Clinical trials: The Cardiac Function
Acute Myocardial Infarction
MAGIC Cell-5-Combicytokine Trial
Combination use of darbepoetin and G-CSF will improve left ventricular systolic function in patients with acute myocardial infarction who receive intracoronary infusion of mobilized peripheral blood stem cell in comparison with…
- Trial name
- MAGIC Cell-5 (NCT00501917)
- Testing
- G-CSF with/without darbepoetin, peripheral blood stem cell infusion
- Where
- South Korea
- Volunteers
- 116 people
- Sponsor
- Seoul National University Hospital
Posttraumatic Stress Disorder (PTSD), Depression - Major Depressive Disorder
To Investigate the Change of Brain and Autonomic Function From Different Protocols of Repeated Transcranial Magnetic Stimulation Therapy for Patients With Post-traumatic Stress Disorder Comorbid Major Depressive Disorder
This study aims to investigate the immediate neurophysiological and autonomic effects of two noninvasive brain stimulation protocols-prolonged intermittent theta-burst stimulation (prolonged iTBS) and high-frequency repetitive…
- Trial name
- NCT07327385
- Testing
- Prolonged Intermittent Theta-Burst Stimulation (prolonged iTBS), High-Frequency Repetitive Transcranial Magnetic Stimulation (HF-rTMS)
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Breast Neoplasms
The Impact of Chronic Mitochondrial Antioxidant Supplementation on CardiovascularToxicity in Breast Cancer Patients
Investigate the protective effect of chronic MitoQ supplementation on cardiovascular toxicity induced by doxorubicin-based adjuvant chemotherapy in breast cancer patients.
- Trial name
- NCT05146843
- Testing
- Mitoquinone
- Volunteers
- 44 people
- Sponsor
- D'Or Institute for Research and Education
Coronary Artery Disease, Percutaneous Coronary Intervention
Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.
Patients who undergo percutaneous coronary intervention (PCI) are commonly treated with antiplatelet therapy to prevent stent thrombosis and recurrence of events.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndromes, Antiplatelet Therapy
- Trial name
- HI-TECH 2 (NCT07582835)
- Testing
- Clopidogrel, Ticagrelor, Prasugrel
- Where
- Switzerland
- Volunteers
- 355 people
- Sponsor
- Cardiocentro Ticino
Heart Disease
Magnetic Resonance Imaging of the Blood Vessels of the Heart
This study is directed at evaluating patients with "myocardial ischemia" or poor blood supply to the heart muscle due to coronary artery disease.
- Trial name
- NCT00001638
- Where
- 2 sites in United States
- Volunteers
- 2,916 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Bypass Graft, Chronic Kidney Disease
Evaluation of the Bone Mineral Density and Muscle Mass in Patients Post Coronary Artery Bypass Graft Surgery With Chronic Kidney Disease
The purposes of this study are: (1) to compare the body composition, physical activity, physical function, and quality of life between patients with and without CKD after CABG; and (2) to analyze the relationships among body…
- Trial name
- NCT01932008
- Volunteers
- 60 people
- Sponsor
- Far Eastern Memorial Hospital
Coronary Artery Disease Acute Coronary Syndrome Myocardial Ischemia Plaque Characterization
The AIPLAQUE Study: An Artificial Intelligence-based Prospective Study to Analyze PLAQUE Using CCTA
This trial is a single-center, prospective, observational clinical study. All patients who have at least one coronary artery stenosis of 30%-90% in diameter ≥ 2mm confirmed by CCTA, and who are scheduled to undergo clinically…
- Trial name
- NCT05750082
- Testing
- CCTA CT-FR CAG OCT
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Harbin Medical University
Atrial Fibrillation, Pulsed-field Ablation
Pulsed-field Ablation for Patients With Asymptomatic Non-paroxysmal Atrial Fibrillation
The goal of the study is to test the hypothesis whether the treatment of patients with asymptomatic non-paroxysmal AF based on catheter ablation will be superior than conservative approach consisting of electrical cardioversion…
- Conditions
- Atrial Fibrillation, Pulsed-field Ablation, Functional Exercise Testing
- Trial name
- NCT06166524
- Testing
- Catheter ablation for atrial fibrillation using pulsed-field energy, Conservative arm
- Where
- Czechia
- Volunteers
- 124 people
- Sponsor
- Charles University, Czech Republic
Diabetes Mellitus, Type 2, Cardiomyopathy, Dilated
Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function
Accumulation of lipid in skeletal and cardiac muscle has been associated with insulin resistance and diabetic cardiomyopathy. In skeletal muscle, lipotoxic damage has been suggested to lead to dysfunction of mitochondria.
- Trial name
- ACP (NCT00943059)
- Testing
- Acipimox, Cellulosum Mycrocryst
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Type 2
Exercise Study on Cardiac Function in Patients With Diabetes Mellitus Type 2 and Diastolic Dysfunction
The aim of the study is to compare the effects of aerobic interval training and the IDF recommendations on physical activity on cardiac function and CV risk factors in patients with diabetes.
- Trial name
- NCT01206725
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Congestive Heart Failure
The Registry Evaluating Functional Outcomes of Resynchronization Management
The purpose of this study is to evaluate the functional outcomes of resynchronization management and to describe the patient psychosocial characteristics (depression ad anxiety) and associated outcomes with electrophysiologic…
- Trial name
- REFORM (NCT00959179)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Saint Luke's Health System
Non-small Cell Lung Cancer, Esophageal Cancer
Radiation-induced Toxicity of the Heart
Late side effects in radio(chemo)therapy [R(CH)T] pose a critical limitation to patients' overall survival and quality of life. Even though toxicities of the heart are highly relevant for patients with cancer in the thoracic…
- Conditions
- Non-small Cell Lung Cancer, Esophageal Cancer, Breast Cancer Female
- Trial name
- CorTox (NCT06986291)
- Testing
- Imaging and biomarkers
- Where
- Germany
- Volunteers
- 325 people
- Sponsor
- Technische Universität Dresden
Heart Failure, Obstructive Sleep Apnea
ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea.
Obstructive sleep apnea (OSA), central sleep apnea (CSA) and heart failure (HF) are states of metabolic demand and sympathetic nervous system (SNS) activation.
- Conditions
- Heart Failure, Obstructive Sleep Apnea, Central Sleep Apnea
- Trial name
- AMEND (NCT02116140)
- Testing
- [C11]Acetate and HED PET
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Stable Coronary Artery Disease, Percutaneous Coronary Intervention
Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery Disease
The purpose of this study is to conduct a single-center, randomized, open-label, controlled, dose-escalating, parallel-group study, evaluating the effects and change of endothelial function and gut microbiota after berberine…
- Trial name
- NCT04434365
- Testing
- Berberine, Aspirin, Clopidogrel
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Tricuspid Regurgitation, Heart Failure With Preserved Ejection Fraction
Enavogliflozin Outcome Trial in Functional Tricuspid Regurgitation
The Enavogliflozin Outcome Trial in Functional Tricuspid Regurgitation (EVENT) was designed to examine the hypothesis that, compared with placebo, therapy with the SGLT2 inhibitor enavogliflozin would improve clinical and…
- Trial name
- EVENT (NCT06027307)
- Testing
- Enavogliflozin
- Where
- 5 sites in South Korea
- Volunteers
- 541 people
- Sponsor
- Asan Medical Center
Heart Failure
Erythropoietin Treatment in Patients With Systolic Left Ventricular Dysfunction, Mild Anemia and Normal Renal Function
Erythropoietin Treatment in Patients with systolic left ventricular dysfunction, mild anemia and normal renal function
- Trial name
- NCT00418119
- Testing
- erythropoietin
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Hypertension, Pre Hypertension
Breathing Exercises of CardioBreath Application on Autonomic and Vascular Function in Hypertension
Hypertension is one of the greatest public health challenges, affecting more than one billion people worldwide and representing a significant financial and public health burden.
- Trial name
- CardioBreath (NCT06917729)
- Testing
- CardioBreath
- Where
- 2 sites in Brazil
- Volunteers
- 66 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Hypertrophic, Familial
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
- Trial name
- NCT02862600
- Testing
- Perhexiline, Use of bioanalytical assay to monitor plasma levels of perhexiline
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Heart Metabolics Limited
Cerebral Palsy, Autonomic Nerveus System
BioFeedBack Breathing Training Influence Cardiac Autonomic Nervous System in Children With Cerebral-Palsy.
The effect of breathing biofeedback training to influence the function of the cardiac autonomic nervous system at rest and in activity in children with cerebral palsy.
- Trial name
- NCT01872507
- Testing
- Biofeedback training
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hadassah Medical Organization
Breast Cancer, Cardiac Toxicity
BreAst Cancer and Cardiotoxicity Induced by RAdioTherapy: the BACCARAT Study
Breast radiotherapy RT used until the 1990s was clearly responsible for increased mortality due to long term cardiac complications.
- Trial name
- BACCARAT (NCT02605512)
- Testing
- Subclinical cardiac lesions and biomarkers
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Sophie JACOB