Clinical trials: Terminal Malignant Tumors
NUT Midline Carcinoma, Triple Negative Breast Cancer
A Dose-Finding Study of Birabresib (MK-8628), a Small Molecule Inhibitor of the Bromodomain and Extra-Terminal (BET) Proteins, in Adults With Selected Advanced Solid Tumors (MK-8628-003)
Open-label, phase I, non-randomized, multicentric study of single-agent birabresib (MK-8628) (formerly known as OTX015) administered according to two distinct regimens to participants with selected advanced tumors.
- Conditions
- NUT Midline Carcinoma, Triple Negative Breast Cancer, Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation, Castrate-resistant Prostate Cancer
- Trial name
- NCT02259114
- Testing
- Birabresib
- Volunteers
- 47 people
- Sponsor
- Oncoethix GmbH, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Solid Tumors
Open-Label Safety and Tolerability Study of INCB057643 in Subjects With Advanced Malignancies
The purpose of the Study is to select a dose and assess the safety and tolerability of INCB057643 as a monotherapy (Part 1 and Part 2) and in combination with standard-of-care (SOC) agents (Part 3 and Part 4) for subjects with…
- Trial name
- NCT02711137
- Testing
- INCB057643, Gemcitabine, Paclitaxel
- Where
- 18 sites in United States, Belgium and 1 more
- Volunteers
- 137 people
- Sponsor
- Incyte Corporation
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Measuring the Impact of MANNA s Medically Tailored Meal Program in Patients With a Non-terminal Cancer Diagnosis
This study identifies patient-important outcome measures and develops a survey that assesses the impact of nutritional interventions among cancer patients.
- Trial name
- NCT05118802
- Testing
- Interview, Survey Administration
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Distress, Malignant Neoplasm
Ringing a Bell on the Final Day of Radiation Therapy in Improving the Memory of Distress in Cancer Patients
This clinical trial studies how well ringing a bell on the final day of radiation therapy works in improving the memory of distress in cancer patients.
- Trial name
- NCT02970617
- Testing
- Memory Intervention, Questionnaire Administration
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- University of Southern California
Peripheral Nerve Tumors
Study of CPI-0610 in Patients With Malignant Peripheral Nerve Sheath Tumors
Establish safety and toxicity profile and preliminary response rate of CPI-0610 in MPNST patients and correlate response with pharmacodynamics markers and BET inhibition.
- Trial name
- NCT02986919
- Testing
- CPI-0610
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Breast Cancer, Pancreatic Cancer
OMT-111 for Terminal Stage Solid Tumors
Patients with terminal stage of metastatic non-small cell lung cancer, metastatic triple negative breast cancer, or advanced or metastatic pancreatic adenocarcinoma resisting to standard therapies.
- Conditions
- Breast Cancer, Pancreatic Cancer, Lung Cancer
- Trial name
- NCT04520386
- Testing
- OMT-111
- Where
- 2 sites in Vietnam
- Volunteers
- 78 people
- Sponsor
- MetiMedi Pharmaceuticals