Clinical trials: Testosterone, active
Skeletal Muscle Physiology
Testosterone-induced Muscle Memory and Underlying Mechanisms
The purpose of this project is to investigate underlying mechanisms of testosterone- and resistance training-induced muscle hypertrophy and muscle memory in humans.
- Trial name
- NCT06188767
- Testing
- Testosterone Undecanoate
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Menopause, Sexual Dysfunction
Transdermal Testosterone Gel for Female Sexual Interest and Arousal Disorder in Peri- and Post Menopause
Hypoactive sexual desire disorder (HSDD) is described as the most common form of female sexual dysfunction, particularly affecting peri- and postmenopausal women and is associated with significant distress and reduced quality of…
- Conditions
- Menopause, Sexual Dysfunction, Libido Disorder, Testosterone Deficiency
- Trial name
- TESTA MIND (NCT07408440)
- Testing
- Transdermal testosterone gel
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Opioid Use, Pain
Pain Alleviation With Testosterone in Opioid-Induced Hypogonadism
The aim of this trial is to evaluate whether testosterone replacement results in greater improvement in pain perception, pain tolerance, sexual function, fatigue, and quality of life when compared with placebo in men with chronic…
- Conditions
- Opioid Use, Pain, Hypogonadism, Male
- Trial name
- PATH (NCT04798469)
- Testing
- Testosterone Undecanoate 250 MG/ML
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Brigham and Women's Hospital
Hypogonadism, Male, Kidney Disease, Chronic
Testosterone Treatment in Men With Chronic Kidney Disease
This study in being conducted in men who have low testosterone and chronic kidney disease. The investigators will evaluate the effects of an oral testosterone preparation, JATENZO, on testosterone levels and hemoglobin (red blood…
- Trial name
- NCT05249634
- Testing
- Jatenzo Pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Louis University
Overweight and Obesity, Hyperandrogenemia
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
The investigators will measure plasma concentrations of the hormones insulin and testosterone as well as measures of insulin sensitivity in women with overweight or obesity who have insulin resistance (IR).
- Conditions
- Overweight and Obesity, Hyperandrogenemia, Insulin Resistance
- Trial name
- WAIST (NCT06998238)
- Testing
- Mediterranean-based, carbohydrate restricted, calorie reduced diet
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Missouri-Columbia
Hypogonadism, Male, Fatigue Syndrome, Chronic
Testosterone Replacement in Male Cancer Survivors With Fatigue and Low Testosterone
The overall goal of this study is to evaluate the effect of a testosterone drug called Depo-Testosterone (or 'testosterone cypionate'), an FDA-approved drug for improving fatigue, sexual function, quality of life, body…
- Trial name
- NCT04049331
- Testing
- Testosterone Undecanoate 750 MG/3 ML Intramuscular Solution [AVEED]
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Prostate Cancer (Adenocarcinoma)
Determining INdividual Preferences for Gynecomastia avOidance (DINGO) - Stage 1
This study aims to explore the perceptions of men with prostate cancer (PCa) and high-risk biochemical recurrence (BCR) regarding the risk of breast-related side effects, including gynaecomastia, from treatment.
- Trial name
- DINGO (NCT07552922)
- Testing
- Semi-structured Interview
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- St Vincent's Hospital, Sydney
Sleep Restriction
Hormonal Mechanisms of Sleep Restriction - Axis Study
The purpose of this study is to 1) determine how hypothalamic-pituitary-adrenal axis (HPA axis) activation occurs with sleep restriction 2) evaluate how hypothalamic-pituitary-gonadal axis (HPG axis) deactivation occurs with…
- Trial name
- NCT03142893
- Testing
- Ketoconazole Pill, Ganirelix, Dexamethasone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peter y. Liu
Metastatic Prostate Cancer
High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers
This study will determine whether the presence of DNA repair deficiency in the form of alterations in the genes ATM, CDK12 or CHEK2 predicts for a high likelihood of responding to the use of intermittent high dose testosterone.
- Trial name
- VA-BAT (NCT05011383)
- Testing
- High dose testosterone
- Where
- 17 sites in United States
- Volunteers
- 51 people
- Sponsor
- VA Office of Research and Development
Male Hypogonadism, Testosterone Deficiency
Clinical Evaluation of Subcutaneous Testosterone Implants in Men With Symptomatic Hypogonadism
Introduction: Male hypogonadism is a clinical syndrome associated with significant consequences for health and quality of life. In Brazil, approved testosterone replacement therapy options are limited to injectable formulations…
- Conditions
- Male Hypogonadism, Testosterone Deficiency, Testosterone Replacement Therapy, Testosterone
- Trial name
- NCT07500766
- Testing
- Subcutaneous Testosterone Implants
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Klinefelter Syndrome
Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome
The study seeks primarily to determine whether modulation of systemic and testicular sex steroids balance by aromatase inhibitors will positively affect the metabolic health and spermatogenesis of men with Klinefelter syndrome…
- Trial name
- KLIN-HEALTH (NCT05586802)
- Testing
- Anastrozole, Semaglutide, human chorionic gonadotropin
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Georgios Papadakis
Hypogonadism, Male, Cancer
Improving Cancer-related Fatigue, Sexual Dysfunction and Quality of Life in Older Men With Cancer and Androgen Deficiency
This is a large randomized, double-blind, placebo-controlled trial to determine the efficacy of testosterone replacement on cancer-related fatigue in older men with solid or hematologic (blood) cancer who report fatigue and have…
- Conditions
- Hypogonadism, Male, Cancer, Fatigue
- Trial name
- TEMEC (NCT04301765)
- Testing
- testosterone 1.62% gel
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Insulin Sensitivity
Insulin Sensitivity and Testosterone Response to Aerobic Exercise Versus Added Sugar Elimination in Polycystic Ovary Syndrome Women
the aim of this study is to investigate the effect of aerobic exercise versus the effect of added sugar elimination on the insulin sensitivity and testosterone levels in females with polycystic ovarian syndrome via measuring the…
- Trial name
- NCT07139275
- Testing
- aerobic exercise, added sugar elimination, aerobic exercise and added sugar elimination
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Weaning Failure, Muscle Weakness
TESTO-TRIAL: Use of Testosterone in Critically Ill Patients
The objective of this study is to evaluate whether the use of the anabolic agent testosterone cypionate in critically ill patients, compared to placebo, increases the number of ventilator-free days
- Conditions
- Weaning Failure, Muscle Weakness, Mechanical Ventilation Complication, ICU Acquired Weakness
- Trial name
- TT (NCT06592144)
- Testing
- Testosterone cypionate (200mg/3ml), Sesame oil (3ml)
- Where
- Brazil
- Volunteers
- 94 people
- Sponsor
- Leticia Maria Defendi Barboza Marson
Gonadal Dysfunction, Gonadal Failure
Fertility Enhancement Through Regenerative Treatment in Ovaries and Testes
This study investigates the safety and efficacy of stem cell or stem cell-derived exosome therapy for gonadal failure, including testicular failure, hypogonadism, ovarian insufficiency, and premature ovarian failure (POF).
- Conditions
- Gonadal Dysfunction, Gonadal Failure, Azoospermia, Testosterone Deficiency
- Trial name
- FERTILE (NCT06841328)
- Testing
- Stem cells
- Where
- United Arab Emirates
- Volunteers
- 60 people
- Sponsor
- Jumeirah American Clinic
Vulvodynia, Dyspareunia
Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled Trial
We are looking to see if patients using both topical testosterone and estrogen will have a greater improvement in pain with vaginal penetration compared to those using topical estrogen alone.
- Conditions
- Vulvodynia, Dyspareunia, Lichen Sclerosus of Vulva
- Trial name
- NCT07260825
- Testing
- Estradiol 0.01% Vag Cream, testosterone 0.1% and estradiol 0.01% vaginal cream
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- TriHealth Inc.
Hypogonadotropism
A Dose Ranging Study to Examine TDS-Testosterone 5%
This study is a continuation of previous studies done in healthy volunteers to prove the efficacy of delivering Testosterone, the male hormone, rapidly across intact skin in s series of doses from low to high in men with…
- Trial name
- PARC-T-D (NCT01894308)
- Testing
- Testosterone, Pump Sprayer
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Transdermal Delivery Solutions Corp
Prostate Cancer
Difluoromethylornithine and High Dose Testosterone With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer
Asymptomatic patients with metastatic castrate resistant prostate cancer (mCRPC) without pain due to prostate cancer will be treated on an open label study to evaluate effectiveness of sequential treatment with the combination of…
- Trial name
- NCT06059118
- Testing
- DFMO, testosterone cypionate, Luteinizing hormone-releasing hormone (LHRH) analogue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Spinal Cord Injuries, Endothelial Dysfunction
Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life.
- Conditions
- Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency
- Trial name
- NCT07227740
- Testing
- Intra-arterial Infusion of Vasoactive Agents, Intra-arterial Vitamin C Infusion, Blood Sampling
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Craig Hospital
Prostatic Neoplasms, Hypogonadism
Impact of Peri-operative tEstosterone Levels on oNcological and Functional Outcomes in RadiCal prostatEctomy
Sexual dysfunction is a common side effect of radical prostatectomy (RP) and has a significant negative impact on quality of life.
- Conditions
- Prostatic Neoplasms, Hypogonadism, Testosterone Deficiency
- Trial name
- ENFORCE (NCT04833426)
- Testing
- Testosterone gel
- Where
- 10 sites in Netherlands
- Volunteers
- 140 people
- Sponsor
- Canisius-Wilhelmina Hospital