Clinical trials: Tear Film
Allergic Conjunctivitis, Dry Eye Disease (DED)
Clinical and Biological Evaluation of NAAGA Versus Azelastine Eye Drops in Allergic Subjects With Tear Film Dysfunction
This randomized, single-blind study aims to compare the efficacy and safety of N-acetyl-aspartyl-glutamate (NAAGA) and azelastine hydrochloride eye drops in patients with allergic conjunctivitis associated with tear film…
- Trial name
- NCT06800274
- Testing
- NAAGA (N-acetyl-aspartyl-glutamate) 49 mg/mL, azelastine hydrochloride 0.05%
- Where
- Italy
- Volunteers
- 134 people
- Sponsor
- Azienda Ospedaliera OO.RR. S. Giovanni di Dio e Ruggi D'Aragona
Dry Eye Disease (DED), Tear Break-Up Time
Efficacy of 0.28% Sodium Hyaluronate Eye Drops in Patient With Moderate to Severe Dry Eye
This study aimed to evaluate the efficacy and safety of 0.28% preservative-free SH and 0.18% SH eye drops in patients with dry eye disease.
- Conditions
- Dry Eye Disease (DED), Tear Break-Up Time, Tear Disorder, Tear Film Insufficiency
- Trial name
- NCT06860659
- Testing
- 0.28% Sodium Hyaluronate , preservative free eye drops, 0.18% Sodium Hyaluronate , preservative free eye drops
- Where
- Thailand
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Ocular Surface Disease, Tear Film Characteristics
Effect of Four Different Diagnostic Eye Drops on Tear Film Thickness
The use of topical anesthesia as well as corneal vital staining with fluorescein is an inevitable part of various ophthalmological examinations and surgical treatments.
- Trial name
- NCT07230548
- Testing
- Oxybuprocaine MDU, Oxybuprocaine SDU, Oxybuprocaine/fluorescein SDU
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye Syndromes
Influence of Three Different Formulations of Lachrymal Substitutes on Tear Film Thickness and Other Signs and Symptoms in Patients With Moderate to Severe Dry Eye Syndrome
Dry eye syndrome is a highly prevalent ocular disease with an increasing incidence in the elderly population. Topically administered lubricants are the basis for treatment of this disease.
- Trial name
- NCT02986750
- Testing
- Thealoz Duo Eye Drops, Optive Eye Drops, Systane Ultra Eye Drops
- Where
- Austria
- Volunteers
- 120 people
- Sponsor
- Medical University of Vienna
Dry Eye Syndrome
A Prospective Clinical Study Assessing the Effects of Tetracycline Antibiotic on Tear Film and Tear Lipid Composition Within a Population of Patients Diagnosed With Blepharitis and Dry Eye Disease
The purpose of this research project is to determine the effects of oral tetracycline such as Minocycline (Minocin) on tear film composition and tear lipid (meibomian gland secretions) characteristics in patients with chronic…
- Trial name
- NCT00355459
- Testing
- Tetracycline: Doxycycline analog
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Myopia
Pre-Lens Tear Film Performance of Silicone Hydrogel Daily Disposable Contact Lenses
The purpose of this study was to compare the pre-lens tear film stability of DAILIES TOTAL1® silicone hydrogel daily disposable contact lenses with that of two other silicone hydrogel daily disposable contact lenses.
- Trial name
- NCT01548833
- Testing
- Delefilcon A contact lens, Narafilcon A contact lens, Filcon II 3 contact lens
- Volunteers
- 39 people
- Sponsor
- Alcon Research
Digital Eye Strain
Study of the Association Between Digital Eye Syndrome With Binocular Vision and the Ocular Surface in Higher Education Students in the Area of Health Technologies
The goal of this observational study is to determinate the association between DES and changes in binocular vision and ocular surface. in higher education students in the area of health technologies.
- Trial name
- DESIROUS (NCT05675475)
- Testing
- Exposure, Orthoptic assessment (Outcome measure), Tear film Break Up Time (BUT) test (Outcome measure)
- Where
- Portugal
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Dry Eye Disease, Tear Film
Effect of Artificial Tears on Ocular Biometry Parameters
Due to the instability of the tear film, the biometry often needs to be done multiple times in a clinical environment. The high variability of both short-term and long-term repeatability in keratometry of dry eyes is well-known.
- Trial name
- NCT06656403
- Testing
- 0.1% sodium hyaluronate
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- He Eye Hospital
Dry Eye Syndrome
Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease
Dry eye syndrome (DES) is a highly prevalent ocular condition with severe consequences for the patients reaching from ocular discomfort in its simplest form up to visual impairment and corneal ulceration in severe cases.
- Trial name
- NCT01753596
- Testing
- GENTEAL HA® Eye Drops (NOVARTIS, Switzerland), Physiological Sodium Chloride solution (0,9%)
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye Disease
Assess the Effects of Spectacles or Orthokeratology on Dry Eye Parameters in Children and Adolescents.
Orthokeratology(OK) is currently one of the effective methods for treating myopia, reshaping the corneal epithelium to change refractive power.
- Trial name
- NCT06023108
- Testing
- Orthokeratology, Spectacles
- Where
- China
- Volunteers
- 300 people
- Sponsor
- He Eye Hospital
Aqueous Deficient Dry Eye, Meibomium Gland Dysfunction
Non-invasive Tear Film Dynamic Measurements in Normal, MGD and ADDE Subjects After Saline Instillation
Compare the objective tear film dynamic measurements in three different populations (MGD [Meibomium Gland Dysfunction], ADDE [Aqueous Deficient Dry Eye] and normal/control [non-dry eye]) and the subjective experience before and…
- Trial name
- NCT01128049
- Testing
- Subjective Questionnaire, Measurement with wavefront sensor (right eye, then left eye), Instill Saline Drop
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Dry Eye Syndromes
Treatment of Dry Eye With Supplements
Dry eye syndrome (DES) is a highly prevalent ocular condition inducing an inflammatory response on the ocular surface. Common symptoms include ocular discomfort, visual impairment and instability of the tear film with potential…
- Trial name
- NCT01364311
- Testing
- Vitamac® Tag and Nacht capsules
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Dry Eye
Tear Film Break-Up Time Evaluation of FID 114657
To evaluate the effects of FID 114657 on tear film break-up time in dry eye patients.
- Trial name
- NCT01023464
- Testing
- FID114657, SootheXP Emollient (Lubricant) Eye Drops
- Volunteers
- 38 people
- Sponsor
- Alcon Research
Tear Film Characteristics
Quantifying Ocular Surface Aberrations After Tear Film Interventions
The CA-800 Corneal Analyzer (Visia Imaging S.R.L., Italy) is a device that can measure small imperfections in the tear film when the eyes are open.
- Trial name
- GAMBIA (NCT06966349)
- Testing
- Systane Complete Preservative-Free, Senofilcon A, Somofilcon A
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
In the Present Study, we Investigated the Effects of Oral Ambroxol on Tear Film and Ocular Surface.
Effects of Oral Mucolytics on Tear Film and Ocular Surface
Ambroxol is a metabolite of bromhexine and possesses mucokinetic and secretolytic properties that are also found in mucolytic agents.1 Ambroxol has been used for decades for the treatment of respiratory disorders associated with…
- Trial name
- NCT01713179
- Testing
- Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Dry Eye Syndromes
Influence of Lachrymal Substitute Gels on Tear Film Thickness in Patients With Moderate to Severe Dry Eye Syndrome
Dry eye syndrome is a highly prevalent ocular disease with an increasing incidence in the elderly population. Topically administered lubricants are the basis for treatment of this disease.
- Trial name
- NCT02585453
- Testing
- Thealoz Duo Gel, Hylo-Gel, Systane Gel Drops
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Glaucoma, Monotherapy With Xalatan From 1 to 18 Months
Assessing Ocular Surface Changes After Changing Glaucoma Medications
Hypothesis: Changing to Travatan Z therapy increases the tear film break up time of subjects on Xalatan therapy presenting with ocular surface disease.
- Conditions
- Glaucoma, Monotherapy With Xalatan From 1 to 18 Months, Ocular Surface Disease
- Trial name
- NCT00554411
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Colorado, Denver
Dry Eye Syndromes
Effect of Single Instillation of Three Different Topical Lubricants on Tear Film Thickness in Patients With Dry Eye Syndrome
The prevalence and incidence of dry eye syndrome (DES) is constantly increasing. Several therapeutic strategies have been proposed, but still no ideal regimen has been found.
- Trial name
- NCT03161080
- Testing
- Neovis Total Multi® Eye Drops, Vismed Multi® Eye Drops, Hydrabak® Eye Drops
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Dry Eye
BL-RX01-TFSTAB-1402
A study to investigate the ability of the iTrace™, BOSA™, OPD-Scan III, and IDRA to detect tear film stability utilizing Miebo®
- Trial name
- NCT07790211
- Testing
- Determine the ability of the iTrace™, BOSA™, OPD-Scan III, and IDRA to detect tear film stability utilizing Miebo®
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Dry Eye Syndromes
Acupuncture for Dry Eye Syndrome
This study is about the effectiveness of acupuncture treatment on dry eye syndrome. Study hypothesis is that a standardized acupuncture would be more effective than a sham acupuncture in dry eye syndrome patients.
- Trial name
- NCT00969280
- Testing
- Standardized Acupuncture, Non-acupuncture point shallow penetration acupuncture
- Where
- South Korea
- Volunteers
- 42 people
- Sponsor
- Korea Institute of Oriental Medicine