Clinical trials: Testicular
Cancer
Genetic Susceptibility and Risk of Second Cancers in Patients Who Have Undergone Stem Cell Transplant for Cancer
RATIONALE: Identifying genes that increase a person's susceptibility to second cancers may help the study of cancer treatment. PURPOSE: This study is looking at genetic susceptibility and risk of second cancers in patients who…
- Trial name
- NCT00949052
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Testes Undescend
Safety and Efficiency of Laparoscopic Management of Intra-canalicular (Emergent) Testis
Undescended testes (UDTs) are a relatively common finding in pediatrics with prevalence about 1-2% in newborns. Upon discovering a non-intrascrotal testis, it is important to determine whether the testis is palpable or…
- Trial name
- LapUDT (NCT04821167)
- Testing
- laparoscopic orchiopexy for intra-canalicular testis
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- dr. Muhammad Abdelhafez Mahmoud, MD
Undescended Testis
Comparison of Single Incision Scrotal vs Standard Two Incision Inguinal Orchidopexy in Children Under 10 Years.
This study compares the outcome of single incision scrotal orchidopexy with standard two incision inguinal orchidopexy in children under 10 years of age presented with palpable undesended tesis.The aim is to evaluate operative…
- Trial name
- NCT07233265
- Testing
- Single scrotal incision orchidopexy, Standard two incision inguinal orchidopexy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Children Hospital Faisalabad
Germ Cell Tumor, Testis Cancer
Study of the Hypomethylating Drug Guadecitabine (SGI-110) Plus Cisplatin in Relapsed Refractory Germ Cell Tumors
This is an open-label, single arm, Phase I dose escalation study in subjects with refractory germ cell tumor (rGCT). This phase I will evaluate the safety and efficacy of SGI-110 in combination with cisplatin in subjects with…
- Conditions
- Germ Cell Tumor, Testis Cancer, Testicular Cancer
- Trial name
- NCT02429466
- Testing
- Guadecitabine (SGI-110)
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Nasser Hanna
Malignant Testicular Germ Cell Tumor
MAGESTIC Trial: MiRNA in Detecting Active Germ Cell Tumors in Early Suspected and MetastaTIC Disease Trial
This study evaluates the accuracy of blood-based biomarker testing to predict the presence of active testicular cancer.
- Trial name
- NCT06060873
- Testing
- Clinical Stage I Disease, Clinical Stage I with relapse, CSII Disease
- Where
- 7 sites in United States, Canada
- Volunteers
- 418 people
- Sponsor
- University of Southern California
Testicular Neoplasm
Whole Body MRI With DWI for Monitoring Patients Treated for Testicular Cancer Stage II-III
Testicular cancer (TC) affects approx. 1% of Danish men and is the most common cancer in men aged 15-35 years. It is the most curable solid cancer type with a 5-year survival rate of 90-95%.
- Trial name
- TENY (NCT03436901)
- Testing
- MRI with DWI vs CT
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Aarhus University Hospital
Breast Cancer, Chronic Myeloproliferative Disorders
Alemtuzumab and Glucocorticoids in Treating Newly Diagnosed Acute Graft-Versus-Host Disease in Patients Who Have Undergone a Donor Stem Cell Transplant
RATIONALE: Alemtuzumab and glucocorticoids, such as prednisone or methylprednisolone, may be an effective treatment for acute graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00410657
- Testing
- alemtuzumab, methylprednisolone, prednisone
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Breast Cancer, Chronic Myeloproliferative Disorders
Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation
RATIONALE: Antifungals such as ravuconazole may be effective in preventing fungal infections in patients undergoing chemotherapy and stem cell transplantation.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Infection
- Trial name
- NCT00064311
- Testing
- ravuconazole
- Where
- United States
- Sponsor
- National Institutes of Health Clinical Center (CC)
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
Methoxyamine and Fludarabine Phosphate in Treating Patients With Relapsed or Refractory Hematologic Malignancies
This phase I trial is studying the side effects and best dose of methoxyamine when given together with fludarabine phosphate in treating patients with relapsed or refractory hematologic malignancies.
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma
- Trial name
- NCT01658319
- Testing
- fludarabine phosphate, methoxyamine, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma
RATIONALE: MS-275 may stop the growth of cancer cells by blocking the enzymes necessary for their growth. PURPOSE: This phase I trial is studying the side effects and best dose of MS-275 in treating patients with advanced solid…
- Trial name
- NCT00020579
- Testing
- entinostat
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Lymphadenopathy, Stage I Testicular Seminoma
Retroperitoneal Lymph Node Dissection in Treating Patients With Testicular Seminoma
This phase II trial studies how well retroperitoneal lymph node dissection (RPLND) works in treating patients with stage I-IIa testicular seminoma.
- Conditions
- Lymphadenopathy, Stage I Testicular Seminoma, Stage II Testicular Seminoma
- Trial name
- NCT02537548
- Testing
- Laboratory Biomarker Analysis, Retroperitoneal Lymph Node Dissection
- Where
- 14 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Southern California
Infertility
The Comparison of Diagnostic TESE and TESA in Non-obstructive Azoospermic
Azoospermia , as the name suggests , refers to the condition in which there are no sperm in the semen. This diagnosis can come as a rude shock, because most men with a zero sperm count have normal libido; normal sexual function…
- Trial name
- NCT01210326
- Testing
- extaction, testicular sperm extraction, testicular sperm aspiration
- Where
- Iran
- Volunteers
- 180 people
- Sponsor
- Royan Institute
Male Infertility
Treatment of Severe Male Infertility - Predictive Factors (Imaging)
Testes of men with non-obstructive azoospermia (NOA) are imaged using MRI to find potential differences depending on the outcome, ie. sperm recovery in consequent microdissection testicular sperm extraction (MD-TESE).
- Trial name
- TESE-MRI (NCT02931721)
- Testing
- MRI
- Where
- 2 sites in Finland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Inguinal Hernia, Cryptorchidism
Caudal Versus Intravenous Dexmedetomidine for Supplementation of Caudal Analgesia in Children
The purpose of this study is to compare the effects of caudal dexmedetomidine with intravenous dexmedetomidine on caudal levobupivacaine analgesia in children undergoing lower abdominal surgeries.
- Trial name
- NCT01701778
- Testing
- Caudal Dexmedetomidine, Intravenous Dexmedetomidine, sevoflurane
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Yao Yusheng
Childhood Malignant Ovarian Germ Cell Tumor, Childhood Malignant Testicular Germ Cell Tumor
DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
This research trial studies deoxyribonucleic acid (DNA) samples from younger patients with germ cell tumor and their parents or siblings.
- Conditions
- Childhood Malignant Ovarian Germ Cell Tumor, Childhood Malignant Testicular Germ Cell Tumor, Ovarian Choriocarcinoma, Ovarian Embryonal Carcinoma
- Trial name
- NCT01434355
- Testing
- Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Volunteers
- 932 people
- Sponsor
- Children's Oncology Group
Semen Quality
A Clinical Trial Evaluating the Efficacy and Safety of Leflutrozole on Testicular Function
The goal of this clinical trial is to evaluate three doses of the drug leflutrozole on improvement of semen quality in men. It will also study the safety of leflutrozole.
- Trial name
- ETNA (NCT06993155)
- Testing
- Leflutrozole, Dose 1, Leflutrozole, Dose 2, Leflutrozole, Dose 3
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- ReproNovo Aps
Recurrent or Metastatic Cancer, Head and Neck Cancer
Safety and Efficacy of FalateScan (Technetium Tc 99m EC20) in Patients With Known Suspected Recurrent or Metastatic Cancer From a Solid Tumor
The folate receptor is over-expressed on many types of cancer cells and new folate receptor targeted therapies are being developed to target cancer cells that over-express the folate receptor.
- Conditions
- Recurrent or Metastatic Cancer, Head and Neck Cancer, Pancreas Cancer, Bladder Cancer
- Trial name
- NCT01684098
- Testing
- Tc 99m EC20
- Volunteers
- 40 people
- Sponsor
- Endocyte
Oxidative Stress
Oxidative Stress in Testicular Tissue Before and After Cryopreservation
The absence of sperms in ejaculated semen, is the most severe form of male-factor infertility and is present in approximately 5 % of all investigated infertile couples.
- Trial name
- NCT03621995
- Testing
- Malondialdehyde and Catalase level measurement
- Where
- Egypt
- Volunteers
- 58 people
- Sponsor
- Assiut University
Childhood Germ Cell Tumor, Leydig Cell Tumor
Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer.
- Conditions
- Childhood Germ Cell Tumor, Leydig Cell Tumor, Ovarian Cancer
- Trial name
- NCT01572467
- Testing
- RNA analysis, gene expression analysis, mutation analysis
- Volunteers
- 50 people
- Sponsor
- Children's Oncology Group
Gender Dysphoria, Adolescent
Fertility Preservation for Transfeminine Adolescents Via Semen Cryopreservation or Testicular Sperm Extraction
The goal of this observational cohort study is to identify and predict parameters for successful testicular sperm extraction (TESE) procedures or semen cryopreservation more accurately and to evaluate the decision making process…
- Trial name
- TESE (NCT06400199)
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc