Clinical trials: Testosterone Replacement Therapy
Obesity and Hypogonadism
Lifestyle Intervention and Testosterone Replacement in Obese Seniors
The prevalence of obesity in Veterans is greater than in the general population, and even more so among users of the VA Health Care System.
- Trial name
- LITROS (NCT02367105)
- Testing
- Testosterone, Lifestyle Therapy
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- VA Office of Research and Development
Prostate Cancer, Hypogonadism, Male
Testosterone Replacement Therapy in Hypogonadal Patients With Prostate Cancer Under Active Surveillance
The purpose of this study is evaluate the safety of testosterone replacement therapy in men with newly diagnosed low-risk prostate cancer and hypogonadism on active surveillance.
- Trial name
- NCT07278362
- Testing
- Testosterone cypionate
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Miami
Hypogonadism
Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure
To further characterize the transfer potential of marketed testosterone gel and new 1.62% formulation.
- Trial name
- NCT00998933
- Testing
- Testosterone gel 1.62%
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Solvay Pharmaceuticals
Type 2 Diabetes, Hypogonadism
Reandron in Diabetic Men Witn Low Testosterone Level
In men with type 2 diabetes, low testosterone levels have been associated with insulin resistance, truncal obesity and symptoms such as fatigue and erectile dysfunction.
- Trial name
- NCT00613782
- Testing
- Reandron 1000
- Where
- Australia
- Volunteers
- 88 people
- Sponsor
- Austin Health
Breast Cancer, Arthralgia
Androgen Therapy for Breast Cancer Patients With Aromatase Inhibitor Induced Side-Effects
The purpose of this study is to evaluate whether increasing blood levels of androgen can reduce some of the side-effects of anti-estrogen therapy (Arimidex)
- Conditions
- Breast Cancer, Arthralgia, Osteoporosis
- Trial name
- ART2 (NCT00497458)
- Testing
- Testosterone
- Where
- Australia
- Volunteers
- 90 people
- Sponsor
- Havah Therapeutics Pty Ltd
Spinal Cord Injury, Spinal Cord Injuries
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial
Spinal cord injury (SCI) results in lower limb muscle loss, bone loss, and high fat mass that impede the recovery of physical function, increase bone fracture risk, and worsen health and quality of life.
- Conditions
- Spinal Cord Injury, Spinal Cord Injuries, Injuries, Spinal Cord, Spinal Cord Contusion
- Trial name
- TRT-SCI (NCT07742553)
- Testing
- testosterone cypionate, finasteride
- Where
- 4 sites in United States
- Volunteers
- 300 people
- Sponsor
- VA Office of Research and Development
Hypogonadism
The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism
The study is designed to answer the following questions: 1) What is the effect of testosteron replacement treatment on the endothelial dysfunction. 2/ What is the effect of testosteron replacement on the bone mineral metabolism.
- Trial name
- NCT02111473
- Testing
- Testosterone
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people
- Sponsor
- Gulhane School of Medicine
Physical Frailty, Hip Fracture
Exercise and Testosterone Therapy in Elderly Men With Physical Frailty
The primary aim of this study is to determine, in hypogonadal older men with physical frailty, whether exercise training combined with testosterone replacement therapy can improve skeletal muscle strength, and lean mass, to a…
- Conditions
- Physical Frailty, Hip Fracture, Elective Hip Replacement, Hypogonadism
- Trial name
- NCT00345969
- Testing
- Transdermal Testosterone gel (1%), Supervised exercise training
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injury
TRT in Combination With Electrical Stimulation and Standing: Effect on Muscle and Bone in Spinal Cord Injured Males
The aim of this study is to understand what happens to muscle and bone in spinal cord injured males after four months of training using stand training, with body weight support (BWS), with testosterone replacement therapy (TRT)…
- Trial name
- NCT02317640
- Testing
- Testosterone Gel applied by a pump, Stand Training, Electrical Stimulation
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Kessler Foundation
Hypogonadism
Testosterone Replacement in Men With Diabetes and Obesity
The purpose of this study is to examine the effect of having testosterone deficiency in men with diabetes and with obesity. The study will also evaluate the effect of testosterone therapy.
- Trial name
- NCT01127659
- Testing
- testosterone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- University at Buffalo
Male Hypogonadism, Testosterone Deficiency
Clinical Evaluation of Subcutaneous Testosterone Implants in Men With Symptomatic Hypogonadism
Introduction: Male hypogonadism is a clinical syndrome associated with significant consequences for health and quality of life. In Brazil, approved testosterone replacement therapy options are limited to injectable formulations…
- Conditions
- Male Hypogonadism, Testosterone Deficiency, Testosterone Replacement Therapy, Testosterone
- Trial name
- NCT07500766
- Testing
- Subcutaneous Testosterone Implants
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Peripheral Vascular Disease
Testosterone Replacement in Diabetes With Vascular Disease (Version 2)
Diabetes is a major cause of peripheral vascular disease(PVD) and is associated with male hypogonadism. Diabetes and PVD are both associated with arterial stiffness and intima -media thickness which are also related to severity…
- Trial name
- NCT00355537
- Testing
- Testosterone, 0.9% saline
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Barnsley Hospital
Hot Flushes, Menopause, Postmenopause
Comparison of Estrogen and Methyltestosterone Combination Treatments for Postmenopausal Hot Flushes
This is a research study to evaluate the effectiveness, safety and side effects of several dose levels of esterified estrogens (EE) and methyltestosterone (MT) given individually and in combination compared to a placebo (a tablet…
- Trial name
- NCT00160342
- Testing
- Esterified Estrogens (EE) and Methyltestosterone (MT)
- Where
- 125 sites in United States, Canada and 1 more
- Volunteers
- 1,251 people
- Sponsor
- Solvay Pharmaceuticals
Nonalcoholic Steatohepatitis, Hypogonadism
Testosterone Replacement in Non-alcoholic Steatohepatitis (TEREPINS)
The main research questions are: In hypogonadal men with non-alcoholic steatohepatitis (NASH), does Testosterone Replacement Therapy (TRT), given for 12 months 1.
- Trial name
- TEREPINS (NCT01919294)
- Testing
- testosterone undecanoate
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Healthy
An Open-Label Study of Serum Testosterone Levels in Non-dosed Females After Secondary Exposure to Testosterone Gel 1.62% Applied to the Upper Arms and Shoulders and Use of a T-shirt Barrier
Single-center, single dose, open-label study in healthy male and female volunteers to further characterize the transfer potential of Testosterone Gel 1.62% formulation.
- Trial name
- NCT01130298
- Testing
- Testosterone Gel 1.62%
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AbbVie
Hypoactive Sexual Desire Disorder
Study of Transdermal Testosterone Patches in Surgically Menopausal Women With Low Libido
This study is designed to evaluate efficacy and safety of a testosterone patch as treatment for low libido in surgically menopausal women who are taking estrogen therapy.
- Trial name
- NCT00331214
- Testing
- Testosterone Transdermal System
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 533 people
- Sponsor
- Warner Chilcott
Hypogonadotrophic Hypogonadism
The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism
The study searched for answers to two questions 1. What is the effect of testosterone replacement therapy on endothelial dysfunction, inflammation and insulin resistance? 2.
- Trial name
- NCT01533129
- Testing
- Testogel 50 mg transdermal gel, Testosterone 250mg injection
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Gulhane School of Medicine
Hypogonadism
Testosterone Therapy in Hypogonadal Men Treated With Opioids
The purpose of this study is to evaluate the efficacy of testosterone replacement therapy in men with low testosterone due to opioid treatment on body composition, the haemostatic system, glucose metabolism, muscle function, pain…
- Trial name
- NCT02433730
- Testing
- Testosterone
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Marianne Andersen
Hypogonadism, Malignant Urinary System Neoplasm
Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone
This phase I trial investigates the safety of testosterone replacement therapy around the time of major urologic surgery (perioperative) in order to improve quality of life and post-operative outcomes such as decreased length of…
- Conditions
- Hypogonadism, Malignant Urinary System Neoplasm, Urinary System Disorder, Urinary System Neoplasm
- Trial name
- NCT04731376
- Testing
- Best Practice, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Emory University
Hypogonadism, Male
Single-Dose Pharmacokinetics of Oral Testosterone Undecanoate With and Without Concomitant Inhibition of UGT2B17
This study will be performed in normal men whose endogenous testosterone production has been temporarily suppressed by the administration of a single dose of 120 mg of the oral GnRH antagonist Relugolix, which is approved for the…
- Trial name
- OralT12 (NCT06312761)
- Testing
- Relugolix 120Mg Tab, Curcumin, Testosterone Undecanoate 237 MG Oral Capsule
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington