Clinical trials: Testicular
Testicular Cancer
Short-term Testosterone Replacement in Testicular Cancer Survivors
To assess the effects of testosterone replacement therapy on fat mass and other components of the metabolic syndrome. A randomized double-blind placebo controlled intervention study, followed by an open-label treatment phase.
- Trial name
- NCT03339635
- Testing
- Androgel (Testosterone gel)
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- University Medical Center Groningen
Cancer
Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD)
RATIONALE: Mycophenolate mofetil added to immunosuppressive treatment regimens may be effective in treating newly diagnosed chronic graft-versus-host disease caused by stem cell transplantation.
- Trial name
- NCT00089141
- Testing
- mycophenolate mofetil
- Where
- 16 sites in United States, Canada
- Volunteers
- 151 people
- Sponsor
- Martin, Paul
Hydrocele
The Use of Ligasure (r) for Hydrocelectomy Surgery
Hydrocele is a condition of fluid retention around the testes, which causes swallowing, pain, with interfering with the normal testes function.
- Trial name
- NCT04406077
- Testing
- Ligasure
- Where
- Israel
- Volunteers
- 61 people
- Sponsor
- Hillel Yaffe Medical Center
CLDN6-positive Solid Tumor, Ovarian Cancer
A Study of ASP1893 in Adults With Advanced CLDN6-positive Solid Tumors
Before a treatment can be approved for use, clinical studies need to be done. This study is for people with certain types of cancer that have become worse and are difficult to treat.
- Conditions
- CLDN6-positive Solid Tumor, Ovarian Cancer, Endometrial Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT06681870
- Testing
- ASP1893
- Sponsor
- Astellas Pharma Global Development, Inc.
Ovarian Granulosa Cell Tumor, Ovarian Gynandroblastoma
Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors
This randomized phase II trial studies paclitaxel and carboplatin to see how well they work compared with bleomycin sulfate, etoposide phosphate, and cisplatin in treating patients with sex cord-ovarian stromal tumors that have…
- Conditions
- Ovarian Granulosa Cell Tumor, Ovarian Gynandroblastoma, Ovarian Sertoli-Leydig Cell Tumor, Ovarian Sex Cord Tumor With Annular Tubules
- Trial name
- NCT01042522
- Testing
- Bleomycin Sulfate, Carboplatin, Cisplatin
- Where
- 219 sites in United States
- Volunteers
- 63 people
- Sponsor
- GOG Foundation
Nausea and Vomiting, Testicular Germ Cell Tumor
Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma
RATIONALE: Antiemetic drugs may help to reduce or prevent nausea and vomiting in patients treated with radiation therapy. It is not yet known whether lerisetron is more effective than granisetron in preventing nausea and…
- Trial name
- NCT00004219
- Testing
- granisetron hydrochloride, lerisetron, radiation therapy
- Volunteers
- 150 people
- Sponsor
- Simbec Research
Infertility, Male, Cancer
Spermatogonial Stem Cell (SSC) Transplant and Testicular Tissue Grafting
Spermatogonial stem cell transplantation through ultrasound guided rete testis injection and testicular tissue grafting will be performed for participants who have frozen testicular tissue prior to gonadotoxic therapy.
- Conditions
- Infertility, Male, Cancer, Autoimmune Disorder
- Trial name
- NCT04452305
- Testing
- Spermatogonial Stem Cell Transplant and Testicular Tissue Grafting
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pittsburgh
Testicular Diseases
Enhancing Men's Awareness of Testicular Diseases (E-MAT): A Feasibility Trial
Hypothesis: Is it feasible to conduct a definitive trial to test the effect of E-MATVR compared to E-MATE on primary and secondary outcomes among Gaelic Athletic Association (GAA) members (players and coaches)? The overall aim of…
- Trial name
- E-MAT (NCT05146466)
- Testing
- E-MATVR, E-MATE
- Where
- Ireland
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University College Cork
Extragonadal Germ Cell Tumor, Teratoma
Combination Chemotherapy in Treating Men With Germ Cell Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Extragonadal Germ Cell Tumor, Teratoma, Testicular Germ Cell Tumor
- Trial name
- NCT00003643
- Testing
- bleomycin sulfate, filgrastim, cisplatin
- Where
- 69 sites in Austria, Belgium and 12 more
- Volunteers
- 498 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Testicular Germ Cell Cancer, Seminoma
MicroRNA as Markers in Testicular Cancer
The main objective of this study is establish the performance of miR371 in management of testicular cancer
- Conditions
- Testicular Germ Cell Cancer, Seminoma, Non-Seminoma Testicular Cancer, Stage I Testicular Cancer
- Trial name
- NCT04914026
- Testing
- Biomarker analysis
- Where
- 6 sites in Norway, Sweden
- Volunteers
- 350 people
- Sponsor
- Haukeland University Hospital
Cancer
Trastuzumab Plus R115777 in Treating Patients With Advanced or Metastatic Cancer
Phase I trial to study the effectiveness of trastuzumab plus R115777 in treating patients who have advanced or metastatic cancer.
- Trial name
- NCT00005842
- Testing
- trastuzumab, tipifarnib
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Testicular Cancer, Colorectal Neoplasms
Diagnostic Yield of Colonoscopy Surveillance in Testicular Cancer Survivors Treated With Platinum-based Chemotherapy
Testicular cancer (TC) survivors treated with platinum-based chemotherapy have an increased risk of colorectal cancer (CRC) (hazard ratio (HR) 3.9 for platinum-containing chemotherapy versus no platinum-containing chemotherapy…
- Trial name
- CATCHER (NCT04180033)
- Testing
- Colonoscopy surveillance
- Where
- 4 sites in Netherlands
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- The Netherlands Cancer Institute
Testicular Cancer
Identification of Predictive Markers for Testis Cancer in a Population of Men With High Risk
Testis cancer with germ cells is the most frequent cancer of young men and its incidence is in constant increase in many industrialized countries, as in France.
- Trial name
- NCT00820287
- Testing
- Biopsy of testicular tumor
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Testicular Appendix Torsion, Testicular Torsion
Deep Learning-Assisted Ultrasonic Diagnosis and Localization of Testicular Appendix Torsion
Ultrasound data were both retrospectively and prospectively collected from the primary center and six other sub-centers. Combined with clinical diagnostic outcomes, the data labeling was completed by physicians with extensive…
- Conditions
- Testicular Appendix Torsion, Testicular Torsion, Epididymitis
- Trial name
- NCT07301086
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ying Jiang
Recurrent Extragonadal Seminoma, Recurrent Malignant Extragonadal Germ Cell Tumor
Alvocidib and Oxaliplatin With or Without Fluorouracil and Leucovorin Calcium in Treating Patients With Relapsed or Refractory Germ Cell Tumors
This phase II trial is studying alvocidib and oxaliplatin to see how well they work when given with or without fluorouracil and leucovorin calcium in treating patients with relapsed or refractory germ cell tumors.
- Conditions
- Recurrent Extragonadal Seminoma, Recurrent Malignant Extragonadal Germ Cell Tumor, Recurrent Malignant Extragonadal Non-Seminomatous Germ Cell Tumor, Recurrent Malignant Testicular Germ Cell Tumor
- Trial name
- NCT00957905
- Testing
- Alvocidib Hydrochloride, Fluorouracil, Leucovorin Calcium
- Where
- 10 sites in United States
- Volunteers
- 36 people
- Sponsor
- National Cancer Institute (NCI)
Germ Cell Tumor, Metachronous Malignant Neoplasm
A Study of miRNA 371 in Patients With Germ Cell Tumors
This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers.
- Conditions
- Germ Cell Tumor, Metachronous Malignant Neoplasm, Seminoma, Stage I Testicular Cancer AJCC v8
- Trial name
- NCT04435756
- Testing
- Biomarker Analysis, Blood Product Collection
- Where
- 424 sites in United States, Canada and 1 more
- Volunteers
- 956 people
- Sponsor
- SWOG Cancer Research Network
Paget Disease, Extramammary, Rhabdomyosarcoma
Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors
The goal of this clinical trial is to learn if albumin-paclitaxel, ifosfamide and cisplatin (Nab-TIP) works to treat advanced rare tumors including PAGET's disease of scrotum with infiltrating sweat gland carcinoma （cohort 1）…
- Conditions
- Paget Disease, Extramammary, Rhabdomyosarcoma, Testicular Cancer, Penile Cancer
- Trial name
- NCT06684327
- Testing
- Albumin-paclitaxel Injection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Ovarian, Melanoma
Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-PP) for Patients With Advanced Cancer.
The present clinical trial is a dose comparison of a multi-component active immunotherapy designed to stimulate an immune reaction to specific tumor associated antigens which are highly expressed on a large number of solid…
- Conditions
- Ovarian, Melanoma, Renal, Prostate
- Trial name
- NCT00423254
- Testing
- PSMA/PRAME
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mannkind Corporation
Non-obstructive Azoospermia, Hormone Deficiency
Sperm Retrieval Rates in Non-obstructive Azoospermic Men Subjected to Gonadotropin Therapy
Azoospermia is defined as the complete absence of spermatozoa in the ejaculate. Two-thirds of azoospermic patients have non-obstructive azoospermia (NOA); the latter comprises up to 10% of infertile men overall.
- Conditions
- Non-obstructive Azoospermia, Hormone Deficiency, Hypogonadism, Male, Male Infertility
- Trial name
- NCT05110391
- Testing
- Hormonal Therapy Agent
- Where
- Brazil
- Volunteers
- 616 people
- Sponsor
- ANDROFERT - Clinica de Andrologia e Reproducao Humana
Cisplatin-induced Hearing Loss
ACOU085 for Hearing Loss Prevention in Testicular Cancer Patients Receiving Cisplatin
Randomized, double-blind, placebo-controlled, multicenter phase IIa clinical trial in adult male TCa patients with the risk to suffer from sensorineural hearing loss (SNHL) due to cisplatin therapy within a chemotherapeutic…
- Trial name
- PROHEAR (NCT06521190)
- Testing
- ACOU085 (bimokalner)
- Where
- 10 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Acousia Therapeutics GmbH