Clinical trials: Teenagers
Covid19
Phase 1 Study of Intranasal PIV5 COVID-19 Vaccine Expressing SARS-CoV-2 Spike Protein in Healthy Adults and Adolescents
This Phase 1 trial is an open-label trial to evaluate the safety, reactogenicity and immunogenicity of two dosages (10^6 PFU and 10^7 PFU) of intranasal CVXGA1 administered as a single dose in healthy adults age 18-55 years and…
- Trial name
- CVXGA1-001 (NCT04954287)
- Testing
- CVXGA1 low dose, CVXGA1 high dose
- Where
- 4 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- CyanVac LLC
Non-celiac Gluten Sensitivity; Adolescents
Non Celiac Gluten Sensitivity, DBPCFC in Adolescents
In a population based on healthy adolescents we will conduct a double blind placebo controlled food challenge (DBPCFC) with cross-over to identify patients with NCGS as recommended by the socalled Salerno criteria.
- Trial name
- NCT04639921
- Testing
- positive test followed by gluten-free diet
- Where
- Denmark
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Adolescent Idiopathic Scoliosis
Impact of Long-Term Schroth Exercises on Scoliosis Severity and Quality of Life in Braced AIS Individuals
Adolescent Idiopathic Scoliosis (AIS) affects individuals aged 10 to 18, leading to spinal deformity and vertebral rotation. The Schroth exercise method, combined with brace usage, has shown promise in reducing the Cobb angle and…
- Trial name
- NCT06500806
- Testing
- Scroth and brace, Brace
- Where
- Greece
- Volunteers
- 80 people
- Sponsor
- International Hellenic University
Fragile X Syndrome
Open Label Extension to Assess the Long-Term Safety and Tolerability of ZYN002 in Children and Adolescents With FXS
ZYN002 is a pharmaceutically manufactured Cannabidiol that is developed as a clear gel that can be applied to the skin (called transdermal delivery).
- Trial name
- NCT03802799
- Testing
- ZYN002 - Cannabidiol Transdermal Gel
- Where
- 26 sites in United States, Australia and 2 more
- Volunteers
- 476 people
- Sponsor
- Zynerba Pharmaceuticals, Inc.
Influenza
Safety and Efficacy Study of Nitazoxanide in the Treatment of Acute Uncomplicated Influenza
This is a randomized clinical trial designed to evaluate the safety/efficacy of two dosing regimens of oral nitazoxanide compared to placebo in the treatment of acute uncomplicated influenza in adults and adolescents.
- Trial name
- NCT01227421
- Testing
- Nitazoxanide
- Where
- United States
- Volunteers
- 624 people
- Sponsor
- Romark Laboratories L.C.
Depression Anxiety Disorder, Psychological Distress
Evaluating the Effectiveness of a School-based Stepped Care Treatment Model for Adolescent Depression in Pakistan
This study aims to test the effectiveness of a stepped-care model to reduce depressive symptoms in adolescents in school settings in Pakistan.
- Conditions
- Depression Anxiety Disorder, Psychological Distress, Well-Being, Psychological
- Trial name
- SMART-STEP (NCT07399314)
- Testing
- Universal Intervention & CBT-based Guided Self-Help Application
- Where
- Pakistan
- Volunteers
- 600 people
- Sponsor
- Global Institute of Human Development
Physical Fitness, Body Image
School-based Multicomponent Intervention on Physical Fitness Related to Health and Body Image
The main purpose of this study is to analyse the effect of a multicomponent intervention, applied during one scholar semester, on body composition, strength, flexibility, cardiorespiratory fitness, lipid and metabolic profile…
- Trial name
- NCT02719704
- Testing
- "MEXA-SE", "Espelho, espelho meu"
- Where
- Brazil
- Volunteers
- 568 people, healthy volunteers welcome
- Sponsor
- Santa Catarina Federal University
Obesity, Childhood
Exercise and Baseline Respiratory Functional Tests Among Obese Teenagers
In obese adolescents, the severity of obesity should not influence the outcome of resting PFT. The amplitudes of the rest PFT should make it possible to predict the performance achieved while exercising on a cycloergometer.
- Trial name
- EFRADO (NCT03675867)
- Testing
- Correlation between resting respiratory parameters and cardio-respiratory parameters at exercise
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hypertension
Factors Associated With Pre-hypertension Among Children With Type 1 Diabetes Mellitus
blood pressure of diabetic patients will be measured
- Trial name
- NCT07172399
- Testing
- blood sampling, • BP will be measured using a calibrated, automated oscillometric device suitable for pediatric use.
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Meningococcal Disease, Meningococcal Meningitis
A Study to Evaluate the Persistence and Immune Response to a Booster Dose of MenACWY
The primary objective is to evaluate the persistence of bactericidal antibodies in adolescent subjects who completed study V59P6 in which they received either Novartis Meningococcal (MenACWY) Conjugate Vaccine or Licensed…
- Trial name
- NCT01018732
- Testing
- Novartis Meningococcal (MenACWY-CRM) vaccine
- Where
- 3 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Scoliosis; Adolescence, Scoliosis Idiopathic
End Growth Results for Conservative Treatment for Idiopahitc Scoliosis
This study evaluates in a prospectively collected multicenter cohort the existence, characteristics and determinants of EBPCA, the obtained results and their determinant, the rate of over- and under-treatment and their…
- Trial name
- NCT03843216
- Testing
- observation, Physiotherapic scoliosis specific exercise, brace
- Where
- Italy
- Volunteers
- 1,938 people
- Sponsor
- Istituto Scientifico Italiano Colonna Vertebrale
Substance Use Disorders
An Intervention to Promote Healthy Behaviors in Homeless Youth
Investigators will use a Solomon 4-group design to test the effectiveness of a brief intervention to promote health behaviors for homeless youth who are 18-23 years of age.
- Trial name
- NCT02553616
- Testing
- Intervention to Promote Healthy Behaviors
- Where
- United States
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Herpes Simplex
Safety Study of Herpes Simplex Vaccine in HSV Seronegative and Seropositive Females Between 10 and 17 Years Old
Main goal of this study is to compare the occurrence of serious adverse events (SAEs) between the herpes simplex (gD2-AS04) vaccine group and the Saline control group throughout the study period (up to month 12).
- Trial name
- NCT00224484
- Testing
- GSK208141, Havrix (investigational formulation)
- Where
- 151 sites in United States, Australia and 16 more
- Volunteers
- 5,960 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Childhood-onset Growth Hormone Deficiency, Pituitary Dwarfism
Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency
The primary objective is to evaluate the efficacy and safety of two different dose regimens of r-hGH (Saizen®) in subjects with childhood-onset growth hormone deficiency (COGHD) during the transition phase from childhood to…
- Trial name
- NCT00109733
- Testing
- recombinant human growth hormone
- Where
- 9 sites in United States
- Volunteers
- 31 people
- Sponsor
- EMD Serono
Asthma
Using Question Prompt Lists During Pediatric Asthma Visits to Increase Adolescent Involvement
The purpose of this study is to conduct a randomized controlled trial with English and Spanish-speaking adolescents to compare the effectiveness of an adolescent "asthma question prompt list" with a supportive educational video…
- Trial name
- NCT02498834
- Testing
- Educational Video and Question Prompt List
- Where
- United States
- Volunteers
- 359 people
- Sponsor
- University of North Carolina, Chapel Hill
Adolescent Idiopathic Scoliosis, Spinal Fusion
Active Video Game-Based Exercise Training and Stability Training After AIS Surgery
The purpose of this clinical trial is to investigate the effects of "Active Video-Based Exercises (AVTE) on postural control and balance in comparison with stabilization exercises is (AIS) after Posterior Spinal Fusion (PSF)…
- Trial name
- NCT06498232
- Testing
- Active Video Based Exercises, Stabilization and Strengthening Exercises, Waiting List-Spine protection principles training
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Istanbul University - Cerrahpasa
Insomnia, Depression
Digital Mood-enhanced CBT-I to Improve Depressive Symptoms in Adolescents
Emerging encouraging evidence showed that sleep focused treatment can simultaneously improve sleep and depression in adult with comorbid conditions.
- Conditions
- Insomnia, Depression, Adolescent
- Trial name
- NCT06358898
- Testing
- Standard dCBT-I, Modified Mood enhanced CBT-I (M-dCBT-I)
- Where
- Hong Kong
- Volunteers
- 343 people
- Sponsor
- Chinese University of Hong Kong
Attention Deficit Hyperactivity Disorder
Skills Training for Adolescents With ADHD
The proposed study will be an initial test of a cognitive-behavioral intervention for adolescents with ADHD who are receiving medication treatment.
- Trial name
- NCT01019252
- Testing
- Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Massachusetts General Hospital
Migraine Disorders
Long-Term Safety of Treximet (Sumatriptan/Naproxen Sodium) for Migraine in Adolescents
This study was designed to determine long-term safety of TREXIMET (sumatriptan/naproxen sodium) in adolescents for the acute treatment of migraine.
- Trial name
- NCT00488514
- Testing
- Combination Tablet of Treximet (sumatriptan/naproxen sodium)
- Where
- 77 sites in United States
- Volunteers
- 656 people
- Sponsor
- GlaxoSmithKline
HIV Infections
Dolutegravir Study in HIV-1 Participants Completing IMPAACT Studies P1093 and P2019
Dolutegravir is a potent integrase strand transfer inhibitor. Abacavir/dolutegravir/lamivudine (ABC/DTG/3TC) is a fixed dose combination regimen containing two nucleoside reverse transcriptase inhibitors and dolutegravir.
- Trial name
- NCT03016533
- Testing
- Dolutegravir film-coated tablets, Dolutegravir film-coated dispersible tablets, ABC/DTG/3TC immediate release tablets
- Where
- 17 sites in United States, Botswana and 5 more
- Volunteers
- 100 people
- Sponsor
- ViiV Healthcare
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