Clinical trials: Temporal Interference Stimulation, active
Autism Spectrum Disorder
Transcranial Temporal Interference Stimulation for Children With Autism Spectrum Disorders
The goal of this single-blinded, randomized controlled trial is to assess the safety, tolerability, and feasibility of tTIS for children with ASD.
- Trial name
- NCT07625748
- Testing
- transcranial Temporal Interference Stimulation
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Major Depressive Disorder
The Efficacy and Safety of Task-state-based Temporal Interference Stimulation (TI) in the Treatment of Patients With Depression
This study intends to investigate the intervention efficacy of temporal interference stimulation (TI) on mood symptoms in depressed patients, as well as to explore the neuroimaging mechanisms of TI improvement in depressed…
- Trial name
- NCT06826469
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 43 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Deep Brain Stimulation, Drug Resistant Epilepsy
Evaluating Modulation Effects of Temporal Interference Using SEEG
This single-center prospective study aims to investigate the electrophysiological mechanisms of temporal interference (TI) in humans by analyzing clinical, imaging, and electrophysiological data from patients aged 14-60 with…
- Trial name
- NCT06663969
- Testing
- Temporal Interference
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xuanwu Hospital, Beijing
Healthy Controls
Temporal Interference Stimulation for Social Cognition
The long-term goal of this project is to evaluate whether a procedure termed transcranial interference stimulation (tIS) may be useful in the future in the treatment of severe neuropsychiatric disorders such as schizophrenia.
- Trial name
- TISSC (NCT06607432)
- Testing
- Transcranial Interference Stimulation (tIS)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Columbia University
Temporal Interference Stimulation (TIS), Parkinson's Disease
Study on the Efficacy of Temporal Interference Stimulation (TIS) for Parkinson's Disease
The primary objective of this clinical study is to evaluate the therapeutic efficacy of Temporal Interference Stimulation (TIS), a non-invasive deep brain stimulation technique, in patients with Parkinson's disease, and to…
- Trial name
- NCT07312279
- Testing
- TIS
- Volunteers
- 24 people
- Sponsor
- Zhongnan Hospital
Epilepsy
Multi-Parameter Temporal Interference Stimulation in Patients With Epilepsy Undergoing SEEG Monitoring
This prospective exploratory interventional study aims to investigate the neurophysiological effects and safety of multi-parameter temporal interference (TI) stimulation in patients undergoing stereoelectroencephalography (SEEG)…
- Trial name
- NCT07790224
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Beijing Sanbo Brain Hospital
Temporal Interference Stimulation, Non Suicidal Self Injury
TIS for NSSI in Adolescent Depression
Temporal Interference Stimulation (TIS) has been successfully used to help patients with depression. However, its role in alleviating self injuries remained uncertain.
- Conditions
- Temporal Interference Stimulation, Non Suicidal Self Injury, Major Depressive Disorder
- Trial name
- NCT07554755
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The Second Hospital of Anhui Medical University
Negative Affectivity, Non-invasive Brain Stimulation
Neural Mechanisms of Interpersonal Expectations on Negative Affect
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shaped by care providers influence…
- Conditions
- Negative Affectivity, Non-invasive Brain Stimulation, Placebo Effect, Expectations
- Trial name
- NCT06980090
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Trustees of Dartmouth College
PARKINSON DISEASE (Disorder), Motor Symptoms
Remotely Supervised Home-based Transcranial Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
The goal of this clinical trial is to learn if home-based temporal interference stimulation (TIS) works to improve motor symptoms in people with Parkinson's disease (PD). It will also learn about the safety of this treatment.
- Trial name
- NCT07518290
- Testing
- Home-based Transcranial Temporal Interference Stimulation (HB-TIS)
- Where
- 2 sites in China
- Volunteers
- 98 people
- Sponsor
- Shanghai University of Sport
Epilepsy
TIS for Drug Resistant TLE
Temporal interference (TI) stimulation is a new neuromodulation method. Compared with traditional neuromodulation therapy, TI has deep targeting and focusing, and it has been confirmed to modulate sleep, cognition, and movement…
- Trial name
- TITE-Effect (NCT07519018)
- Testing
- TI Stimulation
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Traumatic Brain Injury
Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury
Impairments in spatial memory and spatial navigation are commonly reported amongst patients presenting post-traumatic brain injury (TBI).
- Trial name
- NCT07271524
- Testing
- Transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Friedhelm Hummel
Stroke, Stroke Assessment
Non-Invasive Deep Brain Stimulation for Upper Limb Recovery After Stroke (NIMBUS)
NIMBUS is a clinical study evaluating a new, non-invasive brain stimulation treatment to improve arm and hand function in people with long-term effects of stroke.
- Trial name
- NIMBUS (NCT07792811)
- Testing
- Non-invasive transcranial Temporal Interference Stimulation (iTBS-tTIS Striatum), Concurrent Intensive Motor Rehabilitation
- Where
- Switzerland
- Volunteers
- 84 people
- Sponsor
- Friedhelm Hummel
Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy
Overnight TI in TLE
The goal of this clinical trial is to gauge whether overnight, non-invasive temporal interference (TI) stimulation aimed at the hippocampus can reduce abnormal brain activity linked to seizures and improve sleep in adults with…
- Conditions
- Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy, Sleep
- Trial name
- TI-HPC-TLE (NCT07434986)
- Testing
- Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Obsessive - Compulsive Disorder
Efficacy and Mechanism of Transcranial Temporal Interference Stimulation (tTIS) for Patients With Obsessive-Compulsive Disorders
Targeted temporal interference stimulation (tTIS) of the nucleus accumbens (NAc) may modulate the abnormal electrophysiological activity in individuals with obsessive-compulsive disorder (OCD), thereby improving their…
- Trial name
- NCT07805200
- Testing
- Transcranial Temporal Interference Stimulation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Beijing HuiLongGuan Hospital
Deglutition Disorders, Ischemic Stroke
Dentate-Targeted Temporal Interference Stimulation for Post-Stroke Dysphagia
The goal of this clinical trial is to learn whether individualized transcranial temporal interference stimulation can improve swallowing in adults with swallowing difficulties after an ischemic stroke.
- Trial name
- DENTIS-PSD (NCT07766668)
- Testing
- Active Transcranial Temporal Interference Stimulation, Standardized Task-Specific Swallowing Rehabilitation
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Zhejiang University
Adolescent, Depression - Major Depressive Disorder
Efficacy and Mechanism of Transcranial Temporal Interference Stimulation (tTIS) in the Treatment of Adolescent Depression
This trial is a single-center, single-blind, randomized, sham-stimulation controlled clinical trial. The primary objective of the trial is to detect the targeted effect of tTIS on the nucleus accumbens of adolescent depression…
- Trial name
- NCT06902064
- Testing
- Transcranial temporal interference stimulation
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital
Young Healthy Adults
Investigating the Mechanisms of Decision-Making Using Non-Invasive Brain Stimulation
This study aims to investigate which of two brain regions is important for which decision-making strategy. The investigators suppose that one brain region - the *striatum* - is important for repeatedly choosing objects that have…
- Trial name
- StimMaps_YH (NCT07749378)
- Testing
- Hippocampal intermittent-theta burst stimulation, Striatal intermittent-theta burst stimulation, High-frequency control stimulation with striatal electrode set-up
- Where
- Germany
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Wuerzburg University Hospital
Parkinson's Disease, Movement Disorders
Effects of Targeted Temporal Interference Stimulation of Cerebellar Nuclei on Tremor and Gait Disturbance in Parkinson's Disease Patients
The goal of this clinical trial is to explore the effects of cerebellar nuclei TIS stimulation on improving tremor and gait disorders in PD patients.
- Trial name
- NCT07384442
- Testing
- Real Temporal Interference Stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- YangPan
Mild Cognitive Impairment (MCI)
Effects of Transcranial Temporal Interference Stimulation on Cognitive Function in Mild Cognitive Impairment
To explore the effects of transcranial temporal interference stimulation (tTIS) on cognitive function and dual-task walking performance, as well as its underlying neuroimaging mechanisms, in individuals with mild cognitive…
- Trial name
- TIS-MCI (NCT07519798)
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai University of Sport
Obsessive-Compulsive Disorder (OCD)
The Efficacy of Temporal Interference Stimulation in the Treatment of Obsessive-Compulsive Disorder
This study aims to evaluate the efficacy of Temporal Interference (TI) stimulation in treating patients with obsessive-compulsive disorder (OCD) and to explore its potential neural mechanisms using magnetic resonance imaging…
- Trial name
- NCT07113652
- Testing
- TI stimulation device (nerviox-1000）
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center