
- Testing
- Optical Coherence Tomography
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Contact Lens Solutions
Objective Testing of Tear Film Stability
The purpose of this study is to evaluate the in-vivo wettability of soft contact lenses when cared with two different multi-purpose solutions over a two week wearing period.
- Trial name
- NCT00789529
- Testing
- Opti-Free® RepleniSH® MPDS, ReNu MultiPlus®
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Manhattan Vision Associates