Clinical trials: The Effectiveness of Anesthesia
Healthy Volunteer
Study to Compare Active Tymbion Iontophoresis to Sham Tymbion Iontophoresis for Anesthesia of the Tympanic Membrane
A prospective, multicenter study to determine if active Tymbion iontophoresis is superior to sham Tymbion iontophoresis in providing anesthesia to the tympanic membrane (TM).
- Trial name
- ADEPT (NCT03119181)
- Testing
- Tymbion Lidocaine/epinephrine solution, Device: Iontophoresis System (IPS) with Drug: Tymbion lidocaine/epinephrine solution
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tusker Medical
Anesthesia, General
Efficacy and Safety of Ciprofol Compared to Propofol for Nonintubated General Anesthesia in Patients Undergoing TAVR
The purpose of this study is to explore the efficacy and safety of ciprofol compared to propofol for non-intubated general anesthesia in patients undergoing transcatheter aortic valve replacement (TAVR).
- Trial name
- NCT05035069
- Testing
- Ciprofol, Propofol
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Hypotension, Ischemia
Phase III Study of Hemospan® to Prevent Hypotension in Hip Arthroplasty
The purpose of this study is to determine whether Hemospan is superior to Voluven for preventing hypotensive episodes during the perioperative period (from induction of spinal anesthesia until 6 hours after skin closure), and for…
- Trial name
- NCT00421200
- Testing
- Hemospan (MP4OX), Voluven (HES 130/0.4)
- Where
- 18 sites in Belgium, Czechia and 4 more
- Volunteers
- 375 people
- Sponsor
- Sangart
No Disease State or Condition
Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
The purpose of this study is to determine if the topical application to gingival tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT03233737
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Any Ear Nose or Throat Conditions, With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities
Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia
Randomized, prospective, multi-center, double blind placebo-controlled parallel group study of a Placebo Topical Solution versus Cocaine HCl 4% Topical Solution for safety and efficacy, and Cocaine HCl 4% and 10% Topical Solution…
- Trial name
- NCT02500836
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- United States
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Acute Pain
Efficacy and Safety in a Randomised Acute Pain Study of MR308: STARDOM2.
The MR308-3502 study is a multicenter double-blind, randomised, placebo- and active comparator-controlled study in female subjects to evaluate the efficacy and safety of MR308 with acute pain after TAH or STAH (total or subtotal…
- Trial name
- STARDOM2 (NCT03062644)
- Testing
- MR308
- Where
- 8 sites in Belarus, Bulgaria and 6 more
- Volunteers
- 1,138 people
- Sponsor
- Mundipharma Research GmbH & Co KG
Anesthesia, General, Neuromuscular Blockade
Comparison of 2.0 mg/kg Sugammadex and Neostigmine at Reappearance of T2 in Chinese and European Subjects (Study 19.4.324)(P05768AM1)(COMPLETED)
The present trial was set up to evaluate the efficacy and safety of 2.0 mg.kg-1 sugammadex compared to neostigmine administered at reappearance of T2 in Chinese and Caucasian subjects for registration purposes in China.
- Trial name
- NCT00825812
- Testing
- Sugammadex, neostigmine
- Volunteers
- 308 people
- Sponsor
- Merck Sharp & Dohme LLC
Anesthesia
Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Pediatric Patients
The purpose of this study is to compare the efficacy of Kovacaine Mist, and Placebo for inducing pulpal anesthesia of the maxillary teeth in pediatric patients.
- Trial name
- NCT01844830
- Testing
- Tetracaine HCl 3% and Oxymetazoline HCl 0.05%
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- St. Renatus, LLC
Anesthesia
A Multicenter, Open, Controlled, Phase III Clinical Study to Evaluate the Efficacy and Safety of Cipepofol Injection for General Anesthesia in Pediatric Patients Undergoing Elective Surgery
A multicenter, open, controlled, Phase III clinical study to evaluate the efficacy and safety of Cipepofol injection for general anesthesia in pediatric patients undergoing elective surgery
- Trial name
- NCT06391931
- Testing
- Cipepofol, Propofol
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Haisco Pharmaceutical Group Co., Ltd.
Anesthesia
Comparison of Anesthetic Efficacy of Bilateral and Unillateral Application of Kovacaine Mist in Healthy Volunteers
To compare the efficacy of Kovacaine Mist administered bilaterally to that of Kovacaine Mist administered unilaterally with respect to global profound pulpal anesthesia in target teeth numbers 4-13.
- Trial name
- NCT02457806
- Testing
- Tetracaine HCl 3% and Oxymetazoline HCl 0.05%
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- St. Renatus, LLC
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Tracheal Intubation in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia with tracheal intubation. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07252921
- Testing
- HRS-9190
- Where
- 2 sites in China
- Volunteers
- 70 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Catheter Site Pain, Pain, Acute
A Study to Evaluate the Efficacy and Safety of Zingo in Chinese Children
The purpose of the study is to evaluate the efficacy and safety of Zingo in treating pain associated with venipunture and peripheral venous cannulation.
- Conditions
- Catheter Site Pain, Pain, Acute, Anesthesia, Local
- Trial name
- NCT03653260
- Testing
- Lidocaine (Zingo)
- Where
- China
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Lee's Pharmaceutical Limited
Anesthesia, Surgical Procedures, Elective
A Safety and Efficacy Study of Dexmedetomidine in Patients Requiring Sedation During Monitored Anesthesia Care (MAC)
The objective of this study is to evaluate the safety and efficacy of dexmedetomidine as compared to placebo when used for the sedation of subjects requiring monitored anesthesia care (MAC).
- Trial name
- NCT00398827
- Testing
- Dexmedetomidine
- Where
- 27 sites in United States
- Volunteers
- 326 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Neuromuscular Blockade
Safety and Efficacy of HRS-9190 Compared to Rocuronium for Bolus Maintenance in Adults
The study will enroll adult patients scheduled for elective surgery requiring general anesthesia. Participants will be randomly assigned to receive either HRS-9190 for Injection or Rocuronium.
- Trial name
- NCT07404579
- Testing
- HRS-9190, Rocuronium
- Where
- 2 sites in China
- Volunteers
- 103 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Anesthesia
Experimental Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 Anesthetic Spray in Normal Volunteers
The purpose of this study is to determine if the topical application to cheek tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT02908620
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, Two sprays CTY-5339-A
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Anesthesia
Dose-Ranging Study of Intranasal Kovacaine Mist in Pediatric Subjects
The purpose of this study is to assess the efficacy and safety of intranasally administered Kovacaine Mist for anesthetizing maxillary teeth in pediatric subjects.
- Trial name
- NCT01701505
- Testing
- 400uL of Kovacaine Mist, 200uL of Kovacaine Mist, 120uL of Kovacaine Mist
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- St. Renatus, LLC
Rotator Cuff Tear
InSpace™ System Implantation in a Procedure Under Local Anesthesia
The study objective is to assess the feasibility, efficacy and safety of the InSpace™ Device implantation in a surgical procedure under local anesthesia using arthroscopic and/or fluoroscopic visualization of the affected…
- Trial name
- NCT02208453
- Testing
- InSpace Implantation
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- OrthoSpace Ltd.
General Anaesthesia, Induction of Anaesthesia
Efficacy and Safety Study of Two Propofol Formulations
The purpose of the study to compare Propofol-MCT/LCT with LCT in terms of their efficacy and safety during total intravenous anaesthesia
- Trial name
- NCT00506246
- Testing
- Propofol
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- B. Braun Melsungen AG
Anesthesia
Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth
The purpose of this study is to compare the efficacy of Kovacaine Mist, Tetracaine only, and Placebo for inducing pulpal anesthesia of the maxillary teeth in adults.
- Trial name
- NCT01660893
- Testing
- Tetracaine HCl 3% and oxymetazoline HCl 0.05%, Tetracaine HCl 3%
- Where
- 3 sites in United States
- Volunteers
- 26 people
- Sponsor
- St. Renatus, LLC
Sedation
Clinical Study to Investigate the Efficacy and the Safety of DA-9501 in Sedation During the Surgery With Epidural Anesthesia or Spinal Anesthesia Without Intubation
The purpose of this study is to examine the efficacy and safety of DA-9501 (Dexmedetomidine) in patients who require sedation during the surgery that requires epidural or spinal anesthesia without intubation under monitored…
- Trial name
- NCT01438957
- Testing
- Dexmedetomidine hydrochloride
- Where
- 12 sites in Japan
- Volunteers
- 119 people
- Sponsor
- Pfizer