Clinical trials: Tear Film Deficiency
Dry Eye Disease
Study Evaluating the Safety and Efficacy of AR-15512
This will be a Phase 3, multicenter, vehicle-controlled, double-masked, randomized study conducted at approximately 20 sites in the United States. All subjects enrolled will have dry eye disease (DED).
- Trial name
- COMET-2 (NCT05285644)
- Testing
- 0.003% AR-15512 ophthalmic solution, AR-15512 vehicle ophthalmic solution
- Where
- 23 sites in United States
- Volunteers
- 465 people
- Sponsor
- Aerie Pharmaceuticals
Dry Eye Syndromes
Randomized Study of the Safety and Effectiveness of the TearCare System for the Signs and Symptoms of Dry Eye Disease
In this study, the TearCare System will be compared with standard-of-care warm compress treatment and lid massage in patients with dry eye disease.
- Trial name
- NCT03502447
- Testing
- TearCare, Warm Compress and Lid Massage
- Where
- 6 sites in United States
- Volunteers
- 14 people
- Sponsor
- Sight Sciences, Inc.
Healthy, Dry Eye
Punctal Plug Study to Determine the Safety and Retention Times of Various Lengths of Canalicular Stents in Volunteers
The purpose of this study was to determine the safety and retention times of two different lengths (10 mm and 20 mm) of the MINI MONOKA canicular stent when inserted in the eye for up to three months in subjects with or without…
- Trial name
- NCT00743249
- Testing
- MINI MONOKA canalicular stent, 10 mm, MINI MONOKA canalicular stent, 20 mm
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Keratoconjunctivitis Sicca
TearLab Core Validation Study to Establish Referent Values for Dry Eye Disease
This is a prospective, observational case series to determine the clinical utility of tear osmolarity and other commonly used objective tests to diagnose dry eye disease, as well as to establish referent values for objective…
- Trial name
- CVS (NCT00848198)
- Where
- 10 sites in United States, France and 3 more
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- TearLab Corporation
Dry Eye Syndromes, Keratoconjunctivitis Sicca
Safety and Efficacy of KPI-121 in Subjects With Dry Eye Disease
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease.
- Trial name
- STRIDE 1 (NCT02813265)
- Testing
- KPI-121 0.25% Ophthalmic Suspension, Vehicle of KPI-121 0.25% Ophthalmic Suspension
- Where
- 60 sites in United States
- Volunteers
- 918 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Dry Eye
Ocular Effects of Scleral Lens Wear on Dry Eye Patients
The purpose of this study is to investigate the effects of scleral contact lens wear on a DE population using coated (Hydra-PEG) and uncoated (control) lenses.
- Trial name
- NCT05079321
- Testing
- Hydra-PEG, Uncoated
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye Syndromes
A Prospective, Randomized, Placebo and Active Comparator Controlled Study of CP-690,550 in Subjects With Dry Eye.
A prospective, randomized, placebo and active comparator controlled study of CP-690,550 in subjects with dry eye.
- Trial name
- NCT00784719
- Testing
- CP-690,550, Cyclosporine, CP-690,550 Vehicle
- Where
- 27 sites in United States
- Volunteers
- 327 people
- Sponsor
- Pfizer
Dry Eye
Clinical Evaluation of Systane® Balance in Dry Eye Subjects
The purpose of this study is to evaluate the efficacy and safety of Systane® Balance following 90 days of QID (4 times/day) dosing among Indian subjects with dry eye.
- Trial name
- NCT02511379
- Testing
- Propylene Glycol 0.6% eye drops
- Volunteers
- 14 people
- Sponsor
- Alcon Research
Dry Eye Disease
A Study to Evaluate Efficacy and Safety of Lifitegrast in Subjects With Dry Eye (OPUS-3)
Evaluate the efficacy and safety of Lifitegrast in subjects with dry eye disease and a recent history of artificial tear use.
- Trial name
- OPUS-3 (NCT02284516)
- Testing
- Lifitegrast
- Where
- 41 sites in United States
- Volunteers
- 711 people
- Sponsor
- Shire
Dry Eye
Digital Device Users Who Are Treated With Systane Hydration PF
Systane Hydration PF is a recently released preservative-free artificial tear that is able to supplement the ocular surface's moisture while simultaneously soothing the eye.
- Trial name
- NCT04837807
- Testing
- Systane Hydration PF
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kerato Conjunctivitis Sicca
Safety and Efficacy of KPI-121 in Subjects With DED
The primary purpose of this study is to determine the efficacy and safety of KPI-121 0.25% ophthalmic suspension compared to vehicle (placebo) in subjects who have a documented clinical diagnosis of dry eye disease.
- Trial name
- STRIDE 3 (NCT03616899)
- Testing
- KPI-121 Ophthalmic Suspension, Vehicle
- Where
- 81 sites in United States
- Volunteers
- 901 people
- Sponsor
- Kala Pharmaceuticals, Inc.
Dry Eye, Dry Eye Syndromes
Tangible Hydra-PEG: A Promising Solution for Scleral Lens Wearers With Dry Eye
Tangible Hydra-PEG is a novel coating technology designed to improve lens wettability, deposit resistance, and tear film breakup time.
- Trial name
- NCT03417505
- Testing
- Scleral lenses treated with Tangible Hydra-PEG, Untreated scleral lenses
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Tangible Science
Dry Eye
Study to Evaluate a Contact Lens Lubricating and Rewetting Drop
The objective of this study is to evaluate the product performance of investigational lubricating and rewetting drops.
- Trial name
- NCT01267656
- Testing
- Lubricating and Rewetting Drops, AMO Blink Contacts Lubricant Eye Drops
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Bausch & Lomb Incorporated
Contact Lens Discomfort, Dry Eye Disease
Pilot Study for Investigating the Effect of the Bruder Eye Hydrating Compress on Contact Lens Discomfort in Contact Lens Wearers
The purpose of this prospective study is to evaluate the benefits of using the Bruder Moist Heat Compress in contact lens wearers who report reduced comfortable wear time.
- Conditions
- Contact Lens Discomfort, Dry Eye Disease, Meibomian Gland Dysfunction
- Trial name
- NCT02848222
- Testing
- Bruder Moist Heat Compress, Washcloth
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye, Contact Lens Complication
Direct Application of Systane Complete to Contact Lenses
A common first line treatment for patients with dryness symptoms or contact lens discomfort is the application of artificial tears or rewetting drops, respectively.
- Trial name
- NCT03848221
- Testing
- Systane Complete, Sensitive Eyes Rewetting Drops
- Where
- 3 sites in United States
- Volunteers
- 73 people
- Sponsor
- University of Alabama at Birmingham
Dry Eye Syndromes
Comparison of the Efficacy and Safety of T2750 and Vismed® in the Treatment of Moderate to Severe Dry Eye Syndrome
Comparison of the efficacy and safety of T2750 and Vismed® in the treatment of moderate to severe Dry Eye Syndrome
- Trial name
- NCT01568593
- Testing
- T2750, Vismed
- Where
- France
- Volunteers
- 93 people
- Sponsor
- Laboratoires Thea
Dry Eye Disease
Safety and Efficacy of an Ophthalmic Solution in Dry Eye Disease
The purpose of this study is to investigate the safety and efficacy of an ophthalmic solution in dry eye disease.
- Trial name
- NCT00758784
- Testing
- bromfenac ophthalmic solution 0.06%
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Bausch & Lomb Incorporated
Sjogren's Syndrome
Pilot Study of Raptiva to Treat Sjogren's Syndrome
This study will examine the effect of the drug Raptiva (efalizumab) in patients with Sjögren's syndrome (SS), an autoimmune disease affecting the glands producing saliva \& tears.
- Trial name
- NCT00344448
- Testing
- Raptiva
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Dry Eye, Kerato Conjunctivitis Sicca
A Study Evaluating the Safety of the Nasal Pump
The objective of this study is to determine the safety of the Tyrvaya nasal pump.
- Trial name
- NCT06329687
- Testing
- Tyrvaya Nasal Pump
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Oyster Point Pharma, Inc.
Evaporative Dry Eye
Comparison of Tear Evaporation Rate With Systane Complete in Dry Eye and Non-Dry Eye
The objective of the study is to compare the rate of tear evaporation, measured with a novel evaporimeter, before and for one hour after an eye drop containing nano-sized oil droplets has been instilled.
- Trial name
- BULLDOG (NCT04091581)
- Testing
- Systane Complete
- Where
- Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Waterloo