Clinical trials: Tear Film Deficiency
Dry Eye
Phase II Clinical Study to Evaluate the Efficacy of Multidose Lagricel® Ofteno Ophthalmic Solution as Treatment for Dry Eye Disease.
Phase II, comparative, controlled, multicenter, parallel group, open, randomized clinical study. The main outcome variable will be the Ocular Surface Disease Index (OSDI) questionnaire.
- Trial name
- PRO-037 (NCT04704531)
- Testing
- Sodium Hyaluronate Ophthalmic 0.4% one drop twice a day (BID), Sodium Hyaluronate Ophthalmic 0.4% one drop four times a day (QID), Sodium Hyaluronate Ophthalmic 0.4% Six times per day
- Where
- Mexico
- Volunteers
- 141 people
- Sponsor
- Laboratorios Sophia S.A de C.V.
Dry Eye
Evaluating a Device for Blocking the Tear Duct
Participants will receive a tear duct plug to see if their eye comfort improves.
- Trial name
- NCT05748951
- Testing
- Canalicular occlusion device
- Where
- Mexico
- Volunteers
- 33 people
- Sponsor
- AesculaTech, Inc.
Dry Eye Syndrome
A Study of RX-10045 in the Treatment of Dry Eye Disease
The primary purpose of this study is to assess the efficacy, tolerability and safety of RX-10045 Ophthalmic Solution in patients with Dry Eye Disease.
- Trial name
- NCT01675570
- Testing
- RX-10045, Vehicle for RX-10045
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- C.T. Development America, Inc.
Dry Eye Syndromes
A Safety and Efficacy Study of Refresh Optive® Gel Drops in Patients With Dry Eye Disease
This study will evaluate the safety and efficacy o fRefresh Optive® Gel Drops in patients with dry eye disease.
- Trial name
- NCT02280473
- Testing
- Refresh Optive® Gel Drops, REFRESH LIQUIGEL®
- Where
- 10 sites in United States
- Volunteers
- 188 people
- Sponsor
- Allergan
Dry Eye
The Effect of Electrical Stimulation on Tear Production
The purpose of this study is to investigate whether electrical stimulation of the nerve innervating the tear gland results in tear production in subjects with severe Dry Eye.
- Trial name
- NCT01630291
- Testing
- Electrode device
- Where
- Mexico
- Volunteers
- 4 people
- Sponsor
- Oculeve, Inc.
Dry Eye
A Pilot Study of the TearCare System in Adults With Dry Eye Disease
This is a small, pilot study intended to determine the feasibility of this product.
- Trial name
- NCT03006978
- Testing
- TearCare, Warm Compress
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Sight Sciences, Inc.
Dry Eye Syndrome, Tear Film Insufficiency
Tolerability, Safety and Efficacy of Lubricin vs Sodium Hyaluronate Eye Drops in Subjects With Moderate Dry Eye
The objective of the clinical investigation was to evaluate tolerability, safety and efficacy of the tested medical device, eye drop containing Lubricin 150 µg/mL, as compared with a standard sodium hyaluronate 0.13% eye drop…
- Trial name
- NCT02510235
- Testing
- Lubricin, Sodium Hyaluronate
- Where
- 2 sites in Italy
- Volunteers
- 56 people
- Sponsor
- Dompé Farmaceutici S.p.A
Dry Eye
Mucin Levels in Dry Eye and Normal Populations
The purpose of this study is to evaluate changes in ocular mucin levels in response to a drying environment in subjects with dry eye disease as well as patients who report no history of dry eye disease.
- Trial name
- NCT05911555
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
Dry Eye Disease
A Study to Compare the Safety and Efficacy of A New Eye Drop Formulation With OPTIVE™ in Subjects With Dry Eye Disease
This study will evaluate the safety and efficacy of a carboxymethylcellulose based eye drop formulation compared with carboxymethylcellulose based preservative-free lubricant eye drops (OPTIVE™) in subjects with dry eye disease.
- Trial name
- NCT01664949
- Testing
- Carboxymethylcellulose Based Eye Drop Formulation A, Carboxymethylcellulose Based Preservative-Free Lubricant Eye Drops
- Where
- 12 sites in Australia, Belgium and 6 more
- Volunteers
- 460 people
- Sponsor
- Allergan
Ocular Inflammation, Keratoconjunctivitis
Tolerability Comparison of Flarex to Lotemax SM
This study compared the ocular tolerability of fluorometholone acetate ophthalmic suspension 0.1% (FLAREX) to loteprednol etabonate ophthalmic gel 0.38% (Lotemax SM) in adult subjects.
- Conditions
- Ocular Inflammation, Keratoconjunctivitis, Dry Eye Disease (DED), Post-operative Complications
- Trial name
- NCT07588074
- Testing
- Fluorometholone Acetate Ophthalmic Suspension 0.1%, Loteprednol Etabonate Ophthalmic Gel 0.38%
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Harrow Inc
Dry Eye Disease
A Study to Evaluate the Safety, Tolerability, and Efficacy of A197 in Subjects With Dry Eye Disease
The objectives of this trial are to assess the safety, tolerability and efficacy of A197 ophthalmic solution in comparison to a vehicle control in the treatment of subjects with Dry Eye Disease.
- Trial name
- NCT05238597
- Testing
- A197 Ophthalmic Solution, A197 Vehicle Control, Active Comparator
- Where
- 24 sites in United States
- Volunteers
- 207 people
- Sponsor
- Aramis Biosciences, Inc.