Clinical trials: Termination of Pregnancy
Threatened Abortion in First Trimester
Progesterone in Threatened Abortion
The main objective of this study will be to assess the efficacy of natural progesterone at a daily dose of 25 mg/bid in the maintenance of early pregnancy in women with symptoms of threatened abortion.
- Trial name
- NCT02950935
- Testing
- Progesterone
- Where
- 4 sites in Italy
- Volunteers
- 4 people
- Sponsor
- IBSA Institut Biochimique SA
Cervical Incompetence
Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC)
The investigator aimed to compare the effect of anesthesia on overall postoperative outcomes including post-operative pain score and the fetal well-being (heart rate) in patients undergoing transabdominal cervico isthmic…
- Trial name
- NCT03636048
- Testing
- Bupivacaine Hcl 0.5% Inj, Propofol 10 milligram/ML
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Infertility, Miscarriage
Ism1 Versus EmbryoGen Media for Embryo Culture in Previous Pregnancy Loss Cases
Recently, it has been suggested that culture of embryos in EmbryoGen medium can increase the live birth rate in IVF patients with a previous history of pregnancy loss.
- Trial name
- NCT01689428
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Biogenesi
Medical Abortion
The Acceptability and Feasibility of an Alternative to Routine Follow-up Visit After Medical Abortion in Vietnam
This trial will compare the efficacy and acceptability of post-medical abortion follow-up by assigning women to either 1) alternative follow-up via routine semi-quantitative pregnancy test and a self-administered follow-up…
- Trial name
- NCT01150422
- Testing
- Alternative follow-up
- Where
- 4 sites in Vietnam
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy
Effectiveness of Two Regimens of Misoprostol Alone for Early Pregnancy Termination and Use of SQPT for At-Home Follow-Up
This randomized trial will compare the rates of ongoing pregnancy, safety/side effects and acceptability of two medical abortion regimens that are commonly used in Latin America.
- Trial name
- NCT02299401
- Testing
- Misoprostol, Semi-quantitative pregnancy test
- Where
- 2 sites in Bolivia, Ecuador
- Volunteers
- 401 people
- Sponsor
- Gynuity Health Projects
Missed Abortion
Comparative Study Between Combined Vaginal Misoprostol
"Comparative study between Combined Vaginal Misoprostol with Isosorbide-5-Mononitrate
- Trial name
- comparative (NCT04981457)
- Testing
- Misoprostol and iso sorbide mononitrates
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Antiphospholipid Syndrome, Recurrent Miscarriage
A Study of Hydroxychloroquine Sulfate in the Treatment of Recurrent Spontaneous Abortion With Antiphospholipid Syndrome
The efficacy of low-dose aspirin combined with low-molecular-weight heparin treatment for improving antiphospholipid syndrome and maternal-fetal outcome of patients is recognized by various countries and recommended by the…
- Trial name
- NCT04624269
- Testing
- Hydroxychloroquine Sulfate Tablets
- Where
- China
- Volunteers
- 384 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Miscarriage, Pregnancy Loss
Cost-utility Analysis of Outpatient Manual Vacuum Aspiration Versus Operating Room Electric Aspiration for the Management of First-trimester Miscarriage
The ASPIR study aims to evaluate the cost-utility of outpatient manual vacuum aspiration compared with operating room electric aspiration for the management of first-trimester miscarriage.
- Conditions
- Miscarriage, Pregnancy Loss, First Trimester Pregnancy
- Trial name
- ASPIR (NCT07732231)
- Testing
- Manual vacuum aspiration (MVA), Electric aspiration (EA)
- Where
- France
- Volunteers
- 860 people
- Sponsor
- Nantes University Hospital
Placenta, Retained, Postpartum Hemorrhage
Optimisation of the Management of Placental Delivery in Second Trimester Pregnancy Interruption
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness.
- Trial name
- NCT00120042
- Testing
- Misoprostol, Oxytocin
- Where
- Australia
- Volunteers
- 251 people
- Sponsor
- The University of Western Australia
Artificial Abortion, PONV(Post Operative Nausea and Vomiting)
The Time Point of Carboprost Methylate Administration and Perioperative Complications
Artificial abortion is the most widely used procedure in termination of first-trimester pregnancy. Cervical ripening before the operation guarantees operative convenience and decreases complications.
- Trial name
- NCT05834361
- Testing
- early vaginal administration of carboprost methylate, delayed vaginal administration of carboprost methylate
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Helicobacter Pylori Infection, Susceptibility to
Helicobacter Pylori Infection Among Women With Recurrent Abortion of Unknown Cause
Helicobacter pylori (H. pylori) infection affects approximately one half of the world population and it is more prevalent in developing countries. This microorganism colonizes the stomach.
- Trial name
- NCT07293169
- Testing
- H pylori eradication
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Fertility
Fast-release Orodispersible Tramadol as Analgesia in Termination of Pregnancy by Vacuum Aspiration.
If a termination of pregnancy procedure is performed by vacuum aspiration our patients receive a paracervical block. Nevertheless these patients are not free of pain.
- Trial name
- NCT02416141
- Testing
- fast release oro dispersible tramadol 50 mg
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Medical Abortion
'No-test' Tele-abortion: a Multi-centre Randomised Controlled Trial
Brief Summary The goal of this clinical trial is to learn whether a no-test telemedicine medical abortion model can provide abortion care that is as effective and safe as standard clinic-based medical abortion care among women…
- Trial name
- OPTIMISE (NCT07868991)
- Testing
- no-test medical abortion, Standard Care (in control arm)
- Where
- 10 sites in Sweden
- Volunteers
- 978 people
- Sponsor
- Karolinska Institutet
Abortion Seekers
Mifepristone at Same Time Multicenter Study
This is a multicenter, randomized study. 564 healthy women, age 18 years or older, with an intrauterine pregnancy, and requesting a medical abortion, will be recruited to participate in this prospective clinical trial.
- Trial name
- MAST (NCT00269568)
- Testing
- mifepristone and misoprostol
- Where
- 4 sites in United States
- Volunteers
- 1,128 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Hemorrhage
Uterotonic Prophylaxis Trial
Excessive bleeding after dilation and evacuation (D\&E) requiring interventions is common, occurring in approximately 30% of cases at one large abortion-providing clinic.
- Trial name
- UPT (NCT02408965)
- Testing
- Methergine
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Abortion, Spontaneous, Abortion, Habitual
RPL: Interval to Live Birth and Adverse Perinatal Outcomes
This will be a retrospective observational cohort study utilizing the data from the British Columbia Perinatal Data Registry (BCPDR).
- Conditions
- Abortion, Spontaneous, Abortion, Habitual, Birth Intervals, Pregnancy Loss
- Trial name
- NCT04360564
- Testing
- Recurrent pregnancy loss
- Where
- Canada
- Volunteers
- 140,000 people, healthy volunteers welcome
- Sponsor
- Children's & Women's Health Centre of British Columbia
Miscarriage, Recurrent
Unexplained Recurrent Pregnancy Loss: New Therapeutic Perspectives
Evaluation of gut permeability and endometrial inflammasome NLRP3 in women with unexplaid recurrent pregnancy loss before-after administration of Bifidobacteriumlongum ES1.
- Trial name
- NCT06867900
- Testing
- Bifidobacterium Longum ES1
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Abortion
Voluntary Interruption of Pregnancy on Women's Sexuality
The impact on sexuality has been less studied and there is no French study on this subject and the rare studies are contradictory.
- Trial name
- VTOPSimpact (NCT05688228)
- Testing
- questionnaire
- Where
- France
- Volunteers
- 209 people
- Sponsor
- University Hospital, Bordeaux
Medical Abortion
Routine Follow-up Versus Self-assessment in Medical Abortion
The main objective of the study is to optimize the routines for follow-up after medical abortion in order to give women more autonomy by reducing the number of consultations involved and to reduce the frequency of postabortal…
- Trial name
- NCT01487213
- Testing
- Home self assessment of complete medical abortion
- Where
- 4 sites in Austria, Finland and 2 more
- Volunteers
- 929 people
- Sponsor
- Karolinska Institutet
Abortion, Induced
Mifepristone Plus Misoprostol Versus Misoprostol Alone for 2nd Trimester Abortion (14 - 21 Weeks Last Menstrual Period (LMP))
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00969982
- Testing
- mifepristone+misoprostol
- Where
- 2 sites in Moldova, Tunisia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects